CPS1000_Analysis
15 January 2026
This R code includes the analyses and figures of the CPS1000 manuscript, written by Kevin D. Hofer and Junyan Lu.
1 Setup
library(knitr)
options(digits=3, width=80)
opts_chunk$set(echo=TRUE,tidy=FALSE,include=TRUE)1.1 Load libraries
library(ggpmisc)
suppressMessages(library(RColorBrewer))
suppressMessages(library(ggrepel))
suppressMessages(library(cowplot))
suppressMessages(library(gridExtra))
suppressMessages(library(drc))
suppressMessages(library(tidyverse))
detach("package:dplyr")
suppressMessages(library(dplyr))
library("survminer")
library("survival")
library("maxstat")
library("patchwork")
library("glmnet")
library("corrplot")
library("writexl")
library("ggplot2")
library("flextable")
library("ggpubr")
library("ComplexHeatmap")
library("circlize")
library("grid")
library("RColorBrewer")
library("ggplotify")
library("magrittr")
library("Rtsne")
library("paletteer")
library("ggtext")
library("ggh4x")
library("plotrix")
library("scales")
library("corrplot")
library("gridGraphics")
library("draw")
library("stringr")
#maintain function of specific R packages
rename <- dplyr::rename
count <- dplyr::count
filter <- dplyr::filter1.2 Define figure themes
theme_figures <- theme_classic()+
theme(plot.title = element_text(size=8, hjust=0.5, face="bold"),
axis.text = element_text(color="black", size=8),
axis.title = element_text(size=8),
axis.line = element_line(size=0.5),
legend.title = element_text(size=8, face="bold"),
legend.text = element_text(size=8),
legend.key.size = unit(0.5, 'cm'))## Warning: The `size` argument of `element_line()` is deprecated as of ggplot2 3.4.0.
## ℹ Please use the `linewidth` argument instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.theme_figures_angle45_x <- theme_classic()+
theme(plot.title=element_text(size=8, hjust=0.5, face="bold"),
axis.text.x = element_text(color="black", angle = 45, hjust=1, vjust=1, size=8),
axis.text.y = element_text(size=8),
axis.title = element_text(size=8),
legend.title = element_text(size=8, face="bold"),
legend.text = element_text(size=8),
axis.line = element_line(size=0.5),
legend.key.size = unit(0.5, 'cm'))
theme_figures_facet <- theme_bw() +
theme(strip.text.y = element_text(size = 0),
strip.text.x = element_text(size=8),
strip.background.y = element_rect(color=NA),
axis.text = element_text(size=8, color="black"),
axis.title = element_text(size=8, color="black"),
panel.spacing = unit(0.15, "lines"),
legend.position = "none",
panel.border = element_rect(color = "black", linewidth = 0.75, fill = NA),
panel.grid = element_blank(),
strip.background = element_rect(color = "black", linewidth = 0.75, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"))
theme_figures_facet_angle60_x <- theme_bw() +
theme(strip.text.y = element_text(size = 0),
strip.text.x = element_text(size=8),
strip.background.y = element_rect(color=NA),
axis.text.y = element_text(size =8, color="black"),
axis.text.x = element_text(angle = 60, hjust = 1, vjust = 1, size=8, color = "black"),
panel.spacing = unit(0.15, "lines"),
legend.title = element_text(size = 8),
panel.border = element_rect(color = "black", linewidth = 0.75, fill = NA),
strip.background = element_rect(color = "black", linewidth = 0.75, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8))
#set colors
colors_diag <- setNames(c("#1F78B4", "#B2DF8A", "#A6CEE3", "grey", "#E31A1C", "#FB9A99", "#FF7F00", "#CAB2D6"), c("MCL", "CLL", "T-PLL", "other", "AML", "T-ALL", "B-ALL", "B-PLL"))
colors_diag_IGHV <- setNames(c("#1F78B4", "#B2DF8A", "#33A02C", "grey80", "#E31A1C", "#FB9A99", "#FF7F00", "#CAB2D6", "#A6CEE3"), c("MCL", "U-CLL", "M-CLL", "other", "AML", "T-ALL", "B-ALL", "B-PLL", "T-PLL"))
colors_pathways_mod <- setNames(c("lightgrey", "#BC80BD", "#FCCDE5", "#B3DE69", "#FDB462", "#80B1D3", "#FB8072", "#BEBADA", "#FFFFB3", "#8DD3C7"), c("other", "AKT/mTOR", "DNA damage response", "Chemotherapy" , "MAPK" , "B-cell receptor", "PI3K", "Stress pathway", "Bromodomain/PLK", "JAK/STAT"))
colors_cor_heatmap <- setNames(c("#BC80BD", "#FDB462", "#80B1D3", "#FB8072", "#BEBADA"), c("AKT/mTOR", "MEK/ERK" , "B-cell receptor", "PI3K", "Stress pathway"))
colors_drug_type <- c("Chemo" = "#9a6a3d", "Kinase" = "#6A3D9A", "Other" = "#3d9a6a")1.3 Define functions
1.3.1 Functions for supplementary tables
stab_theme <- function(ft) {
ft |>
theme_alafoli() |>
autofit() |>
fontsize(size = 8, part = "header") |>
fontsize(size = 8, part = "body") |>
padding(padding.top = 3, padding.bottom = 3, part = "all") |>
align(align = "left", part = "body") |>
align(align = "left", part = "header") |>
bold(part = "header") |>
width(j = 1, width = 1.25) |>
width(j = 2, width = 3.5) |>
width(j = 3, width = 0.75) |>
line_spacing(space = 1, part = "all") |>
color(color = "black", part = "all")
}1.3.2 Functions for analyses (???)
#function for t-test
tTest <- function(val, fac) {
res <- t.test(val ~ fac, var.equal = TRUE)
data.frame(p = res$p.value,
mean1 = res$estimate[[1]],
mean2 = res$estimate[[2]],
diff = res$estimate[[2]] - res$estimate[[1]])
}
#helper function for mean viability boxplots
create_boxplot <- function(data, diagnosis_filter, colors, title) {
#order drugs by median viability
drug_order <- data |>
filter(diagnosis == diagnosis_filter) |>
group_by(drug) |>
summarise(median = median(mean_viab)) |>
arrange(desc(median)) |>
pull(drug)
#filter and reorder data
plot_data <- data |>
filter(diagnosis == diagnosis_filter) |>
mutate(drug = factor(drug, levels = drug_order))
#create plot
plot_data |>
filter(diagnosis == diagnosis_filter) |>
ggplot(aes(x=mean_viab, y=drug, color=diagnosis))+
geom_boxplot(alpha=0.8, outlier.shape=NA) +
geom_jitter(alpha=0.2, size=0.2, width = 0.15)+
scale_x_continuous(name ="Mean viability", breaks=seq(0,1.2, 0.2), limits=c(0,1.2))+
theme_bw() +
theme(
axis.text = element_text(color = "black", size = 8),
axis.title = element_text(size = 8),
plot.title = element_text(size = 8, hjust = 0.5, face = "bold"),
legend.position = "none",
panel.border = element_rect(color = "black", linewidth = 1, fill = NA)) +
labs(y = "", x = "Mean viability", title = title) +
scale_color_manual(values = colors_diag_IGHV)
}2 Load data
2.1 File path
# Modify according to directory
#filepath <-"../../"
filepath <- "~/Dropbox/Medizin/Forschung/Aktuelle Forschungsprojekte/CLL CPS1000/figures/github/"2.2 Load processed CPS1000 data
load(paste0(filepath,"data/CPS1000_data.RData"))Description of datasets:
- screen: processed DMSO-normalized ex vivo viability measurements for all patients and drugs
- drugs: list of drugs used in the screen
- patients: list of patients with corresponding diagnoses
- metadata: annotation of genetic aberrations
- treatments: treatment contexts for the longitudinal analysis of paired samples
- survival: overall survival and time-to-treatment data
3 Drugs
3.1 Drug overview (Fig. 2A)
#prepare data
drugs <- drugs |> as.data.frame()
as.factor(drugs$Pathway)## [1] MYC Apoptosis PI3K/AKT/mTOR
## [4] EGFR Histone methylation JAK/STAT
## [7] DNA damage response PI3K/AKT/mTOR FGFR
## [10] DNA damage response ITK ALK
## [13] Chemotherapy MAPK Chemotherapy
## [16] Wnt MAPK ABL (BCR)
## [19] Chemotherapy PI3K/AKT/mTOR Histone methylation
## [22] Chemotherapy HGF Stress pathway
## [25] B-cell receptor PI3K/AKT/mTOR ABL (BCR)
## [28] TLR MAPK DNA damage response
## [31] MEN1 Chemotherapy MEN1
## [34] PKC PI3K/AKT/mTOR TLR
## [37] DNA damage response DNA damage response Stress pathway
## [40] B-cell receptor Bromodomain Cell cycle control
## [43] Histone deacetylation Cytoskeleton B-cell receptor
## [46] Cytokine receptor PI3K/AKT/mTOR DNA damage response
## [49] JAK/STAT MAPK MAPK
## [52] Nuclear export DNA damage response Histone methylation
## [55] Cytokine receptor JAK/STAT Cell cycle control
## [58] MAPK Apoptosis Apoptosis
## [61] Hedgehog PLK MAPK
## 28 Levels: ABL (BCR) ALK Apoptosis B-cell receptor ... WntFig2a <- ggplot(drugs, aes(x = factor(Pathway))) +
geom_bar(aes(fill = Type)) +
scale_fill_brewer(palette = "PuRd", direction = 1) +
labs(y="Number of drugs", x="", fill="Drug type") +
theme_figures_angle45_x +
scale_y_continuous(expand = c(0.01,0), breaks=c(1,2,3,4,5,6,7,8)) +
scale_x_discrete(expand = c(0.025,0)) +
theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig2a
ggsave(path=(paste0(filepath,"figures")), filename = "Fig2a_drug_compounds.svg")## Saving 12 x 6 in image3.2 Drug list
#prepare data
drugs$Drug <- drugs$Drug |>
gsub("\\.", "-", x = _) |>
gsub("D4476", "D 4476", x = _) |>
gsub("IRAK1/4 Inhibitor I", "IRAK-1/4 Inhibitor I", x = _) |>
gsub("SB-203580", "SB 203580", x = _)
drugs$Drug <- sort(drugs$Drug)
drug_list <- drugs |>
dplyr::select(Drug, Target, Pathway) #add supplier
drugs$Drug## [1] "10058-F4" "A-1210477" "A-674563"
## [4] "Afatinib" "AMI-1" "AZD1208"
## [7] "AZD6738" "AZD8055" "BGJ398"
## [10] "BML-277" "BMS-509744" "Ceritinib"
## [13] "Cisplatin" "Cobimetinib" "Cytarabine"
## [16] "D 4476" "Dabrafenib" "Dasatinib"
## [19] "Doxorubicine" "Duvelisib" "EPZ-6438"
## [22] "Fludarabine" "Foretinib" "Ganetespib"
## [25] "Ibrutinib" "Idelalisib" "Imatinib"
## [28] "IRAK-1/4 Inhibitor I" "JNK-IN-8" "KU-55933"
## [31] "Menin-MLL Inhibitor" "Methotrexate" "MI-503"
## [34] "Midostaurin" "MK-2206" "Motolimod"
## [37] "Nutlin-3a" "Olaparib" "Onalespib"
## [40] "ONO-4059" "OTX015" "Palbociclib"
## [43] "Panobinostat" "PF-3758309" "PRT062607"
## [46] "Quizartinib" "Rapamycin" "RO5963"
## [49] "Ruxolitinib" "SB 203580" "SCH772984"
## [52] "Selinexor" "Selisistat" "SGC 0946"
## [55] "Sunitinib" "Tofacitinib" "Tozasertib"
## [58] "Trametinib" "TW-37" "Venetoclax"
## [61] "Vismodegib" "Volasertib" "ZM 336372"stab3 <- flextable(drug_list) # |> stab_theme()
ft_grob <- gen_grob(stab3, fit = "width", scaling = "min", hjust = 0)
STab3 <- ggplot() +
annotation_custom(ft_grob) +
theme_void() +
theme(plot.margin = margin(t = 1, r = 1, b = 1, l = 1, unit = "cm"))
ggsave(width=21, height=29.7, units = "cm", path=(paste0(filepath,"tables")), filename = "STab3_drugs_and_targets.svg")4 Patient characteristics
4.1 Diagnoses (Fig. 2C)
#prepare data
patients <- patients |>
filter(diagnosis != "") |>
as.data.frame()
patients$cohort <- patients$cohort |>
str_replace("IC50", "IC50 + CPS1000") |>
as.factor()
Fig2c <- ggplot(patients, aes(x = forcats::fct_infreq(diagnosis))) +
geom_bar(aes(fill = cohort)) +
geom_text(stat = "count", aes(label = after_stat(count)), vjust = -0.5, size=2.5) +
scale_fill_brewer(palette = "Greens", direction =-1)+
labs(y="Number of patients", x="", fill="Drug screen")+
theme_figures_angle45_x +
scale_y_continuous(expand = c(0.02,0), breaks=seq(0,300,50), limits = c(0,300))+
scale_x_discrete(expand = c(0.04,0)) +
theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig2c
ggsave(path=(paste0(filepath,"figures")), filename = "Fig2c_disease_distribution.svg")## Saving 12 x 6 in image4.2 Longitudinal data (Fig. 2D)
#prepare data
treatments$sample1 <- gsub("-[1234]$", "", treatments$sample1)
treatments$sample2 <- gsub("-[1234]$", "", treatments$sample2)
length(unique(treatments$patientID))## [1] 110#merge data
sample_date <- survival[,1:3]
merged_table <- merge(treatments, sample_date, by.x="sample1", by.y="sampleID", all.x=TRUE) |>
merge(patients[,c("patientID", "diagnosis")], by="patientID") |>
dplyr::rename(sampleDate1 = sampleDate)
#add date for 2. sampling and calculate time interval
merged_table <- merge(sample_date, merged_table, by.x="sampleID", by.y="sample2", ) |>
dplyr::rename(sample2 = sampleID, sampleDate2 = sampleDate) |>
dplyr::select(c(patientID, sample1, sample2, sampleDate1, sampleDate2, diagnosis)) |>
mutate(diff = sampleDate2-sampleDate1)
#plot
merged_table$diff <- as.numeric(merged_table$diff)
summary(merged_table$diff)## Min. 1st Qu. Median Mean 3rd Qu. Max.
## 7 224 515 578 884 1757Fig2d <- ggplot(merged_table, aes(x="", y=diff)) +
geom_boxplot(color="black", linewidth=0.5, outliers = FALSE, width=0.4) +
geom_jitter(width = 0.1, alpha = 0.75, size=1, color="#74c476")+
theme_figures+
labs(x = "", y = "Days between samples")+
theme(axis.ticks.x = element_blank())+
scale_y_continuous(expand = c(0.02,0), breaks=c(seq(0,1750,500))) +
theme(plot.margin = margin(t=1, r=1, l=1, b=1, unit="cm"))
Fig2d
ggsave(path=(paste0(filepath,"figures")), filename = "Fig2d_interval_samples.svg")## Saving 3 x 6 in image4.3 Oncoprint of genetic alterations in the CLL cohort (Fig. 2E)
#prepare data
#remove del5IgH
oncoprint_data <- merge(patients, metadata, by.x="patientID", by.y="Patient.ID") |>
filter(diagnosis.x == "CLL") |>
dplyr::select(!del5IgH)
#remove the first two columns (IGHV.status and Methylation_Cluster)
matrix_data <- as.matrix(oncoprint_data[, -c(1:13)])
rownames(matrix_data) <- oncoprint_data$patientID
genetic_variations <- t(matrix_data)
#exclude aberrations with less than 8 events
genetic_variations <- data.matrix(genetic_variations)
genetic_variations_num <- matrix(as.numeric(genetic_variations), ncol = 275)## Warning in matrix(as.numeric(genetic_variations), ncol = 275): NAs introduced
## by coercionrownames(genetic_variations_num) <- rownames(genetic_variations)
colnames(genetic_variations_num) <- colnames(genetic_variations)
genetic_variations_num <- as.data.frame(genetic_variations_num)
genetic_variations_num$count <- rowSums(!(is.na(genetic_variations_num) | genetic_variations_num == 0))
genetic_variations_num <- genetic_variations_num |>
filter(count >7)
#re-adjust matrix für heatmap
genetic_variations_num[genetic_variations_num==0]<-""
genetic_variations_num[is.na(genetic_variations_num)]<-""
genetic_variations_red <- dplyr::select(genetic_variations_num, !count)
genetic_variations_red <- as.matrix(genetic_variations_red)
#annotations
#annotation for IGHV status
ighv_anno <- oncoprint_data[,"IGHV.status"]
ighv_anno <- ighv_anno %>% replace(is.na(.), "unknown")
ighv_colors <- colorRampPalette(brewer.pal(9, "Set1"))(length(unique(ighv_anno)))
annotation_colors <- setNames(ighv_colors, unique(ighv_anno))
#annotation for Methylation
meth_anno <- oncoprint_data[,"Methylation_Cluster"]
meth_anno <- factor(meth_anno, levels = c("HP", "IP","LP", "unknown"))
meth_anno <- meth_anno %>% replace(is.na(.), "unknown")
meth_colors <- colorRampPalette(brewer.pal(8, "Set2"))(length(unique(meth_anno)))
annotation_colors_meth <- setNames(meth_colors, unique(meth_anno))
#annotation for center
center_anno <- oncoprint_data[,"project"]
center_anno <- factor(center_anno, levels = c("HD", "HD-DNA", "H68", "MIR34a", "FB", "NOV", "MDACC", "MUN", "HCL_HD_Andrulis", "OX", "BARC", "ZCH_2"))
center_colors <- colorRampPalette(brewer.pal(3, "Paired"))(length(unique(center_anno)))
#change center label
center_anno <- fct_recode(center_anno,
"Zürich" = "ZCH_2",
"Barcelona" = "BARC",
"Heidelberg" = "HD")
annotation_colors_center <- setNames(center_colors, unique(center_anno))
#change IGHV label
ighv_anno <- fct_recode(ighv_anno,
"mutated" = "M",
"unmutated" = "U")
annotation_colors <- setNames(ighv_colors, unique(ighv_anno))
ha <- HeatmapAnnotation(Center = center_anno, IGHV = ighv_anno, Methylation = meth_anno, annotation_name_gp = gpar(fontsize = 8), col = list(Center = annotation_colors_center, IGHV = annotation_colors, Methylation = annotation_colors_meth), annotation_legend_param = list(
Center = list(
title_gp = gpar(fontsize = 8, fontface = "bold"),
labels_gp = gpar(fontsize = 8)
),
IGHV = list(
title_gp = gpar(fontsize = 8, fontface = "bold"),
labels_gp = gpar(fontsize = 8)
),
Methylation = list(
title_gp = gpar(fontsize = 8, fontface = "bold"),
labels_gp = gpar(fontsize = 8)
)))
heatmap_legend_param = list(title="Alteration", at = c("1"), title_gp = gpar(fontsize = 8), labels_gp = gpar(fontsize = 8))
#create the oncoprint
oncoprint <- oncoPrint(
genetic_variations_red,
alter_fun = list(
background = function(x, y, w, h) {
grid.rect(x, y, w, h, gp = gpar(fill = "#F8F8F8", col = "white"))
},
"1" = function(x, y, w, h) grid.rect(x, y, w, h, gp = gpar(fill = "black", col = "white")), col = "white"),
col = c("1" = "black"), na_col = "white",
remove_empty_rows = FALSE,
remove_empty_columns = FALSE,
row_names_gp = gpar(fontsize = 8),
column_names_gp = gpar(fontsize = 8),
row_names_side = "left", pct_side = "right", pct_digits = 1,
right_annotation = rowAnnotation(row_barplot = anno_oncoprint_barplot(c("1"), border = FALSE, height = unit(4, "cm"), axis_param = list(side = "bottom", labels_rot = 0))),
pct_gp = gpar(fontsize = 8), top_annotation = ha, heatmap_legend_param = heatmap_legend_param)## All mutation types: 1.## `alter_fun` is assumed vectorizable. If it does not generate correct
## plot, please set `alter_fun_is_vectorized = FALSE` in `oncoPrint()`.draw(oncoprint, heatmap_legend_side = "left", annotation_legend_side = "right", show_heatmap_legend = FALSE)
Fig2e <- grid.grabExpr(draw(oncoprint, heatmap_legend_side = "left", annotation_legend_side = "right", show_heatmap_legend = FALSE))
ggsave(Fig2e, path=(paste0(filepath,"figures")), filename = "Fig2e_CLL_genetic_landscape.svg")## Saving 12 x 8 in image5 Drug response
5.1 Comparison with previous data sets (Fig. 2B)
#prepare data
screen <- screen |>
as.data.frame()
colnames(screen) <- colnames(screen) |>
gsub("\\.", "-", x = _) |>
gsub("X10058-F4", "10058-F4", x = _) |>
gsub("D4476", "D 4476", x = _) |>
gsub("IRAK1-4-Inhibitor-I", "IRAK-1/4 Inhibitor I", x = _) |>
gsub("Menin-MLL-Inhibitor", "Menin-MLL Inhibitor", x = _) |>
gsub("SB-203580", "SB 203580", x = _) |>
gsub("SGC-0946", "SGC 0946", x = _) |>
gsub("ZM-336372", "ZM 336372", x = _)
screen_long <- patients |>
as.data.frame() |>
arrange(patientID) |>
dplyr::select (patientID, diagnosis) |>
merge(screen) |>
pivot_longer(cols = c(4:318), names_to = "drug", values_to = "viability")
#merge with concentrations by drug group (see Table S1)
concentrations_A <- c(10, 2, 0.4, 0.08, 0.016)
concentrations_B <- c(2, 0.4, 0.08, 0.016, 0.0032)
concentrations_C <- c(0.4, 0.08, 0.016, 0.0032, 0.00064)
drug_list <- list(
A = concentrations_A,
B = concentrations_B,
C = concentrations_C
)
#add concentrations
screen_long <- screen_long |>
mutate(
conc_index = as.numeric(str_extract(drug, "\\d+$")),
drug = str_replace(drug, "_\\d+$", "")
) |>
left_join(drugs |>
dplyr::select(Drug, Group), by = c("drug" = "Drug")) |>
rowwise() |>
mutate(concentration = drug_list[[Group]][conc_index]) |>
ungroup()
#load data from IC50 screen (Dietrich et al. 2018)
IC50 <- read.csv("~/Dropbox/Medizin/Forschung/Aktuelle Forschungsprojekte/CLL CPS1000/raw data/IC50_170823.csv") #adjust
#preparate data for IC50 screen, create bins
IC50 <- IC50 |>
mutate(bin = cut(Concentration, breaks=c(0.004, 0.033, 0.156, 0.625, 2.5, 10, 40))) |>
filter(!is.na(bin))
#plot
density_cps1000 <- ggplot(screen_long, aes(viability)) +
geom_density(aes(fill=factor(concentration)), alpha=0.3, linewidth=0.25) +
labs(y="Densitiy", x="Viability", title="CPS1000", fill = expression(bold(paste("Concentration (", mu, "M)"))))+
theme_figures+
scale_fill_brewer(palette = "Blues", direction = 1)+
scale_y_continuous(expand = c(0.02,0))+
scale_x_continuous(limits=c(0,1.25), expand = c(0.02,0))
density_ic50 <- ggplot(IC50, aes(normVal)) +
geom_density(aes(fill=factor(bin)), alpha=0.3, linewidth=0.25) +
labs(y="Densitiy", x="Viability", title="IC50 (Dietrich et al. 2018)", fill = expression(bold(paste("Concentration (", mu, "M)"))))+
theme_figures+
scale_fill_brewer(palette = "Reds", direction = 1, labels = c("0.004 to 0.033", "0.033 to 0.156", "0.156 to 0.625", "0.625 to 2.5", "2.5 to 10", "10 to 40"))+
scale_y_continuous(expand = c(0.02,0))+
scale_x_continuous(limits=c(0,1.25), expand = c(0.02,0))
Fig2b <- density_cps1000 + density_ic50 & theme(plot.margin = margin(r=1, l=0.5, t=0.5, b=0.5, unit="cm"))
Fig2b## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).## Warning: Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).
ggsave(path=(paste0(filepath,"figures")), filename = "Fig2c_density_plots.svg")## Saving 12 x 4 in image## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).
## Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).## Warning: Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).5.2 Drug response patterns (Fig. 3A)
#cap supravital viability results (cut-off <1.2)
screen_long$viability[screen_long$viability>1.2] <- 1.2
screen_long$viability[screen_long$viability<0] <- 0
#show diseases separately with at least 10 samples
pat_nr_per_disease <- patients |>
group_by(diagnosis) |>
summarize(n_pat = n()) |>
arrange(desc(n_pat))
diagnoses_show <- pat_nr_per_disease |>
filter(n_pat >=10) |>
pull(diagnosis)
df_tsne <- patients[,c("patientID", "diagnosis")] |>
merge(screen, by="patientID") |>
dplyr::select(-patientID, -sampleID) |>
mutate(diagnosis= case_when(diagnosis %in% diagnoses_show ~ diagnosis,
TRUE ~ "other"))
#split dataframe in measures and subsetting
df_meas <- df_tsne[, !names(df_tsne) %in% "diagnosis"]
df_subset <- df_tsne[, names(df_tsne) %in% "diagnosis"]
#define order
order <- c("AML", "B-ALL", "B-PLL", "CLL", "MCL", "T-ALL", "T-PLL", "other")
df_subset <- factor(df_tsne$diagnosis, levels = order)
#t-sne
set.seed(12)
tsne_results <- Rtsne(df_meas, perplexity=25, check_duplicates = FALSE)
#plot
tsne_plot <- data.frame(
x = tsne_results$Y[,1],
y = tsne_results$Y[,2],
diagnosis = df_subset
)
Fig3a <- ggplot(tsne_plot) +
geom_point(aes(x=x, y=y, color=diagnosis), size=2, alpha=0.8) +
theme_figures+
labs(color="Diagnosis")+
scale_color_manual(values=colors_diag)+
theme(plot.margin = margin(t=2, b=2, r=1, l=1, unit="cm"))
Fig3a
ggsave(path=(paste0(filepath,"figures")), filename = "Fig3a_tsne.svg")## Saving 6 x 6 in image5.3 Mean viability by drug and disease
5.3.1 Overall Heatmap (Fig. 3B)
#prepare data
screen_long_topdiag <- screen_long |>
mutate(diagnosis = case_when(diagnosis %in% diagnoses_show ~ diagnosis,
TRUE ~ "other"))
#calculate mean viability
screen_means <- screen_long_topdiag |>
group_by(patientID, diagnosis, drug) |>
summarize(mean_viab = mean(viability))## `summarise()` has grouped output by 'patientID', 'diagnosis'. You can override
## using the `.groups` argument.screen_means## # A tibble: 28,665 × 4
## # Groups: patientID, diagnosis [455]
## patientID diagnosis drug mean_viab
## <chr> <chr> <chr> <dbl>
## 1 P0001 CLL 10058-F4 0.998
## 2 P0001 CLL A-1210477 0.983
## 3 P0001 CLL A-674563 0.898
## 4 P0001 CLL AMI-1 1.00
## 5 P0001 CLL AZD1208 0.871
## 6 P0001 CLL AZD6738 0.980
## 7 P0001 CLL AZD8055 0.912
## 8 P0001 CLL Afatinib 0.863
## 9 P0001 CLL BGJ398 1.04
## 10 P0001 CLL BML-277 1.06
## # ℹ 28,655 more rows#merge with metadata for IGHV status in CLL, drop CLL without IGHV annotation
ighv <- metadata[, names(metadata) %in% c("Patient.ID", "IGHV.status")]
screen_means_ighv <- merge(screen_means, ighv, by.x = "patientID", by.y= "Patient.ID") |>
mutate(diagnosis = case_when(IGHV.status == "U" ~ "U-CLL",
IGHV.status == "M" ~ "M-CLL",
TRUE ~ diagnosis)) |>
filter (diagnosis != "CLL") |>
dplyr::select(-IGHV.status)
#prepare for heatmap
df <- screen_means_ighv |>
dplyr::select(-diagnosis) |>
pivot_wider(names_from = patientID, values_from = mean_viab)
df_use <- df |>
dplyr::select(-drug) |>
colnames()
df_subset <- df |>
dplyr::select(-drug)
#diagnoses
df_diagnoses <- screen_means_ighv |>
filter(drug == "10058-F4") |>
dplyr::select(patientID, diagnosis)
#add pathways
df_pathway <- drugs[, names(drugs) %in% c("Drug", "Pathway_mod")]
df_combined <- merge(df_pathway, df, , by.x = "Drug", by.y = "drug")
#order pathways and diagnoses
df_combined$Pathway_mod <- factor(df_combined$Pathway_mod,
levels = c("AKT/mTOR", "B-cell receptor", "Bromodomain/PLK", "Chemotherapy",
"DNA damage response", "JAK/STAT", "MAPK", "PI3K", "Stress pathway", "other"))
df_diagnoses$diagnosis <- factor(df_diagnoses$diagnosis,
levels = c("AML", "B-ALL", "B-PLL", "M-CLL", "MCL", "T-ALL", "T-PLL", "U-CLL", "other"))
#scale
x <- data.frame(df_subset)
y <- data.frame(t(scale(t(x))))
#create matrix
rownames(y) = df$drug
colnames(y) = colnames(df_subset)
z <- as.matrix(y)
#annotations
color_fun_reversed <- colorRamp2(c(4, median(z), -4), c("red", "white", "blue"))
ha = HeatmapAnnotation(
Diagnosis = df_diagnoses$diagnosis,
annotation_name_gp = gpar(fontsize = 8),
col = list(Diagnosis = colors_diag_IGHV),
annotation_legend_param = list(
Diagnosis = list(
title_gp = gpar(fontsize = 8, fontface = "bold"),
labels_gp = gpar(fontsize = 8),
nrow = 2
)
)
)
pway <- as.data.frame(df_combined[,1:2])
pway_ordered = pway[match(rownames(z), pway$Drug), ]
ha2 = rowAnnotation(
Pathway = pway_ordered$Pathway_mod,
annotation_name_gp = gpar(fontsize = 8),
col = list(Pathway = colors_pathways_mod),
annotation_legend_param = list(
Pathway = list(
title_gp = gpar(fontsize = 8, fontface = "bold"),
labels_gp = gpar(fontsize = 8),
nrow = 2
)
)
)
#heatmap
h1 <- Heatmap(z, name = "Z-score", show_row_names = TRUE, show_column_names=FALSE, row_names_gp = gpar(fontsize = 8), width = ncol(z)*unit(0.25, "mm"), height = nrow(z)*unit(3.5, "mm"), col = color_fun_reversed, top_annotation = ha, left_annotation = ha2, show_column_dend = FALSE, row_km = 4, row_title = NULL,
show_parent_dend_line = FALSE, heatmap_legend_param = list(direction = "horizontal", title_gp = gpar(fontsize = 8, fontface = "bold"), labels_gp = gpar(fontsize = 8)))
set.seed(1234)
#set spacing to legend
ht_opt(HEATMAP_LEGEND_PADDING = unit(1.5, "cm"))
Fig3b <- grid.grabExpr(draw(h1, merge_legends = TRUE, heatmap_legend_side = "bottom"))
# Reset options
ht_opt(RESET = TRUE)
#save?5.3.2 Drug-specific heatmaps (Fig. S2)
5.3.3 Overview of drug effects (Fig. 3C)
#create diagnosis-specific means
screen_mean_diag <- screen_long |>
group_by(diagnosis, drug) |>
summarize(mean_diag = mean(viability)) |>
filter(diagnosis %in% diagnoses_show) |>
pivot_wider(names_from = diagnosis, values_from = mean_diag)## `summarise()` has grouped output by 'diagnosis'. You can override using the
## `.groups` argument.#create heatmap
w <- screen_mean_diag[, names(screen_mean_diag) != "drug"]
rownames(w) = screen_mean_diag$drug## Warning: Setting row names on a tibble is deprecated.w <- as.matrix(t(w))
set.seed(123)
ha = rowAnnotation(foo = anno_text(rownames(w), gp = gpar(fontsize=8), just="right", offset=1))## Warning: `offset` is deprecated, use `location` instead.column_ha = HeatmapAnnotation(foo = anno_text(colnames(w), gp = gpar(fontsize=8), just = "left", offset =0))## Warning: `offset` is deprecated, use `location` instead.h2 <- Heatmap(w, name = "Mean viability", left_annotation = ha,
top_annotation = column_ha,
show_row_names = FALSE, show_column_names=FALSE, width = ncol(z)*unit(0.45, "mm"), height = nrow(z)*unit(0.4, "mm"), show_row_dend=TRUE, row_dend_side = "left", show_column_dend=FALSE,
row_dend_width = unit(7, "mm"), heatmap_legend_param = list(title_gp = gpar(fontsize = 8, fontface = "bold"), labels_gp = gpar(fontsize = 8)))
Fig3c_top <- draw(h2, heatmap_legend_side = "right", padding = unit(c(2, 2, 0, 2), "mm"))
#extract heatmap order
clustered_col_indices <- column_order(h2)## Warning: The heatmap has not been initialized. You might have different results
## if you repeatedly execute this function, e.g. when row_km/column_km was
## set. It is more suggested to do as `ht = draw(ht); column_order(ht)`.clustered_col_names <- colnames(w)[clustered_col_indices]
#create patient-specific means
screen_mean_pat <- screen_long |>
filter(diagnosis %in% diagnoses_show) |>
group_by(drug, patientID) |>
summarize(mean_pat = mean(viability)) |>
merge(drugs[,c("Drug", "Category")], by.x="drug", by.y="Drug") |>
mutate(drug = factor(drug, levels = clustered_col_names)) |>
arrange(drug)## `summarise()` has grouped output by 'drug'. You can override using the
## `.groups` argument.#add boxplots
Fig3c_bottom <- ggplot(screen_mean_pat, aes(x=drug, y=mean_pat, color=Category))+
geom_boxplot(alpha=0.6, outlier.shape=NA) +
geom_jitter(alpha=0.1, size=0.2, width = 0.15)+
theme_figures+
theme(axis.text.x = element_text(color="black", size=8, angle=90, hjust=1, vjust=0.5),
legend.position = "bottom",
panel.spacing = unit(0, "mm"),
plot.margin = margin(t=0, b=2, r=33, l=21, unit = "mm"))+
scale_y_continuous(name ="Mean viability", breaks=seq(0,1.2, 0.2), limits=c(0,1.2)) +
scale_x_discrete(name="")+
scale_color_manual(values=colors_drug_type, name = "Drug type", labels=c("Chemotherapy", "Kinase inhibitor", "Other"))
Fig3c_bottom## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
Fig3c_bottom_aligned <- ggdraw(Fig3c_bottom) +
theme(plot.margin = margin(0, 0, 0, 0))## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).Fig3c <- plot_grid(grid.grabExpr(draw(h2, heatmap_legend_side = "right")), Fig3c_bottom_aligned, ncol=1, rel_heights = c(0.5, 0.5))
#save?5.3.4 Disease-specific drug effects
5.3.4.1 Overview (Fig. S3 and S4)
#create plots
aml <- create_boxplot(screen_means_ighv, "AML", colors_diag_IGHV, "AML")
ball <- create_boxplot(screen_means_ighv, "B-ALL", colors_diag_IGHV, "B-ALL")
tall <- create_boxplot(screen_means_ighv, "T-ALL", colors_diag_IGHV, "T-ALL")
SFig3 <- plot_grid(aml, ball, tall, NULL, NULL, ncol = 5, nrow = 1)## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 31 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 21 rows containing missing values or values outside the scale range
## (`geom_point()`).ggsave(path=(paste0(filepath,"figures")), filename = "SFig3_viab_leucemia.svg", width=42, height=20, units = "cm")
bpll <- create_boxplot(screen_means_ighv, "B-PLL", colors_diag_IGHV, "B-PLL")
mcll <- create_boxplot(screen_means_ighv, "M-CLL", colors_diag_IGHV, "M-CLL")
mcl <- create_boxplot(screen_means_ighv, "MCL", colors_diag_IGHV, "MCL")
ucll <- create_boxplot(screen_means_ighv, "U-CLL", colors_diag_IGHV, "U-CLL")
tpll <- create_boxplot(screen_means_ighv, "T-PLL", colors_diag_IGHV, "T-PLL")
SFig4 <- plot_grid(bpll, mcll, mcl, ucll, tpll, ncol = 5, nrow = 1)## Warning: Removed 3 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 51 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 3 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 22 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 4 rows containing missing values or values outside the scale range
## (`geom_point()`).ggsave(path=(paste0(filepath,"figures")), filename = "SFig4_viab_lymphoma.svg", width=42, height=20, units = "cm")5.3.4.2 Heatmap (Fig. 3D)
#prepare data
diagnoses_show_ighv <- c(diagnoses_show, "U-CLL", "M-CLL")
diagnoses_show_ighv <- diagnoses_show_ighv[diagnoses_show_ighv != "CLL"]
viabTab.mean <- screen_means_ighv |>
filter(diagnosis %in% diagnoses_show_ighv)
#create p-values
allDiag <- unique(viabTab.mean$diagnosis)
pTabAll <- lapply(allDiag, function(diagBase) {
#calculate p value matrix
pTab <- lapply(allDiag[allDiag != diagBase], function(diagCompare) {
testTab <- filter(viabTab.mean, diagnosis %in% c(diagBase, diagCompare)) |>
mutate(diagnosis = factor(diagnosis, levels = c(diagBase,diagCompare)))
res <- group_by(testTab, drug) |> do(tTest(.$mean_viab, .$diagnosis)) |>
mutate(diagCompare = diagCompare, diagBase = diagBase)
res
}) |> bind_rows() |> ungroup() |> mutate(p.adj = p.adjust(p, method = "BH"))
}) |> bind_rows()
#prepare data table for plot
plotTab <- pTabAll |> mutate(p = ifelse(p < 1e-12, 1e-12, p)) |>
mutate(pSign = -log10(p)*sign(diff)) |>
mutate(pSign = ifelse(p.adj < 0.1, pSign, 0)) |>
ungroup()
#order drugs by their association similarity (hierarchical clustering)
pMat <- mutate(plotTab, diagPair = paste0(diagBase,"_",diagCompare)) |>
dplyr::select(drug, pSign, diagPair) |>
spread(key = diagPair, value = pSign) |> data.frame() |>
column_to_rownames("drug") |> as.matrix()
#cut
set.seed(123)
nClust = 9
hcRes <- hclust(dist(pMat), method = "ward.D2")
drugOrder <- rownames(pMat)[hcRes$order]
clustMap <- cutree(hcRes,nClust)
diagOrder <- c("U-CLL", "M-CLL","MCL", "B-PLL", "T-PLL", "B-ALL", "T-ALL","AML")
plotTab <- mutate(plotTab, drug = factor(drug, levels = drugOrder),
diagBase = factor(diagBase, levels= diagOrder),
diagCompare = factor(diagCompare, levels = diagOrder)) |>
arrange(drug) |> mutate(drugClust = paste0("",nClust-clustMap[as.character(drug)]+1))
#color strips in y-direction
strip <- strip_themed(background_y = elem_list_rect(fill = "white"))
#add pathway annotation
plotTab <- merge(plotTab, drugs[,c("Drug", "Pathway_mod")], by.x="drug", by.y="Drug")
#plot
main_plot <- ggplot(plotTab, aes(x=diagCompare, y = drug, fill = pSign)) +
geom_tile(size = 0.3, color = "white") +
facet_grid2(rows = vars(drugClust), cols = vars(diagBase), scales = "free", space = "free_y", strip = strip) +
scale_fill_gradient2(
high = "blue", mid = "white", low = "red", midpoint = 0)+
theme_figures_facet_angle60_x+
labs(fill = "**-log<sub>10</sub>*P*<br>with direction**") +
theme(legend.title = ggtext::element_markdown())+
ylab("") + xlab("")## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.main_plot
#add pathway annotation
anno_plot <- ggplot(plotTab, aes(x = diagCompare, y = drug, fill = Pathway_mod)) +
geom_tile(size = 0.3) +
facet_grid(rows = vars(drugClust), scales = "free", space = "free_y") +
scale_fill_manual(values = colors_pathways_mod,
name = "Drug Class")+
theme_minimal() +
theme(axis.text = element_blank(),
axis.title = element_blank(),
panel.grid = element_blank(),
panel.border = element_rect(linewidth = 0.75),
panel.background = element_blank(),
plot.background = element_blank(),
strip.text.y = element_blank(),
panel.spacing = unit(0.15, "lines"),
legend.position = "none")
Fig3d <- ggdraw() +
draw_plot(main_plot, x=0,y=0,width=1,height=1)+
draw_plot(anno_plot,x=0.8612,y=0.0765,width=0.03,height=0.895) &
theme(plot.margin = margin(t=1, unit="cm"))
ggsave(path=(paste0(filepath,"figures")), filename = "Fig3d_pvalue_heatmap.svg", width=42, height=30, units = "cm")5.3.4.3 Drug ranking
#prepare data
#rank drugs
rankTab <- screen_long |>
group_by(patientID, drug, diagnosis) |>
summarise(meanViab = mean(viability)) |>
dplyr::ungroup()## `summarise()` has grouped output by 'patientID', 'drug'. You can override using
## the `.groups` argument.medTab <- screen_long |>
group_by(drug) |>
summarise(medVal = median(viability))
rankTab <- left_join(rankTab, medTab, by = "drug") |>
mutate(score = meanViab - medVal)
#make rank plot
rank_score_tab <- rankTab |>
group_by(patientID, diagnosis) |>
arrange((score)) |>
mutate(rank_score=row_number(), l2fc = log2(meanViab)-log2(medVal)) |>
ungroup()
#show ranks for AML with venetoclax and cytarabine
aml_cyt <- rank_score_tab |>
filter(diagnosis %in% c("AML")) |>
mutate(drug_col = ifelse(drug %in% c("Cytarabine"), drug, "other")) |>
ggplot(aes(x=rank_score, y=score, alpha=drug_col, group=patientID))+
geom_hline(yintercept = 0, color="grey70")+
geom_line(alpha=0.25, color="black")+
geom_point(aes(alpha=drug_col, fill=drug_col, color=drug_col), size=1.5, shape=21)+
scale_alpha_manual(values=c(0.75,0))+
scale_fill_manual(name="Drug", breaks=c("Cytarabine"), values=c("#E31A1C", ""))+
scale_color_manual(name="Drug", breaks=c("Cytarabine"), values=c("#E31A1C", ""))+
labs(title="Cytarabine", y="Score", x="Drug rank")+
theme_bw()+
theme(axis.text = element_text(color="black", size=8),
legend.position = "none", axis.title = element_text(size=8), plot.title = element_text(hjust=0.5, size=8),
panel.grid.major = element_blank(),
panel.grid.minor = element_blank(),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA))
aml_ven <- rank_score_tab |>
filter(diagnosis %in% c("AML")) |>
mutate(drug_col = ifelse(drug %in% c("Venetoclax"), drug, "other")) |>
ggplot(aes(x=rank_score, y=score, alpha=drug_col, group=patientID))+
geom_hline(yintercept = 0, color="grey70")+
geom_line(alpha=0.25, color="black")+
geom_point(aes(alpha=drug_col, fill=drug_col, color=drug_col), size=1.5, shape=21)+
scale_alpha_manual(values=c(0, 0.75))+
scale_fill_manual(name="Drug", breaks=c("Venetoclax"), values=c("#E31A1C", ""))+
scale_color_manual(name="Drug", breaks=c("Venetoclax"), values=c("#E31A1C", ""))+
labs(title="Venetoclax", y="Score", x="Drug rank")+
theme_bw()+
theme(axis.text = element_text(color="black", size=8),
legend.position = "none", axis.title = element_text(size=8), plot.title = element_text(hjust=0.5, size=8),
panel.grid.major = element_blank(),
panel.grid.minor = element_blank(),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA))
SFig8c <- aml_cyt + aml_ven + plot_annotation(title = "AML", theme = theme(plot.title = element_text(hjust=0.5, size=8, face="bold"))) + theme(plot.margin = margin(t=1, unit = "cm"))
SFig8c
#combine with IGHV annotation
cll_meta <- metadata[, c("Patient.ID", "diagnosis", "IGHV.status")] |>
filter(diagnosis == "CLL")
rank_score_tab_mod <- merge(rank_score_tab, cll_meta[,c("Patient.ID", "IGHV.status")], by.x="patientID", by.y="Patient.ID", all.x = TRUE) |>
mutate(diagnosis = case_when(IGHV.status == "U" ~ "U-CLL",
IGHV.status == "M" ~ "M-CLL",
TRUE ~ diagnosis)) |>
filter(diagnosis != "CLL")
drug_ranking_diag <- rank_score_tab_mod |>
group_by(drug, diagnosis) |>
summarize(median_score = median(score), score_sd = sd(score)) |>
arrange(median_score) |>
group_by(diagnosis) |>
mutate(rank_median = row_number())## `summarise()` has grouped output by 'drug'. You can override using the
## `.groups` argument.# plot: aml
drug_order_aml <- drug_ranking_diag |>
filter(diagnosis == "AML") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_aml)
rank_aml <- drug_ranking_diag |>
filter(diagnosis == "AML") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="Median score", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: u-cll
drug_order_ucll <- drug_ranking_diag |>
filter(diagnosis == "U-CLL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_ucll)
rank_ucll <- drug_ranking_diag |>
filter(diagnosis == "U-CLL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag_IGHV)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: m-cll
drug_order_mcll <- drug_ranking_diag |>
filter(diagnosis == "M-CLL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_mcll)
rank_mcll <- drug_ranking_diag |>
filter(diagnosis == "M-CLL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag_IGHV)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: b-all
drug_order_ball <- drug_ranking_diag |>
filter(diagnosis == "B-ALL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_ball)
rank_ball <- drug_ranking_diag |>
filter(diagnosis == "B-ALL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: t-all
drug_order_tall <- drug_ranking_diag |>
filter(diagnosis == "T-ALL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_tall)
rank_tall <- drug_ranking_diag |>
filter(diagnosis == "T-ALL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="Median score", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: mcl
drug_order_mcl <- drug_ranking_diag |>
filter(diagnosis == "MCL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_mcl)
rank_mcl <- drug_ranking_diag |>
filter(diagnosis == "MCL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="Median score", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: tpll
drug_order_tpll <- drug_ranking_diag |>
filter(diagnosis == "T-PLL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_tpll)
rank_tpll <- drug_ranking_diag |>
filter(diagnosis == "T-PLL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
# plot: bpll
drug_order_bpll <- drug_ranking_diag |>
filter(diagnosis == "B-PLL") |>
arrange(median_score) |>
pull(drug)
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_bpll)
rank_bpll <- drug_ranking_diag |>
filter(diagnosis == "B-PLL") |>
mutate(direction = sign(median_score)) |>
ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
geom_col(alpha=0.9) +
geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd),
color="black", alpha=0.75, width=0.5, linewidth=0.5)+
facet_wrap(~diagnosis) +
labs(title="", y="Median score", x="") +
theme_bw() +
guides(color="none")+
scale_fill_manual(values=colors_diag)+
theme(legend.position = "none",
axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
SFig8b <- (rank_aml+plot_spacer()+rank_ball+plot_layout(widths = c(1, -0.1 ,1)))/(rank_bpll+plot_spacer()+rank_mcll+plot_layout(widths = c(1, -0.1 ,1)))/(rank_mcl+plot_spacer()+rank_ucll+plot_layout(widths = c(1, -0.1 ,1)))/(rank_tall+plot_spacer()+rank_tpll+plot_layout(widths = c(1, -0.1 ,1))) + theme(plot.margin = margin(t=1, unit = "cm"))
#calculate global ranks
#show all diseases
global_rank_tab <- rank_score_tab_mod |>
group_by(patientID) |>
mutate(global_score = sum(score)) |>
arrange(global_score) |>
group_by(drug) |>
mutate(global_rank = row_number()) |>
filter(drug == "Ibrutinib") |>
#calculate median global rank per diagnosis
group_by(diagnosis) |>
mutate(global_score_median_diag = median(global_score),
global_rank_median_diag = median(global_rank))
#plot
diagSelected <- c("AML", "B-ALL", "T-ALL", "T-PLL", "B-PLL", "MCL", "U-CLL", "M-CLL")
global_rank_tab <- global_rank_tab |>
mutate(diag_col = ifelse(diagnosis %in% diagSelected, diagnosis, "other"))
global_rank_tab$diag_col <- factor(global_rank_tab$diag_col, levels = sort(diagSelected))
# Calculate the line for all data
reference_line <- global_rank_tab |>
arrange(global_rank) |>
dplyr::select(global_rank, global_score)## Adding missing grouping variables: `diagnosis`global_rank_tab <- global_rank_tab |>
filter(!is.na(diag_col))
score_ranking <- global_rank_tab |>
arrange(global_score_median_diag) |>
distinct(diag_col) |>
pull(diag_col)
global_rank_tab$diag_col <- factor(global_rank_tab$diag_col, levels = score_ranking)
# Now plot with facets
all_diag <- global_rank_tab |>
ggplot(aes(x=global_rank, y=global_score)) +
geom_hline(data = global_rank_tab |>
distinct(diag_col, global_score_median_diag),
aes(yintercept = global_score_median_diag),
color="grey90")+
geom_line(data = reference_line, color="grey30", linewidth=0.5, inherit.aes=TRUE) +
geom_hline(data = global_rank_tab |>
distinct(diag_col, global_score_median_diag),
aes(yintercept = global_score_median_diag),
color="grey80")+
geom_point(aes(color=diag_col), alpha=0.8, size=1.5) +
#geom_point(aes(x=global_rank_median_diag, y=global_score_median_diag), color="grey80",size=1.5, shape=21) +
facet_wrap(~diag_col, ncol=4) +
scale_alpha_manual(values=c(rep(0.5, length(diagSelected)))) +
scale_color_manual(values=colors_diag_IGHV)+
labs(title="", y="Sum of drug scores", x="Sample rank") +
theme_bw() +
guides(alpha = "none", color="none")+
theme(legend.position = "none",
axis.text.x = element_text(angle = 0, color="black", size=8),
panel.grid = element_line(colour = "white"),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
axis.title.x = element_text(size=8),
panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
plot.title = element_text(hjust=0.5, size=8, face="bold"),
strip.text = element_text(size = 8),
plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
SFig8a <- all_diag + theme(plot.margin = margin(t=1, l=1, r=1, unit = "cm"))
#multipanel
row3 <- plot_grid(SFig8c, NULL, ncol = 2, rel_widths = c(0.4, 0.6))
SFig.5 <- plot_grid(SFig8a, SFig8b, row3, rel_heights = c(0.2, 0.65, 0.15), ncol = 1,
align = "v", axis = c("l", "r"),
labels=c("A", "B", "C"), label_size=14) & theme(plot.margin=margin(r=1,l=1,t=1,b=1,unit="cm"))
ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.svg", width=42, height=59.4, units = "cm")
ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.pdf", width=42, height=59.4, units = "cm")
ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.png", width=42, height=59.4, units = "cm", dpi=600) #remove later5.3.4.4 Signature drugs at the single concentration level (multivariate binary logistic regression)
5.3.4.5 Specific drugs
#prepare data
drugs_show <- c("Ibrutinib", "PF-3758309", "AZD8055", "Venetoclax", "Duvelisib")
drug_targets <- c("Ibrutinib" = "BTK", "PF-3758309" = "PAK", "AZD8055" = "mTOR", "Venetoclax" = "BCL2", "Duvelisib" = "PI3K")
screen_long_selected_drugs <- screen_long |>
filter(drug %in% drugs_show) |>
group_by(drug, diagnosis, conc_index) |>
mutate(mean_viab=mean(viability),
std.error=std.error(viability))
screen_long_selected_drugs$concentration <- as.character(screen_long_selected_drugs$concentration)
#show drug-response for BTK, PAK and mTOR inhibitor
#helper function for plots
viab_plot_list <- list()
viab_plot_list <- map(drugs_show, ~{
screen_long_selected_drugs |>
filter(drug == .x, diagnosis %in% diagnoses_show) |>
ggplot(aes(x=concentration, y=mean_viab, group=diagnosis, color=diagnosis)) +
geom_errorbar(aes(ymin=mean_viab-std.error, ymax=mean_viab+std.error),
width=.5, position=position_dodge(0.01)) +
geom_line() +
theme_figures_angle45_x +
labs(title=paste0(.x, " (", drug_targets[.x], ")"),
y="Viability", x=bquote("Concentration ("*mu*"M)"),
color="Diagnosis") +
scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1)) +
scale_color_manual(values=colors_diag)
}) |>
set_names(drugs_show)
#combine plots
Fig3e <- viab_plot_list$Ibrutinib + viab_plot_list$`PF-3758309` + viab_plot_list$AZD8055 +
plot_layout(ncol=3, guides = 'collect') &
theme(legend.position='right', legend.title= element_text(size=8, face="bold"),
plot.margin = margin(t=0.5, b=1, l=0.5, r=0.5, unit = "cm")) &
guides(
color = guide_legend(ncol = 1),
fill = guide_legend(ncol = 1),
shape = guide_legend(ncol = 1),
linetype = guide_legend(ncol = 1)
)
Fig3e
ggsave(path=(paste0(filepath,"figures")), filename = "Fig3e_viab_btk_pak_mtor.svg")## Saving 8 x 5 in image#show drug-response for BCL2 inhibtor (venetoclax)
diagnoses_ven <- c("CLL", "AML", "B-ALL", "T-ALL", "MCL", "Sezary")
screen_long_ven <- screen_long_selected_drugs |>
filter(drug == "Venetoclax", diagnosis %in% diagnoses_ven) |>
group_by(diagnosis, concentration) |>
summarize(med_viab=median(viability))## `summarise()` has grouped output by 'diagnosis'. You can override using the
## `.groups` argument.#fit dose-response models
screen_long_ven$concentration <- as.numeric(screen_long_ven$concentration)
models_ven <- map(diagnoses_ven, function(dx) {
data <- screen_long_ven |> filter(diagnosis == dx)
drm(med_viab ~ concentration,
data = data,
fct = LL.4(names = c("hill", "min_value", "max_value", "ec_50")))
})
names(models_ven) <- tolower(diagnoses_ven)
#create predictions based on models
predictions_ven <- map(diagnoses_ven, function(dx) {
data <- screen_long_ven |> filter(diagnosis == dx)
model <- models_ven[[tolower(dx)]]
new_data <- data.frame(
concentration = seq(min(data$concentration), max(data$concentration), length.out = 100)
)
new_data$pred <- predict(model, newdata = new_data)
new_data$diagnosis <- dx
new_data
}) |>
bind_rows()
#calculate IC50 values for all diagnoses
ic50_ven <- do.call(rbind, lapply(diagnoses_ven, function(dx) {
model <- models_ven[[tolower(dx)]]
coefs <- setNames(model$coefficients, c("hill", "min_value", "max_value", "ec_50"))
ic_50 <- with(as.list(coefs),
exp(log(ec_50) + (1 / hill) * log(max_value / (max_value - 2 * min_value))))
data.frame(ic50 = ic_50, diagnosis = dx)
}))## Warning in log(max_value/(max_value - 2 * min_value)): NaNs produced#set colors
colors_ven <- c(setNames("darkgrey", "Sezary"), colors_diag)
#order of diagnoses
order_ven <- ic50_ven |>
arrange(ic50) |>
pull(diagnosis)
#plot
data_ven <- screen_long_selected_drugs |>
filter(drug == "Venetoclax", diagnosis %in% diagnoses_ven)
data_ven$diagnosis <- factor(data_ven$diagnosis, levels = order_ven)
data_ven$concentration <- as.numeric(data_ven$concentration)
predictions_ven$diagnosis <- factor(predictions_ven$diagnosis, levels = order_ven)
ic50_ven$diagnosis <- factor(ic50_ven$diagnosis, levels = order_ven)
Fig3f <- data_ven |>
ggplot(aes(x=concentration, y=viability, group=diagnosis, color=diagnosis)) +
geom_boxplot(aes(group=concentration), alpha = 0.8, outlier.shape = NA) +
geom_jitter(aes(group=concentration), alpha=0.2, size=1, width = 0.15) +
facet_wrap(~diagnosis, ncol=6) +
geom_line(data = predictions_ven, aes(x = concentration, y = pred, color = diagnosis))+
geom_vline(data = ic50_ven, aes(xintercept = ic50),
linetype = "dashed", color = "black", size = 0.4) +
scale_x_log10(breaks = c(0.001, 0.01, 0.1, 1),
labels = trans_format("log10", math_format(10^.x)))+
scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1)) +
theme_figures_facet+
labs(title="Venetoclax (BCL2)", x=bquote("Concentration ("*mu*"M)"), y = "Viability") +
scale_color_manual(values=colors_ven)+
theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig3f## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).
ggsave(path=(paste0(filepath,"figures")), filename = "Fig3f_venetoclax.svg")## Saving 8 x 5 in image## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).#duvelisib
Fig3g <- screen_long_selected_drugs |>
filter(diagnosis %in% c("B-ALL", "T-ALL"), drug == "Duvelisib") |>
ggplot(aes(x=factor(concentration), y=viability, group=interaction(diagnosis, concentration), color=diagnosis)) +
geom_boxplot(alpha = 0.8, outlier.shape = NA)+
geom_jitter(alpha = 0.2, size=1, position = position_jitterdodge())+
labs(title="Duvelisib (PI3K)", y="Viability", x=bquote("Concentration ("*mu*"M)"), color = "Diagnosis")+
scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1))+
theme_figures_angle45_x+
scale_color_manual(values=colors_diag)+
theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig3g ## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
ggsave(path=(paste0(filepath,"figures")), filename = "Fig3g_duvelisib.svg")## Saving 8 x 5 in image## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).#cobimetinib (...)
#quizartinib (...)## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).## Warning: Removed 22 rows containing missing values or values outside the scale range
## (`geom_point()`).## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).6 Drug-drug correlations
6.1 Drug-drug correlation heatmap
#output not as desired in R Markdown !!! -> check with Junyan (output fine in R script)
#prepare data for CLL
cll_df <- screen_long |>
filter(diagnosis == "CLL") |>
group_by(patientID, drug) |>
summarize(mean_viab = mean(viability)) |>
pivot_wider(names_from = drug, values_from = mean_viab)## `summarise()` has grouped output by 'patientID'. You can override using the
## `.groups` argument.cll_corr_df <- scale(cll_df[3:length(cll_df)])
#calculate correlations
cll_corr <- round(cor(cll_corr_df), 2)
#set colors, make correlations between -0.2 and 0.2 white
colors_cor_heatmap <- colorRampPalette(c(
colorRampPalette(brewer.pal(9, "Spectral")[1:4])(7), #for correlations below -0.2
rep("white", 6), # For correlations between -0.2 and 0.2
colorRampPalette(brewer.pal(9, "Spectral")[6:9])(7) #for correlations above 0.2
))
#add colors for pathways (names not correct!)
all_labels <- colnames(cll_corr)
highlight_hsp <- c("AMI.1", "AZD1208")
highlight_bcr <- c("BMS.509744", "Ceritinib", "Cisplatin", "Cobimetinib")
highlight_pi3k <- c("BGJ398", "BML.277")
highlight_aktmtor <- c("A.1210477", "A.674563", "Fludarabine", "Ganetespib")
highlight_mapk <- c("Cytarabine", "D4476", "Dabrafenib")
label_colors <- setNames(rep("black", length(all_labels)), all_labels)
label_colors[highlight_hsp] <- "#BEBADA"
label_colors[highlight_bcr] <- "#80B1D3"
label_colors[highlight_pi3k] <- "#FB8072"
label_colors[highlight_aktmtor] <- "#BC80BD"
label_colors[highlight_mapk] <- "#FDB462"
#plot
cll_cor_heatmap <- corrplot(cll_corr, type="lower", order="hclust", method="color",
col = colors_cor_heatmap(20), sig.level = 0.05, addgrid.col = "grey",
insig = "blank", tl.col = label_colors, tl.cex = 0.7, tl.pos = "ld",
tl.offset = c(0.3), cl.ratio = 0.1, title="CLL", cex.main = 0.75, col.main = "black", mar = c(0,0,0.5,0),
cl.cex = 0.7, cl.col = "grey", asp=1)## Warning in text.default(pos.xlabel[, 1], pos.xlabel[, 2], newcolnames, srt =
## tl.srt, : "cl.col" is not a graphical parameter## Warning in text.default(pos.ylabel[, 1], pos.ylabel[, 2], newrownames, col =
## tl.col, : "cl.col" is not a graphical parameter## Warning in title(title, ...): "cl.col" is not a graphical parameter
#prepare for multipanel figure
cll_cor_heatmap## $corr
## AZD6738 Rapamycin Ganetespib Onalespib Palbociclib
## AZD6738 1.00 0.30 0.28 0.25 0.41
## Rapamycin 0.30 1.00 0.33 0.34 0.49
## Ganetespib 0.28 0.33 1.00 0.96 0.69
## Onalespib 0.25 0.34 0.96 1.00 0.69
## Palbociclib 0.41 0.49 0.69 0.69 1.00
## Sunitinib 0.48 0.39 0.69 0.66 0.76
## Midostaurin 0.37 0.34 0.60 0.58 0.58
## Duvelisib 0.38 0.42 0.66 0.60 0.65
## Idelalisib 0.42 0.41 0.62 0.55 0.64
## Dasatinib 0.30 0.22 0.75 0.71 0.64
## PRT062607 0.29 0.25 0.70 0.67 0.69
## Ibrutinib 0.32 0.28 0.72 0.67 0.63
## ONO-4059 0.28 0.31 0.68 0.63 0.64
## Cobimetinib 0.27 0.26 0.47 0.40 0.38
## SCH772984 0.34 0.37 0.46 0.39 0.43
## Trametinib 0.33 0.37 0.54 0.47 0.46
## A-674563 0.44 0.34 0.41 0.41 0.65
## Tozasertib 0.31 0.25 0.51 0.46 0.54
## BMS-509744 0.34 0.03 0.07 0.01 0.17
## Ceritinib 0.26 -0.02 0.12 0.15 0.21
## MK-2206 0.20 0.44 0.36 0.32 0.46
## AZD1208 0.34 0.12 0.31 0.28 0.30
## AZD8055 0.48 0.26 0.41 0.37 0.47
## Dabrafenib 0.10 0.10 0.24 0.17 0.27
## Imatinib 0.24 0.14 0.40 0.37 0.46
## KU-55933 0.08 0.29 0.33 0.29 0.29
## Quizartinib 0.10 0.05 -0.24 -0.22 -0.01
## Afatinib 0.05 0.20 0.04 0.13 0.21
## TW-37 0.16 0.04 -0.11 -0.05 0.08
## ZM 336372 0.18 0.03 -0.11 -0.05 -0.04
## BML-277 -0.02 -0.08 -0.30 -0.25 -0.14
## EPZ-6438 -0.24 -0.06 -0.33 -0.30 -0.24
## PF-3758309 0.28 0.38 0.42 0.45 0.59
## Venetoclax 0.08 0.10 0.16 0.28 0.24
## Doxorubicine 0.00 0.06 0.14 0.11 0.29
## Panobinostat 0.23 0.24 0.32 0.31 0.33
## Selinexor 0.09 0.15 0.21 0.21 0.37
## OTX015 0.22 0.35 0.42 0.42 0.46
## Volasertib 0.34 0.24 0.42 0.41 0.47
## Nutlin-3a 0.28 0.39 0.55 0.56 0.59
## RO5963 0.33 0.37 0.44 0.46 0.47
## Cytarabine 0.16 0.20 0.45 0.44 0.47
## Fludarabine 0.22 0.26 0.32 0.32 0.37
## Ruxolitinib 0.25 0.11 0.13 0.11 0.20
## Tofacitinib 0.19 0.14 0.00 0.05 0.05
## Motolimod -0.11 0.12 -0.06 -0.05 0.04
## Menin-MLL Inhibitor -0.10 0.22 0.03 0.11 0.12
## MI-503 0.01 0.06 -0.07 -0.03 0.10
## Olaparib 0.01 -0.13 -0.01 0.00 -0.06
## SB 203580 0.01 0.05 0.03 0.05 -0.01
## AMI-1 0.36 0.09 -0.10 -0.07 0.05
## Vismodegib 0.25 0.12 -0.05 -0.03 0.17
## Methotrexate 0.29 0.08 -0.02 -0.04 0.09
## IRAK-1/4 Inhibitor I 0.22 0.28 0.14 0.20 0.39
## Selisistat 0.24 0.37 0.03 0.07 0.33
## Foretinib 0.01 -0.34 0.08 0.01 -0.10
## JNK-IN-8 -0.06 -0.22 0.10 0.06 0.15
## BGJ398 0.17 -0.04 0.04 0.05 0.19
## SGC 0946 0.30 0.07 -0.02 -0.06 0.14
## D 4476 0.10 -0.08 -0.10 -0.09 0.05
## A-1210477 0.34 0.33 0.17 0.18 0.47
## Cisplatin 0.28 0.08 0.14 0.10 0.29
## Sunitinib Midostaurin Duvelisib Idelalisib Dasatinib
## AZD6738 0.48 0.37 0.38 0.42 0.30
## Rapamycin 0.39 0.34 0.42 0.41 0.22
## Ganetespib 0.69 0.60 0.66 0.62 0.75
## Onalespib 0.66 0.58 0.60 0.55 0.71
## Palbociclib 0.76 0.58 0.65 0.64 0.64
## Sunitinib 1.00 0.55 0.61 0.58 0.60
## Midostaurin 0.55 1.00 0.63 0.66 0.63
## Duvelisib 0.61 0.63 1.00 0.93 0.82
## Idelalisib 0.58 0.66 0.93 1.00 0.74
## Dasatinib 0.60 0.63 0.82 0.74 1.00
## PRT062607 0.65 0.58 0.85 0.78 0.84
## Ibrutinib 0.61 0.62 0.89 0.84 0.87
## ONO-4059 0.59 0.58 0.87 0.82 0.80
## Cobimetinib 0.46 0.35 0.62 0.57 0.63
## SCH772984 0.52 0.41 0.59 0.58 0.55
## Trametinib 0.51 0.51 0.69 0.66 0.67
## A-674563 0.64 0.27 0.45 0.46 0.40
## Tozasertib 0.61 0.36 0.58 0.57 0.52
## BMS-509744 0.23 0.19 0.30 0.33 0.25
## Ceritinib 0.21 0.11 0.09 0.13 0.13
## MK-2206 0.38 0.47 0.39 0.49 0.33
## AZD1208 0.25 0.50 0.48 0.56 0.44
## AZD8055 0.47 0.44 0.53 0.60 0.53
## Dabrafenib 0.23 0.28 0.35 0.39 0.38
## Imatinib 0.48 0.48 0.50 0.52 0.60
## KU-55933 0.25 0.47 0.41 0.46 0.34
## Quizartinib 0.02 -0.11 -0.30 -0.22 -0.37
## Afatinib 0.18 -0.05 -0.21 -0.22 -0.14
## TW-37 0.15 -0.21 -0.21 -0.18 -0.28
## ZM 336372 -0.11 -0.16 -0.25 -0.23 -0.24
## BML-277 -0.21 -0.30 -0.43 -0.42 -0.40
## EPZ-6438 -0.37 -0.23 -0.36 -0.37 -0.39
## PF-3758309 0.42 0.33 0.34 0.31 0.38
## Venetoclax 0.10 0.13 0.03 0.04 0.08
## Doxorubicine 0.22 -0.01 0.03 0.04 -0.02
## Panobinostat 0.38 0.24 0.16 0.16 0.06
## Selinexor 0.29 0.07 0.16 0.12 0.11
## OTX015 0.51 0.12 0.31 0.25 0.22
## Volasertib 0.59 0.09 0.30 0.25 0.23
## Nutlin-3a 0.52 0.36 0.48 0.44 0.45
## RO5963 0.45 0.32 0.42 0.39 0.36
## Cytarabine 0.43 0.20 0.32 0.29 0.30
## Fludarabine 0.33 0.16 0.21 0.19 0.11
## Ruxolitinib 0.30 0.22 0.22 0.22 0.33
## Tofacitinib 0.08 0.10 -0.10 -0.11 0.06
## Motolimod 0.00 -0.01 -0.06 -0.06 -0.09
## Menin-MLL Inhibitor -0.01 0.17 -0.08 -0.02 -0.03
## MI-503 0.04 0.04 -0.21 -0.13 -0.10
## Olaparib -0.11 0.09 -0.07 -0.02 0.08
## SB 203580 0.13 -0.14 -0.10 -0.10 0.02
## AMI-1 0.09 -0.14 -0.17 -0.10 -0.15
## Vismodegib 0.16 -0.11 -0.11 -0.04 -0.07
## Methotrexate 0.23 0.11 -0.10 -0.02 -0.09
## IRAK-1/4 Inhibitor I 0.30 0.21 0.07 0.13 0.09
## Selisistat 0.24 0.03 0.02 0.06 -0.01
## Foretinib 0.09 -0.16 0.02 0.07 0.11
## JNK-IN-8 0.04 0.05 -0.04 0.09 0.09
## BGJ398 0.24 0.04 0.02 0.00 -0.02
## SGC 0946 0.22 -0.04 0.14 0.15 0.06
## D 4476 0.05 -0.30 -0.17 -0.16 -0.18
## A-1210477 0.38 0.11 0.32 0.34 0.19
## Cisplatin 0.37 0.02 0.16 0.24 0.07
## PRT062607 Ibrutinib ONO-4059 Cobimetinib SCH772984
## AZD6738 0.29 0.32 0.28 0.27 0.34
## Rapamycin 0.25 0.28 0.31 0.26 0.37
## Ganetespib 0.70 0.72 0.68 0.47 0.46
## Onalespib 0.67 0.67 0.63 0.40 0.39
## Palbociclib 0.69 0.63 0.64 0.38 0.43
## Sunitinib 0.65 0.61 0.59 0.46 0.52
## Midostaurin 0.58 0.62 0.58 0.35 0.41
## Duvelisib 0.85 0.89 0.87 0.62 0.59
## Idelalisib 0.78 0.84 0.82 0.57 0.58
## Dasatinib 0.84 0.87 0.80 0.63 0.55
## PRT062607 1.00 0.92 0.91 0.58 0.51
## Ibrutinib 0.92 1.00 0.96 0.61 0.54
## ONO-4059 0.91 0.96 1.00 0.56 0.51
## Cobimetinib 0.58 0.61 0.56 1.00 0.88
## SCH772984 0.51 0.54 0.51 0.88 1.00
## Trametinib 0.61 0.66 0.61 0.90 0.92
## A-674563 0.50 0.43 0.42 0.40 0.43
## Tozasertib 0.67 0.62 0.63 0.52 0.45
## BMS-509744 0.32 0.28 0.25 0.37 0.25
## Ceritinib 0.19 0.13 0.09 0.08 -0.02
## MK-2206 0.33 0.33 0.34 0.30 0.32
## AZD1208 0.44 0.42 0.38 0.28 0.27
## AZD8055 0.52 0.52 0.45 0.48 0.45
## Dabrafenib 0.34 0.36 0.38 0.33 0.29
## Imatinib 0.55 0.54 0.51 0.46 0.40
## KU-55933 0.43 0.47 0.49 0.31 0.31
## Quizartinib -0.29 -0.35 -0.37 -0.32 -0.18
## Afatinib -0.15 -0.21 -0.23 -0.20 -0.11
## TW-37 -0.15 -0.20 -0.16 -0.15 -0.06
## ZM 336372 -0.15 -0.25 -0.20 -0.30 -0.23
## BML-277 -0.39 -0.46 -0.45 -0.27 -0.32
## EPZ-6438 -0.37 -0.42 -0.39 -0.34 -0.30
## PF-3758309 0.34 0.29 0.23 0.15 0.27
## Venetoclax 0.12 0.04 0.06 -0.17 -0.11
## Doxorubicine 0.10 0.06 0.12 -0.03 0.05
## Panobinostat 0.04 0.07 0.09 0.05 0.19
## Selinexor 0.23 0.14 0.18 0.17 0.25
## OTX015 0.29 0.29 0.31 0.26 0.35
## Volasertib 0.34 0.30 0.32 0.31 0.38
## Nutlin-3a 0.48 0.47 0.46 0.46 0.52
## RO5963 0.41 0.40 0.38 0.42 0.50
## Cytarabine 0.34 0.34 0.31 0.29 0.33
## Fludarabine 0.12 0.14 0.13 0.17 0.29
## Ruxolitinib 0.29 0.30 0.25 0.52 0.57
## Tofacitinib -0.01 -0.04 -0.12 0.16 0.23
## Motolimod 0.00 -0.01 0.05 -0.08 -0.06
## Menin-MLL Inhibitor 0.00 -0.01 -0.04 -0.09 -0.06
## MI-503 -0.15 -0.18 -0.18 -0.09 -0.12
## Olaparib 0.07 0.04 0.01 0.14 0.05
## SB 203580 0.08 0.04 0.01 0.20 0.20
## AMI-1 -0.05 -0.14 -0.17 -0.01 0.02
## Vismodegib 0.01 -0.07 -0.09 0.09 0.12
## Methotrexate -0.10 -0.09 -0.13 0.02 0.06
## IRAK-1/4 Inhibitor I 0.15 0.11 0.05 0.03 0.08
## Selisistat 0.13 0.05 0.05 0.09 0.09
## Foretinib 0.16 0.15 0.12 0.20 0.05
## JNK-IN-8 0.13 0.06 0.04 -0.11 -0.12
## BGJ398 0.02 0.01 0.01 0.09 0.12
## SGC 0946 0.20 0.16 0.21 0.25 0.29
## D 4476 -0.05 -0.14 -0.12 0.07 -0.06
## A-1210477 0.30 0.28 0.30 0.26 0.25
## Cisplatin 0.23 0.24 0.21 0.27 0.24
## Trametinib A-674563 Tozasertib BMS-509744 Ceritinib
## AZD6738 0.33 0.44 0.31 0.34 0.26
## Rapamycin 0.37 0.34 0.25 0.03 -0.02
## Ganetespib 0.54 0.41 0.51 0.07 0.12
## Onalespib 0.47 0.41 0.46 0.01 0.15
## Palbociclib 0.46 0.65 0.54 0.17 0.21
## Sunitinib 0.51 0.64 0.61 0.23 0.21
## Midostaurin 0.51 0.27 0.36 0.19 0.11
## Duvelisib 0.69 0.45 0.58 0.30 0.09
## Idelalisib 0.66 0.46 0.57 0.33 0.13
## Dasatinib 0.67 0.40 0.52 0.25 0.13
## PRT062607 0.61 0.50 0.67 0.32 0.19
## Ibrutinib 0.66 0.43 0.62 0.28 0.13
## ONO-4059 0.61 0.42 0.63 0.25 0.09
## Cobimetinib 0.90 0.40 0.52 0.37 0.08
## SCH772984 0.92 0.43 0.45 0.25 -0.02
## Trametinib 1.00 0.39 0.49 0.30 0.01
## A-674563 0.39 1.00 0.56 0.23 0.27
## Tozasertib 0.49 0.56 1.00 0.44 0.34
## BMS-509744 0.30 0.23 0.44 1.00 0.56
## Ceritinib 0.01 0.27 0.34 0.56 1.00
## MK-2206 0.33 0.34 0.42 0.31 0.33
## AZD1208 0.37 0.17 0.36 0.49 0.39
## AZD8055 0.47 0.47 0.59 0.50 0.49
## Dabrafenib 0.32 0.08 0.27 0.33 0.17
## Imatinib 0.40 0.32 0.46 0.28 0.22
## KU-55933 0.33 0.18 0.39 0.24 0.11
## Quizartinib -0.25 0.17 0.00 -0.06 0.08
## Afatinib -0.15 0.18 -0.12 -0.12 0.13
## TW-37 -0.17 0.27 0.04 -0.13 0.08
## ZM 336372 -0.29 0.04 -0.01 0.02 0.16
## BML-277 -0.43 -0.02 -0.13 0.09 0.24
## EPZ-6438 -0.33 -0.30 -0.36 -0.12 -0.08
## PF-3758309 0.28 0.50 0.26 -0.02 0.10
## Venetoclax -0.08 0.18 0.04 -0.03 0.21
## Doxorubicine -0.01 0.25 0.09 -0.16 -0.19
## Panobinostat 0.14 0.26 0.05 -0.07 -0.11
## Selinexor 0.16 0.38 0.23 -0.03 0.02
## OTX015 0.29 0.49 0.22 -0.08 -0.07
## Volasertib 0.29 0.58 0.42 0.08 0.11
## Nutlin-3a 0.51 0.46 0.37 0.02 0.07
## RO5963 0.47 0.43 0.33 0.03 0.07
## Cytarabine 0.33 0.39 0.25 -0.04 0.03
## Fludarabine 0.25 0.35 0.09 -0.10 -0.08
## Ruxolitinib 0.49 0.32 0.31 0.30 0.15
## Tofacitinib 0.17 0.22 0.02 0.12 0.10
## Motolimod -0.14 -0.10 0.00 -0.09 -0.05
## Menin-MLL Inhibitor -0.11 0.02 -0.10 -0.08 0.10
## MI-503 -0.18 0.12 0.09 0.05 0.31
## Olaparib 0.02 -0.10 0.10 0.26 0.32
## SB 203580 0.09 0.19 0.24 0.12 0.19
## AMI-1 -0.13 0.28 0.19 0.29 0.42
## Vismodegib -0.04 0.35 0.29 0.26 0.39
## Methotrexate -0.05 0.11 0.12 0.05 0.08
## IRAK-1/4 Inhibitor I 0.00 0.36 0.22 0.10 0.29
## Selisistat -0.01 0.34 0.28 0.16 0.29
## Foretinib 0.03 0.08 0.45 0.29 0.30
## JNK-IN-8 -0.10 0.13 0.14 0.12 0.27
## BGJ398 0.06 0.23 0.22 0.15 0.30
## SGC 0946 0.20 0.41 0.35 0.18 0.16
## D 4476 -0.19 0.23 0.20 0.23 0.35
## A-1210477 0.22 0.49 0.36 0.26 0.30
## Cisplatin 0.16 0.39 0.43 0.20 0.20
## MK-2206 AZD1208 AZD8055 Dabrafenib Imatinib KU-55933
## AZD6738 0.20 0.34 0.48 0.10 0.24 0.08
## Rapamycin 0.44 0.12 0.26 0.10 0.14 0.29
## Ganetespib 0.36 0.31 0.41 0.24 0.40 0.33
## Onalespib 0.32 0.28 0.37 0.17 0.37 0.29
## Palbociclib 0.46 0.30 0.47 0.27 0.46 0.29
## Sunitinib 0.38 0.25 0.47 0.23 0.48 0.25
## Midostaurin 0.47 0.50 0.44 0.28 0.48 0.47
## Duvelisib 0.39 0.48 0.53 0.35 0.50 0.41
## Idelalisib 0.49 0.56 0.60 0.39 0.52 0.46
## Dasatinib 0.33 0.44 0.53 0.38 0.60 0.34
## PRT062607 0.33 0.44 0.52 0.34 0.55 0.43
## Ibrutinib 0.33 0.42 0.52 0.36 0.54 0.47
## ONO-4059 0.34 0.38 0.45 0.38 0.51 0.49
## Cobimetinib 0.30 0.28 0.48 0.33 0.46 0.31
## SCH772984 0.32 0.27 0.45 0.29 0.40 0.31
## Trametinib 0.33 0.37 0.47 0.32 0.40 0.33
## A-674563 0.34 0.17 0.47 0.08 0.32 0.18
## Tozasertib 0.42 0.36 0.59 0.27 0.46 0.39
## BMS-509744 0.31 0.49 0.50 0.33 0.28 0.24
## Ceritinib 0.33 0.39 0.49 0.17 0.22 0.11
## MK-2206 1.00 0.45 0.57 0.28 0.43 0.47
## AZD1208 0.45 1.00 0.67 0.24 0.38 0.21
## AZD8055 0.57 0.67 1.00 0.27 0.56 0.27
## Dabrafenib 0.28 0.24 0.27 1.00 0.19 0.22
## Imatinib 0.43 0.38 0.56 0.19 1.00 0.51
## KU-55933 0.47 0.21 0.27 0.22 0.51 1.00
## Quizartinib -0.06 -0.09 -0.04 -0.16 -0.16 -0.11
## Afatinib -0.05 -0.24 -0.19 0.02 -0.17 -0.13
## TW-37 -0.05 -0.30 -0.10 -0.11 -0.19 -0.12
## ZM 336372 0.07 0.00 0.10 -0.11 -0.13 -0.12
## BML-277 -0.08 -0.13 -0.02 -0.16 -0.08 -0.17
## EPZ-6438 -0.13 -0.18 -0.33 -0.06 -0.30 -0.04
## PF-3758309 0.26 0.26 0.34 -0.10 0.16 0.04
## Venetoclax 0.08 0.17 0.08 -0.08 -0.11 -0.14
## Doxorubicine 0.04 -0.25 -0.16 0.09 -0.05 0.04
## Panobinostat 0.13 0.01 0.03 0.03 -0.01 0.03
## Selinexor 0.21 -0.01 0.19 0.04 0.12 0.03
## OTX015 0.09 -0.22 0.02 0.10 0.00 0.11
## Volasertib 0.14 -0.13 0.21 0.12 0.07 0.10
## Nutlin-3a 0.27 0.05 0.30 0.22 0.20 0.17
## RO5963 0.22 0.04 0.31 0.12 0.16 0.12
## Cytarabine 0.14 -0.07 0.07 0.17 0.08 0.08
## Fludarabine 0.10 -0.10 0.05 0.03 -0.11 -0.07
## Ruxolitinib 0.24 0.21 0.43 0.05 0.38 0.24
## Tofacitinib 0.11 0.10 0.23 -0.18 0.12 0.00
## Motolimod 0.05 -0.25 -0.11 0.13 0.04 0.21
## Menin-MLL Inhibitor 0.29 -0.02 -0.03 0.00 0.24 0.44
## MI-503 0.31 0.10 0.22 -0.12 0.38 0.15
## Olaparib 0.25 0.28 0.30 0.10 0.39 0.30
## SB 203580 0.16 -0.13 0.24 0.09 0.20 0.20
## AMI-1 0.11 0.01 0.30 0.02 0.11 0.05
## Vismodegib 0.21 -0.02 0.34 0.03 0.24 0.17
## Methotrexate 0.16 -0.06 0.16 -0.14 0.34 0.16
## IRAK-1/4 Inhibitor I 0.30 0.00 0.25 0.05 0.39 0.32
## Selisistat 0.29 -0.06 0.26 0.06 0.32 0.25
## Foretinib 0.06 0.14 0.36 0.01 0.33 0.06
## JNK-IN-8 0.13 0.19 0.19 0.17 0.18 0.11
## BGJ398 -0.01 0.00 0.17 0.00 0.07 -0.04
## SGC 0946 0.11 0.01 0.30 0.15 0.13 0.13
## D 4476 -0.06 -0.17 0.15 0.10 -0.04 -0.09
## A-1210477 0.24 0.05 0.28 0.34 0.12 0.10
## Cisplatin 0.14 -0.07 0.23 0.09 0.27 0.21
## Quizartinib Afatinib TW-37 ZM 336372 BML-277 EPZ-6438
## AZD6738 0.10 0.05 0.16 0.18 -0.02 -0.24
## Rapamycin 0.05 0.20 0.04 0.03 -0.08 -0.06
## Ganetespib -0.24 0.04 -0.11 -0.11 -0.30 -0.33
## Onalespib -0.22 0.13 -0.05 -0.05 -0.25 -0.30
## Palbociclib -0.01 0.21 0.08 -0.04 -0.14 -0.24
## Sunitinib 0.02 0.18 0.15 -0.11 -0.21 -0.37
## Midostaurin -0.11 -0.05 -0.21 -0.16 -0.30 -0.23
## Duvelisib -0.30 -0.21 -0.21 -0.25 -0.43 -0.36
## Idelalisib -0.22 -0.22 -0.18 -0.23 -0.42 -0.37
## Dasatinib -0.37 -0.14 -0.28 -0.24 -0.40 -0.39
## PRT062607 -0.29 -0.15 -0.15 -0.15 -0.39 -0.37
## Ibrutinib -0.35 -0.21 -0.20 -0.25 -0.46 -0.42
## ONO-4059 -0.37 -0.23 -0.16 -0.20 -0.45 -0.39
## Cobimetinib -0.32 -0.20 -0.15 -0.30 -0.27 -0.34
## SCH772984 -0.18 -0.11 -0.06 -0.23 -0.32 -0.30
## Trametinib -0.25 -0.15 -0.17 -0.29 -0.43 -0.33
## A-674563 0.17 0.18 0.27 0.04 -0.02 -0.30
## Tozasertib 0.00 -0.12 0.04 -0.01 -0.13 -0.36
## BMS-509744 -0.06 -0.12 -0.13 0.02 0.09 -0.12
## Ceritinib 0.08 0.13 0.08 0.16 0.24 -0.08
## MK-2206 -0.06 -0.05 -0.05 0.07 -0.08 -0.13
## AZD1208 -0.09 -0.24 -0.30 0.00 -0.13 -0.18
## AZD8055 -0.04 -0.19 -0.10 0.10 -0.02 -0.33
## Dabrafenib -0.16 0.02 -0.11 -0.11 -0.16 -0.06
## Imatinib -0.16 -0.17 -0.19 -0.13 -0.08 -0.30
## KU-55933 -0.11 -0.13 -0.12 -0.12 -0.17 -0.04
## Quizartinib 1.00 0.30 0.38 0.20 0.29 0.17
## Afatinib 0.30 1.00 0.41 0.13 0.29 0.23
## TW-37 0.38 0.41 1.00 0.25 0.31 0.13
## ZM 336372 0.20 0.13 0.25 1.00 0.39 0.27
## BML-277 0.29 0.29 0.31 0.39 1.00 0.48
## EPZ-6438 0.17 0.23 0.13 0.27 0.48 1.00
## PF-3758309 0.20 0.24 -0.03 0.08 -0.04 -0.13
## Venetoclax -0.01 0.34 0.12 0.21 0.11 0.01
## Doxorubicine 0.09 0.20 0.30 -0.15 -0.08 -0.02
## Panobinostat 0.10 0.17 0.23 -0.12 -0.06 -0.06
## Selinexor 0.06 0.16 0.20 0.07 -0.03 -0.09
## OTX015 0.01 0.23 0.37 -0.07 -0.09 -0.11
## Volasertib 0.09 0.19 0.45 0.04 0.03 -0.15
## Nutlin-3a -0.04 0.22 0.14 -0.02 -0.09 -0.14
## RO5963 0.00 0.14 0.14 0.04 -0.06 -0.14
## Cytarabine 0.02 0.29 0.29 -0.06 -0.08 -0.06
## Fludarabine 0.16 0.27 0.30 -0.02 -0.03 -0.05
## Ruxolitinib 0.03 -0.02 0.08 -0.03 -0.01 -0.17
## Tofacitinib 0.19 0.15 0.04 0.26 0.17 0.02
## Motolimod 0.00 0.11 0.14 0.07 0.13 0.21
## Menin-MLL Inhibitor 0.05 0.25 0.03 0.10 0.16 0.24
## MI-503 0.16 0.15 0.12 0.22 0.42 0.10
## Olaparib -0.17 -0.12 -0.08 0.07 0.19 -0.01
## SB 203580 0.12 0.02 0.19 0.23 0.17 -0.08
## AMI-1 0.29 0.19 0.34 0.41 0.45 0.05
## Vismodegib 0.29 0.18 0.38 0.28 0.43 -0.03
## Methotrexate 0.33 0.07 0.22 0.07 0.25 -0.13
## IRAK-1/4 Inhibitor I 0.28 0.36 0.17 0.10 0.23 -0.01
## Selisistat 0.26 0.24 0.33 0.21 0.31 0.01
## Foretinib -0.03 -0.30 0.00 0.12 0.16 -0.16
## JNK-IN-8 0.25 0.15 0.06 0.19 0.17 0.14
## BGJ398 0.08 0.23 0.22 0.03 0.31 0.05
## SGC 0946 0.18 -0.07 0.25 0.27 0.04 -0.04
## D 4476 0.18 0.19 0.36 0.26 0.47 0.11
## A-1210477 0.03 0.32 0.28 -0.04 0.13 -0.13
## Cisplatin 0.09 0.12 0.43 0.02 0.22 -0.08
## PF-3758309 Venetoclax Doxorubicine Panobinostat Selinexor
## AZD6738 0.28 0.08 0.00 0.23 0.09
## Rapamycin 0.38 0.10 0.06 0.24 0.15
## Ganetespib 0.42 0.16 0.14 0.32 0.21
## Onalespib 0.45 0.28 0.11 0.31 0.21
## Palbociclib 0.59 0.24 0.29 0.33 0.37
## Sunitinib 0.42 0.10 0.22 0.38 0.29
## Midostaurin 0.33 0.13 -0.01 0.24 0.07
## Duvelisib 0.34 0.03 0.03 0.16 0.16
## Idelalisib 0.31 0.04 0.04 0.16 0.12
## Dasatinib 0.38 0.08 -0.02 0.06 0.11
## PRT062607 0.34 0.12 0.10 0.04 0.23
## Ibrutinib 0.29 0.04 0.06 0.07 0.14
## ONO-4059 0.23 0.06 0.12 0.09 0.18
## Cobimetinib 0.15 -0.17 -0.03 0.05 0.17
## SCH772984 0.27 -0.11 0.05 0.19 0.25
## Trametinib 0.28 -0.08 -0.01 0.14 0.16
## A-674563 0.50 0.18 0.25 0.26 0.38
## Tozasertib 0.26 0.04 0.09 0.05 0.23
## BMS-509744 -0.02 -0.03 -0.16 -0.07 -0.03
## Ceritinib 0.10 0.21 -0.19 -0.11 0.02
## MK-2206 0.26 0.08 0.04 0.13 0.21
## AZD1208 0.26 0.17 -0.25 0.01 -0.01
## AZD8055 0.34 0.08 -0.16 0.03 0.19
## Dabrafenib -0.10 -0.08 0.09 0.03 0.04
## Imatinib 0.16 -0.11 -0.05 -0.01 0.12
## KU-55933 0.04 -0.14 0.04 0.03 0.03
## Quizartinib 0.20 -0.01 0.09 0.10 0.06
## Afatinib 0.24 0.34 0.20 0.17 0.16
## TW-37 -0.03 0.12 0.30 0.23 0.20
## ZM 336372 0.08 0.21 -0.15 -0.12 0.07
## BML-277 -0.04 0.11 -0.08 -0.06 -0.03
## EPZ-6438 -0.13 0.01 -0.02 -0.06 -0.09
## PF-3758309 1.00 0.39 0.12 0.26 0.32
## Venetoclax 0.39 1.00 0.00 0.02 0.05
## Doxorubicine 0.12 0.00 1.00 0.44 0.44
## Panobinostat 0.26 0.02 0.44 1.00 0.31
## Selinexor 0.32 0.05 0.44 0.31 1.00
## OTX015 0.36 0.08 0.46 0.56 0.36
## Volasertib 0.29 0.06 0.36 0.45 0.36
## Nutlin-3a 0.36 0.20 0.22 0.31 0.37
## RO5963 0.38 0.22 0.22 0.35 0.40
## Cytarabine 0.36 0.18 0.42 0.32 0.35
## Fludarabine 0.41 0.15 0.37 0.52 0.42
## Ruxolitinib 0.16 -0.14 -0.04 0.04 0.23
## Tofacitinib 0.30 0.00 -0.17 0.05 0.15
## Motolimod -0.12 -0.06 0.25 0.05 0.17
## Menin-MLL Inhibitor 0.11 0.01 0.03 -0.01 0.04
## MI-503 0.10 0.17 -0.16 0.07 0.06
## Olaparib -0.12 -0.03 -0.27 -0.17 -0.12
## SB 203580 -0.05 -0.16 -0.04 -0.13 0.17
## AMI-1 0.07 0.05 -0.08 -0.07 0.09
## Vismodegib 0.10 -0.01 0.02 -0.08 0.15
## Methotrexate -0.03 -0.18 0.03 0.04 -0.04
## IRAK-1/4 Inhibitor I 0.32 0.16 0.17 0.04 0.22
## Selisistat 0.13 0.03 0.10 0.01 0.19
## Foretinib -0.14 -0.18 -0.17 -0.21 -0.01
## JNK-IN-8 0.12 0.16 0.06 -0.18 0.05
## BGJ398 0.11 0.11 0.05 0.13 0.13
## SGC 0946 0.03 -0.09 0.10 0.03 0.22
## D 4476 -0.08 0.02 0.11 -0.04 0.19
## A-1210477 0.16 0.17 0.21 0.14 0.22
## Cisplatin 0.04 -0.05 0.31 0.13 0.14
## OTX015 Volasertib Nutlin-3a RO5963 Cytarabine Fludarabine
## AZD6738 0.22 0.34 0.28 0.33 0.16 0.22
## Rapamycin 0.35 0.24 0.39 0.37 0.20 0.26
## Ganetespib 0.42 0.42 0.55 0.44 0.45 0.32
## Onalespib 0.42 0.41 0.56 0.46 0.44 0.32
## Palbociclib 0.46 0.47 0.59 0.47 0.47 0.37
## Sunitinib 0.51 0.59 0.52 0.45 0.43 0.33
## Midostaurin 0.12 0.09 0.36 0.32 0.20 0.16
## Duvelisib 0.31 0.30 0.48 0.42 0.32 0.21
## Idelalisib 0.25 0.25 0.44 0.39 0.29 0.19
## Dasatinib 0.22 0.23 0.45 0.36 0.30 0.11
## PRT062607 0.29 0.34 0.48 0.41 0.34 0.12
## Ibrutinib 0.29 0.30 0.47 0.40 0.34 0.14
## ONO-4059 0.31 0.32 0.46 0.38 0.31 0.13
## Cobimetinib 0.26 0.31 0.46 0.42 0.29 0.17
## SCH772984 0.35 0.38 0.52 0.50 0.33 0.29
## Trametinib 0.29 0.29 0.51 0.47 0.33 0.25
## A-674563 0.49 0.58 0.46 0.43 0.39 0.35
## Tozasertib 0.22 0.42 0.37 0.33 0.25 0.09
## BMS-509744 -0.08 0.08 0.02 0.03 -0.04 -0.10
## Ceritinib -0.07 0.11 0.07 0.07 0.03 -0.08
## MK-2206 0.09 0.14 0.27 0.22 0.14 0.10
## AZD1208 -0.22 -0.13 0.05 0.04 -0.07 -0.10
## AZD8055 0.02 0.21 0.30 0.31 0.07 0.05
## Dabrafenib 0.10 0.12 0.22 0.12 0.17 0.03
## Imatinib 0.00 0.07 0.20 0.16 0.08 -0.11
## KU-55933 0.11 0.10 0.17 0.12 0.08 -0.07
## Quizartinib 0.01 0.09 -0.04 0.00 0.02 0.16
## Afatinib 0.23 0.19 0.22 0.14 0.29 0.27
## TW-37 0.37 0.45 0.14 0.14 0.29 0.30
## ZM 336372 -0.07 0.04 -0.02 0.04 -0.06 -0.02
## BML-277 -0.09 0.03 -0.09 -0.06 -0.08 -0.03
## EPZ-6438 -0.11 -0.15 -0.14 -0.14 -0.06 -0.05
## PF-3758309 0.36 0.29 0.36 0.38 0.36 0.41
## Venetoclax 0.08 0.06 0.20 0.22 0.18 0.15
## Doxorubicine 0.46 0.36 0.22 0.22 0.42 0.37
## Panobinostat 0.56 0.45 0.31 0.35 0.32 0.52
## Selinexor 0.36 0.36 0.37 0.40 0.35 0.42
## OTX015 1.00 0.85 0.54 0.49 0.52 0.56
## Volasertib 0.85 1.00 0.55 0.47 0.49 0.47
## Nutlin-3a 0.54 0.55 1.00 0.88 0.70 0.63
## RO5963 0.49 0.47 0.88 1.00 0.59 0.59
## Cytarabine 0.52 0.49 0.70 0.59 1.00 0.73
## Fludarabine 0.56 0.47 0.63 0.59 0.73 1.00
## Ruxolitinib 0.08 0.22 0.16 0.16 0.06 0.03
## Tofacitinib -0.03 0.03 0.09 0.16 0.01 0.06
## Motolimod 0.20 0.17 0.05 0.02 0.12 0.09
## Menin-MLL Inhibitor 0.04 -0.06 0.14 0.11 0.11 0.02
## MI-503 -0.16 -0.09 -0.03 0.00 -0.09 -0.10
## Olaparib -0.28 -0.13 0.02 0.01 -0.11 -0.27
## SB 203580 0.10 0.28 0.19 0.20 0.08 -0.01
## AMI-1 -0.01 0.22 0.08 0.16 0.05 0.01
## Vismodegib 0.07 0.29 0.21 0.22 0.11 0.04
## Methotrexate 0.01 0.13 0.08 0.06 0.03 0.03
## IRAK-1/4 Inhibitor I 0.20 0.20 0.31 0.28 0.25 0.15
## Selisistat 0.15 0.21 0.29 0.30 0.19 0.07
## Foretinib -0.13 0.10 -0.06 -0.05 -0.09 -0.24
## JNK-IN-8 -0.08 -0.01 0.07 -0.01 0.10 -0.02
## BGJ398 0.16 0.30 0.08 0.09 0.08 0.13
## SGC 0946 0.21 0.38 0.07 0.12 0.05 0.04
## D 4476 0.15 0.33 0.10 0.10 0.09 0.05
## A-1210477 0.38 0.47 0.35 0.28 0.32 0.24
## Cisplatin 0.38 0.49 0.21 0.15 0.37 0.23
## Ruxolitinib Tofacitinib Motolimod Menin-MLL Inhibitor
## AZD6738 0.25 0.19 -0.11 -0.10
## Rapamycin 0.11 0.14 0.12 0.22
## Ganetespib 0.13 0.00 -0.06 0.03
## Onalespib 0.11 0.05 -0.05 0.11
## Palbociclib 0.20 0.05 0.04 0.12
## Sunitinib 0.30 0.08 0.00 -0.01
## Midostaurin 0.22 0.10 -0.01 0.17
## Duvelisib 0.22 -0.10 -0.06 -0.08
## Idelalisib 0.22 -0.11 -0.06 -0.02
## Dasatinib 0.33 0.06 -0.09 -0.03
## PRT062607 0.29 -0.01 0.00 0.00
## Ibrutinib 0.30 -0.04 -0.01 -0.01
## ONO-4059 0.25 -0.12 0.05 -0.04
## Cobimetinib 0.52 0.16 -0.08 -0.09
## SCH772984 0.57 0.23 -0.06 -0.06
## Trametinib 0.49 0.17 -0.14 -0.11
## A-674563 0.32 0.22 -0.10 0.02
## Tozasertib 0.31 0.02 0.00 -0.10
## BMS-509744 0.30 0.12 -0.09 -0.08
## Ceritinib 0.15 0.10 -0.05 0.10
## MK-2206 0.24 0.11 0.05 0.29
## AZD1208 0.21 0.10 -0.25 -0.02
## AZD8055 0.43 0.23 -0.11 -0.03
## Dabrafenib 0.05 -0.18 0.13 0.00
## Imatinib 0.38 0.12 0.04 0.24
## KU-55933 0.24 0.00 0.21 0.44
## Quizartinib 0.03 0.19 0.00 0.05
## Afatinib -0.02 0.15 0.11 0.25
## TW-37 0.08 0.04 0.14 0.03
## ZM 336372 -0.03 0.26 0.07 0.10
## BML-277 -0.01 0.17 0.13 0.16
## EPZ-6438 -0.17 0.02 0.21 0.24
## PF-3758309 0.16 0.30 -0.12 0.11
## Venetoclax -0.14 0.00 -0.06 0.01
## Doxorubicine -0.04 -0.17 0.25 0.03
## Panobinostat 0.04 0.05 0.05 -0.01
## Selinexor 0.23 0.15 0.17 0.04
## OTX015 0.08 -0.03 0.20 0.04
## Volasertib 0.22 0.03 0.17 -0.06
## Nutlin-3a 0.16 0.09 0.05 0.14
## RO5963 0.16 0.16 0.02 0.11
## Cytarabine 0.06 0.01 0.12 0.11
## Fludarabine 0.03 0.06 0.09 0.02
## Ruxolitinib 1.00 0.59 0.06 0.07
## Tofacitinib 0.59 1.00 0.03 0.21
## Motolimod 0.06 0.03 1.00 0.30
## Menin-MLL Inhibitor 0.07 0.21 0.30 1.00
## MI-503 0.14 0.23 0.16 0.32
## Olaparib 0.25 0.30 0.12 0.31
## SB 203580 0.37 0.35 0.22 0.21
## AMI-1 0.21 0.38 0.12 0.22
## Vismodegib 0.36 0.35 0.17 0.25
## Methotrexate 0.16 0.09 0.09 0.16
## IRAK-1/4 Inhibitor I 0.17 0.25 0.18 0.52
## Selisistat 0.21 0.26 0.25 0.39
## Foretinib 0.23 0.01 -0.03 -0.18
## JNK-IN-8 0.03 0.00 0.05 0.17
## BGJ398 0.14 0.03 0.04 -0.13
## SGC 0946 0.36 0.13 0.17 -0.05
## D 4476 0.09 0.04 0.20 0.02
## A-1210477 0.10 -0.08 0.07 -0.04
## Cisplatin 0.22 -0.05 0.17 0.02
## MI-503 Olaparib SB 203580 AMI-1 Vismodegib Methotrexate
## AZD6738 0.01 0.01 0.01 0.36 0.25 0.29
## Rapamycin 0.06 -0.13 0.05 0.09 0.12 0.08
## Ganetespib -0.07 -0.01 0.03 -0.10 -0.05 -0.02
## Onalespib -0.03 0.00 0.05 -0.07 -0.03 -0.04
## Palbociclib 0.10 -0.06 -0.01 0.05 0.17 0.09
## Sunitinib 0.04 -0.11 0.13 0.09 0.16 0.23
## Midostaurin 0.04 0.09 -0.14 -0.14 -0.11 0.11
## Duvelisib -0.21 -0.07 -0.10 -0.17 -0.11 -0.10
## Idelalisib -0.13 -0.02 -0.10 -0.10 -0.04 -0.02
## Dasatinib -0.10 0.08 0.02 -0.15 -0.07 -0.09
## PRT062607 -0.15 0.07 0.08 -0.05 0.01 -0.10
## Ibrutinib -0.18 0.04 0.04 -0.14 -0.07 -0.09
## ONO-4059 -0.18 0.01 0.01 -0.17 -0.09 -0.13
## Cobimetinib -0.09 0.14 0.20 -0.01 0.09 0.02
## SCH772984 -0.12 0.05 0.20 0.02 0.12 0.06
## Trametinib -0.18 0.02 0.09 -0.13 -0.04 -0.05
## A-674563 0.12 -0.10 0.19 0.28 0.35 0.11
## Tozasertib 0.09 0.10 0.24 0.19 0.29 0.12
## BMS-509744 0.05 0.26 0.12 0.29 0.26 0.05
## Ceritinib 0.31 0.32 0.19 0.42 0.39 0.08
## MK-2206 0.31 0.25 0.16 0.11 0.21 0.16
## AZD1208 0.10 0.28 -0.13 0.01 -0.02 -0.06
## AZD8055 0.22 0.30 0.24 0.30 0.34 0.16
## Dabrafenib -0.12 0.10 0.09 0.02 0.03 -0.14
## Imatinib 0.38 0.39 0.20 0.11 0.24 0.34
## KU-55933 0.15 0.30 0.20 0.05 0.17 0.16
## Quizartinib 0.16 -0.17 0.12 0.29 0.29 0.33
## Afatinib 0.15 -0.12 0.02 0.19 0.18 0.07
## TW-37 0.12 -0.08 0.19 0.34 0.38 0.22
## ZM 336372 0.22 0.07 0.23 0.41 0.28 0.07
## BML-277 0.42 0.19 0.17 0.45 0.43 0.25
## EPZ-6438 0.10 -0.01 -0.08 0.05 -0.03 -0.13
## PF-3758309 0.10 -0.12 -0.05 0.07 0.10 -0.03
## Venetoclax 0.17 -0.03 -0.16 0.05 -0.01 -0.18
## Doxorubicine -0.16 -0.27 -0.04 -0.08 0.02 0.03
## Panobinostat 0.07 -0.17 -0.13 -0.07 -0.08 0.04
## Selinexor 0.06 -0.12 0.17 0.09 0.15 -0.04
## OTX015 -0.16 -0.28 0.10 -0.01 0.07 0.01
## Volasertib -0.09 -0.13 0.28 0.22 0.29 0.13
## Nutlin-3a -0.03 0.02 0.19 0.08 0.21 0.08
## RO5963 0.00 0.01 0.20 0.16 0.22 0.06
## Cytarabine -0.09 -0.11 0.08 0.05 0.11 0.03
## Fludarabine -0.10 -0.27 -0.01 0.01 0.04 0.03
## Ruxolitinib 0.14 0.25 0.37 0.21 0.36 0.16
## Tofacitinib 0.23 0.30 0.35 0.38 0.35 0.09
## Motolimod 0.16 0.12 0.22 0.12 0.17 0.09
## Menin-MLL Inhibitor 0.32 0.31 0.21 0.22 0.25 0.16
## MI-503 1.00 0.44 0.15 0.35 0.36 0.34
## Olaparib 0.44 1.00 0.33 0.38 0.40 0.25
## SB 203580 0.15 0.33 1.00 0.45 0.57 0.22
## AMI-1 0.35 0.38 0.45 1.00 0.75 0.36
## Vismodegib 0.36 0.40 0.57 0.75 1.00 0.43
## Methotrexate 0.34 0.25 0.22 0.36 0.43 1.00
## IRAK-1/4 Inhibitor I 0.37 0.19 0.31 0.42 0.57 0.45
## Selisistat 0.39 0.33 0.47 0.61 0.72 0.45
## Foretinib 0.20 0.31 0.40 0.23 0.28 0.23
## JNK-IN-8 0.20 0.09 0.10 0.11 0.16 0.02
## BGJ398 0.18 -0.02 0.00 0.23 0.17 0.05
## SGC 0946 0.03 0.01 0.38 0.41 0.31 0.08
## D 4476 0.13 0.06 0.31 0.47 0.44 0.17
## A-1210477 0.04 -0.03 0.12 0.26 0.33 0.14
## Cisplatin 0.17 0.05 0.23 0.33 0.41 0.37
## IRAK-1/4 Inhibitor I Selisistat Foretinib JNK-IN-8 BGJ398
## AZD6738 0.22 0.24 0.01 -0.06 0.17
## Rapamycin 0.28 0.37 -0.34 -0.22 -0.04
## Ganetespib 0.14 0.03 0.08 0.10 0.04
## Onalespib 0.20 0.07 0.01 0.06 0.05
## Palbociclib 0.39 0.33 -0.10 0.15 0.19
## Sunitinib 0.30 0.24 0.09 0.04 0.24
## Midostaurin 0.21 0.03 -0.16 0.05 0.04
## Duvelisib 0.07 0.02 0.02 -0.04 0.02
## Idelalisib 0.13 0.06 0.07 0.09 0.00
## Dasatinib 0.09 -0.01 0.11 0.09 -0.02
## PRT062607 0.15 0.13 0.16 0.13 0.02
## Ibrutinib 0.11 0.05 0.15 0.06 0.01
## ONO-4059 0.05 0.05 0.12 0.04 0.01
## Cobimetinib 0.03 0.09 0.20 -0.11 0.09
## SCH772984 0.08 0.09 0.05 -0.12 0.12
## Trametinib 0.00 -0.01 0.03 -0.10 0.06
## A-674563 0.36 0.34 0.08 0.13 0.23
## Tozasertib 0.22 0.28 0.45 0.14 0.22
## BMS-509744 0.10 0.16 0.29 0.12 0.15
## Ceritinib 0.29 0.29 0.30 0.27 0.30
## MK-2206 0.30 0.29 0.06 0.13 -0.01
## AZD1208 0.00 -0.06 0.14 0.19 0.00
## AZD8055 0.25 0.26 0.36 0.19 0.17
## Dabrafenib 0.05 0.06 0.01 0.17 0.00
## Imatinib 0.39 0.32 0.33 0.18 0.07
## KU-55933 0.32 0.25 0.06 0.11 -0.04
## Quizartinib 0.28 0.26 -0.03 0.25 0.08
## Afatinib 0.36 0.24 -0.30 0.15 0.23
## TW-37 0.17 0.33 0.00 0.06 0.22
## ZM 336372 0.10 0.21 0.12 0.19 0.03
## BML-277 0.23 0.31 0.16 0.17 0.31
## EPZ-6438 -0.01 0.01 -0.16 0.14 0.05
## PF-3758309 0.32 0.13 -0.14 0.12 0.11
## Venetoclax 0.16 0.03 -0.18 0.16 0.11
## Doxorubicine 0.17 0.10 -0.17 0.06 0.05
## Panobinostat 0.04 0.01 -0.21 -0.18 0.13
## Selinexor 0.22 0.19 -0.01 0.05 0.13
## OTX015 0.20 0.15 -0.13 -0.08 0.16
## Volasertib 0.20 0.21 0.10 -0.01 0.30
## Nutlin-3a 0.31 0.29 -0.06 0.07 0.08
## RO5963 0.28 0.30 -0.05 -0.01 0.09
## Cytarabine 0.25 0.19 -0.09 0.10 0.08
## Fludarabine 0.15 0.07 -0.24 -0.02 0.13
## Ruxolitinib 0.17 0.21 0.23 0.03 0.14
## Tofacitinib 0.25 0.26 0.01 0.00 0.03
## Motolimod 0.18 0.25 -0.03 0.05 0.04
## Menin-MLL Inhibitor 0.52 0.39 -0.18 0.17 -0.13
## MI-503 0.37 0.39 0.20 0.20 0.18
## Olaparib 0.19 0.33 0.31 0.09 -0.02
## SB 203580 0.31 0.47 0.40 0.10 0.00
## AMI-1 0.42 0.61 0.23 0.11 0.23
## Vismodegib 0.57 0.72 0.28 0.16 0.17
## Methotrexate 0.45 0.45 0.23 0.02 0.05
## IRAK-1/4 Inhibitor I 1.00 0.65 -0.02 0.26 0.08
## Selisistat 0.65 1.00 0.09 0.06 -0.01
## Foretinib -0.02 0.09 1.00 0.29 0.15
## JNK-IN-8 0.26 0.06 0.29 1.00 0.07
## BGJ398 0.08 -0.01 0.15 0.07 1.00
## SGC 0946 0.09 0.28 0.30 0.04 0.27
## D 4476 0.21 0.37 0.31 0.17 0.29
## A-1210477 0.32 0.36 0.02 0.03 0.31
## Cisplatin 0.35 0.39 0.36 0.12 0.38
## SGC 0946 D 4476 A-1210477 Cisplatin
## AZD6738 0.30 0.10 0.34 0.28
## Rapamycin 0.07 -0.08 0.33 0.08
## Ganetespib -0.02 -0.10 0.17 0.14
## Onalespib -0.06 -0.09 0.18 0.10
## Palbociclib 0.14 0.05 0.47 0.29
## Sunitinib 0.22 0.05 0.38 0.37
## Midostaurin -0.04 -0.30 0.11 0.02
## Duvelisib 0.14 -0.17 0.32 0.16
## Idelalisib 0.15 -0.16 0.34 0.24
## Dasatinib 0.06 -0.18 0.19 0.07
## PRT062607 0.20 -0.05 0.30 0.23
## Ibrutinib 0.16 -0.14 0.28 0.24
## ONO-4059 0.21 -0.12 0.30 0.21
## Cobimetinib 0.25 0.07 0.26 0.27
## SCH772984 0.29 -0.06 0.25 0.24
## Trametinib 0.20 -0.19 0.22 0.16
## A-674563 0.41 0.23 0.49 0.39
## Tozasertib 0.35 0.20 0.36 0.43
## BMS-509744 0.18 0.23 0.26 0.20
## Ceritinib 0.16 0.35 0.30 0.20
## MK-2206 0.11 -0.06 0.24 0.14
## AZD1208 0.01 -0.17 0.05 -0.07
## AZD8055 0.30 0.15 0.28 0.23
## Dabrafenib 0.15 0.10 0.34 0.09
## Imatinib 0.13 -0.04 0.12 0.27
## KU-55933 0.13 -0.09 0.10 0.21
## Quizartinib 0.18 0.18 0.03 0.09
## Afatinib -0.07 0.19 0.32 0.12
## TW-37 0.25 0.36 0.28 0.43
## ZM 336372 0.27 0.26 -0.04 0.02
## BML-277 0.04 0.47 0.13 0.22
## EPZ-6438 -0.04 0.11 -0.13 -0.08
## PF-3758309 0.03 -0.08 0.16 0.04
## Venetoclax -0.09 0.02 0.17 -0.05
## Doxorubicine 0.10 0.11 0.21 0.31
## Panobinostat 0.03 -0.04 0.14 0.13
## Selinexor 0.22 0.19 0.22 0.14
## OTX015 0.21 0.15 0.38 0.38
## Volasertib 0.38 0.33 0.47 0.49
## Nutlin-3a 0.07 0.10 0.35 0.21
## RO5963 0.12 0.10 0.28 0.15
## Cytarabine 0.05 0.09 0.32 0.37
## Fludarabine 0.04 0.05 0.24 0.23
## Ruxolitinib 0.36 0.09 0.10 0.22
## Tofacitinib 0.13 0.04 -0.08 -0.05
## Motolimod 0.17 0.20 0.07 0.17
## Menin-MLL Inhibitor -0.05 0.02 -0.04 0.02
## MI-503 0.03 0.13 0.04 0.17
## Olaparib 0.01 0.06 -0.03 0.05
## SB 203580 0.38 0.31 0.12 0.23
## AMI-1 0.41 0.47 0.26 0.33
## Vismodegib 0.31 0.44 0.33 0.41
## Methotrexate 0.08 0.17 0.14 0.37
## IRAK-1/4 Inhibitor I 0.09 0.21 0.32 0.35
## Selisistat 0.28 0.37 0.36 0.39
## Foretinib 0.30 0.31 0.02 0.36
## JNK-IN-8 0.04 0.17 0.03 0.12
## BGJ398 0.27 0.29 0.31 0.38
## SGC 0946 1.00 0.35 0.31 0.37
## D 4476 0.35 1.00 0.36 0.41
## A-1210477 0.31 0.36 1.00 0.48
## Cisplatin 0.37 0.41 0.48 1.00
##
## $corrPos
## xName yName x y corr
## 1 AZD6738 AZD6738 1 62 1.00
## 2 AZD6738 Rapamycin 1 61 0.30
## 3 AZD6738 Ganetespib 1 60 0.28
## 4 AZD6738 Onalespib 1 59 0.25
## 5 AZD6738 Palbociclib 1 58 0.41
## 6 AZD6738 Sunitinib 1 57 0.48
## 7 AZD6738 Midostaurin 1 56 0.37
## 8 AZD6738 Duvelisib 1 55 0.38
## 9 AZD6738 Idelalisib 1 54 0.42
## 10 AZD6738 Dasatinib 1 53 0.30
## 11 AZD6738 PRT062607 1 52 0.29
## 12 AZD6738 Ibrutinib 1 51 0.32
## 13 AZD6738 ONO-4059 1 50 0.28
## 14 AZD6738 Cobimetinib 1 49 0.27
## 15 AZD6738 SCH772984 1 48 0.34
## 16 AZD6738 Trametinib 1 47 0.33
## 17 AZD6738 A-674563 1 46 0.44
## 18 AZD6738 Tozasertib 1 45 0.31
## 19 AZD6738 BMS-509744 1 44 0.34
## 20 AZD6738 Ceritinib 1 43 0.26
## 21 AZD6738 MK-2206 1 42 0.20
## 22 AZD6738 AZD1208 1 41 0.34
## 23 AZD6738 AZD8055 1 40 0.48
## 24 AZD6738 Dabrafenib 1 39 0.10
## 25 AZD6738 Imatinib 1 38 0.24
## 26 AZD6738 KU-55933 1 37 0.08
## 27 AZD6738 Quizartinib 1 36 0.10
## 28 AZD6738 Afatinib 1 35 0.05
## 29 AZD6738 TW-37 1 34 0.16
## 30 AZD6738 ZM 336372 1 33 0.18
## 31 AZD6738 BML-277 1 32 -0.02
## 32 AZD6738 EPZ-6438 1 31 -0.24
## 33 AZD6738 PF-3758309 1 30 0.28
## 34 AZD6738 Venetoclax 1 29 0.08
## 35 AZD6738 Doxorubicine 1 28 0.00
## 36 AZD6738 Panobinostat 1 27 0.23
## 37 AZD6738 Selinexor 1 26 0.09
## 38 AZD6738 OTX015 1 25 0.22
## 39 AZD6738 Volasertib 1 24 0.34
## 40 AZD6738 Nutlin-3a 1 23 0.28
## 41 AZD6738 RO5963 1 22 0.33
## 42 AZD6738 Cytarabine 1 21 0.16
## 43 AZD6738 Fludarabine 1 20 0.22
## 44 AZD6738 Ruxolitinib 1 19 0.25
## 45 AZD6738 Tofacitinib 1 18 0.19
## 46 AZD6738 Motolimod 1 17 -0.11
## 47 AZD6738 Menin-MLL Inhibitor 1 16 -0.10
## 48 AZD6738 MI-503 1 15 0.01
## 49 AZD6738 Olaparib 1 14 0.01
## 50 AZD6738 SB 203580 1 13 0.01
## 51 AZD6738 AMI-1 1 12 0.36
## 52 AZD6738 Vismodegib 1 11 0.25
## 53 AZD6738 Methotrexate 1 10 0.29
## 54 AZD6738 IRAK-1/4 Inhibitor I 1 9 0.22
## 55 AZD6738 Selisistat 1 8 0.24
## 56 AZD6738 Foretinib 1 7 0.01
## 57 AZD6738 JNK-IN-8 1 6 -0.06
## 58 AZD6738 BGJ398 1 5 0.17
## 59 AZD6738 SGC 0946 1 4 0.30
## 60 AZD6738 D 4476 1 3 0.10
## 61 AZD6738 A-1210477 1 2 0.34
## 62 AZD6738 Cisplatin 1 1 0.28
## 63 Rapamycin Rapamycin 2 61 1.00
## 64 Rapamycin Ganetespib 2 60 0.33
## 65 Rapamycin Onalespib 2 59 0.34
## 66 Rapamycin Palbociclib 2 58 0.49
## 67 Rapamycin Sunitinib 2 57 0.39
## 68 Rapamycin Midostaurin 2 56 0.34
## 69 Rapamycin Duvelisib 2 55 0.42
## 70 Rapamycin Idelalisib 2 54 0.41
## 71 Rapamycin Dasatinib 2 53 0.22
## 72 Rapamycin PRT062607 2 52 0.25
## 73 Rapamycin Ibrutinib 2 51 0.28
## 74 Rapamycin ONO-4059 2 50 0.31
## 75 Rapamycin Cobimetinib 2 49 0.26
## 76 Rapamycin SCH772984 2 48 0.37
## 77 Rapamycin Trametinib 2 47 0.37
## 78 Rapamycin A-674563 2 46 0.34
## 79 Rapamycin Tozasertib 2 45 0.25
## 80 Rapamycin BMS-509744 2 44 0.03
## 81 Rapamycin Ceritinib 2 43 -0.02
## 82 Rapamycin MK-2206 2 42 0.44
## 83 Rapamycin AZD1208 2 41 0.12
## 84 Rapamycin AZD8055 2 40 0.26
## 85 Rapamycin Dabrafenib 2 39 0.10
## 86 Rapamycin Imatinib 2 38 0.14
## 87 Rapamycin KU-55933 2 37 0.29
## 88 Rapamycin Quizartinib 2 36 0.05
## 89 Rapamycin Afatinib 2 35 0.20
## 90 Rapamycin TW-37 2 34 0.04
## 91 Rapamycin ZM 336372 2 33 0.03
## 92 Rapamycin BML-277 2 32 -0.08
## 93 Rapamycin EPZ-6438 2 31 -0.06
## 94 Rapamycin PF-3758309 2 30 0.38
## 95 Rapamycin Venetoclax 2 29 0.10
## 96 Rapamycin Doxorubicine 2 28 0.06
## 97 Rapamycin Panobinostat 2 27 0.24
## 98 Rapamycin Selinexor 2 26 0.15
## 99 Rapamycin OTX015 2 25 0.35
## 100 Rapamycin Volasertib 2 24 0.24
## 101 Rapamycin Nutlin-3a 2 23 0.39
## 102 Rapamycin RO5963 2 22 0.37
## 103 Rapamycin Cytarabine 2 21 0.20
## 104 Rapamycin Fludarabine 2 20 0.26
## 105 Rapamycin Ruxolitinib 2 19 0.11
## 106 Rapamycin Tofacitinib 2 18 0.14
## 107 Rapamycin Motolimod 2 17 0.12
## 108 Rapamycin Menin-MLL Inhibitor 2 16 0.22
## 109 Rapamycin MI-503 2 15 0.06
## 110 Rapamycin Olaparib 2 14 -0.13
## 111 Rapamycin SB 203580 2 13 0.05
## 112 Rapamycin AMI-1 2 12 0.09
## 113 Rapamycin Vismodegib 2 11 0.12
## 114 Rapamycin Methotrexate 2 10 0.08
## 115 Rapamycin IRAK-1/4 Inhibitor I 2 9 0.28
## 116 Rapamycin Selisistat 2 8 0.37
## 117 Rapamycin Foretinib 2 7 -0.34
## 118 Rapamycin JNK-IN-8 2 6 -0.22
## 119 Rapamycin BGJ398 2 5 -0.04
## 120 Rapamycin SGC 0946 2 4 0.07
## 121 Rapamycin D 4476 2 3 -0.08
## 122 Rapamycin A-1210477 2 2 0.33
## 123 Rapamycin Cisplatin 2 1 0.08
## 124 Ganetespib Ganetespib 3 60 1.00
## 125 Ganetespib Onalespib 3 59 0.96
## 126 Ganetespib Palbociclib 3 58 0.69
## 127 Ganetespib Sunitinib 3 57 0.69
## 128 Ganetespib Midostaurin 3 56 0.60
## 129 Ganetespib Duvelisib 3 55 0.66
## 130 Ganetespib Idelalisib 3 54 0.62
## 131 Ganetespib Dasatinib 3 53 0.75
## 132 Ganetespib PRT062607 3 52 0.70
## 133 Ganetespib Ibrutinib 3 51 0.72
## 134 Ganetespib ONO-4059 3 50 0.68
## 135 Ganetespib Cobimetinib 3 49 0.47
## 136 Ganetespib SCH772984 3 48 0.46
## 137 Ganetespib Trametinib 3 47 0.54
## 138 Ganetespib A-674563 3 46 0.41
## 139 Ganetespib Tozasertib 3 45 0.51
## 140 Ganetespib BMS-509744 3 44 0.07
## 141 Ganetespib Ceritinib 3 43 0.12
## 142 Ganetespib MK-2206 3 42 0.36
## 143 Ganetespib AZD1208 3 41 0.31
## 144 Ganetespib AZD8055 3 40 0.41
## 145 Ganetespib Dabrafenib 3 39 0.24
## 146 Ganetespib Imatinib 3 38 0.40
## 147 Ganetespib KU-55933 3 37 0.33
## 148 Ganetespib Quizartinib 3 36 -0.24
## 149 Ganetespib Afatinib 3 35 0.04
## 150 Ganetespib TW-37 3 34 -0.11
## 151 Ganetespib ZM 336372 3 33 -0.11
## 152 Ganetespib BML-277 3 32 -0.30
## 153 Ganetespib EPZ-6438 3 31 -0.33
## 154 Ganetespib PF-3758309 3 30 0.42
## 155 Ganetespib Venetoclax 3 29 0.16
## 156 Ganetespib Doxorubicine 3 28 0.14
## 157 Ganetespib Panobinostat 3 27 0.32
## 158 Ganetespib Selinexor 3 26 0.21
## 159 Ganetespib OTX015 3 25 0.42
## 160 Ganetespib Volasertib 3 24 0.42
## 161 Ganetespib Nutlin-3a 3 23 0.55
## 162 Ganetespib RO5963 3 22 0.44
## 163 Ganetespib Cytarabine 3 21 0.45
## 164 Ganetespib Fludarabine 3 20 0.32
## 165 Ganetespib Ruxolitinib 3 19 0.13
## 166 Ganetespib Tofacitinib 3 18 0.00
## 167 Ganetespib Motolimod 3 17 -0.06
## 168 Ganetespib Menin-MLL Inhibitor 3 16 0.03
## 169 Ganetespib MI-503 3 15 -0.07
## 170 Ganetespib Olaparib 3 14 -0.01
## 171 Ganetespib SB 203580 3 13 0.03
## 172 Ganetespib AMI-1 3 12 -0.10
## 173 Ganetespib Vismodegib 3 11 -0.05
## 174 Ganetespib Methotrexate 3 10 -0.02
## 175 Ganetespib IRAK-1/4 Inhibitor I 3 9 0.14
## 176 Ganetespib Selisistat 3 8 0.03
## 177 Ganetespib Foretinib 3 7 0.08
## 178 Ganetespib JNK-IN-8 3 6 0.10
## 179 Ganetespib BGJ398 3 5 0.04
## 180 Ganetespib SGC 0946 3 4 -0.02
## 181 Ganetespib D 4476 3 3 -0.10
## 182 Ganetespib A-1210477 3 2 0.17
## 183 Ganetespib Cisplatin 3 1 0.14
## 184 Onalespib Onalespib 4 59 1.00
## 185 Onalespib Palbociclib 4 58 0.69
## 186 Onalespib Sunitinib 4 57 0.66
## 187 Onalespib Midostaurin 4 56 0.58
## 188 Onalespib Duvelisib 4 55 0.60
## 189 Onalespib Idelalisib 4 54 0.55
## 190 Onalespib Dasatinib 4 53 0.71
## 191 Onalespib PRT062607 4 52 0.67
## 192 Onalespib Ibrutinib 4 51 0.67
## 193 Onalespib ONO-4059 4 50 0.63
## 194 Onalespib Cobimetinib 4 49 0.40
## 195 Onalespib SCH772984 4 48 0.39
## 196 Onalespib Trametinib 4 47 0.47
## 197 Onalespib A-674563 4 46 0.41
## 198 Onalespib Tozasertib 4 45 0.46
## 199 Onalespib BMS-509744 4 44 0.01
## 200 Onalespib Ceritinib 4 43 0.15
## 201 Onalespib MK-2206 4 42 0.32
## 202 Onalespib AZD1208 4 41 0.28
## 203 Onalespib AZD8055 4 40 0.37
## 204 Onalespib Dabrafenib 4 39 0.17
## 205 Onalespib Imatinib 4 38 0.37
## 206 Onalespib KU-55933 4 37 0.29
## 207 Onalespib Quizartinib 4 36 -0.22
## 208 Onalespib Afatinib 4 35 0.13
## 209 Onalespib TW-37 4 34 -0.05
## 210 Onalespib ZM 336372 4 33 -0.05
## 211 Onalespib BML-277 4 32 -0.25
## 212 Onalespib EPZ-6438 4 31 -0.30
## 213 Onalespib PF-3758309 4 30 0.45
## 214 Onalespib Venetoclax 4 29 0.28
## 215 Onalespib Doxorubicine 4 28 0.11
## 216 Onalespib Panobinostat 4 27 0.31
## 217 Onalespib Selinexor 4 26 0.21
## 218 Onalespib OTX015 4 25 0.42
## 219 Onalespib Volasertib 4 24 0.41
## 220 Onalespib Nutlin-3a 4 23 0.56
## 221 Onalespib RO5963 4 22 0.46
## 222 Onalespib Cytarabine 4 21 0.44
## 223 Onalespib Fludarabine 4 20 0.32
## 224 Onalespib Ruxolitinib 4 19 0.11
## 225 Onalespib Tofacitinib 4 18 0.05
## 226 Onalespib Motolimod 4 17 -0.05
## 227 Onalespib Menin-MLL Inhibitor 4 16 0.11
## 228 Onalespib MI-503 4 15 -0.03
## 229 Onalespib Olaparib 4 14 0.00
## 230 Onalespib SB 203580 4 13 0.05
## 231 Onalespib AMI-1 4 12 -0.07
## 232 Onalespib Vismodegib 4 11 -0.03
## 233 Onalespib Methotrexate 4 10 -0.04
## 234 Onalespib IRAK-1/4 Inhibitor I 4 9 0.20
## 235 Onalespib Selisistat 4 8 0.07
## 236 Onalespib Foretinib 4 7 0.01
## 237 Onalespib JNK-IN-8 4 6 0.06
## 238 Onalespib BGJ398 4 5 0.05
## 239 Onalespib SGC 0946 4 4 -0.06
## 240 Onalespib D 4476 4 3 -0.09
## 241 Onalespib A-1210477 4 2 0.18
## 242 Onalespib Cisplatin 4 1 0.10
## 243 Palbociclib Palbociclib 5 58 1.00
## 244 Palbociclib Sunitinib 5 57 0.76
## 245 Palbociclib Midostaurin 5 56 0.58
## 246 Palbociclib Duvelisib 5 55 0.65
## 247 Palbociclib Idelalisib 5 54 0.64
## 248 Palbociclib Dasatinib 5 53 0.64
## 249 Palbociclib PRT062607 5 52 0.69
## 250 Palbociclib Ibrutinib 5 51 0.63
## 251 Palbociclib ONO-4059 5 50 0.64
## 252 Palbociclib Cobimetinib 5 49 0.38
## 253 Palbociclib SCH772984 5 48 0.43
## 254 Palbociclib Trametinib 5 47 0.46
## 255 Palbociclib A-674563 5 46 0.65
## 256 Palbociclib Tozasertib 5 45 0.54
## 257 Palbociclib BMS-509744 5 44 0.17
## 258 Palbociclib Ceritinib 5 43 0.21
## 259 Palbociclib MK-2206 5 42 0.46
## 260 Palbociclib AZD1208 5 41 0.30
## 261 Palbociclib AZD8055 5 40 0.47
## 262 Palbociclib Dabrafenib 5 39 0.27
## 263 Palbociclib Imatinib 5 38 0.46
## 264 Palbociclib KU-55933 5 37 0.29
## 265 Palbociclib Quizartinib 5 36 -0.01
## 266 Palbociclib Afatinib 5 35 0.21
## 267 Palbociclib TW-37 5 34 0.08
## 268 Palbociclib ZM 336372 5 33 -0.04
## 269 Palbociclib BML-277 5 32 -0.14
## 270 Palbociclib EPZ-6438 5 31 -0.24
## 271 Palbociclib PF-3758309 5 30 0.59
## 272 Palbociclib Venetoclax 5 29 0.24
## 273 Palbociclib Doxorubicine 5 28 0.29
## 274 Palbociclib Panobinostat 5 27 0.33
## 275 Palbociclib Selinexor 5 26 0.37
## 276 Palbociclib OTX015 5 25 0.46
## 277 Palbociclib Volasertib 5 24 0.47
## 278 Palbociclib Nutlin-3a 5 23 0.59
## 279 Palbociclib RO5963 5 22 0.47
## 280 Palbociclib Cytarabine 5 21 0.47
## 281 Palbociclib Fludarabine 5 20 0.37
## 282 Palbociclib Ruxolitinib 5 19 0.20
## 283 Palbociclib Tofacitinib 5 18 0.05
## 284 Palbociclib Motolimod 5 17 0.04
## 285 Palbociclib Menin-MLL Inhibitor 5 16 0.12
## 286 Palbociclib MI-503 5 15 0.10
## 287 Palbociclib Olaparib 5 14 -0.06
## 288 Palbociclib SB 203580 5 13 -0.01
## 289 Palbociclib AMI-1 5 12 0.05
## 290 Palbociclib Vismodegib 5 11 0.17
## 291 Palbociclib Methotrexate 5 10 0.09
## 292 Palbociclib IRAK-1/4 Inhibitor I 5 9 0.39
## 293 Palbociclib Selisistat 5 8 0.33
## 294 Palbociclib Foretinib 5 7 -0.10
## 295 Palbociclib JNK-IN-8 5 6 0.15
## 296 Palbociclib BGJ398 5 5 0.19
## 297 Palbociclib SGC 0946 5 4 0.14
## 298 Palbociclib D 4476 5 3 0.05
## 299 Palbociclib A-1210477 5 2 0.47
## 300 Palbociclib Cisplatin 5 1 0.29
## 301 Sunitinib Sunitinib 6 57 1.00
## 302 Sunitinib Midostaurin 6 56 0.55
## 303 Sunitinib Duvelisib 6 55 0.61
## 304 Sunitinib Idelalisib 6 54 0.58
## 305 Sunitinib Dasatinib 6 53 0.60
## 306 Sunitinib PRT062607 6 52 0.65
## 307 Sunitinib Ibrutinib 6 51 0.61
## 308 Sunitinib ONO-4059 6 50 0.59
## 309 Sunitinib Cobimetinib 6 49 0.46
## 310 Sunitinib SCH772984 6 48 0.52
## 311 Sunitinib Trametinib 6 47 0.51
## 312 Sunitinib A-674563 6 46 0.64
## 313 Sunitinib Tozasertib 6 45 0.61
## 314 Sunitinib BMS-509744 6 44 0.23
## 315 Sunitinib Ceritinib 6 43 0.21
## 316 Sunitinib MK-2206 6 42 0.38
## 317 Sunitinib AZD1208 6 41 0.25
## 318 Sunitinib AZD8055 6 40 0.47
## 319 Sunitinib Dabrafenib 6 39 0.23
## 320 Sunitinib Imatinib 6 38 0.48
## 321 Sunitinib KU-55933 6 37 0.25
## 322 Sunitinib Quizartinib 6 36 0.02
## 323 Sunitinib Afatinib 6 35 0.18
## 324 Sunitinib TW-37 6 34 0.15
## 325 Sunitinib ZM 336372 6 33 -0.11
## 326 Sunitinib BML-277 6 32 -0.21
## 327 Sunitinib EPZ-6438 6 31 -0.37
## 328 Sunitinib PF-3758309 6 30 0.42
## 329 Sunitinib Venetoclax 6 29 0.10
## 330 Sunitinib Doxorubicine 6 28 0.22
## 331 Sunitinib Panobinostat 6 27 0.38
## 332 Sunitinib Selinexor 6 26 0.29
## 333 Sunitinib OTX015 6 25 0.51
## 334 Sunitinib Volasertib 6 24 0.59
## 335 Sunitinib Nutlin-3a 6 23 0.52
## 336 Sunitinib RO5963 6 22 0.45
## 337 Sunitinib Cytarabine 6 21 0.43
## 338 Sunitinib Fludarabine 6 20 0.33
## 339 Sunitinib Ruxolitinib 6 19 0.30
## 340 Sunitinib Tofacitinib 6 18 0.08
## 341 Sunitinib Motolimod 6 17 0.00
## 342 Sunitinib Menin-MLL Inhibitor 6 16 -0.01
## 343 Sunitinib MI-503 6 15 0.04
## 344 Sunitinib Olaparib 6 14 -0.11
## 345 Sunitinib SB 203580 6 13 0.13
## 346 Sunitinib AMI-1 6 12 0.09
## 347 Sunitinib Vismodegib 6 11 0.16
## 348 Sunitinib Methotrexate 6 10 0.23
## 349 Sunitinib IRAK-1/4 Inhibitor I 6 9 0.30
## 350 Sunitinib Selisistat 6 8 0.24
## 351 Sunitinib Foretinib 6 7 0.09
## 352 Sunitinib JNK-IN-8 6 6 0.04
## 353 Sunitinib BGJ398 6 5 0.24
## 354 Sunitinib SGC 0946 6 4 0.22
## 355 Sunitinib D 4476 6 3 0.05
## 356 Sunitinib A-1210477 6 2 0.38
## 357 Sunitinib Cisplatin 6 1 0.37
## 358 Midostaurin Midostaurin 7 56 1.00
## 359 Midostaurin Duvelisib 7 55 0.63
## 360 Midostaurin Idelalisib 7 54 0.66
## 361 Midostaurin Dasatinib 7 53 0.63
## 362 Midostaurin PRT062607 7 52 0.58
## 363 Midostaurin Ibrutinib 7 51 0.62
## 364 Midostaurin ONO-4059 7 50 0.58
## 365 Midostaurin Cobimetinib 7 49 0.35
## 366 Midostaurin SCH772984 7 48 0.41
## 367 Midostaurin Trametinib 7 47 0.51
## 368 Midostaurin A-674563 7 46 0.27
## 369 Midostaurin Tozasertib 7 45 0.36
## 370 Midostaurin BMS-509744 7 44 0.19
## 371 Midostaurin Ceritinib 7 43 0.11
## 372 Midostaurin MK-2206 7 42 0.47
## 373 Midostaurin AZD1208 7 41 0.50
## 374 Midostaurin AZD8055 7 40 0.44
## 375 Midostaurin Dabrafenib 7 39 0.28
## 376 Midostaurin Imatinib 7 38 0.48
## 377 Midostaurin KU-55933 7 37 0.47
## 378 Midostaurin Quizartinib 7 36 -0.11
## 379 Midostaurin Afatinib 7 35 -0.05
## 380 Midostaurin TW-37 7 34 -0.21
## 381 Midostaurin ZM 336372 7 33 -0.16
## 382 Midostaurin BML-277 7 32 -0.30
## 383 Midostaurin EPZ-6438 7 31 -0.23
## 384 Midostaurin PF-3758309 7 30 0.33
## 385 Midostaurin Venetoclax 7 29 0.13
## 386 Midostaurin Doxorubicine 7 28 -0.01
## 387 Midostaurin Panobinostat 7 27 0.24
## 388 Midostaurin Selinexor 7 26 0.07
## 389 Midostaurin OTX015 7 25 0.12
## 390 Midostaurin Volasertib 7 24 0.09
## 391 Midostaurin Nutlin-3a 7 23 0.36
## 392 Midostaurin RO5963 7 22 0.32
## 393 Midostaurin Cytarabine 7 21 0.20
## 394 Midostaurin Fludarabine 7 20 0.16
## 395 Midostaurin Ruxolitinib 7 19 0.22
## 396 Midostaurin Tofacitinib 7 18 0.10
## 397 Midostaurin Motolimod 7 17 -0.01
## 398 Midostaurin Menin-MLL Inhibitor 7 16 0.17
## 399 Midostaurin MI-503 7 15 0.04
## 400 Midostaurin Olaparib 7 14 0.09
## 401 Midostaurin SB 203580 7 13 -0.14
## 402 Midostaurin AMI-1 7 12 -0.14
## 403 Midostaurin Vismodegib 7 11 -0.11
## 404 Midostaurin Methotrexate 7 10 0.11
## 405 Midostaurin IRAK-1/4 Inhibitor I 7 9 0.21
## 406 Midostaurin Selisistat 7 8 0.03
## 407 Midostaurin Foretinib 7 7 -0.16
## 408 Midostaurin JNK-IN-8 7 6 0.05
## 409 Midostaurin BGJ398 7 5 0.04
## 410 Midostaurin SGC 0946 7 4 -0.04
## 411 Midostaurin D 4476 7 3 -0.30
## 412 Midostaurin A-1210477 7 2 0.11
## 413 Midostaurin Cisplatin 7 1 0.02
## 414 Duvelisib Duvelisib 8 55 1.00
## 415 Duvelisib Idelalisib 8 54 0.93
## 416 Duvelisib Dasatinib 8 53 0.82
## 417 Duvelisib PRT062607 8 52 0.85
## 418 Duvelisib Ibrutinib 8 51 0.89
## 419 Duvelisib ONO-4059 8 50 0.87
## 420 Duvelisib Cobimetinib 8 49 0.62
## 421 Duvelisib SCH772984 8 48 0.59
## 422 Duvelisib Trametinib 8 47 0.69
## 423 Duvelisib A-674563 8 46 0.45
## 424 Duvelisib Tozasertib 8 45 0.58
## 425 Duvelisib BMS-509744 8 44 0.30
## 426 Duvelisib Ceritinib 8 43 0.09
## 427 Duvelisib MK-2206 8 42 0.39
## 428 Duvelisib AZD1208 8 41 0.48
## 429 Duvelisib AZD8055 8 40 0.53
## 430 Duvelisib Dabrafenib 8 39 0.35
## 431 Duvelisib Imatinib 8 38 0.50
## 432 Duvelisib KU-55933 8 37 0.41
## 433 Duvelisib Quizartinib 8 36 -0.30
## 434 Duvelisib Afatinib 8 35 -0.21
## 435 Duvelisib TW-37 8 34 -0.21
## 436 Duvelisib ZM 336372 8 33 -0.25
## 437 Duvelisib BML-277 8 32 -0.43
## 438 Duvelisib EPZ-6438 8 31 -0.36
## 439 Duvelisib PF-3758309 8 30 0.34
## 440 Duvelisib Venetoclax 8 29 0.03
## 441 Duvelisib Doxorubicine 8 28 0.03
## 442 Duvelisib Panobinostat 8 27 0.16
## 443 Duvelisib Selinexor 8 26 0.16
## 444 Duvelisib OTX015 8 25 0.31
## 445 Duvelisib Volasertib 8 24 0.30
## 446 Duvelisib Nutlin-3a 8 23 0.48
## 447 Duvelisib RO5963 8 22 0.42
## 448 Duvelisib Cytarabine 8 21 0.32
## 449 Duvelisib Fludarabine 8 20 0.21
## 450 Duvelisib Ruxolitinib 8 19 0.22
## 451 Duvelisib Tofacitinib 8 18 -0.10
## 452 Duvelisib Motolimod 8 17 -0.06
## 453 Duvelisib Menin-MLL Inhibitor 8 16 -0.08
## 454 Duvelisib MI-503 8 15 -0.21
## 455 Duvelisib Olaparib 8 14 -0.07
## 456 Duvelisib SB 203580 8 13 -0.10
## 457 Duvelisib AMI-1 8 12 -0.17
## 458 Duvelisib Vismodegib 8 11 -0.11
## 459 Duvelisib Methotrexate 8 10 -0.10
## 460 Duvelisib IRAK-1/4 Inhibitor I 8 9 0.07
## 461 Duvelisib Selisistat 8 8 0.02
## 462 Duvelisib Foretinib 8 7 0.02
## 463 Duvelisib JNK-IN-8 8 6 -0.04
## 464 Duvelisib BGJ398 8 5 0.02
## 465 Duvelisib SGC 0946 8 4 0.14
## 466 Duvelisib D 4476 8 3 -0.17
## 467 Duvelisib A-1210477 8 2 0.32
## 468 Duvelisib Cisplatin 8 1 0.16
## 469 Idelalisib Idelalisib 9 54 1.00
## 470 Idelalisib Dasatinib 9 53 0.74
## 471 Idelalisib PRT062607 9 52 0.78
## 472 Idelalisib Ibrutinib 9 51 0.84
## 473 Idelalisib ONO-4059 9 50 0.82
## 474 Idelalisib Cobimetinib 9 49 0.57
## 475 Idelalisib SCH772984 9 48 0.58
## 476 Idelalisib Trametinib 9 47 0.66
## 477 Idelalisib A-674563 9 46 0.46
## 478 Idelalisib Tozasertib 9 45 0.57
## 479 Idelalisib BMS-509744 9 44 0.33
## 480 Idelalisib Ceritinib 9 43 0.13
## 481 Idelalisib MK-2206 9 42 0.49
## 482 Idelalisib AZD1208 9 41 0.56
## 483 Idelalisib AZD8055 9 40 0.60
## 484 Idelalisib Dabrafenib 9 39 0.39
## 485 Idelalisib Imatinib 9 38 0.52
## 486 Idelalisib KU-55933 9 37 0.46
## 487 Idelalisib Quizartinib 9 36 -0.22
## 488 Idelalisib Afatinib 9 35 -0.22
## 489 Idelalisib TW-37 9 34 -0.18
## 490 Idelalisib ZM 336372 9 33 -0.23
## 491 Idelalisib BML-277 9 32 -0.42
## 492 Idelalisib EPZ-6438 9 31 -0.37
## 493 Idelalisib PF-3758309 9 30 0.31
## 494 Idelalisib Venetoclax 9 29 0.04
## 495 Idelalisib Doxorubicine 9 28 0.04
## 496 Idelalisib Panobinostat 9 27 0.16
## 497 Idelalisib Selinexor 9 26 0.12
## 498 Idelalisib OTX015 9 25 0.25
## 499 Idelalisib Volasertib 9 24 0.25
## 500 Idelalisib Nutlin-3a 9 23 0.44
## 501 Idelalisib RO5963 9 22 0.39
## 502 Idelalisib Cytarabine 9 21 0.29
## 503 Idelalisib Fludarabine 9 20 0.19
## 504 Idelalisib Ruxolitinib 9 19 0.22
## 505 Idelalisib Tofacitinib 9 18 -0.11
## 506 Idelalisib Motolimod 9 17 -0.06
## 507 Idelalisib Menin-MLL Inhibitor 9 16 -0.02
## 508 Idelalisib MI-503 9 15 -0.13
## 509 Idelalisib Olaparib 9 14 -0.02
## 510 Idelalisib SB 203580 9 13 -0.10
## 511 Idelalisib AMI-1 9 12 -0.10
## 512 Idelalisib Vismodegib 9 11 -0.04
## 513 Idelalisib Methotrexate 9 10 -0.02
## 514 Idelalisib IRAK-1/4 Inhibitor I 9 9 0.13
## 515 Idelalisib Selisistat 9 8 0.06
## 516 Idelalisib Foretinib 9 7 0.07
## 517 Idelalisib JNK-IN-8 9 6 0.09
## 518 Idelalisib BGJ398 9 5 0.00
## 519 Idelalisib SGC 0946 9 4 0.15
## 520 Idelalisib D 4476 9 3 -0.16
## 521 Idelalisib A-1210477 9 2 0.34
## 522 Idelalisib Cisplatin 9 1 0.24
## 523 Dasatinib Dasatinib 10 53 1.00
## 524 Dasatinib PRT062607 10 52 0.84
## 525 Dasatinib Ibrutinib 10 51 0.87
## 526 Dasatinib ONO-4059 10 50 0.80
## 527 Dasatinib Cobimetinib 10 49 0.63
## 528 Dasatinib SCH772984 10 48 0.55
## 529 Dasatinib Trametinib 10 47 0.67
## 530 Dasatinib A-674563 10 46 0.40
## 531 Dasatinib Tozasertib 10 45 0.52
## 532 Dasatinib BMS-509744 10 44 0.25
## 533 Dasatinib Ceritinib 10 43 0.13
## 534 Dasatinib MK-2206 10 42 0.33
## 535 Dasatinib AZD1208 10 41 0.44
## 536 Dasatinib AZD8055 10 40 0.53
## 537 Dasatinib Dabrafenib 10 39 0.38
## 538 Dasatinib Imatinib 10 38 0.60
## 539 Dasatinib KU-55933 10 37 0.34
## 540 Dasatinib Quizartinib 10 36 -0.37
## 541 Dasatinib Afatinib 10 35 -0.14
## 542 Dasatinib TW-37 10 34 -0.28
## 543 Dasatinib ZM 336372 10 33 -0.24
## 544 Dasatinib BML-277 10 32 -0.40
## 545 Dasatinib EPZ-6438 10 31 -0.39
## 546 Dasatinib PF-3758309 10 30 0.38
## 547 Dasatinib Venetoclax 10 29 0.08
## 548 Dasatinib Doxorubicine 10 28 -0.02
## 549 Dasatinib Panobinostat 10 27 0.06
## 550 Dasatinib Selinexor 10 26 0.11
## 551 Dasatinib OTX015 10 25 0.22
## 552 Dasatinib Volasertib 10 24 0.23
## 553 Dasatinib Nutlin-3a 10 23 0.45
## 554 Dasatinib RO5963 10 22 0.36
## 555 Dasatinib Cytarabine 10 21 0.30
## 556 Dasatinib Fludarabine 10 20 0.11
## 557 Dasatinib Ruxolitinib 10 19 0.33
## 558 Dasatinib Tofacitinib 10 18 0.06
## 559 Dasatinib Motolimod 10 17 -0.09
## 560 Dasatinib Menin-MLL Inhibitor 10 16 -0.03
## 561 Dasatinib MI-503 10 15 -0.10
## 562 Dasatinib Olaparib 10 14 0.08
## 563 Dasatinib SB 203580 10 13 0.02
## 564 Dasatinib AMI-1 10 12 -0.15
## 565 Dasatinib Vismodegib 10 11 -0.07
## 566 Dasatinib Methotrexate 10 10 -0.09
## 567 Dasatinib IRAK-1/4 Inhibitor I 10 9 0.09
## 568 Dasatinib Selisistat 10 8 -0.01
## 569 Dasatinib Foretinib 10 7 0.11
## 570 Dasatinib JNK-IN-8 10 6 0.09
## 571 Dasatinib BGJ398 10 5 -0.02
## 572 Dasatinib SGC 0946 10 4 0.06
## 573 Dasatinib D 4476 10 3 -0.18
## 574 Dasatinib A-1210477 10 2 0.19
## 575 Dasatinib Cisplatin 10 1 0.07
## 576 PRT062607 PRT062607 11 52 1.00
## 577 PRT062607 Ibrutinib 11 51 0.92
## 578 PRT062607 ONO-4059 11 50 0.91
## 579 PRT062607 Cobimetinib 11 49 0.58
## 580 PRT062607 SCH772984 11 48 0.51
## 581 PRT062607 Trametinib 11 47 0.61
## 582 PRT062607 A-674563 11 46 0.50
## 583 PRT062607 Tozasertib 11 45 0.67
## 584 PRT062607 BMS-509744 11 44 0.32
## 585 PRT062607 Ceritinib 11 43 0.19
## 586 PRT062607 MK-2206 11 42 0.33
## 587 PRT062607 AZD1208 11 41 0.44
## 588 PRT062607 AZD8055 11 40 0.52
## 589 PRT062607 Dabrafenib 11 39 0.34
## 590 PRT062607 Imatinib 11 38 0.55
## 591 PRT062607 KU-55933 11 37 0.43
## 592 PRT062607 Quizartinib 11 36 -0.29
## 593 PRT062607 Afatinib 11 35 -0.15
## 594 PRT062607 TW-37 11 34 -0.15
## 595 PRT062607 ZM 336372 11 33 -0.15
## 596 PRT062607 BML-277 11 32 -0.39
## 597 PRT062607 EPZ-6438 11 31 -0.37
## 598 PRT062607 PF-3758309 11 30 0.34
## 599 PRT062607 Venetoclax 11 29 0.12
## 600 PRT062607 Doxorubicine 11 28 0.10
## 601 PRT062607 Panobinostat 11 27 0.04
## 602 PRT062607 Selinexor 11 26 0.23
## 603 PRT062607 OTX015 11 25 0.29
## 604 PRT062607 Volasertib 11 24 0.34
## 605 PRT062607 Nutlin-3a 11 23 0.48
## 606 PRT062607 RO5963 11 22 0.41
## 607 PRT062607 Cytarabine 11 21 0.34
## 608 PRT062607 Fludarabine 11 20 0.12
## 609 PRT062607 Ruxolitinib 11 19 0.29
## 610 PRT062607 Tofacitinib 11 18 -0.01
## 611 PRT062607 Motolimod 11 17 0.00
## 612 PRT062607 Menin-MLL Inhibitor 11 16 0.00
## 613 PRT062607 MI-503 11 15 -0.15
## 614 PRT062607 Olaparib 11 14 0.07
## 615 PRT062607 SB 203580 11 13 0.08
## 616 PRT062607 AMI-1 11 12 -0.05
## 617 PRT062607 Vismodegib 11 11 0.01
## 618 PRT062607 Methotrexate 11 10 -0.10
## 619 PRT062607 IRAK-1/4 Inhibitor I 11 9 0.15
## 620 PRT062607 Selisistat 11 8 0.13
## 621 PRT062607 Foretinib 11 7 0.16
## 622 PRT062607 JNK-IN-8 11 6 0.13
## 623 PRT062607 BGJ398 11 5 0.02
## 624 PRT062607 SGC 0946 11 4 0.20
## 625 PRT062607 D 4476 11 3 -0.05
## 626 PRT062607 A-1210477 11 2 0.30
## 627 PRT062607 Cisplatin 11 1 0.23
## 628 Ibrutinib Ibrutinib 12 51 1.00
## 629 Ibrutinib ONO-4059 12 50 0.96
## 630 Ibrutinib Cobimetinib 12 49 0.61
## 631 Ibrutinib SCH772984 12 48 0.54
## 632 Ibrutinib Trametinib 12 47 0.66
## 633 Ibrutinib A-674563 12 46 0.43
## 634 Ibrutinib Tozasertib 12 45 0.62
## 635 Ibrutinib BMS-509744 12 44 0.28
## 636 Ibrutinib Ceritinib 12 43 0.13
## 637 Ibrutinib MK-2206 12 42 0.33
## 638 Ibrutinib AZD1208 12 41 0.42
## 639 Ibrutinib AZD8055 12 40 0.52
## 640 Ibrutinib Dabrafenib 12 39 0.36
## 641 Ibrutinib Imatinib 12 38 0.54
## 642 Ibrutinib KU-55933 12 37 0.47
## 643 Ibrutinib Quizartinib 12 36 -0.35
## 644 Ibrutinib Afatinib 12 35 -0.21
## 645 Ibrutinib TW-37 12 34 -0.20
## 646 Ibrutinib ZM 336372 12 33 -0.25
## 647 Ibrutinib BML-277 12 32 -0.46
## 648 Ibrutinib EPZ-6438 12 31 -0.42
## 649 Ibrutinib PF-3758309 12 30 0.29
## 650 Ibrutinib Venetoclax 12 29 0.04
## 651 Ibrutinib Doxorubicine 12 28 0.06
## 652 Ibrutinib Panobinostat 12 27 0.07
## 653 Ibrutinib Selinexor 12 26 0.14
## 654 Ibrutinib OTX015 12 25 0.29
## 655 Ibrutinib Volasertib 12 24 0.30
## 656 Ibrutinib Nutlin-3a 12 23 0.47
## 657 Ibrutinib RO5963 12 22 0.40
## 658 Ibrutinib Cytarabine 12 21 0.34
## 659 Ibrutinib Fludarabine 12 20 0.14
## 660 Ibrutinib Ruxolitinib 12 19 0.30
## 661 Ibrutinib Tofacitinib 12 18 -0.04
## 662 Ibrutinib Motolimod 12 17 -0.01
## 663 Ibrutinib Menin-MLL Inhibitor 12 16 -0.01
## 664 Ibrutinib MI-503 12 15 -0.18
## 665 Ibrutinib Olaparib 12 14 0.04
## 666 Ibrutinib SB 203580 12 13 0.04
## 667 Ibrutinib AMI-1 12 12 -0.14
## 668 Ibrutinib Vismodegib 12 11 -0.07
## 669 Ibrutinib Methotrexate 12 10 -0.09
## 670 Ibrutinib IRAK-1/4 Inhibitor I 12 9 0.11
## 671 Ibrutinib Selisistat 12 8 0.05
## 672 Ibrutinib Foretinib 12 7 0.15
## 673 Ibrutinib JNK-IN-8 12 6 0.06
## 674 Ibrutinib BGJ398 12 5 0.01
## 675 Ibrutinib SGC 0946 12 4 0.16
## 676 Ibrutinib D 4476 12 3 -0.14
## 677 Ibrutinib A-1210477 12 2 0.28
## 678 Ibrutinib Cisplatin 12 1 0.24
## 679 ONO-4059 ONO-4059 13 50 1.00
## 680 ONO-4059 Cobimetinib 13 49 0.56
## 681 ONO-4059 SCH772984 13 48 0.51
## 682 ONO-4059 Trametinib 13 47 0.61
## 683 ONO-4059 A-674563 13 46 0.42
## 684 ONO-4059 Tozasertib 13 45 0.63
## 685 ONO-4059 BMS-509744 13 44 0.25
## 686 ONO-4059 Ceritinib 13 43 0.09
## 687 ONO-4059 MK-2206 13 42 0.34
## 688 ONO-4059 AZD1208 13 41 0.38
## 689 ONO-4059 AZD8055 13 40 0.45
## 690 ONO-4059 Dabrafenib 13 39 0.38
## 691 ONO-4059 Imatinib 13 38 0.51
## 692 ONO-4059 KU-55933 13 37 0.49
## 693 ONO-4059 Quizartinib 13 36 -0.37
## 694 ONO-4059 Afatinib 13 35 -0.23
## 695 ONO-4059 TW-37 13 34 -0.16
## 696 ONO-4059 ZM 336372 13 33 -0.20
## 697 ONO-4059 BML-277 13 32 -0.45
## 698 ONO-4059 EPZ-6438 13 31 -0.39
## 699 ONO-4059 PF-3758309 13 30 0.23
## 700 ONO-4059 Venetoclax 13 29 0.06
## 701 ONO-4059 Doxorubicine 13 28 0.12
## 702 ONO-4059 Panobinostat 13 27 0.09
## 703 ONO-4059 Selinexor 13 26 0.18
## 704 ONO-4059 OTX015 13 25 0.31
## 705 ONO-4059 Volasertib 13 24 0.32
## 706 ONO-4059 Nutlin-3a 13 23 0.46
## 707 ONO-4059 RO5963 13 22 0.38
## 708 ONO-4059 Cytarabine 13 21 0.31
## 709 ONO-4059 Fludarabine 13 20 0.13
## 710 ONO-4059 Ruxolitinib 13 19 0.25
## 711 ONO-4059 Tofacitinib 13 18 -0.12
## 712 ONO-4059 Motolimod 13 17 0.05
## 713 ONO-4059 Menin-MLL Inhibitor 13 16 -0.04
## 714 ONO-4059 MI-503 13 15 -0.18
## 715 ONO-4059 Olaparib 13 14 0.01
## 716 ONO-4059 SB 203580 13 13 0.01
## 717 ONO-4059 AMI-1 13 12 -0.17
## 718 ONO-4059 Vismodegib 13 11 -0.09
## 719 ONO-4059 Methotrexate 13 10 -0.13
## 720 ONO-4059 IRAK-1/4 Inhibitor I 13 9 0.05
## 721 ONO-4059 Selisistat 13 8 0.05
## 722 ONO-4059 Foretinib 13 7 0.12
## 723 ONO-4059 JNK-IN-8 13 6 0.04
## 724 ONO-4059 BGJ398 13 5 0.01
## 725 ONO-4059 SGC 0946 13 4 0.21
## 726 ONO-4059 D 4476 13 3 -0.12
## 727 ONO-4059 A-1210477 13 2 0.30
## 728 ONO-4059 Cisplatin 13 1 0.21
## 729 Cobimetinib Cobimetinib 14 49 1.00
## 730 Cobimetinib SCH772984 14 48 0.88
## 731 Cobimetinib Trametinib 14 47 0.90
## 732 Cobimetinib A-674563 14 46 0.40
## 733 Cobimetinib Tozasertib 14 45 0.52
## 734 Cobimetinib BMS-509744 14 44 0.37
## 735 Cobimetinib Ceritinib 14 43 0.08
## 736 Cobimetinib MK-2206 14 42 0.30
## 737 Cobimetinib AZD1208 14 41 0.28
## 738 Cobimetinib AZD8055 14 40 0.48
## 739 Cobimetinib Dabrafenib 14 39 0.33
## 740 Cobimetinib Imatinib 14 38 0.46
## 741 Cobimetinib KU-55933 14 37 0.31
## 742 Cobimetinib Quizartinib 14 36 -0.32
## 743 Cobimetinib Afatinib 14 35 -0.20
## 744 Cobimetinib TW-37 14 34 -0.15
## 745 Cobimetinib ZM 336372 14 33 -0.30
## 746 Cobimetinib BML-277 14 32 -0.27
## 747 Cobimetinib EPZ-6438 14 31 -0.34
## 748 Cobimetinib PF-3758309 14 30 0.15
## 749 Cobimetinib Venetoclax 14 29 -0.17
## 750 Cobimetinib Doxorubicine 14 28 -0.03
## 751 Cobimetinib Panobinostat 14 27 0.05
## 752 Cobimetinib Selinexor 14 26 0.17
## 753 Cobimetinib OTX015 14 25 0.26
## 754 Cobimetinib Volasertib 14 24 0.31
## 755 Cobimetinib Nutlin-3a 14 23 0.46
## 756 Cobimetinib RO5963 14 22 0.42
## 757 Cobimetinib Cytarabine 14 21 0.29
## 758 Cobimetinib Fludarabine 14 20 0.17
## 759 Cobimetinib Ruxolitinib 14 19 0.52
## 760 Cobimetinib Tofacitinib 14 18 0.16
## 761 Cobimetinib Motolimod 14 17 -0.08
## 762 Cobimetinib Menin-MLL Inhibitor 14 16 -0.09
## 763 Cobimetinib MI-503 14 15 -0.09
## 764 Cobimetinib Olaparib 14 14 0.14
## 765 Cobimetinib SB 203580 14 13 0.20
## 766 Cobimetinib AMI-1 14 12 -0.01
## 767 Cobimetinib Vismodegib 14 11 0.09
## 768 Cobimetinib Methotrexate 14 10 0.02
## 769 Cobimetinib IRAK-1/4 Inhibitor I 14 9 0.03
## 770 Cobimetinib Selisistat 14 8 0.09
## 771 Cobimetinib Foretinib 14 7 0.20
## 772 Cobimetinib JNK-IN-8 14 6 -0.11
## 773 Cobimetinib BGJ398 14 5 0.09
## 774 Cobimetinib SGC 0946 14 4 0.25
## 775 Cobimetinib D 4476 14 3 0.07
## 776 Cobimetinib A-1210477 14 2 0.26
## 777 Cobimetinib Cisplatin 14 1 0.27
## 778 SCH772984 SCH772984 15 48 1.00
## 779 SCH772984 Trametinib 15 47 0.92
## 780 SCH772984 A-674563 15 46 0.43
## 781 SCH772984 Tozasertib 15 45 0.45
## 782 SCH772984 BMS-509744 15 44 0.25
## 783 SCH772984 Ceritinib 15 43 -0.02
## 784 SCH772984 MK-2206 15 42 0.32
## 785 SCH772984 AZD1208 15 41 0.27
## 786 SCH772984 AZD8055 15 40 0.45
## 787 SCH772984 Dabrafenib 15 39 0.29
## 788 SCH772984 Imatinib 15 38 0.40
## 789 SCH772984 KU-55933 15 37 0.31
## 790 SCH772984 Quizartinib 15 36 -0.18
## 791 SCH772984 Afatinib 15 35 -0.11
## 792 SCH772984 TW-37 15 34 -0.06
## 793 SCH772984 ZM 336372 15 33 -0.23
## 794 SCH772984 BML-277 15 32 -0.32
## 795 SCH772984 EPZ-6438 15 31 -0.30
## 796 SCH772984 PF-3758309 15 30 0.27
## 797 SCH772984 Venetoclax 15 29 -0.11
## 798 SCH772984 Doxorubicine 15 28 0.05
## 799 SCH772984 Panobinostat 15 27 0.19
## 800 SCH772984 Selinexor 15 26 0.25
## 801 SCH772984 OTX015 15 25 0.35
## 802 SCH772984 Volasertib 15 24 0.38
## 803 SCH772984 Nutlin-3a 15 23 0.52
## 804 SCH772984 RO5963 15 22 0.50
## 805 SCH772984 Cytarabine 15 21 0.33
## 806 SCH772984 Fludarabine 15 20 0.29
## 807 SCH772984 Ruxolitinib 15 19 0.57
## 808 SCH772984 Tofacitinib 15 18 0.23
## 809 SCH772984 Motolimod 15 17 -0.06
## 810 SCH772984 Menin-MLL Inhibitor 15 16 -0.06
## 811 SCH772984 MI-503 15 15 -0.12
## 812 SCH772984 Olaparib 15 14 0.05
## 813 SCH772984 SB 203580 15 13 0.20
## 814 SCH772984 AMI-1 15 12 0.02
## 815 SCH772984 Vismodegib 15 11 0.12
## 816 SCH772984 Methotrexate 15 10 0.06
## 817 SCH772984 IRAK-1/4 Inhibitor I 15 9 0.08
## 818 SCH772984 Selisistat 15 8 0.09
## 819 SCH772984 Foretinib 15 7 0.05
## 820 SCH772984 JNK-IN-8 15 6 -0.12
## 821 SCH772984 BGJ398 15 5 0.12
## 822 SCH772984 SGC 0946 15 4 0.29
## 823 SCH772984 D 4476 15 3 -0.06
## 824 SCH772984 A-1210477 15 2 0.25
## 825 SCH772984 Cisplatin 15 1 0.24
## 826 Trametinib Trametinib 16 47 1.00
## 827 Trametinib A-674563 16 46 0.39
## 828 Trametinib Tozasertib 16 45 0.49
## 829 Trametinib BMS-509744 16 44 0.30
## 830 Trametinib Ceritinib 16 43 0.01
## 831 Trametinib MK-2206 16 42 0.33
## 832 Trametinib AZD1208 16 41 0.37
## 833 Trametinib AZD8055 16 40 0.47
## 834 Trametinib Dabrafenib 16 39 0.32
## 835 Trametinib Imatinib 16 38 0.40
## 836 Trametinib KU-55933 16 37 0.33
## 837 Trametinib Quizartinib 16 36 -0.25
## 838 Trametinib Afatinib 16 35 -0.15
## 839 Trametinib TW-37 16 34 -0.17
## 840 Trametinib ZM 336372 16 33 -0.29
## 841 Trametinib BML-277 16 32 -0.43
## 842 Trametinib EPZ-6438 16 31 -0.33
## 843 Trametinib PF-3758309 16 30 0.28
## 844 Trametinib Venetoclax 16 29 -0.08
## 845 Trametinib Doxorubicine 16 28 -0.01
## 846 Trametinib Panobinostat 16 27 0.14
## 847 Trametinib Selinexor 16 26 0.16
## 848 Trametinib OTX015 16 25 0.29
## 849 Trametinib Volasertib 16 24 0.29
## 850 Trametinib Nutlin-3a 16 23 0.51
## 851 Trametinib RO5963 16 22 0.47
## 852 Trametinib Cytarabine 16 21 0.33
## 853 Trametinib Fludarabine 16 20 0.25
## 854 Trametinib Ruxolitinib 16 19 0.49
## 855 Trametinib Tofacitinib 16 18 0.17
## 856 Trametinib Motolimod 16 17 -0.14
## 857 Trametinib Menin-MLL Inhibitor 16 16 -0.11
## 858 Trametinib MI-503 16 15 -0.18
## 859 Trametinib Olaparib 16 14 0.02
## 860 Trametinib SB 203580 16 13 0.09
## 861 Trametinib AMI-1 16 12 -0.13
## 862 Trametinib Vismodegib 16 11 -0.04
## 863 Trametinib Methotrexate 16 10 -0.05
## 864 Trametinib IRAK-1/4 Inhibitor I 16 9 0.00
## 865 Trametinib Selisistat 16 8 -0.01
## 866 Trametinib Foretinib 16 7 0.03
## 867 Trametinib JNK-IN-8 16 6 -0.10
## 868 Trametinib BGJ398 16 5 0.06
## 869 Trametinib SGC 0946 16 4 0.20
## 870 Trametinib D 4476 16 3 -0.19
## 871 Trametinib A-1210477 16 2 0.22
## 872 Trametinib Cisplatin 16 1 0.16
## 873 A-674563 A-674563 17 46 1.00
## 874 A-674563 Tozasertib 17 45 0.56
## 875 A-674563 BMS-509744 17 44 0.23
## 876 A-674563 Ceritinib 17 43 0.27
## 877 A-674563 MK-2206 17 42 0.34
## 878 A-674563 AZD1208 17 41 0.17
## 879 A-674563 AZD8055 17 40 0.47
## 880 A-674563 Dabrafenib 17 39 0.08
## 881 A-674563 Imatinib 17 38 0.32
## 882 A-674563 KU-55933 17 37 0.18
## 883 A-674563 Quizartinib 17 36 0.17
## 884 A-674563 Afatinib 17 35 0.18
## 885 A-674563 TW-37 17 34 0.27
## 886 A-674563 ZM 336372 17 33 0.04
## 887 A-674563 BML-277 17 32 -0.02
## 888 A-674563 EPZ-6438 17 31 -0.30
## 889 A-674563 PF-3758309 17 30 0.50
## 890 A-674563 Venetoclax 17 29 0.18
## 891 A-674563 Doxorubicine 17 28 0.25
## 892 A-674563 Panobinostat 17 27 0.26
## 893 A-674563 Selinexor 17 26 0.38
## 894 A-674563 OTX015 17 25 0.49
## 895 A-674563 Volasertib 17 24 0.58
## 896 A-674563 Nutlin-3a 17 23 0.46
## 897 A-674563 RO5963 17 22 0.43
## 898 A-674563 Cytarabine 17 21 0.39
## 899 A-674563 Fludarabine 17 20 0.35
## 900 A-674563 Ruxolitinib 17 19 0.32
## 901 A-674563 Tofacitinib 17 18 0.22
## 902 A-674563 Motolimod 17 17 -0.10
## 903 A-674563 Menin-MLL Inhibitor 17 16 0.02
## 904 A-674563 MI-503 17 15 0.12
## 905 A-674563 Olaparib 17 14 -0.10
## 906 A-674563 SB 203580 17 13 0.19
## 907 A-674563 AMI-1 17 12 0.28
## 908 A-674563 Vismodegib 17 11 0.35
## 909 A-674563 Methotrexate 17 10 0.11
## 910 A-674563 IRAK-1/4 Inhibitor I 17 9 0.36
## 911 A-674563 Selisistat 17 8 0.34
## 912 A-674563 Foretinib 17 7 0.08
## 913 A-674563 JNK-IN-8 17 6 0.13
## 914 A-674563 BGJ398 17 5 0.23
## 915 A-674563 SGC 0946 17 4 0.41
## 916 A-674563 D 4476 17 3 0.23
## 917 A-674563 A-1210477 17 2 0.49
## 918 A-674563 Cisplatin 17 1 0.39
## 919 Tozasertib Tozasertib 18 45 1.00
## 920 Tozasertib BMS-509744 18 44 0.44
## 921 Tozasertib Ceritinib 18 43 0.34
## 922 Tozasertib MK-2206 18 42 0.42
## 923 Tozasertib AZD1208 18 41 0.36
## 924 Tozasertib AZD8055 18 40 0.59
## 925 Tozasertib Dabrafenib 18 39 0.27
## 926 Tozasertib Imatinib 18 38 0.46
## 927 Tozasertib KU-55933 18 37 0.39
## 928 Tozasertib Quizartinib 18 36 0.00
## 929 Tozasertib Afatinib 18 35 -0.12
## 930 Tozasertib TW-37 18 34 0.04
## 931 Tozasertib ZM 336372 18 33 -0.01
## 932 Tozasertib BML-277 18 32 -0.13
## 933 Tozasertib EPZ-6438 18 31 -0.36
## 934 Tozasertib PF-3758309 18 30 0.26
## 935 Tozasertib Venetoclax 18 29 0.04
## 936 Tozasertib Doxorubicine 18 28 0.09
## 937 Tozasertib Panobinostat 18 27 0.05
## 938 Tozasertib Selinexor 18 26 0.23
## 939 Tozasertib OTX015 18 25 0.22
## 940 Tozasertib Volasertib 18 24 0.42
## 941 Tozasertib Nutlin-3a 18 23 0.37
## 942 Tozasertib RO5963 18 22 0.33
## 943 Tozasertib Cytarabine 18 21 0.25
## 944 Tozasertib Fludarabine 18 20 0.09
## 945 Tozasertib Ruxolitinib 18 19 0.31
## 946 Tozasertib Tofacitinib 18 18 0.02
## 947 Tozasertib Motolimod 18 17 0.00
## 948 Tozasertib Menin-MLL Inhibitor 18 16 -0.10
## 949 Tozasertib MI-503 18 15 0.09
## 950 Tozasertib Olaparib 18 14 0.10
## 951 Tozasertib SB 203580 18 13 0.24
## 952 Tozasertib AMI-1 18 12 0.19
## 953 Tozasertib Vismodegib 18 11 0.29
## 954 Tozasertib Methotrexate 18 10 0.12
## 955 Tozasertib IRAK-1/4 Inhibitor I 18 9 0.22
## 956 Tozasertib Selisistat 18 8 0.28
## 957 Tozasertib Foretinib 18 7 0.45
## 958 Tozasertib JNK-IN-8 18 6 0.14
## 959 Tozasertib BGJ398 18 5 0.22
## 960 Tozasertib SGC 0946 18 4 0.35
## 961 Tozasertib D 4476 18 3 0.20
## 962 Tozasertib A-1210477 18 2 0.36
## 963 Tozasertib Cisplatin 18 1 0.43
## 964 BMS-509744 BMS-509744 19 44 1.00
## 965 BMS-509744 Ceritinib 19 43 0.56
## 966 BMS-509744 MK-2206 19 42 0.31
## 967 BMS-509744 AZD1208 19 41 0.49
## 968 BMS-509744 AZD8055 19 40 0.50
## 969 BMS-509744 Dabrafenib 19 39 0.33
## 970 BMS-509744 Imatinib 19 38 0.28
## 971 BMS-509744 KU-55933 19 37 0.24
## 972 BMS-509744 Quizartinib 19 36 -0.06
## 973 BMS-509744 Afatinib 19 35 -0.12
## 974 BMS-509744 TW-37 19 34 -0.13
## 975 BMS-509744 ZM 336372 19 33 0.02
## 976 BMS-509744 BML-277 19 32 0.09
## 977 BMS-509744 EPZ-6438 19 31 -0.12
## 978 BMS-509744 PF-3758309 19 30 -0.02
## 979 BMS-509744 Venetoclax 19 29 -0.03
## 980 BMS-509744 Doxorubicine 19 28 -0.16
## 981 BMS-509744 Panobinostat 19 27 -0.07
## 982 BMS-509744 Selinexor 19 26 -0.03
## 983 BMS-509744 OTX015 19 25 -0.08
## 984 BMS-509744 Volasertib 19 24 0.08
## 985 BMS-509744 Nutlin-3a 19 23 0.02
## 986 BMS-509744 RO5963 19 22 0.03
## 987 BMS-509744 Cytarabine 19 21 -0.04
## 988 BMS-509744 Fludarabine 19 20 -0.10
## 989 BMS-509744 Ruxolitinib 19 19 0.30
## 990 BMS-509744 Tofacitinib 19 18 0.12
## 991 BMS-509744 Motolimod 19 17 -0.09
## 992 BMS-509744 Menin-MLL Inhibitor 19 16 -0.08
## 993 BMS-509744 MI-503 19 15 0.05
## 994 BMS-509744 Olaparib 19 14 0.26
## 995 BMS-509744 SB 203580 19 13 0.12
## 996 BMS-509744 AMI-1 19 12 0.29
## 997 BMS-509744 Vismodegib 19 11 0.26
## 998 BMS-509744 Methotrexate 19 10 0.05
## 999 BMS-509744 IRAK-1/4 Inhibitor I 19 9 0.10
## 1000 BMS-509744 Selisistat 19 8 0.16
## 1001 BMS-509744 Foretinib 19 7 0.29
## 1002 BMS-509744 JNK-IN-8 19 6 0.12
## 1003 BMS-509744 BGJ398 19 5 0.15
## 1004 BMS-509744 SGC 0946 19 4 0.18
## 1005 BMS-509744 D 4476 19 3 0.23
## 1006 BMS-509744 A-1210477 19 2 0.26
## 1007 BMS-509744 Cisplatin 19 1 0.20
## 1008 Ceritinib Ceritinib 20 43 1.00
## 1009 Ceritinib MK-2206 20 42 0.33
## 1010 Ceritinib AZD1208 20 41 0.39
## 1011 Ceritinib AZD8055 20 40 0.49
## 1012 Ceritinib Dabrafenib 20 39 0.17
## 1013 Ceritinib Imatinib 20 38 0.22
## 1014 Ceritinib KU-55933 20 37 0.11
## 1015 Ceritinib Quizartinib 20 36 0.08
## 1016 Ceritinib Afatinib 20 35 0.13
## 1017 Ceritinib TW-37 20 34 0.08
## 1018 Ceritinib ZM 336372 20 33 0.16
## 1019 Ceritinib BML-277 20 32 0.24
## 1020 Ceritinib EPZ-6438 20 31 -0.08
## 1021 Ceritinib PF-3758309 20 30 0.10
## 1022 Ceritinib Venetoclax 20 29 0.21
## 1023 Ceritinib Doxorubicine 20 28 -0.19
## 1024 Ceritinib Panobinostat 20 27 -0.11
## 1025 Ceritinib Selinexor 20 26 0.02
## 1026 Ceritinib OTX015 20 25 -0.07
## 1027 Ceritinib Volasertib 20 24 0.11
## 1028 Ceritinib Nutlin-3a 20 23 0.07
## 1029 Ceritinib RO5963 20 22 0.07
## 1030 Ceritinib Cytarabine 20 21 0.03
## 1031 Ceritinib Fludarabine 20 20 -0.08
## 1032 Ceritinib Ruxolitinib 20 19 0.15
## 1033 Ceritinib Tofacitinib 20 18 0.10
## 1034 Ceritinib Motolimod 20 17 -0.05
## 1035 Ceritinib Menin-MLL Inhibitor 20 16 0.10
## 1036 Ceritinib MI-503 20 15 0.31
## 1037 Ceritinib Olaparib 20 14 0.32
## 1038 Ceritinib SB 203580 20 13 0.19
## 1039 Ceritinib AMI-1 20 12 0.42
## 1040 Ceritinib Vismodegib 20 11 0.39
## 1041 Ceritinib Methotrexate 20 10 0.08
## 1042 Ceritinib IRAK-1/4 Inhibitor I 20 9 0.29
## 1043 Ceritinib Selisistat 20 8 0.29
## 1044 Ceritinib Foretinib 20 7 0.30
## 1045 Ceritinib JNK-IN-8 20 6 0.27
## 1046 Ceritinib BGJ398 20 5 0.30
## 1047 Ceritinib SGC 0946 20 4 0.16
## 1048 Ceritinib D 4476 20 3 0.35
## 1049 Ceritinib A-1210477 20 2 0.30
## 1050 Ceritinib Cisplatin 20 1 0.20
## 1051 MK-2206 MK-2206 21 42 1.00
## 1052 MK-2206 AZD1208 21 41 0.45
## 1053 MK-2206 AZD8055 21 40 0.57
## 1054 MK-2206 Dabrafenib 21 39 0.28
## 1055 MK-2206 Imatinib 21 38 0.43
## 1056 MK-2206 KU-55933 21 37 0.47
## 1057 MK-2206 Quizartinib 21 36 -0.06
## 1058 MK-2206 Afatinib 21 35 -0.05
## 1059 MK-2206 TW-37 21 34 -0.05
## 1060 MK-2206 ZM 336372 21 33 0.07
## 1061 MK-2206 BML-277 21 32 -0.08
## 1062 MK-2206 EPZ-6438 21 31 -0.13
## 1063 MK-2206 PF-3758309 21 30 0.26
## 1064 MK-2206 Venetoclax 21 29 0.08
## 1065 MK-2206 Doxorubicine 21 28 0.04
## 1066 MK-2206 Panobinostat 21 27 0.13
## 1067 MK-2206 Selinexor 21 26 0.21
## 1068 MK-2206 OTX015 21 25 0.09
## 1069 MK-2206 Volasertib 21 24 0.14
## 1070 MK-2206 Nutlin-3a 21 23 0.27
## 1071 MK-2206 RO5963 21 22 0.22
## 1072 MK-2206 Cytarabine 21 21 0.14
## 1073 MK-2206 Fludarabine 21 20 0.10
## 1074 MK-2206 Ruxolitinib 21 19 0.24
## 1075 MK-2206 Tofacitinib 21 18 0.11
## 1076 MK-2206 Motolimod 21 17 0.05
## 1077 MK-2206 Menin-MLL Inhibitor 21 16 0.29
## 1078 MK-2206 MI-503 21 15 0.31
## 1079 MK-2206 Olaparib 21 14 0.25
## 1080 MK-2206 SB 203580 21 13 0.16
## 1081 MK-2206 AMI-1 21 12 0.11
## 1082 MK-2206 Vismodegib 21 11 0.21
## 1083 MK-2206 Methotrexate 21 10 0.16
## 1084 MK-2206 IRAK-1/4 Inhibitor I 21 9 0.30
## 1085 MK-2206 Selisistat 21 8 0.29
## 1086 MK-2206 Foretinib 21 7 0.06
## 1087 MK-2206 JNK-IN-8 21 6 0.13
## 1088 MK-2206 BGJ398 21 5 -0.01
## 1089 MK-2206 SGC 0946 21 4 0.11
## 1090 MK-2206 D 4476 21 3 -0.06
## 1091 MK-2206 A-1210477 21 2 0.24
## 1092 MK-2206 Cisplatin 21 1 0.14
## 1093 AZD1208 AZD1208 22 41 1.00
## 1094 AZD1208 AZD8055 22 40 0.67
## 1095 AZD1208 Dabrafenib 22 39 0.24
## 1096 AZD1208 Imatinib 22 38 0.38
## 1097 AZD1208 KU-55933 22 37 0.21
## 1098 AZD1208 Quizartinib 22 36 -0.09
## 1099 AZD1208 Afatinib 22 35 -0.24
## 1100 AZD1208 TW-37 22 34 -0.30
## 1101 AZD1208 ZM 336372 22 33 0.00
## 1102 AZD1208 BML-277 22 32 -0.13
## 1103 AZD1208 EPZ-6438 22 31 -0.18
## 1104 AZD1208 PF-3758309 22 30 0.26
## 1105 AZD1208 Venetoclax 22 29 0.17
## 1106 AZD1208 Doxorubicine 22 28 -0.25
## 1107 AZD1208 Panobinostat 22 27 0.01
## 1108 AZD1208 Selinexor 22 26 -0.01
## 1109 AZD1208 OTX015 22 25 -0.22
## 1110 AZD1208 Volasertib 22 24 -0.13
## 1111 AZD1208 Nutlin-3a 22 23 0.05
## 1112 AZD1208 RO5963 22 22 0.04
## 1113 AZD1208 Cytarabine 22 21 -0.07
## 1114 AZD1208 Fludarabine 22 20 -0.10
## 1115 AZD1208 Ruxolitinib 22 19 0.21
## 1116 AZD1208 Tofacitinib 22 18 0.10
## 1117 AZD1208 Motolimod 22 17 -0.25
## 1118 AZD1208 Menin-MLL Inhibitor 22 16 -0.02
## 1119 AZD1208 MI-503 22 15 0.10
## 1120 AZD1208 Olaparib 22 14 0.28
## 1121 AZD1208 SB 203580 22 13 -0.13
## 1122 AZD1208 AMI-1 22 12 0.01
## 1123 AZD1208 Vismodegib 22 11 -0.02
## 1124 AZD1208 Methotrexate 22 10 -0.06
## 1125 AZD1208 IRAK-1/4 Inhibitor I 22 9 0.00
## 1126 AZD1208 Selisistat 22 8 -0.06
## 1127 AZD1208 Foretinib 22 7 0.14
## 1128 AZD1208 JNK-IN-8 22 6 0.19
## 1129 AZD1208 BGJ398 22 5 0.00
## 1130 AZD1208 SGC 0946 22 4 0.01
## 1131 AZD1208 D 4476 22 3 -0.17
## 1132 AZD1208 A-1210477 22 2 0.05
## 1133 AZD1208 Cisplatin 22 1 -0.07
## 1134 AZD8055 AZD8055 23 40 1.00
## 1135 AZD8055 Dabrafenib 23 39 0.27
## 1136 AZD8055 Imatinib 23 38 0.56
## 1137 AZD8055 KU-55933 23 37 0.27
## 1138 AZD8055 Quizartinib 23 36 -0.04
## 1139 AZD8055 Afatinib 23 35 -0.19
## 1140 AZD8055 TW-37 23 34 -0.10
## 1141 AZD8055 ZM 336372 23 33 0.10
## 1142 AZD8055 BML-277 23 32 -0.02
## 1143 AZD8055 EPZ-6438 23 31 -0.33
## 1144 AZD8055 PF-3758309 23 30 0.34
## 1145 AZD8055 Venetoclax 23 29 0.08
## 1146 AZD8055 Doxorubicine 23 28 -0.16
## 1147 AZD8055 Panobinostat 23 27 0.03
## 1148 AZD8055 Selinexor 23 26 0.19
## 1149 AZD8055 OTX015 23 25 0.02
## 1150 AZD8055 Volasertib 23 24 0.21
## 1151 AZD8055 Nutlin-3a 23 23 0.30
## 1152 AZD8055 RO5963 23 22 0.31
## 1153 AZD8055 Cytarabine 23 21 0.07
## 1154 AZD8055 Fludarabine 23 20 0.05
## 1155 AZD8055 Ruxolitinib 23 19 0.43
## 1156 AZD8055 Tofacitinib 23 18 0.23
## 1157 AZD8055 Motolimod 23 17 -0.11
## 1158 AZD8055 Menin-MLL Inhibitor 23 16 -0.03
## 1159 AZD8055 MI-503 23 15 0.22
## 1160 AZD8055 Olaparib 23 14 0.30
## 1161 AZD8055 SB 203580 23 13 0.24
## 1162 AZD8055 AMI-1 23 12 0.30
## 1163 AZD8055 Vismodegib 23 11 0.34
## 1164 AZD8055 Methotrexate 23 10 0.16
## 1165 AZD8055 IRAK-1/4 Inhibitor I 23 9 0.25
## 1166 AZD8055 Selisistat 23 8 0.26
## 1167 AZD8055 Foretinib 23 7 0.36
## 1168 AZD8055 JNK-IN-8 23 6 0.19
## 1169 AZD8055 BGJ398 23 5 0.17
## 1170 AZD8055 SGC 0946 23 4 0.30
## 1171 AZD8055 D 4476 23 3 0.15
## 1172 AZD8055 A-1210477 23 2 0.28
## 1173 AZD8055 Cisplatin 23 1 0.23
## 1174 Dabrafenib Dabrafenib 24 39 1.00
## 1175 Dabrafenib Imatinib 24 38 0.19
## 1176 Dabrafenib KU-55933 24 37 0.22
## 1177 Dabrafenib Quizartinib 24 36 -0.16
## 1178 Dabrafenib Afatinib 24 35 0.02
## 1179 Dabrafenib TW-37 24 34 -0.11
## 1180 Dabrafenib ZM 336372 24 33 -0.11
## 1181 Dabrafenib BML-277 24 32 -0.16
## 1182 Dabrafenib EPZ-6438 24 31 -0.06
## 1183 Dabrafenib PF-3758309 24 30 -0.10
## 1184 Dabrafenib Venetoclax 24 29 -0.08
## 1185 Dabrafenib Doxorubicine 24 28 0.09
## 1186 Dabrafenib Panobinostat 24 27 0.03
## 1187 Dabrafenib Selinexor 24 26 0.04
## 1188 Dabrafenib OTX015 24 25 0.10
## 1189 Dabrafenib Volasertib 24 24 0.12
## 1190 Dabrafenib Nutlin-3a 24 23 0.22
## 1191 Dabrafenib RO5963 24 22 0.12
## 1192 Dabrafenib Cytarabine 24 21 0.17
## 1193 Dabrafenib Fludarabine 24 20 0.03
## 1194 Dabrafenib Ruxolitinib 24 19 0.05
## 1195 Dabrafenib Tofacitinib 24 18 -0.18
## 1196 Dabrafenib Motolimod 24 17 0.13
## 1197 Dabrafenib Menin-MLL Inhibitor 24 16 0.00
## 1198 Dabrafenib MI-503 24 15 -0.12
## 1199 Dabrafenib Olaparib 24 14 0.10
## 1200 Dabrafenib SB 203580 24 13 0.09
## 1201 Dabrafenib AMI-1 24 12 0.02
## 1202 Dabrafenib Vismodegib 24 11 0.03
## 1203 Dabrafenib Methotrexate 24 10 -0.14
## 1204 Dabrafenib IRAK-1/4 Inhibitor I 24 9 0.05
## 1205 Dabrafenib Selisistat 24 8 0.06
## 1206 Dabrafenib Foretinib 24 7 0.01
## 1207 Dabrafenib JNK-IN-8 24 6 0.17
## 1208 Dabrafenib BGJ398 24 5 0.00
## 1209 Dabrafenib SGC 0946 24 4 0.15
## 1210 Dabrafenib D 4476 24 3 0.10
## 1211 Dabrafenib A-1210477 24 2 0.34
## 1212 Dabrafenib Cisplatin 24 1 0.09
## 1213 Imatinib Imatinib 25 38 1.00
## 1214 Imatinib KU-55933 25 37 0.51
## 1215 Imatinib Quizartinib 25 36 -0.16
## 1216 Imatinib Afatinib 25 35 -0.17
## 1217 Imatinib TW-37 25 34 -0.19
## 1218 Imatinib ZM 336372 25 33 -0.13
## 1219 Imatinib BML-277 25 32 -0.08
## 1220 Imatinib EPZ-6438 25 31 -0.30
## 1221 Imatinib PF-3758309 25 30 0.16
## 1222 Imatinib Venetoclax 25 29 -0.11
## 1223 Imatinib Doxorubicine 25 28 -0.05
## 1224 Imatinib Panobinostat 25 27 -0.01
## 1225 Imatinib Selinexor 25 26 0.12
## 1226 Imatinib OTX015 25 25 0.00
## 1227 Imatinib Volasertib 25 24 0.07
## 1228 Imatinib Nutlin-3a 25 23 0.20
## 1229 Imatinib RO5963 25 22 0.16
## 1230 Imatinib Cytarabine 25 21 0.08
## 1231 Imatinib Fludarabine 25 20 -0.11
## 1232 Imatinib Ruxolitinib 25 19 0.38
## 1233 Imatinib Tofacitinib 25 18 0.12
## 1234 Imatinib Motolimod 25 17 0.04
## 1235 Imatinib Menin-MLL Inhibitor 25 16 0.24
## 1236 Imatinib MI-503 25 15 0.38
## 1237 Imatinib Olaparib 25 14 0.39
## 1238 Imatinib SB 203580 25 13 0.20
## 1239 Imatinib AMI-1 25 12 0.11
## 1240 Imatinib Vismodegib 25 11 0.24
## 1241 Imatinib Methotrexate 25 10 0.34
## 1242 Imatinib IRAK-1/4 Inhibitor I 25 9 0.39
## 1243 Imatinib Selisistat 25 8 0.32
## 1244 Imatinib Foretinib 25 7 0.33
## 1245 Imatinib JNK-IN-8 25 6 0.18
## 1246 Imatinib BGJ398 25 5 0.07
## 1247 Imatinib SGC 0946 25 4 0.13
## 1248 Imatinib D 4476 25 3 -0.04
## 1249 Imatinib A-1210477 25 2 0.12
## 1250 Imatinib Cisplatin 25 1 0.27
## 1251 KU-55933 KU-55933 26 37 1.00
## 1252 KU-55933 Quizartinib 26 36 -0.11
## 1253 KU-55933 Afatinib 26 35 -0.13
## 1254 KU-55933 TW-37 26 34 -0.12
## 1255 KU-55933 ZM 336372 26 33 -0.12
## 1256 KU-55933 BML-277 26 32 -0.17
## 1257 KU-55933 EPZ-6438 26 31 -0.04
## 1258 KU-55933 PF-3758309 26 30 0.04
## 1259 KU-55933 Venetoclax 26 29 -0.14
## 1260 KU-55933 Doxorubicine 26 28 0.04
## 1261 KU-55933 Panobinostat 26 27 0.03
## 1262 KU-55933 Selinexor 26 26 0.03
## 1263 KU-55933 OTX015 26 25 0.11
## 1264 KU-55933 Volasertib 26 24 0.10
## 1265 KU-55933 Nutlin-3a 26 23 0.17
## 1266 KU-55933 RO5963 26 22 0.12
## 1267 KU-55933 Cytarabine 26 21 0.08
## 1268 KU-55933 Fludarabine 26 20 -0.07
## 1269 KU-55933 Ruxolitinib 26 19 0.24
## 1270 KU-55933 Tofacitinib 26 18 0.00
## 1271 KU-55933 Motolimod 26 17 0.21
## 1272 KU-55933 Menin-MLL Inhibitor 26 16 0.44
## 1273 KU-55933 MI-503 26 15 0.15
## 1274 KU-55933 Olaparib 26 14 0.30
## 1275 KU-55933 SB 203580 26 13 0.20
## 1276 KU-55933 AMI-1 26 12 0.05
## 1277 KU-55933 Vismodegib 26 11 0.17
## 1278 KU-55933 Methotrexate 26 10 0.16
## 1279 KU-55933 IRAK-1/4 Inhibitor I 26 9 0.32
## 1280 KU-55933 Selisistat 26 8 0.25
## 1281 KU-55933 Foretinib 26 7 0.06
## 1282 KU-55933 JNK-IN-8 26 6 0.11
## 1283 KU-55933 BGJ398 26 5 -0.04
## 1284 KU-55933 SGC 0946 26 4 0.13
## 1285 KU-55933 D 4476 26 3 -0.09
## 1286 KU-55933 A-1210477 26 2 0.10
## 1287 KU-55933 Cisplatin 26 1 0.21
## 1288 Quizartinib Quizartinib 27 36 1.00
## 1289 Quizartinib Afatinib 27 35 0.30
## 1290 Quizartinib TW-37 27 34 0.38
## 1291 Quizartinib ZM 336372 27 33 0.20
## 1292 Quizartinib BML-277 27 32 0.29
## 1293 Quizartinib EPZ-6438 27 31 0.17
## 1294 Quizartinib PF-3758309 27 30 0.20
## 1295 Quizartinib Venetoclax 27 29 -0.01
## 1296 Quizartinib Doxorubicine 27 28 0.09
## 1297 Quizartinib Panobinostat 27 27 0.10
## 1298 Quizartinib Selinexor 27 26 0.06
## 1299 Quizartinib OTX015 27 25 0.01
## 1300 Quizartinib Volasertib 27 24 0.09
## 1301 Quizartinib Nutlin-3a 27 23 -0.04
## 1302 Quizartinib RO5963 27 22 0.00
## 1303 Quizartinib Cytarabine 27 21 0.02
## 1304 Quizartinib Fludarabine 27 20 0.16
## 1305 Quizartinib Ruxolitinib 27 19 0.03
## 1306 Quizartinib Tofacitinib 27 18 0.19
## 1307 Quizartinib Motolimod 27 17 0.00
## 1308 Quizartinib Menin-MLL Inhibitor 27 16 0.05
## 1309 Quizartinib MI-503 27 15 0.16
## 1310 Quizartinib Olaparib 27 14 -0.17
## 1311 Quizartinib SB 203580 27 13 0.12
## 1312 Quizartinib AMI-1 27 12 0.29
## 1313 Quizartinib Vismodegib 27 11 0.29
## 1314 Quizartinib Methotrexate 27 10 0.33
## 1315 Quizartinib IRAK-1/4 Inhibitor I 27 9 0.28
## 1316 Quizartinib Selisistat 27 8 0.26
## 1317 Quizartinib Foretinib 27 7 -0.03
## 1318 Quizartinib JNK-IN-8 27 6 0.25
## 1319 Quizartinib BGJ398 27 5 0.08
## 1320 Quizartinib SGC 0946 27 4 0.18
## 1321 Quizartinib D 4476 27 3 0.18
## 1322 Quizartinib A-1210477 27 2 0.03
## 1323 Quizartinib Cisplatin 27 1 0.09
## 1324 Afatinib Afatinib 28 35 1.00
## 1325 Afatinib TW-37 28 34 0.41
## 1326 Afatinib ZM 336372 28 33 0.13
## 1327 Afatinib BML-277 28 32 0.29
## 1328 Afatinib EPZ-6438 28 31 0.23
## 1329 Afatinib PF-3758309 28 30 0.24
## 1330 Afatinib Venetoclax 28 29 0.34
## 1331 Afatinib Doxorubicine 28 28 0.20
## 1332 Afatinib Panobinostat 28 27 0.17
## 1333 Afatinib Selinexor 28 26 0.16
## 1334 Afatinib OTX015 28 25 0.23
## 1335 Afatinib Volasertib 28 24 0.19
## 1336 Afatinib Nutlin-3a 28 23 0.22
## 1337 Afatinib RO5963 28 22 0.14
## 1338 Afatinib Cytarabine 28 21 0.29
## 1339 Afatinib Fludarabine 28 20 0.27
## 1340 Afatinib Ruxolitinib 28 19 -0.02
## 1341 Afatinib Tofacitinib 28 18 0.15
## 1342 Afatinib Motolimod 28 17 0.11
## 1343 Afatinib Menin-MLL Inhibitor 28 16 0.25
## 1344 Afatinib MI-503 28 15 0.15
## 1345 Afatinib Olaparib 28 14 -0.12
## 1346 Afatinib SB 203580 28 13 0.02
## 1347 Afatinib AMI-1 28 12 0.19
## 1348 Afatinib Vismodegib 28 11 0.18
## 1349 Afatinib Methotrexate 28 10 0.07
## 1350 Afatinib IRAK-1/4 Inhibitor I 28 9 0.36
## 1351 Afatinib Selisistat 28 8 0.24
## 1352 Afatinib Foretinib 28 7 -0.30
## 1353 Afatinib JNK-IN-8 28 6 0.15
## 1354 Afatinib BGJ398 28 5 0.23
## 1355 Afatinib SGC 0946 28 4 -0.07
## 1356 Afatinib D 4476 28 3 0.19
## 1357 Afatinib A-1210477 28 2 0.32
## 1358 Afatinib Cisplatin 28 1 0.12
## 1359 TW-37 TW-37 29 34 1.00
## 1360 TW-37 ZM 336372 29 33 0.25
## 1361 TW-37 BML-277 29 32 0.31
## 1362 TW-37 EPZ-6438 29 31 0.13
## 1363 TW-37 PF-3758309 29 30 -0.03
## 1364 TW-37 Venetoclax 29 29 0.12
## 1365 TW-37 Doxorubicine 29 28 0.30
## 1366 TW-37 Panobinostat 29 27 0.23
## 1367 TW-37 Selinexor 29 26 0.20
## 1368 TW-37 OTX015 29 25 0.37
## 1369 TW-37 Volasertib 29 24 0.45
## 1370 TW-37 Nutlin-3a 29 23 0.14
## 1371 TW-37 RO5963 29 22 0.14
## 1372 TW-37 Cytarabine 29 21 0.29
## 1373 TW-37 Fludarabine 29 20 0.30
## 1374 TW-37 Ruxolitinib 29 19 0.08
## 1375 TW-37 Tofacitinib 29 18 0.04
## 1376 TW-37 Motolimod 29 17 0.14
## 1377 TW-37 Menin-MLL Inhibitor 29 16 0.03
## 1378 TW-37 MI-503 29 15 0.12
## 1379 TW-37 Olaparib 29 14 -0.08
## 1380 TW-37 SB 203580 29 13 0.19
## 1381 TW-37 AMI-1 29 12 0.34
## 1382 TW-37 Vismodegib 29 11 0.38
## 1383 TW-37 Methotrexate 29 10 0.22
## 1384 TW-37 IRAK-1/4 Inhibitor I 29 9 0.17
## 1385 TW-37 Selisistat 29 8 0.33
## 1386 TW-37 Foretinib 29 7 0.00
## 1387 TW-37 JNK-IN-8 29 6 0.06
## 1388 TW-37 BGJ398 29 5 0.22
## 1389 TW-37 SGC 0946 29 4 0.25
## 1390 TW-37 D 4476 29 3 0.36
## 1391 TW-37 A-1210477 29 2 0.28
## 1392 TW-37 Cisplatin 29 1 0.43
## 1393 ZM 336372 ZM 336372 30 33 1.00
## 1394 ZM 336372 BML-277 30 32 0.39
## 1395 ZM 336372 EPZ-6438 30 31 0.27
## 1396 ZM 336372 PF-3758309 30 30 0.08
## 1397 ZM 336372 Venetoclax 30 29 0.21
## 1398 ZM 336372 Doxorubicine 30 28 -0.15
## 1399 ZM 336372 Panobinostat 30 27 -0.12
## 1400 ZM 336372 Selinexor 30 26 0.07
## 1401 ZM 336372 OTX015 30 25 -0.07
## 1402 ZM 336372 Volasertib 30 24 0.04
## 1403 ZM 336372 Nutlin-3a 30 23 -0.02
## 1404 ZM 336372 RO5963 30 22 0.04
## 1405 ZM 336372 Cytarabine 30 21 -0.06
## 1406 ZM 336372 Fludarabine 30 20 -0.02
## 1407 ZM 336372 Ruxolitinib 30 19 -0.03
## 1408 ZM 336372 Tofacitinib 30 18 0.26
## 1409 ZM 336372 Motolimod 30 17 0.07
## 1410 ZM 336372 Menin-MLL Inhibitor 30 16 0.10
## 1411 ZM 336372 MI-503 30 15 0.22
## 1412 ZM 336372 Olaparib 30 14 0.07
## 1413 ZM 336372 SB 203580 30 13 0.23
## 1414 ZM 336372 AMI-1 30 12 0.41
## 1415 ZM 336372 Vismodegib 30 11 0.28
## 1416 ZM 336372 Methotrexate 30 10 0.07
## 1417 ZM 336372 IRAK-1/4 Inhibitor I 30 9 0.10
## 1418 ZM 336372 Selisistat 30 8 0.21
## 1419 ZM 336372 Foretinib 30 7 0.12
## 1420 ZM 336372 JNK-IN-8 30 6 0.19
## 1421 ZM 336372 BGJ398 30 5 0.03
## 1422 ZM 336372 SGC 0946 30 4 0.27
## 1423 ZM 336372 D 4476 30 3 0.26
## 1424 ZM 336372 A-1210477 30 2 -0.04
## 1425 ZM 336372 Cisplatin 30 1 0.02
## 1426 BML-277 BML-277 31 32 1.00
## 1427 BML-277 EPZ-6438 31 31 0.48
## 1428 BML-277 PF-3758309 31 30 -0.04
## 1429 BML-277 Venetoclax 31 29 0.11
## 1430 BML-277 Doxorubicine 31 28 -0.08
## 1431 BML-277 Panobinostat 31 27 -0.06
## 1432 BML-277 Selinexor 31 26 -0.03
## 1433 BML-277 OTX015 31 25 -0.09
## 1434 BML-277 Volasertib 31 24 0.03
## 1435 BML-277 Nutlin-3a 31 23 -0.09
## 1436 BML-277 RO5963 31 22 -0.06
## 1437 BML-277 Cytarabine 31 21 -0.08
## 1438 BML-277 Fludarabine 31 20 -0.03
## 1439 BML-277 Ruxolitinib 31 19 -0.01
## 1440 BML-277 Tofacitinib 31 18 0.17
## 1441 BML-277 Motolimod 31 17 0.13
## 1442 BML-277 Menin-MLL Inhibitor 31 16 0.16
## 1443 BML-277 MI-503 31 15 0.42
## 1444 BML-277 Olaparib 31 14 0.19
## 1445 BML-277 SB 203580 31 13 0.17
## 1446 BML-277 AMI-1 31 12 0.45
## 1447 BML-277 Vismodegib 31 11 0.43
## 1448 BML-277 Methotrexate 31 10 0.25
## 1449 BML-277 IRAK-1/4 Inhibitor I 31 9 0.23
## 1450 BML-277 Selisistat 31 8 0.31
## 1451 BML-277 Foretinib 31 7 0.16
## 1452 BML-277 JNK-IN-8 31 6 0.17
## 1453 BML-277 BGJ398 31 5 0.31
## 1454 BML-277 SGC 0946 31 4 0.04
## 1455 BML-277 D 4476 31 3 0.47
## 1456 BML-277 A-1210477 31 2 0.13
## 1457 BML-277 Cisplatin 31 1 0.22
## 1458 EPZ-6438 EPZ-6438 32 31 1.00
## 1459 EPZ-6438 PF-3758309 32 30 -0.13
## 1460 EPZ-6438 Venetoclax 32 29 0.01
## 1461 EPZ-6438 Doxorubicine 32 28 -0.02
## 1462 EPZ-6438 Panobinostat 32 27 -0.06
## 1463 EPZ-6438 Selinexor 32 26 -0.09
## 1464 EPZ-6438 OTX015 32 25 -0.11
## 1465 EPZ-6438 Volasertib 32 24 -0.15
## 1466 EPZ-6438 Nutlin-3a 32 23 -0.14
## 1467 EPZ-6438 RO5963 32 22 -0.14
## 1468 EPZ-6438 Cytarabine 32 21 -0.06
## 1469 EPZ-6438 Fludarabine 32 20 -0.05
## 1470 EPZ-6438 Ruxolitinib 32 19 -0.17
## 1471 EPZ-6438 Tofacitinib 32 18 0.02
## 1472 EPZ-6438 Motolimod 32 17 0.21
## 1473 EPZ-6438 Menin-MLL Inhibitor 32 16 0.24
## 1474 EPZ-6438 MI-503 32 15 0.10
## 1475 EPZ-6438 Olaparib 32 14 -0.01
## 1476 EPZ-6438 SB 203580 32 13 -0.08
## 1477 EPZ-6438 AMI-1 32 12 0.05
## 1478 EPZ-6438 Vismodegib 32 11 -0.03
## 1479 EPZ-6438 Methotrexate 32 10 -0.13
## 1480 EPZ-6438 IRAK-1/4 Inhibitor I 32 9 -0.01
## 1481 EPZ-6438 Selisistat 32 8 0.01
## 1482 EPZ-6438 Foretinib 32 7 -0.16
## 1483 EPZ-6438 JNK-IN-8 32 6 0.14
## 1484 EPZ-6438 BGJ398 32 5 0.05
## 1485 EPZ-6438 SGC 0946 32 4 -0.04
## 1486 EPZ-6438 D 4476 32 3 0.11
## 1487 EPZ-6438 A-1210477 32 2 -0.13
## 1488 EPZ-6438 Cisplatin 32 1 -0.08
## 1489 PF-3758309 PF-3758309 33 30 1.00
## 1490 PF-3758309 Venetoclax 33 29 0.39
## 1491 PF-3758309 Doxorubicine 33 28 0.12
## 1492 PF-3758309 Panobinostat 33 27 0.26
## 1493 PF-3758309 Selinexor 33 26 0.32
## 1494 PF-3758309 OTX015 33 25 0.36
## 1495 PF-3758309 Volasertib 33 24 0.29
## 1496 PF-3758309 Nutlin-3a 33 23 0.36
## 1497 PF-3758309 RO5963 33 22 0.38
## 1498 PF-3758309 Cytarabine 33 21 0.36
## 1499 PF-3758309 Fludarabine 33 20 0.41
## 1500 PF-3758309 Ruxolitinib 33 19 0.16
## 1501 PF-3758309 Tofacitinib 33 18 0.30
## 1502 PF-3758309 Motolimod 33 17 -0.12
## 1503 PF-3758309 Menin-MLL Inhibitor 33 16 0.11
## 1504 PF-3758309 MI-503 33 15 0.10
## 1505 PF-3758309 Olaparib 33 14 -0.12
## 1506 PF-3758309 SB 203580 33 13 -0.05
## 1507 PF-3758309 AMI-1 33 12 0.07
## 1508 PF-3758309 Vismodegib 33 11 0.10
## 1509 PF-3758309 Methotrexate 33 10 -0.03
## 1510 PF-3758309 IRAK-1/4 Inhibitor I 33 9 0.32
## 1511 PF-3758309 Selisistat 33 8 0.13
## 1512 PF-3758309 Foretinib 33 7 -0.14
## 1513 PF-3758309 JNK-IN-8 33 6 0.12
## 1514 PF-3758309 BGJ398 33 5 0.11
## 1515 PF-3758309 SGC 0946 33 4 0.03
## 1516 PF-3758309 D 4476 33 3 -0.08
## 1517 PF-3758309 A-1210477 33 2 0.16
## 1518 PF-3758309 Cisplatin 33 1 0.04
## 1519 Venetoclax Venetoclax 34 29 1.00
## 1520 Venetoclax Doxorubicine 34 28 0.00
## 1521 Venetoclax Panobinostat 34 27 0.02
## 1522 Venetoclax Selinexor 34 26 0.05
## 1523 Venetoclax OTX015 34 25 0.08
## 1524 Venetoclax Volasertib 34 24 0.06
## 1525 Venetoclax Nutlin-3a 34 23 0.20
## 1526 Venetoclax RO5963 34 22 0.22
## 1527 Venetoclax Cytarabine 34 21 0.18
## 1528 Venetoclax Fludarabine 34 20 0.15
## 1529 Venetoclax Ruxolitinib 34 19 -0.14
## 1530 Venetoclax Tofacitinib 34 18 0.00
## 1531 Venetoclax Motolimod 34 17 -0.06
## 1532 Venetoclax Menin-MLL Inhibitor 34 16 0.01
## 1533 Venetoclax MI-503 34 15 0.17
## 1534 Venetoclax Olaparib 34 14 -0.03
## 1535 Venetoclax SB 203580 34 13 -0.16
## 1536 Venetoclax AMI-1 34 12 0.05
## 1537 Venetoclax Vismodegib 34 11 -0.01
## 1538 Venetoclax Methotrexate 34 10 -0.18
## 1539 Venetoclax IRAK-1/4 Inhibitor I 34 9 0.16
## 1540 Venetoclax Selisistat 34 8 0.03
## 1541 Venetoclax Foretinib 34 7 -0.18
## 1542 Venetoclax JNK-IN-8 34 6 0.16
## 1543 Venetoclax BGJ398 34 5 0.11
## 1544 Venetoclax SGC 0946 34 4 -0.09
## 1545 Venetoclax D 4476 34 3 0.02
## 1546 Venetoclax A-1210477 34 2 0.17
## 1547 Venetoclax Cisplatin 34 1 -0.05
## 1548 Doxorubicine Doxorubicine 35 28 1.00
## 1549 Doxorubicine Panobinostat 35 27 0.44
## 1550 Doxorubicine Selinexor 35 26 0.44
## 1551 Doxorubicine OTX015 35 25 0.46
## 1552 Doxorubicine Volasertib 35 24 0.36
## 1553 Doxorubicine Nutlin-3a 35 23 0.22
## 1554 Doxorubicine RO5963 35 22 0.22
## 1555 Doxorubicine Cytarabine 35 21 0.42
## 1556 Doxorubicine Fludarabine 35 20 0.37
## 1557 Doxorubicine Ruxolitinib 35 19 -0.04
## 1558 Doxorubicine Tofacitinib 35 18 -0.17
## 1559 Doxorubicine Motolimod 35 17 0.25
## 1560 Doxorubicine Menin-MLL Inhibitor 35 16 0.03
## 1561 Doxorubicine MI-503 35 15 -0.16
## 1562 Doxorubicine Olaparib 35 14 -0.27
## 1563 Doxorubicine SB 203580 35 13 -0.04
## 1564 Doxorubicine AMI-1 35 12 -0.08
## 1565 Doxorubicine Vismodegib 35 11 0.02
## 1566 Doxorubicine Methotrexate 35 10 0.03
## 1567 Doxorubicine IRAK-1/4 Inhibitor I 35 9 0.17
## 1568 Doxorubicine Selisistat 35 8 0.10
## 1569 Doxorubicine Foretinib 35 7 -0.17
## 1570 Doxorubicine JNK-IN-8 35 6 0.06
## 1571 Doxorubicine BGJ398 35 5 0.05
## 1572 Doxorubicine SGC 0946 35 4 0.10
## 1573 Doxorubicine D 4476 35 3 0.11
## 1574 Doxorubicine A-1210477 35 2 0.21
## 1575 Doxorubicine Cisplatin 35 1 0.31
## 1576 Panobinostat Panobinostat 36 27 1.00
## 1577 Panobinostat Selinexor 36 26 0.31
## 1578 Panobinostat OTX015 36 25 0.56
## 1579 Panobinostat Volasertib 36 24 0.45
## 1580 Panobinostat Nutlin-3a 36 23 0.31
## 1581 Panobinostat RO5963 36 22 0.35
## 1582 Panobinostat Cytarabine 36 21 0.32
## 1583 Panobinostat Fludarabine 36 20 0.52
## 1584 Panobinostat Ruxolitinib 36 19 0.04
## 1585 Panobinostat Tofacitinib 36 18 0.05
## 1586 Panobinostat Motolimod 36 17 0.05
## 1587 Panobinostat Menin-MLL Inhibitor 36 16 -0.01
## 1588 Panobinostat MI-503 36 15 0.07
## 1589 Panobinostat Olaparib 36 14 -0.17
## 1590 Panobinostat SB 203580 36 13 -0.13
## 1591 Panobinostat AMI-1 36 12 -0.07
## 1592 Panobinostat Vismodegib 36 11 -0.08
## 1593 Panobinostat Methotrexate 36 10 0.04
## 1594 Panobinostat IRAK-1/4 Inhibitor I 36 9 0.04
## 1595 Panobinostat Selisistat 36 8 0.01
## 1596 Panobinostat Foretinib 36 7 -0.21
## 1597 Panobinostat JNK-IN-8 36 6 -0.18
## 1598 Panobinostat BGJ398 36 5 0.13
## 1599 Panobinostat SGC 0946 36 4 0.03
## 1600 Panobinostat D 4476 36 3 -0.04
## 1601 Panobinostat A-1210477 36 2 0.14
## 1602 Panobinostat Cisplatin 36 1 0.13
## 1603 Selinexor Selinexor 37 26 1.00
## 1604 Selinexor OTX015 37 25 0.36
## 1605 Selinexor Volasertib 37 24 0.36
## 1606 Selinexor Nutlin-3a 37 23 0.37
## 1607 Selinexor RO5963 37 22 0.40
## 1608 Selinexor Cytarabine 37 21 0.35
## 1609 Selinexor Fludarabine 37 20 0.42
## 1610 Selinexor Ruxolitinib 37 19 0.23
## 1611 Selinexor Tofacitinib 37 18 0.15
## 1612 Selinexor Motolimod 37 17 0.17
## 1613 Selinexor Menin-MLL Inhibitor 37 16 0.04
## 1614 Selinexor MI-503 37 15 0.06
## 1615 Selinexor Olaparib 37 14 -0.12
## 1616 Selinexor SB 203580 37 13 0.17
## 1617 Selinexor AMI-1 37 12 0.09
## 1618 Selinexor Vismodegib 37 11 0.15
## 1619 Selinexor Methotrexate 37 10 -0.04
## 1620 Selinexor IRAK-1/4 Inhibitor I 37 9 0.22
## 1621 Selinexor Selisistat 37 8 0.19
## 1622 Selinexor Foretinib 37 7 -0.01
## 1623 Selinexor JNK-IN-8 37 6 0.05
## 1624 Selinexor BGJ398 37 5 0.13
## 1625 Selinexor SGC 0946 37 4 0.22
## 1626 Selinexor D 4476 37 3 0.19
## 1627 Selinexor A-1210477 37 2 0.22
## 1628 Selinexor Cisplatin 37 1 0.14
## 1629 OTX015 OTX015 38 25 1.00
## 1630 OTX015 Volasertib 38 24 0.85
## 1631 OTX015 Nutlin-3a 38 23 0.54
## 1632 OTX015 RO5963 38 22 0.49
## 1633 OTX015 Cytarabine 38 21 0.52
## 1634 OTX015 Fludarabine 38 20 0.56
## 1635 OTX015 Ruxolitinib 38 19 0.08
## 1636 OTX015 Tofacitinib 38 18 -0.03
## 1637 OTX015 Motolimod 38 17 0.20
## 1638 OTX015 Menin-MLL Inhibitor 38 16 0.04
## 1639 OTX015 MI-503 38 15 -0.16
## 1640 OTX015 Olaparib 38 14 -0.28
## 1641 OTX015 SB 203580 38 13 0.10
## 1642 OTX015 AMI-1 38 12 -0.01
## 1643 OTX015 Vismodegib 38 11 0.07
## 1644 OTX015 Methotrexate 38 10 0.01
## 1645 OTX015 IRAK-1/4 Inhibitor I 38 9 0.20
## 1646 OTX015 Selisistat 38 8 0.15
## 1647 OTX015 Foretinib 38 7 -0.13
## 1648 OTX015 JNK-IN-8 38 6 -0.08
## 1649 OTX015 BGJ398 38 5 0.16
## 1650 OTX015 SGC 0946 38 4 0.21
## 1651 OTX015 D 4476 38 3 0.15
## 1652 OTX015 A-1210477 38 2 0.38
## 1653 OTX015 Cisplatin 38 1 0.38
## 1654 Volasertib Volasertib 39 24 1.00
## 1655 Volasertib Nutlin-3a 39 23 0.55
## 1656 Volasertib RO5963 39 22 0.47
## 1657 Volasertib Cytarabine 39 21 0.49
## 1658 Volasertib Fludarabine 39 20 0.47
## 1659 Volasertib Ruxolitinib 39 19 0.22
## 1660 Volasertib Tofacitinib 39 18 0.03
## 1661 Volasertib Motolimod 39 17 0.17
## 1662 Volasertib Menin-MLL Inhibitor 39 16 -0.06
## 1663 Volasertib MI-503 39 15 -0.09
## 1664 Volasertib Olaparib 39 14 -0.13
## 1665 Volasertib SB 203580 39 13 0.28
## 1666 Volasertib AMI-1 39 12 0.22
## 1667 Volasertib Vismodegib 39 11 0.29
## 1668 Volasertib Methotrexate 39 10 0.13
## 1669 Volasertib IRAK-1/4 Inhibitor I 39 9 0.20
## 1670 Volasertib Selisistat 39 8 0.21
## 1671 Volasertib Foretinib 39 7 0.10
## 1672 Volasertib JNK-IN-8 39 6 -0.01
## 1673 Volasertib BGJ398 39 5 0.30
## 1674 Volasertib SGC 0946 39 4 0.38
## 1675 Volasertib D 4476 39 3 0.33
## 1676 Volasertib A-1210477 39 2 0.47
## 1677 Volasertib Cisplatin 39 1 0.49
## 1678 Nutlin-3a Nutlin-3a 40 23 1.00
## 1679 Nutlin-3a RO5963 40 22 0.88
## 1680 Nutlin-3a Cytarabine 40 21 0.70
## 1681 Nutlin-3a Fludarabine 40 20 0.63
## 1682 Nutlin-3a Ruxolitinib 40 19 0.16
## 1683 Nutlin-3a Tofacitinib 40 18 0.09
## 1684 Nutlin-3a Motolimod 40 17 0.05
## 1685 Nutlin-3a Menin-MLL Inhibitor 40 16 0.14
## 1686 Nutlin-3a MI-503 40 15 -0.03
## 1687 Nutlin-3a Olaparib 40 14 0.02
## 1688 Nutlin-3a SB 203580 40 13 0.19
## 1689 Nutlin-3a AMI-1 40 12 0.08
## 1690 Nutlin-3a Vismodegib 40 11 0.21
## 1691 Nutlin-3a Methotrexate 40 10 0.08
## 1692 Nutlin-3a IRAK-1/4 Inhibitor I 40 9 0.31
## 1693 Nutlin-3a Selisistat 40 8 0.29
## 1694 Nutlin-3a Foretinib 40 7 -0.06
## 1695 Nutlin-3a JNK-IN-8 40 6 0.07
## 1696 Nutlin-3a BGJ398 40 5 0.08
## 1697 Nutlin-3a SGC 0946 40 4 0.07
## 1698 Nutlin-3a D 4476 40 3 0.10
## 1699 Nutlin-3a A-1210477 40 2 0.35
## 1700 Nutlin-3a Cisplatin 40 1 0.21
## 1701 RO5963 RO5963 41 22 1.00
## 1702 RO5963 Cytarabine 41 21 0.59
## 1703 RO5963 Fludarabine 41 20 0.59
## 1704 RO5963 Ruxolitinib 41 19 0.16
## 1705 RO5963 Tofacitinib 41 18 0.16
## 1706 RO5963 Motolimod 41 17 0.02
## 1707 RO5963 Menin-MLL Inhibitor 41 16 0.11
## 1708 RO5963 MI-503 41 15 0.00
## 1709 RO5963 Olaparib 41 14 0.01
## 1710 RO5963 SB 203580 41 13 0.20
## 1711 RO5963 AMI-1 41 12 0.16
## 1712 RO5963 Vismodegib 41 11 0.22
## 1713 RO5963 Methotrexate 41 10 0.06
## 1714 RO5963 IRAK-1/4 Inhibitor I 41 9 0.28
## 1715 RO5963 Selisistat 41 8 0.30
## 1716 RO5963 Foretinib 41 7 -0.05
## 1717 RO5963 JNK-IN-8 41 6 -0.01
## 1718 RO5963 BGJ398 41 5 0.09
## 1719 RO5963 SGC 0946 41 4 0.12
## 1720 RO5963 D 4476 41 3 0.10
## 1721 RO5963 A-1210477 41 2 0.28
## 1722 RO5963 Cisplatin 41 1 0.15
## 1723 Cytarabine Cytarabine 42 21 1.00
## 1724 Cytarabine Fludarabine 42 20 0.73
## 1725 Cytarabine Ruxolitinib 42 19 0.06
## 1726 Cytarabine Tofacitinib 42 18 0.01
## 1727 Cytarabine Motolimod 42 17 0.12
## 1728 Cytarabine Menin-MLL Inhibitor 42 16 0.11
## 1729 Cytarabine MI-503 42 15 -0.09
## 1730 Cytarabine Olaparib 42 14 -0.11
## 1731 Cytarabine SB 203580 42 13 0.08
## 1732 Cytarabine AMI-1 42 12 0.05
## 1733 Cytarabine Vismodegib 42 11 0.11
## 1734 Cytarabine Methotrexate 42 10 0.03
## 1735 Cytarabine IRAK-1/4 Inhibitor I 42 9 0.25
## 1736 Cytarabine Selisistat 42 8 0.19
## 1737 Cytarabine Foretinib 42 7 -0.09
## 1738 Cytarabine JNK-IN-8 42 6 0.10
## 1739 Cytarabine BGJ398 42 5 0.08
## 1740 Cytarabine SGC 0946 42 4 0.05
## 1741 Cytarabine D 4476 42 3 0.09
## 1742 Cytarabine A-1210477 42 2 0.32
## 1743 Cytarabine Cisplatin 42 1 0.37
## 1744 Fludarabine Fludarabine 43 20 1.00
## 1745 Fludarabine Ruxolitinib 43 19 0.03
## 1746 Fludarabine Tofacitinib 43 18 0.06
## 1747 Fludarabine Motolimod 43 17 0.09
## 1748 Fludarabine Menin-MLL Inhibitor 43 16 0.02
## 1749 Fludarabine MI-503 43 15 -0.10
## 1750 Fludarabine Olaparib 43 14 -0.27
## 1751 Fludarabine SB 203580 43 13 -0.01
## 1752 Fludarabine AMI-1 43 12 0.01
## 1753 Fludarabine Vismodegib 43 11 0.04
## 1754 Fludarabine Methotrexate 43 10 0.03
## 1755 Fludarabine IRAK-1/4 Inhibitor I 43 9 0.15
## 1756 Fludarabine Selisistat 43 8 0.07
## 1757 Fludarabine Foretinib 43 7 -0.24
## 1758 Fludarabine JNK-IN-8 43 6 -0.02
## 1759 Fludarabine BGJ398 43 5 0.13
## 1760 Fludarabine SGC 0946 43 4 0.04
## 1761 Fludarabine D 4476 43 3 0.05
## 1762 Fludarabine A-1210477 43 2 0.24
## 1763 Fludarabine Cisplatin 43 1 0.23
## 1764 Ruxolitinib Ruxolitinib 44 19 1.00
## 1765 Ruxolitinib Tofacitinib 44 18 0.59
## 1766 Ruxolitinib Motolimod 44 17 0.06
## 1767 Ruxolitinib Menin-MLL Inhibitor 44 16 0.07
## 1768 Ruxolitinib MI-503 44 15 0.14
## 1769 Ruxolitinib Olaparib 44 14 0.25
## 1770 Ruxolitinib SB 203580 44 13 0.37
## 1771 Ruxolitinib AMI-1 44 12 0.21
## 1772 Ruxolitinib Vismodegib 44 11 0.36
## 1773 Ruxolitinib Methotrexate 44 10 0.16
## 1774 Ruxolitinib IRAK-1/4 Inhibitor I 44 9 0.17
## 1775 Ruxolitinib Selisistat 44 8 0.21
## 1776 Ruxolitinib Foretinib 44 7 0.23
## 1777 Ruxolitinib JNK-IN-8 44 6 0.03
## 1778 Ruxolitinib BGJ398 44 5 0.14
## 1779 Ruxolitinib SGC 0946 44 4 0.36
## 1780 Ruxolitinib D 4476 44 3 0.09
## 1781 Ruxolitinib A-1210477 44 2 0.10
## 1782 Ruxolitinib Cisplatin 44 1 0.22
## 1783 Tofacitinib Tofacitinib 45 18 1.00
## 1784 Tofacitinib Motolimod 45 17 0.03
## 1785 Tofacitinib Menin-MLL Inhibitor 45 16 0.21
## 1786 Tofacitinib MI-503 45 15 0.23
## 1787 Tofacitinib Olaparib 45 14 0.30
## 1788 Tofacitinib SB 203580 45 13 0.35
## 1789 Tofacitinib AMI-1 45 12 0.38
## 1790 Tofacitinib Vismodegib 45 11 0.35
## 1791 Tofacitinib Methotrexate 45 10 0.09
## 1792 Tofacitinib IRAK-1/4 Inhibitor I 45 9 0.25
## 1793 Tofacitinib Selisistat 45 8 0.26
## 1794 Tofacitinib Foretinib 45 7 0.01
## 1795 Tofacitinib JNK-IN-8 45 6 0.00
## 1796 Tofacitinib BGJ398 45 5 0.03
## 1797 Tofacitinib SGC 0946 45 4 0.13
## 1798 Tofacitinib D 4476 45 3 0.04
## 1799 Tofacitinib A-1210477 45 2 -0.08
## 1800 Tofacitinib Cisplatin 45 1 -0.05
## 1801 Motolimod Motolimod 46 17 1.00
## 1802 Motolimod Menin-MLL Inhibitor 46 16 0.30
## 1803 Motolimod MI-503 46 15 0.16
## 1804 Motolimod Olaparib 46 14 0.12
## 1805 Motolimod SB 203580 46 13 0.22
## 1806 Motolimod AMI-1 46 12 0.12
## 1807 Motolimod Vismodegib 46 11 0.17
## 1808 Motolimod Methotrexate 46 10 0.09
## 1809 Motolimod IRAK-1/4 Inhibitor I 46 9 0.18
## 1810 Motolimod Selisistat 46 8 0.25
## 1811 Motolimod Foretinib 46 7 -0.03
## 1812 Motolimod JNK-IN-8 46 6 0.05
## 1813 Motolimod BGJ398 46 5 0.04
## 1814 Motolimod SGC 0946 46 4 0.17
## 1815 Motolimod D 4476 46 3 0.20
## 1816 Motolimod A-1210477 46 2 0.07
## 1817 Motolimod Cisplatin 46 1 0.17
## 1818 Menin-MLL Inhibitor Menin-MLL Inhibitor 47 16 1.00
## 1819 Menin-MLL Inhibitor MI-503 47 15 0.32
## 1820 Menin-MLL Inhibitor Olaparib 47 14 0.31
## 1821 Menin-MLL Inhibitor SB 203580 47 13 0.21
## 1822 Menin-MLL Inhibitor AMI-1 47 12 0.22
## 1823 Menin-MLL Inhibitor Vismodegib 47 11 0.25
## 1824 Menin-MLL Inhibitor Methotrexate 47 10 0.16
## 1825 Menin-MLL Inhibitor IRAK-1/4 Inhibitor I 47 9 0.52
## 1826 Menin-MLL Inhibitor Selisistat 47 8 0.39
## 1827 Menin-MLL Inhibitor Foretinib 47 7 -0.18
## 1828 Menin-MLL Inhibitor JNK-IN-8 47 6 0.17
## 1829 Menin-MLL Inhibitor BGJ398 47 5 -0.13
## 1830 Menin-MLL Inhibitor SGC 0946 47 4 -0.05
## 1831 Menin-MLL Inhibitor D 4476 47 3 0.02
## 1832 Menin-MLL Inhibitor A-1210477 47 2 -0.04
## 1833 Menin-MLL Inhibitor Cisplatin 47 1 0.02
## 1834 MI-503 MI-503 48 15 1.00
## 1835 MI-503 Olaparib 48 14 0.44
## 1836 MI-503 SB 203580 48 13 0.15
## 1837 MI-503 AMI-1 48 12 0.35
## 1838 MI-503 Vismodegib 48 11 0.36
## 1839 MI-503 Methotrexate 48 10 0.34
## 1840 MI-503 IRAK-1/4 Inhibitor I 48 9 0.37
## 1841 MI-503 Selisistat 48 8 0.39
## 1842 MI-503 Foretinib 48 7 0.20
## 1843 MI-503 JNK-IN-8 48 6 0.20
## 1844 MI-503 BGJ398 48 5 0.18
## 1845 MI-503 SGC 0946 48 4 0.03
## 1846 MI-503 D 4476 48 3 0.13
## 1847 MI-503 A-1210477 48 2 0.04
## 1848 MI-503 Cisplatin 48 1 0.17
## 1849 Olaparib Olaparib 49 14 1.00
## 1850 Olaparib SB 203580 49 13 0.33
## 1851 Olaparib AMI-1 49 12 0.38
## 1852 Olaparib Vismodegib 49 11 0.40
## 1853 Olaparib Methotrexate 49 10 0.25
## 1854 Olaparib IRAK-1/4 Inhibitor I 49 9 0.19
## 1855 Olaparib Selisistat 49 8 0.33
## 1856 Olaparib Foretinib 49 7 0.31
## 1857 Olaparib JNK-IN-8 49 6 0.09
## 1858 Olaparib BGJ398 49 5 -0.02
## 1859 Olaparib SGC 0946 49 4 0.01
## 1860 Olaparib D 4476 49 3 0.06
## 1861 Olaparib A-1210477 49 2 -0.03
## 1862 Olaparib Cisplatin 49 1 0.05
## 1863 SB 203580 SB 203580 50 13 1.00
## 1864 SB 203580 AMI-1 50 12 0.45
## 1865 SB 203580 Vismodegib 50 11 0.57
## 1866 SB 203580 Methotrexate 50 10 0.22
## 1867 SB 203580 IRAK-1/4 Inhibitor I 50 9 0.31
## 1868 SB 203580 Selisistat 50 8 0.47
## 1869 SB 203580 Foretinib 50 7 0.40
## 1870 SB 203580 JNK-IN-8 50 6 0.10
## 1871 SB 203580 BGJ398 50 5 0.00
## 1872 SB 203580 SGC 0946 50 4 0.38
## 1873 SB 203580 D 4476 50 3 0.31
## 1874 SB 203580 A-1210477 50 2 0.12
## 1875 SB 203580 Cisplatin 50 1 0.23
## 1876 AMI-1 AMI-1 51 12 1.00
## 1877 AMI-1 Vismodegib 51 11 0.75
## 1878 AMI-1 Methotrexate 51 10 0.36
## 1879 AMI-1 IRAK-1/4 Inhibitor I 51 9 0.42
## 1880 AMI-1 Selisistat 51 8 0.61
## 1881 AMI-1 Foretinib 51 7 0.23
## 1882 AMI-1 JNK-IN-8 51 6 0.11
## 1883 AMI-1 BGJ398 51 5 0.23
## 1884 AMI-1 SGC 0946 51 4 0.41
## 1885 AMI-1 D 4476 51 3 0.47
## 1886 AMI-1 A-1210477 51 2 0.26
## 1887 AMI-1 Cisplatin 51 1 0.33
## 1888 Vismodegib Vismodegib 52 11 1.00
## 1889 Vismodegib Methotrexate 52 10 0.43
## 1890 Vismodegib IRAK-1/4 Inhibitor I 52 9 0.57
## 1891 Vismodegib Selisistat 52 8 0.72
## 1892 Vismodegib Foretinib 52 7 0.28
## 1893 Vismodegib JNK-IN-8 52 6 0.16
## 1894 Vismodegib BGJ398 52 5 0.17
## 1895 Vismodegib SGC 0946 52 4 0.31
## 1896 Vismodegib D 4476 52 3 0.44
## 1897 Vismodegib A-1210477 52 2 0.33
## 1898 Vismodegib Cisplatin 52 1 0.41
## 1899 Methotrexate Methotrexate 53 10 1.00
## 1900 Methotrexate IRAK-1/4 Inhibitor I 53 9 0.45
## 1901 Methotrexate Selisistat 53 8 0.45
## 1902 Methotrexate Foretinib 53 7 0.23
## 1903 Methotrexate JNK-IN-8 53 6 0.02
## 1904 Methotrexate BGJ398 53 5 0.05
## 1905 Methotrexate SGC 0946 53 4 0.08
## 1906 Methotrexate D 4476 53 3 0.17
## 1907 Methotrexate A-1210477 53 2 0.14
## 1908 Methotrexate Cisplatin 53 1 0.37
## 1909 IRAK-1/4 Inhibitor I IRAK-1/4 Inhibitor I 54 9 1.00
## 1910 IRAK-1/4 Inhibitor I Selisistat 54 8 0.65
## 1911 IRAK-1/4 Inhibitor I Foretinib 54 7 -0.02
## 1912 IRAK-1/4 Inhibitor I JNK-IN-8 54 6 0.26
## 1913 IRAK-1/4 Inhibitor I BGJ398 54 5 0.08
## 1914 IRAK-1/4 Inhibitor I SGC 0946 54 4 0.09
## 1915 IRAK-1/4 Inhibitor I D 4476 54 3 0.21
## 1916 IRAK-1/4 Inhibitor I A-1210477 54 2 0.32
## 1917 IRAK-1/4 Inhibitor I Cisplatin 54 1 0.35
## 1918 Selisistat Selisistat 55 8 1.00
## 1919 Selisistat Foretinib 55 7 0.09
## 1920 Selisistat JNK-IN-8 55 6 0.06
## 1921 Selisistat BGJ398 55 5 -0.01
## 1922 Selisistat SGC 0946 55 4 0.28
## 1923 Selisistat D 4476 55 3 0.37
## 1924 Selisistat A-1210477 55 2 0.36
## 1925 Selisistat Cisplatin 55 1 0.39
## 1926 Foretinib Foretinib 56 7 1.00
## 1927 Foretinib JNK-IN-8 56 6 0.29
## 1928 Foretinib BGJ398 56 5 0.15
## 1929 Foretinib SGC 0946 56 4 0.30
## 1930 Foretinib D 4476 56 3 0.31
## 1931 Foretinib A-1210477 56 2 0.02
## 1932 Foretinib Cisplatin 56 1 0.36
## 1933 JNK-IN-8 JNK-IN-8 57 6 1.00
## 1934 JNK-IN-8 BGJ398 57 5 0.07
## 1935 JNK-IN-8 SGC 0946 57 4 0.04
## 1936 JNK-IN-8 D 4476 57 3 0.17
## 1937 JNK-IN-8 A-1210477 57 2 0.03
## 1938 JNK-IN-8 Cisplatin 57 1 0.12
## 1939 BGJ398 BGJ398 58 5 1.00
## 1940 BGJ398 SGC 0946 58 4 0.27
## 1941 BGJ398 D 4476 58 3 0.29
## 1942 BGJ398 A-1210477 58 2 0.31
## 1943 BGJ398 Cisplatin 58 1 0.38
## 1944 SGC 0946 SGC 0946 59 4 1.00
## 1945 SGC 0946 D 4476 59 3 0.35
## 1946 SGC 0946 A-1210477 59 2 0.31
## 1947 SGC 0946 Cisplatin 59 1 0.37
## 1948 D 4476 D 4476 60 3 1.00
## 1949 D 4476 A-1210477 60 2 0.36
## 1950 D 4476 Cisplatin 60 1 0.41
## 1951 A-1210477 A-1210477 61 2 1.00
## 1952 A-1210477 Cisplatin 61 1 0.48
## 1953 Cisplatin Cisplatin 62 1 1.00
##
## $arg
## $arg$type
## [1] "lower"grid.echo()
P1 <- grid.grab()
grid.draw(P1)
#Plot1
matrix.colors1 <- getGrob(P1, gPath("square"), grep = TRUE)[["gp"]][["fill"]]
P1 <- editGrob(P1,
gPath("square"), grep = TRUE,
gp = gpar(col = NA,
fill = NA))
# apply the saved colours to the underlying matrix grob
P1 <- editGrob(P1,
gPath("symbols-rect-1"), grep = TRUE,
gp = gpar(fill = matrix.colors1))
# convert the background fill from white to transparent, while we are at it
P1 <- editGrob(P1,
gPath("background"), grep = TRUE,
gp = gpar(fill = NA))
#prepare data for AML
aml_df <- screen_long |>
filter(diagnosis == "AML") |>
group_by(patientID, drug) |>
summarize(mean_viab = mean(viability)) |>
pivot_wider(names_from = drug, values_from = mean_viab)## `summarise()` has grouped output by 'patientID'. You can override using the
## `.groups` argument.aml_corr_df <- scale(aml_df[3:length(aml_df)])
#calculate correlations
aml_corr <- round(cor(aml_corr_df), 2)
#add colors for pathways (names not correct!)
all_labels <- colnames(aml_corr)
highlight_hsp <- c("Onalespib", "PF.3758309") # verify order
highlight_bcr <- c("KU.55933", "MI.503", "MK.2206", "Menin.MLL.Inhibitor")
highlight_pi3k <- c("SCH772984", "SGC.0946")
highlight_aktmtor <- c("Selisistat", "Sunitinib","Afatinib", "X10058.F4")
highlight_mapk <- c("PRT062607", "Palbociclib", "Panobinostat")
label_colors <- setNames(rep("black", length(all_labels)), all_labels)
label_colors[highlight_hsp] <- "#BEBADA"
label_colors[highlight_bcr] <- "#80B1D3"
label_colors[highlight_pi3k] <- "#FB8072"
label_colors[highlight_aktmtor] <- "#BC80BD"
label_colors[highlight_mapk] <- "#FDB462"
aml_cor_heatmap <- corrplot(aml_corr, type="lower", order="hclust", method="color",
col = colors_cor_heatmap(20), sig.level = 0.05, addgrid.col = "grey",
insig = "blank", tl.col = label_colors, tl.cex = 0.7, tl.pos = NULL,
tl.offset = c(0.3), title="AML", cex.main = 0.75, col.main = "black", mar = c(0,0,0.5,0),
cl.ratio = 0.1, , cl.cex = 0.7, cl.col = "grey", asp=1)## Warning in text.default(pos.xlabel[, 1], pos.xlabel[, 2], newcolnames, srt =
## tl.srt, : "cl.col" is not a graphical parameter## Warning in text.default(pos.ylabel[, 1], pos.ylabel[, 2], newrownames, col =
## tl.col, : "cl.col" is not a graphical parameter## Warning in title(title, ...): "cl.col" is not a graphical parameter
#prepare for multipanel figure
aml_cor_heatmap## $corr
## BMS-509744 Ceritinib Fludarabine Selinexor Nutlin-3a
## BMS-509744 1.00 0.48 0.19 0.22 0.38
## Ceritinib 0.48 1.00 0.14 0.33 0.44
## Fludarabine 0.19 0.14 1.00 0.59 0.62
## Selinexor 0.22 0.33 0.59 1.00 0.69
## Nutlin-3a 0.38 0.44 0.62 0.69 1.00
## Venetoclax 0.16 0.48 0.60 0.64 0.79
## Cytarabine 0.17 0.09 0.43 0.29 0.35
## RO5963 0.44 0.24 0.51 0.46 0.57
## A-1210477 0.26 0.30 0.47 0.43 0.46
## Panobinostat 0.25 0.27 0.48 0.57 0.40
## A-674563 0.28 0.34 0.54 0.56 0.60
## Palbociclib 0.39 0.31 0.47 0.56 0.44
## Dabrafenib -0.32 -0.31 -0.06 -0.32 -0.18
## ZM 336372 0.11 0.09 -0.04 -0.08 0.01
## EPZ-6438 -0.10 -0.10 0.06 -0.06 0.06
## ONO-4059 0.38 0.07 0.18 0.01 0.27
## Midostaurin 0.04 -0.15 0.03 -0.12 -0.01
## Methotrexate -0.07 -0.16 -0.36 -0.30 -0.30
## Motolimod -0.04 -0.27 -0.34 -0.25 -0.44
## Olaparib 0.34 0.25 0.25 0.28 0.32
## Cisplatin 0.16 0.29 0.22 0.24 0.22
## BGJ398 0.18 0.10 -0.05 -0.09 -0.22
## BML-277 0.13 0.28 0.05 0.05 0.12
## AMI-1 0.14 0.14 0.04 -0.16 0.02
## Vismodegib -0.04 0.13 -0.06 -0.01 0.07
## Selisistat 0.22 0.04 -0.06 -0.01 0.11
## TW-37 0.10 -0.14 -0.10 -0.03 -0.06
## D 4476 0.03 -0.15 0.02 -0.10 -0.21
## Doxorubicine 0.11 -0.10 0.26 0.31 0.11
## Dasatinib 0.15 -0.07 -0.10 -0.07 -0.22
## Duvelisib 0.40 0.11 0.18 0.12 -0.05
## Idelalisib 0.39 0.17 0.30 0.28 0.21
## Ibrutinib 0.18 0.17 0.20 0.10 0.15
## PRT062607 0.28 0.12 0.01 0.03 -0.03
## Afatinib 0.19 0.41 0.31 0.43 0.41
## SB 203580 0.10 0.24 0.36 0.36 0.38
## IRAK-1/4 Inhibitor I 0.20 0.25 0.28 0.27 0.34
## Quizartinib 0.21 0.23 0.22 0.23 0.33
## MK-2206 0.37 0.25 0.02 0.14 0.07
## AZD1208 0.39 0.44 0.35 0.48 0.35
## AZD8055 0.35 0.27 0.24 0.25 0.08
## Rapamycin 0.34 -0.01 0.32 0.23 0.12
## MI-503 0.12 0.20 0.16 0.29 0.12
## Imatinib 0.30 0.16 0.05 0.03 0.03
## Sunitinib 0.30 0.29 0.27 0.29 0.21
## Foretinib 0.47 0.19 0.27 0.27 0.30
## Tozasertib 0.36 0.20 0.04 0.11 0.03
## Ruxolitinib 0.06 -0.07 -0.08 0.11 -0.17
## Tofacitinib -0.06 -0.14 -0.02 0.00 -0.17
## PF-3758309 -0.10 -0.05 0.13 0.09 -0.22
## OTX015 -0.18 -0.18 0.00 0.05 -0.32
## Volasertib -0.09 0.00 0.05 0.14 -0.14
## Ganetespib 0.09 0.12 -0.15 -0.06 -0.28
## Onalespib 0.18 0.22 -0.09 0.00 -0.14
## SCH772984 0.06 -0.02 -0.09 0.05 -0.21
## Cobimetinib 0.02 -0.13 -0.22 -0.09 -0.37
## Trametinib 0.02 -0.15 -0.17 -0.08 -0.35
## JNK-IN-8 0.10 -0.05 0.17 0.03 0.17
## Menin-MLL Inhibitor 0.05 0.03 0.14 0.20 0.18
## AZD6738 0.45 0.17 0.03 0.03 0.02
## KU-55933 0.30 0.08 0.07 0.20 0.10
## SGC 0946 0.26 0.18 0.24 0.26 0.23
## Venetoclax Cytarabine RO5963 A-1210477 Panobinostat
## BMS-509744 0.16 0.17 0.44 0.26 0.25
## Ceritinib 0.48 0.09 0.24 0.30 0.27
## Fludarabine 0.60 0.43 0.51 0.47 0.48
## Selinexor 0.64 0.29 0.46 0.43 0.57
## Nutlin-3a 0.79 0.35 0.57 0.46 0.40
## Venetoclax 1.00 0.14 0.41 0.33 0.33
## Cytarabine 0.14 1.00 0.47 0.31 0.40
## RO5963 0.41 0.47 1.00 0.36 0.38
## A-1210477 0.33 0.31 0.36 1.00 0.52
## Panobinostat 0.33 0.40 0.38 0.52 1.00
## A-674563 0.52 0.31 0.38 0.54 0.58
## Palbociclib 0.30 0.32 0.38 0.46 0.57
## Dabrafenib -0.10 -0.19 -0.41 -0.11 -0.10
## ZM 336372 0.04 -0.11 0.02 -0.14 -0.08
## EPZ-6438 0.02 0.17 -0.07 -0.02 0.07
## ONO-4059 0.12 0.19 0.47 0.30 0.06
## Midostaurin -0.07 -0.11 -0.17 -0.14 -0.11
## Methotrexate -0.45 -0.12 -0.30 0.02 0.04
## Motolimod -0.52 -0.18 -0.32 -0.28 -0.09
## Olaparib 0.07 0.33 0.26 0.26 0.38
## Cisplatin 0.06 0.34 0.17 0.22 0.18
## BGJ398 -0.33 0.32 0.10 0.05 0.20
## BML-277 0.08 0.07 0.06 0.08 0.05
## AMI-1 -0.03 -0.03 -0.04 -0.09 -0.08
## Vismodegib -0.11 0.01 -0.06 -0.04 0.06
## Selisistat -0.14 0.22 0.20 0.06 0.00
## TW-37 -0.25 0.25 0.14 -0.21 -0.20
## D 4476 -0.28 0.03 0.15 -0.03 -0.07
## Doxorubicine 0.09 -0.01 0.32 0.06 0.21
## Dasatinib -0.36 0.36 0.12 0.07 0.20
## Duvelisib -0.17 0.34 0.40 0.29 0.42
## Idelalisib 0.05 0.44 0.62 0.41 0.51
## Ibrutinib 0.06 0.41 0.44 0.37 0.23
## PRT062607 -0.11 0.20 0.23 0.21 0.28
## Afatinib 0.28 0.44 0.25 0.43 0.40
## SB 203580 0.41 0.28 0.46 0.36 0.49
## IRAK-1/4 Inhibitor I 0.15 0.45 0.33 0.34 0.41
## Quizartinib 0.29 0.07 0.22 0.17 0.25
## MK-2206 0.01 0.23 0.15 0.11 0.43
## AZD1208 0.35 0.37 0.38 0.34 0.60
## AZD8055 0.00 0.28 0.30 0.35 0.63
## Rapamycin -0.04 0.34 0.41 0.32 0.49
## MI-503 0.04 0.20 0.29 0.27 0.34
## Imatinib -0.14 0.31 0.15 -0.01 0.19
## Sunitinib 0.07 0.45 0.35 0.24 0.35
## Foretinib 0.02 0.46 0.46 0.25 0.37
## Tozasertib -0.17 0.35 0.27 0.23 0.40
## Ruxolitinib -0.21 0.22 0.14 0.17 0.41
## Tofacitinib -0.20 0.17 0.05 -0.02 0.31
## PF-3758309 -0.27 0.24 0.05 0.27 0.42
## OTX015 -0.34 0.09 -0.06 0.19 0.35
## Volasertib -0.18 0.13 -0.04 0.31 0.40
## Ganetespib -0.42 0.30 0.00 0.19 0.34
## Onalespib -0.31 0.29 0.08 0.23 0.37
## SCH772984 -0.41 0.20 0.06 0.25 0.28
## Cobimetinib -0.58 0.15 -0.02 0.17 0.19
## Trametinib -0.53 0.13 -0.04 0.16 0.22
## JNK-IN-8 0.05 0.29 0.22 0.22 0.32
## Menin-MLL Inhibitor 0.09 0.24 0.05 0.22 0.34
## AZD6738 -0.06 0.19 0.23 0.11 0.26
## KU-55933 0.04 0.08 0.15 0.27 0.38
## SGC 0946 0.23 0.23 0.09 0.41 0.33
## A-674563 Palbociclib Dabrafenib ZM 336372 EPZ-6438
## BMS-509744 0.28 0.39 -0.32 0.11 -0.10
## Ceritinib 0.34 0.31 -0.31 0.09 -0.10
## Fludarabine 0.54 0.47 -0.06 -0.04 0.06
## Selinexor 0.56 0.56 -0.32 -0.08 -0.06
## Nutlin-3a 0.60 0.44 -0.18 0.01 0.06
## Venetoclax 0.52 0.30 -0.10 0.04 0.02
## Cytarabine 0.31 0.32 -0.19 -0.11 0.17
## RO5963 0.38 0.38 -0.41 0.02 -0.07
## A-1210477 0.54 0.46 -0.11 -0.14 -0.02
## Panobinostat 0.58 0.57 -0.10 -0.08 0.07
## A-674563 1.00 0.71 -0.13 -0.14 0.00
## Palbociclib 0.71 1.00 -0.24 -0.07 -0.11
## Dabrafenib -0.13 -0.24 1.00 0.30 0.14
## ZM 336372 -0.14 -0.07 0.30 1.00 -0.01
## EPZ-6438 0.00 -0.11 0.14 -0.01 1.00
## ONO-4059 0.28 0.32 -0.04 0.14 0.24
## Midostaurin 0.20 0.12 0.27 -0.04 -0.05
## Methotrexate -0.16 -0.07 0.13 -0.15 -0.05
## Motolimod -0.36 -0.14 0.18 0.26 -0.08
## Olaparib 0.21 0.39 -0.21 -0.08 -0.08
## Cisplatin 0.09 0.26 -0.19 0.11 -0.03
## BGJ398 -0.04 0.15 -0.11 0.04 0.09
## BML-277 -0.03 0.10 0.07 0.16 0.20
## AMI-1 -0.02 -0.04 0.12 0.16 0.14
## Vismodegib 0.08 0.01 0.09 0.00 0.35
## Selisistat 0.01 0.16 -0.11 0.23 0.26
## TW-37 -0.34 -0.07 -0.17 0.15 0.18
## D 4476 -0.18 0.04 0.24 0.18 -0.06
## Doxorubicine 0.03 0.11 -0.15 0.01 -0.29
## Dasatinib 0.05 0.20 -0.12 -0.12 0.03
## Duvelisib 0.42 0.53 -0.29 -0.04 -0.09
## Idelalisib 0.54 0.58 -0.28 -0.08 0.00
## Ibrutinib 0.47 0.39 -0.25 -0.24 0.19
## PRT062607 0.42 0.47 -0.30 -0.24 0.07
## Afatinib 0.53 0.57 -0.18 -0.19 -0.06
## SB 203580 0.48 0.31 -0.21 -0.18 0.10
## IRAK-1/4 Inhibitor I 0.58 0.56 -0.32 -0.31 0.18
## Quizartinib 0.53 0.40 -0.03 0.05 0.02
## MK-2206 0.29 0.44 -0.16 0.02 -0.09
## AZD1208 0.67 0.55 -0.27 -0.07 0.01
## AZD8055 0.48 0.56 -0.23 -0.05 -0.04
## Rapamycin 0.44 0.57 -0.17 -0.08 -0.02
## MI-503 0.38 0.51 -0.15 0.06 -0.14
## Imatinib 0.32 0.46 -0.24 -0.17 -0.10
## Sunitinib 0.59 0.58 -0.28 -0.14 -0.16
## Foretinib 0.47 0.62 -0.29 -0.16 -0.13
## Tozasertib 0.41 0.57 -0.35 -0.27 -0.03
## Ruxolitinib 0.27 0.28 -0.11 -0.19 0.18
## Tofacitinib 0.25 0.16 0.09 0.03 0.07
## PF-3758309 0.36 0.51 -0.06 -0.22 0.01
## OTX015 0.15 0.37 0.15 -0.03 -0.04
## Volasertib 0.30 0.47 0.11 -0.08 0.00
## Ganetespib 0.24 0.47 -0.24 -0.16 0.02
## Onalespib 0.33 0.53 -0.31 -0.14 0.10
## SCH772984 0.22 0.35 -0.28 -0.25 -0.05
## Cobimetinib 0.08 0.27 -0.17 -0.11 -0.16
## Trametinib 0.14 0.30 -0.12 -0.09 -0.08
## JNK-IN-8 0.20 0.11 0.11 -0.11 0.35
## Menin-MLL Inhibitor 0.48 0.31 -0.08 -0.28 -0.01
## AZD6738 0.17 0.17 -0.10 0.11 -0.11
## KU-55933 0.27 0.35 -0.13 -0.22 -0.18
## SGC 0946 0.49 0.43 -0.18 0.01 0.24
## ONO-4059 Midostaurin Methotrexate Motolimod Olaparib
## BMS-509744 0.38 0.04 -0.07 -0.04 0.34
## Ceritinib 0.07 -0.15 -0.16 -0.27 0.25
## Fludarabine 0.18 0.03 -0.36 -0.34 0.25
## Selinexor 0.01 -0.12 -0.30 -0.25 0.28
## Nutlin-3a 0.27 -0.01 -0.30 -0.44 0.32
## Venetoclax 0.12 -0.07 -0.45 -0.52 0.07
## Cytarabine 0.19 -0.11 -0.12 -0.18 0.33
## RO5963 0.47 -0.17 -0.30 -0.32 0.26
## A-1210477 0.30 -0.14 0.02 -0.28 0.26
## Panobinostat 0.06 -0.11 0.04 -0.09 0.38
## A-674563 0.28 0.20 -0.16 -0.36 0.21
## Palbociclib 0.32 0.12 -0.07 -0.14 0.39
## Dabrafenib -0.04 0.27 0.13 0.18 -0.21
## ZM 336372 0.14 -0.04 -0.15 0.26 -0.08
## EPZ-6438 0.24 -0.05 -0.05 -0.08 -0.08
## ONO-4059 1.00 0.09 -0.16 -0.19 -0.03
## Midostaurin 0.09 1.00 0.18 0.15 0.11
## Methotrexate -0.16 0.18 1.00 0.35 0.13
## Motolimod -0.19 0.15 0.35 1.00 0.20
## Olaparib -0.03 0.11 0.13 0.20 1.00
## Cisplatin -0.01 -0.02 0.10 0.12 0.40
## BGJ398 0.01 -0.05 0.14 0.24 0.40
## BML-277 0.08 -0.03 -0.04 0.08 0.28
## AMI-1 -0.09 0.20 0.12 0.02 0.25
## Vismodegib 0.02 0.21 0.14 0.04 0.16
## Selisistat 0.33 0.02 -0.04 0.14 0.35
## TW-37 0.04 0.00 -0.01 0.11 0.28
## D 4476 0.03 -0.02 0.03 0.28 0.12
## Doxorubicine -0.09 -0.15 -0.23 0.22 0.00
## Dasatinib 0.31 -0.20 0.15 0.06 0.02
## Duvelisib 0.37 -0.14 -0.04 0.07 0.13
## Idelalisib 0.53 -0.12 -0.10 -0.11 0.09
## Ibrutinib 0.60 -0.04 -0.12 -0.30 -0.04
## PRT062607 0.50 0.03 0.15 -0.18 -0.09
## Afatinib 0.17 -0.01 0.07 -0.18 0.32
## SB 203580 0.30 -0.21 -0.16 -0.36 -0.07
## IRAK-1/4 Inhibitor I 0.23 0.20 0.11 -0.20 0.32
## Quizartinib 0.27 0.48 -0.11 -0.19 0.00
## MK-2206 0.09 0.13 -0.02 0.14 0.40
## AZD1208 0.27 -0.04 -0.24 -0.27 0.13
## AZD8055 0.18 -0.02 -0.07 0.06 0.34
## Rapamycin 0.44 -0.04 -0.14 -0.03 0.17
## MI-503 0.20 0.04 0.04 -0.06 0.20
## Imatinib 0.18 0.18 -0.01 0.01 0.30
## Sunitinib 0.20 0.27 -0.06 -0.18 0.23
## Foretinib 0.45 0.28 -0.07 -0.11 0.38
## Tozasertib 0.32 0.13 0.11 -0.02 0.37
## Ruxolitinib 0.22 -0.07 0.19 0.00 0.07
## Tofacitinib -0.02 0.12 0.15 0.09 0.04
## PF-3758309 0.08 -0.03 0.18 0.08 0.04
## OTX015 -0.07 -0.13 0.28 0.32 0.12
## Volasertib -0.06 -0.10 0.26 0.18 0.19
## Ganetespib 0.17 0.02 0.37 0.22 0.34
## Onalespib 0.25 0.01 0.30 0.17 0.33
## SCH772984 0.10 -0.13 0.35 0.17 0.19
## Cobimetinib 0.06 -0.14 0.36 0.34 0.22
## Trametinib 0.05 -0.13 0.35 0.31 0.18
## JNK-IN-8 0.18 0.10 0.06 0.00 0.28
## Menin-MLL Inhibitor -0.14 0.19 0.16 0.09 0.20
## AZD6738 0.02 -0.01 -0.01 0.03 0.25
## KU-55933 0.22 -0.03 0.17 0.11 0.13
## SGC 0946 0.35 -0.05 -0.06 -0.25 0.00
## Cisplatin BGJ398 BML-277 AMI-1 Vismodegib Selisistat TW-37
## BMS-509744 0.16 0.18 0.13 0.14 -0.04 0.22 0.10
## Ceritinib 0.29 0.10 0.28 0.14 0.13 0.04 -0.14
## Fludarabine 0.22 -0.05 0.05 0.04 -0.06 -0.06 -0.10
## Selinexor 0.24 -0.09 0.05 -0.16 -0.01 -0.01 -0.03
## Nutlin-3a 0.22 -0.22 0.12 0.02 0.07 0.11 -0.06
## Venetoclax 0.06 -0.33 0.08 -0.03 -0.11 -0.14 -0.25
## Cytarabine 0.34 0.32 0.07 -0.03 0.01 0.22 0.25
## RO5963 0.17 0.10 0.06 -0.04 -0.06 0.20 0.14
## A-1210477 0.22 0.05 0.08 -0.09 -0.04 0.06 -0.21
## Panobinostat 0.18 0.20 0.05 -0.08 0.06 0.00 -0.20
## A-674563 0.09 -0.04 -0.03 -0.02 0.08 0.01 -0.34
## Palbociclib 0.26 0.15 0.10 -0.04 0.01 0.16 -0.07
## Dabrafenib -0.19 -0.11 0.07 0.12 0.09 -0.11 -0.17
## ZM 336372 0.11 0.04 0.16 0.16 0.00 0.23 0.15
## EPZ-6438 -0.03 0.09 0.20 0.14 0.35 0.26 0.18
## ONO-4059 -0.01 0.01 0.08 -0.09 0.02 0.33 0.04
## Midostaurin -0.02 -0.05 -0.03 0.20 0.21 0.02 0.00
## Methotrexate 0.10 0.14 -0.04 0.12 0.14 -0.04 -0.01
## Motolimod 0.12 0.24 0.08 0.02 0.04 0.14 0.11
## Olaparib 0.40 0.40 0.28 0.25 0.16 0.35 0.28
## Cisplatin 1.00 0.46 0.41 0.30 0.31 0.34 0.31
## BGJ398 0.46 1.00 0.50 0.13 0.14 0.34 0.30
## BML-277 0.41 0.50 1.00 0.38 0.31 0.34 0.17
## AMI-1 0.30 0.13 0.38 1.00 0.57 0.24 0.33
## Vismodegib 0.31 0.14 0.31 0.57 1.00 0.39 0.26
## Selisistat 0.34 0.34 0.34 0.24 0.39 1.00 0.48
## TW-37 0.31 0.30 0.17 0.33 0.26 0.48 1.00
## D 4476 0.23 0.26 0.18 0.31 0.19 0.19 0.32
## Doxorubicine 0.19 -0.05 0.05 -0.08 -0.03 0.04 0.02
## Dasatinib 0.10 0.39 -0.01 -0.11 0.05 0.08 0.11
## Duvelisib 0.11 0.36 -0.08 -0.23 -0.18 0.11 -0.07
## Idelalisib 0.23 0.25 -0.09 -0.19 0.00 0.21 -0.03
## Ibrutinib 0.12 0.13 -0.06 -0.09 0.12 0.05 -0.19
## PRT062607 0.01 0.21 -0.13 -0.19 0.03 0.03 -0.15
## Afatinib 0.30 0.19 0.14 -0.01 0.10 0.03 0.02
## SB 203580 0.08 0.06 0.04 -0.20 0.05 -0.11 -0.29
## IRAK-1/4 Inhibitor I 0.42 0.33 0.08 -0.02 0.20 0.21 -0.03
## Quizartinib -0.02 0.01 0.01 -0.12 -0.05 -0.03 -0.37
## MK-2206 0.01 0.31 -0.02 -0.28 -0.20 0.28 -0.01
## AZD1208 0.03 0.18 -0.07 -0.22 -0.07 0.01 -0.32
## AZD8055 -0.01 0.30 -0.03 -0.22 -0.17 0.18 -0.14
## Rapamycin -0.06 0.21 -0.14 -0.35 -0.22 0.19 -0.09
## MI-503 0.35 0.35 0.15 0.07 0.02 0.21 0.02
## Imatinib 0.21 0.38 0.10 0.04 0.03 0.25 0.05
## Sunitinib 0.29 0.37 0.04 0.01 0.02 0.11 -0.05
## Foretinib 0.27 0.31 -0.01 -0.10 -0.04 0.26 0.10
## Tozasertib 0.19 0.43 0.05 0.03 0.09 0.19 0.04
## Ruxolitinib 0.16 0.45 0.14 0.02 0.25 0.15 0.09
## Tofacitinib 0.03 0.17 -0.03 0.22 0.34 0.01 0.10
## PF-3758309 0.00 0.39 0.01 -0.14 0.03 -0.02 -0.24
## OTX015 0.08 0.39 0.09 -0.08 0.01 0.03 -0.06
## Volasertib 0.15 0.42 0.22 0.07 0.09 0.07 -0.11
## Ganetespib 0.18 0.48 0.08 -0.06 0.14 0.20 -0.02
## Onalespib 0.16 0.42 0.10 -0.08 0.16 0.24 -0.06
## SCH772984 0.36 0.46 0.09 -0.07 0.10 0.18 0.06
## Cobimetinib 0.19 0.47 0.07 -0.08 0.00 0.20 0.09
## Trametinib 0.21 0.43 0.04 -0.04 0.02 0.22 0.09
## JNK-IN-8 -0.03 0.04 0.09 0.09 0.17 0.09 0.01
## Menin-MLL Inhibitor 0.13 0.00 -0.13 0.00 0.15 -0.01 -0.29
## AZD6738 0.16 0.28 0.02 0.17 0.09 0.26 0.19
## KU-55933 0.15 0.03 -0.14 -0.25 -0.10 -0.05 -0.11
## SGC 0946 0.25 0.02 -0.01 -0.05 -0.05 0.12 0.05
## D 4476 Doxorubicine Dasatinib Duvelisib Idelalisib
## BMS-509744 0.03 0.11 0.15 0.40 0.39
## Ceritinib -0.15 -0.10 -0.07 0.11 0.17
## Fludarabine 0.02 0.26 -0.10 0.18 0.30
## Selinexor -0.10 0.31 -0.07 0.12 0.28
## Nutlin-3a -0.21 0.11 -0.22 -0.05 0.21
## Venetoclax -0.28 0.09 -0.36 -0.17 0.05
## Cytarabine 0.03 -0.01 0.36 0.34 0.44
## RO5963 0.15 0.32 0.12 0.40 0.62
## A-1210477 -0.03 0.06 0.07 0.29 0.41
## Panobinostat -0.07 0.21 0.20 0.42 0.51
## A-674563 -0.18 0.03 0.05 0.42 0.54
## Palbociclib 0.04 0.11 0.20 0.53 0.58
## Dabrafenib 0.24 -0.15 -0.12 -0.29 -0.28
## ZM 336372 0.18 0.01 -0.12 -0.04 -0.08
## EPZ-6438 -0.06 -0.29 0.03 -0.09 0.00
## ONO-4059 0.03 -0.09 0.31 0.37 0.53
## Midostaurin -0.02 -0.15 -0.20 -0.14 -0.12
## Methotrexate 0.03 -0.23 0.15 -0.04 -0.10
## Motolimod 0.28 0.22 0.06 0.07 -0.11
## Olaparib 0.12 0.00 0.02 0.13 0.09
## Cisplatin 0.23 0.19 0.10 0.11 0.23
## BGJ398 0.26 -0.05 0.39 0.36 0.25
## BML-277 0.18 0.05 -0.01 -0.08 -0.09
## AMI-1 0.31 -0.08 -0.11 -0.23 -0.19
## Vismodegib 0.19 -0.03 0.05 -0.18 0.00
## Selisistat 0.19 0.04 0.08 0.11 0.21
## TW-37 0.32 0.02 0.11 -0.07 -0.03
## D 4476 1.00 0.30 0.18 0.07 0.16
## Doxorubicine 0.30 1.00 -0.09 0.16 0.24
## Dasatinib 0.18 -0.09 1.00 0.55 0.50
## Duvelisib 0.07 0.16 0.55 1.00 0.83
## Idelalisib 0.16 0.24 0.50 0.83 1.00
## Ibrutinib 0.06 -0.14 0.59 0.60 0.73
## PRT062607 -0.12 -0.15 0.66 0.67 0.66
## Afatinib -0.01 -0.17 0.35 0.33 0.38
## SB 203580 -0.15 0.09 0.34 0.34 0.55
## IRAK-1/4 Inhibitor I -0.12 -0.15 0.25 0.44 0.56
## Quizartinib -0.23 -0.15 0.01 0.27 0.31
## MK-2206 -0.12 0.06 0.10 0.51 0.35
## AZD1208 -0.20 0.04 0.34 0.58 0.60
## AZD8055 -0.09 0.14 0.26 0.74 0.60
## Rapamycin 0.05 0.20 0.41 0.79 0.70
## MI-503 0.20 0.00 0.27 0.43 0.49
## Imatinib 0.13 -0.04 0.52 0.47 0.42
## Sunitinib -0.06 -0.01 0.40 0.60 0.56
## Foretinib 0.02 -0.01 0.44 0.63 0.62
## Tozasertib 0.03 -0.14 0.56 0.69 0.60
## Ruxolitinib 0.11 -0.11 0.58 0.47 0.52
## Tofacitinib 0.19 -0.15 0.43 0.31 0.31
## PF-3758309 0.04 0.01 0.45 0.65 0.48
## OTX015 0.31 0.20 0.25 0.43 0.27
## Volasertib 0.25 0.08 0.20 0.37 0.25
## Ganetespib 0.05 -0.26 0.57 0.62 0.47
## Onalespib 0.00 -0.20 0.54 0.63 0.53
## SCH772984 0.07 -0.01 0.52 0.58 0.50
## Cobimetinib 0.18 0.04 0.52 0.60 0.40
## Trametinib 0.18 0.00 0.48 0.60 0.42
## JNK-IN-8 0.29 -0.20 0.12 0.09 0.15
## Menin-MLL Inhibitor 0.05 0.13 0.05 0.12 0.25
## AZD6738 0.19 0.03 0.09 0.31 0.29
## KU-55933 0.09 0.35 0.14 0.35 0.40
## SGC 0946 -0.07 -0.08 0.20 0.34 0.43
## Ibrutinib PRT062607 Afatinib SB 203580
## BMS-509744 0.18 0.28 0.19 0.10
## Ceritinib 0.17 0.12 0.41 0.24
## Fludarabine 0.20 0.01 0.31 0.36
## Selinexor 0.10 0.03 0.43 0.36
## Nutlin-3a 0.15 -0.03 0.41 0.38
## Venetoclax 0.06 -0.11 0.28 0.41
## Cytarabine 0.41 0.20 0.44 0.28
## RO5963 0.44 0.23 0.25 0.46
## A-1210477 0.37 0.21 0.43 0.36
## Panobinostat 0.23 0.28 0.40 0.49
## A-674563 0.47 0.42 0.53 0.48
## Palbociclib 0.39 0.47 0.57 0.31
## Dabrafenib -0.25 -0.30 -0.18 -0.21
## ZM 336372 -0.24 -0.24 -0.19 -0.18
## EPZ-6438 0.19 0.07 -0.06 0.10
## ONO-4059 0.60 0.50 0.17 0.30
## Midostaurin -0.04 0.03 -0.01 -0.21
## Methotrexate -0.12 0.15 0.07 -0.16
## Motolimod -0.30 -0.18 -0.18 -0.36
## Olaparib -0.04 -0.09 0.32 -0.07
## Cisplatin 0.12 0.01 0.30 0.08
## BGJ398 0.13 0.21 0.19 0.06
## BML-277 -0.06 -0.13 0.14 0.04
## AMI-1 -0.09 -0.19 -0.01 -0.20
## Vismodegib 0.12 0.03 0.10 0.05
## Selisistat 0.05 0.03 0.03 -0.11
## TW-37 -0.19 -0.15 0.02 -0.29
## D 4476 0.06 -0.12 -0.01 -0.15
## Doxorubicine -0.14 -0.15 -0.17 0.09
## Dasatinib 0.59 0.66 0.35 0.34
## Duvelisib 0.60 0.67 0.33 0.34
## Idelalisib 0.73 0.66 0.38 0.55
## Ibrutinib 1.00 0.75 0.44 0.57
## PRT062607 0.75 1.00 0.46 0.53
## Afatinib 0.44 0.46 1.00 0.45
## SB 203580 0.57 0.53 0.45 1.00
## IRAK-1/4 Inhibitor I 0.58 0.53 0.46 0.40
## Quizartinib 0.33 0.33 0.18 0.32
## MK-2206 0.04 0.26 0.14 0.06
## AZD1208 0.54 0.55 0.44 0.57
## AZD8055 0.30 0.39 0.22 0.27
## Rapamycin 0.46 0.53 0.22 0.38
## MI-503 0.34 0.39 0.37 0.15
## Imatinib 0.39 0.42 0.25 0.09
## Sunitinib 0.52 0.58 0.50 0.36
## Foretinib 0.50 0.57 0.49 0.32
## Tozasertib 0.57 0.70 0.43 0.30
## Ruxolitinib 0.49 0.60 0.33 0.38
## Tofacitinib 0.32 0.34 0.30 0.24
## PF-3758309 0.46 0.57 0.37 0.31
## OTX015 0.11 0.23 0.16 0.02
## Volasertib 0.15 0.21 0.26 0.07
## Ganetespib 0.49 0.60 0.42 0.16
## Onalespib 0.54 0.64 0.43 0.24
## SCH772984 0.42 0.57 0.30 0.17
## Cobimetinib 0.29 0.45 0.19 -0.02
## Trametinib 0.27 0.44 0.19 -0.03
## JNK-IN-8 0.28 0.02 0.16 0.10
## Menin-MLL Inhibitor 0.24 0.12 0.23 0.21
## AZD6738 0.04 0.07 0.02 -0.10
## KU-55933 0.17 0.31 0.19 0.19
## SGC 0946 0.37 0.43 0.26 0.24
## IRAK-1/4 Inhibitor I Quizartinib MK-2206 AZD1208 AZD8055
## BMS-509744 0.20 0.21 0.37 0.39 0.35
## Ceritinib 0.25 0.23 0.25 0.44 0.27
## Fludarabine 0.28 0.22 0.02 0.35 0.24
## Selinexor 0.27 0.23 0.14 0.48 0.25
## Nutlin-3a 0.34 0.33 0.07 0.35 0.08
## Venetoclax 0.15 0.29 0.01 0.35 0.00
## Cytarabine 0.45 0.07 0.23 0.37 0.28
## RO5963 0.33 0.22 0.15 0.38 0.30
## A-1210477 0.34 0.17 0.11 0.34 0.35
## Panobinostat 0.41 0.25 0.43 0.60 0.63
## A-674563 0.58 0.53 0.29 0.67 0.48
## Palbociclib 0.56 0.40 0.44 0.55 0.56
## Dabrafenib -0.32 -0.03 -0.16 -0.27 -0.23
## ZM 336372 -0.31 0.05 0.02 -0.07 -0.05
## EPZ-6438 0.18 0.02 -0.09 0.01 -0.04
## ONO-4059 0.23 0.27 0.09 0.27 0.18
## Midostaurin 0.20 0.48 0.13 -0.04 -0.02
## Methotrexate 0.11 -0.11 -0.02 -0.24 -0.07
## Motolimod -0.20 -0.19 0.14 -0.27 0.06
## Olaparib 0.32 0.00 0.40 0.13 0.34
## Cisplatin 0.42 -0.02 0.01 0.03 -0.01
## BGJ398 0.33 0.01 0.31 0.18 0.30
## BML-277 0.08 0.01 -0.02 -0.07 -0.03
## AMI-1 -0.02 -0.12 -0.28 -0.22 -0.22
## Vismodegib 0.20 -0.05 -0.20 -0.07 -0.17
## Selisistat 0.21 -0.03 0.28 0.01 0.18
## TW-37 -0.03 -0.37 -0.01 -0.32 -0.14
## D 4476 -0.12 -0.23 -0.12 -0.20 -0.09
## Doxorubicine -0.15 -0.15 0.06 0.04 0.14
## Dasatinib 0.25 0.01 0.10 0.34 0.26
## Duvelisib 0.44 0.27 0.51 0.58 0.74
## Idelalisib 0.56 0.31 0.35 0.60 0.60
## Ibrutinib 0.58 0.33 0.04 0.54 0.30
## PRT062607 0.53 0.33 0.26 0.55 0.39
## Afatinib 0.46 0.18 0.14 0.44 0.22
## SB 203580 0.40 0.32 0.06 0.57 0.27
## IRAK-1/4 Inhibitor I 1.00 0.54 0.30 0.41 0.36
## Quizartinib 0.54 1.00 0.34 0.46 0.32
## MK-2206 0.30 0.34 1.00 0.51 0.71
## AZD1208 0.41 0.46 0.51 1.00 0.66
## AZD8055 0.36 0.32 0.71 0.66 1.00
## Rapamycin 0.30 0.30 0.65 0.66 0.79
## MI-503 0.34 0.24 0.30 0.35 0.35
## Imatinib 0.46 0.31 0.47 0.40 0.42
## Sunitinib 0.61 0.56 0.46 0.66 0.52
## Foretinib 0.59 0.56 0.54 0.56 0.54
## Tozasertib 0.58 0.38 0.49 0.54 0.59
## Ruxolitinib 0.42 0.01 0.15 0.33 0.30
## Tofacitinib 0.26 0.06 -0.02 0.12 0.16
## PF-3758309 0.36 0.17 0.27 0.49 0.62
## OTX015 0.04 -0.20 0.20 0.19 0.43
## Volasertib 0.19 -0.08 0.18 0.26 0.39
## Ganetespib 0.47 0.14 0.44 0.39 0.57
## Onalespib 0.55 0.25 0.46 0.45 0.62
## SCH772984 0.45 -0.05 0.16 0.22 0.39
## Cobimetinib 0.23 -0.16 0.24 0.17 0.46
## Trametinib 0.25 -0.14 0.24 0.16 0.44
## JNK-IN-8 0.22 0.08 0.12 0.06 0.15
## Menin-MLL Inhibitor 0.42 0.25 0.25 0.29 0.16
## AZD6738 0.17 -0.08 0.31 0.20 0.32
## KU-55933 0.16 -0.08 0.35 0.29 0.23
## SGC 0946 0.40 0.16 0.25 0.39 0.24
## Rapamycin MI-503 Imatinib Sunitinib Foretinib Tozasertib
## BMS-509744 0.34 0.12 0.30 0.30 0.47 0.36
## Ceritinib -0.01 0.20 0.16 0.29 0.19 0.20
## Fludarabine 0.32 0.16 0.05 0.27 0.27 0.04
## Selinexor 0.23 0.29 0.03 0.29 0.27 0.11
## Nutlin-3a 0.12 0.12 0.03 0.21 0.30 0.03
## Venetoclax -0.04 0.04 -0.14 0.07 0.02 -0.17
## Cytarabine 0.34 0.20 0.31 0.45 0.46 0.35
## RO5963 0.41 0.29 0.15 0.35 0.46 0.27
## A-1210477 0.32 0.27 -0.01 0.24 0.25 0.23
## Panobinostat 0.49 0.34 0.19 0.35 0.37 0.40
## A-674563 0.44 0.38 0.32 0.59 0.47 0.41
## Palbociclib 0.57 0.51 0.46 0.58 0.62 0.57
## Dabrafenib -0.17 -0.15 -0.24 -0.28 -0.29 -0.35
## ZM 336372 -0.08 0.06 -0.17 -0.14 -0.16 -0.27
## EPZ-6438 -0.02 -0.14 -0.10 -0.16 -0.13 -0.03
## ONO-4059 0.44 0.20 0.18 0.20 0.45 0.32
## Midostaurin -0.04 0.04 0.18 0.27 0.28 0.13
## Methotrexate -0.14 0.04 -0.01 -0.06 -0.07 0.11
## Motolimod -0.03 -0.06 0.01 -0.18 -0.11 -0.02
## Olaparib 0.17 0.20 0.30 0.23 0.38 0.37
## Cisplatin -0.06 0.35 0.21 0.29 0.27 0.19
## BGJ398 0.21 0.35 0.38 0.37 0.31 0.43
## BML-277 -0.14 0.15 0.10 0.04 -0.01 0.05
## AMI-1 -0.35 0.07 0.04 0.01 -0.10 0.03
## Vismodegib -0.22 0.02 0.03 0.02 -0.04 0.09
## Selisistat 0.19 0.21 0.25 0.11 0.26 0.19
## TW-37 -0.09 0.02 0.05 -0.05 0.10 0.04
## D 4476 0.05 0.20 0.13 -0.06 0.02 0.03
## Doxorubicine 0.20 0.00 -0.04 -0.01 -0.01 -0.14
## Dasatinib 0.41 0.27 0.52 0.40 0.44 0.56
## Duvelisib 0.79 0.43 0.47 0.60 0.63 0.69
## Idelalisib 0.70 0.49 0.42 0.56 0.62 0.60
## Ibrutinib 0.46 0.34 0.39 0.52 0.50 0.57
## PRT062607 0.53 0.39 0.42 0.58 0.57 0.70
## Afatinib 0.22 0.37 0.25 0.50 0.49 0.43
## SB 203580 0.38 0.15 0.09 0.36 0.32 0.30
## IRAK-1/4 Inhibitor I 0.30 0.34 0.46 0.61 0.59 0.58
## Quizartinib 0.30 0.24 0.31 0.56 0.56 0.38
## MK-2206 0.65 0.30 0.47 0.46 0.54 0.49
## AZD1208 0.66 0.35 0.40 0.66 0.56 0.54
## AZD8055 0.79 0.35 0.42 0.52 0.54 0.59
## Rapamycin 1.00 0.37 0.47 0.52 0.66 0.60
## MI-503 0.37 1.00 0.44 0.52 0.45 0.48
## Imatinib 0.47 0.44 1.00 0.59 0.62 0.65
## Sunitinib 0.52 0.52 0.59 1.00 0.76 0.69
## Foretinib 0.66 0.45 0.62 0.76 1.00 0.79
## Tozasertib 0.60 0.48 0.65 0.69 0.79 1.00
## Ruxolitinib 0.37 0.44 0.32 0.34 0.27 0.52
## Tofacitinib 0.16 0.21 0.25 0.20 0.14 0.34
## PF-3758309 0.59 0.39 0.33 0.54 0.36 0.55
## OTX015 0.41 0.35 0.18 0.18 0.04 0.25
## Volasertib 0.34 0.40 0.25 0.27 0.07 0.30
## Ganetespib 0.48 0.40 0.54 0.49 0.47 0.72
## Onalespib 0.50 0.35 0.53 0.53 0.50 0.71
## SCH772984 0.37 0.44 0.41 0.35 0.34 0.59
## Cobimetinib 0.43 0.38 0.40 0.32 0.27 0.54
## Trametinib 0.43 0.38 0.41 0.28 0.25 0.52
## JNK-IN-8 0.20 0.05 0.14 -0.06 0.16 0.21
## Menin-MLL Inhibitor 0.19 0.11 0.35 0.26 0.18 0.19
## AZD6738 0.17 0.17 0.17 0.15 0.17 0.18
## KU-55933 0.43 0.12 0.20 0.09 0.23 0.25
## SGC 0946 0.35 0.36 0.31 0.26 0.26 0.36
## Ruxolitinib Tofacitinib PF-3758309 OTX015 Volasertib
## BMS-509744 0.06 -0.06 -0.10 -0.18 -0.09
## Ceritinib -0.07 -0.14 -0.05 -0.18 0.00
## Fludarabine -0.08 -0.02 0.13 0.00 0.05
## Selinexor 0.11 0.00 0.09 0.05 0.14
## Nutlin-3a -0.17 -0.17 -0.22 -0.32 -0.14
## Venetoclax -0.21 -0.20 -0.27 -0.34 -0.18
## Cytarabine 0.22 0.17 0.24 0.09 0.13
## RO5963 0.14 0.05 0.05 -0.06 -0.04
## A-1210477 0.17 -0.02 0.27 0.19 0.31
## Panobinostat 0.41 0.31 0.42 0.35 0.40
## A-674563 0.27 0.25 0.36 0.15 0.30
## Palbociclib 0.28 0.16 0.51 0.37 0.47
## Dabrafenib -0.11 0.09 -0.06 0.15 0.11
## ZM 336372 -0.19 0.03 -0.22 -0.03 -0.08
## EPZ-6438 0.18 0.07 0.01 -0.04 0.00
## ONO-4059 0.22 -0.02 0.08 -0.07 -0.06
## Midostaurin -0.07 0.12 -0.03 -0.13 -0.10
## Methotrexate 0.19 0.15 0.18 0.28 0.26
## Motolimod 0.00 0.09 0.08 0.32 0.18
## Olaparib 0.07 0.04 0.04 0.12 0.19
## Cisplatin 0.16 0.03 0.00 0.08 0.15
## BGJ398 0.45 0.17 0.39 0.39 0.42
## BML-277 0.14 -0.03 0.01 0.09 0.22
## AMI-1 0.02 0.22 -0.14 -0.08 0.07
## Vismodegib 0.25 0.34 0.03 0.01 0.09
## Selisistat 0.15 0.01 -0.02 0.03 0.07
## TW-37 0.09 0.10 -0.24 -0.06 -0.11
## D 4476 0.11 0.19 0.04 0.31 0.25
## Doxorubicine -0.11 -0.15 0.01 0.20 0.08
## Dasatinib 0.58 0.43 0.45 0.25 0.20
## Duvelisib 0.47 0.31 0.65 0.43 0.37
## Idelalisib 0.52 0.31 0.48 0.27 0.25
## Ibrutinib 0.49 0.32 0.46 0.11 0.15
## PRT062607 0.60 0.34 0.57 0.23 0.21
## Afatinib 0.33 0.30 0.37 0.16 0.26
## SB 203580 0.38 0.24 0.31 0.02 0.07
## IRAK-1/4 Inhibitor I 0.42 0.26 0.36 0.04 0.19
## Quizartinib 0.01 0.06 0.17 -0.20 -0.08
## MK-2206 0.15 -0.02 0.27 0.20 0.18
## AZD1208 0.33 0.12 0.49 0.19 0.26
## AZD8055 0.30 0.16 0.62 0.43 0.39
## Rapamycin 0.37 0.16 0.59 0.41 0.34
## MI-503 0.44 0.21 0.39 0.35 0.40
## Imatinib 0.32 0.25 0.33 0.18 0.25
## Sunitinib 0.34 0.20 0.54 0.18 0.27
## Foretinib 0.27 0.14 0.36 0.04 0.07
## Tozasertib 0.52 0.34 0.55 0.25 0.30
## Ruxolitinib 1.00 0.69 0.52 0.43 0.44
## Tofacitinib 0.69 1.00 0.36 0.30 0.28
## PF-3758309 0.52 0.36 1.00 0.78 0.74
## OTX015 0.43 0.30 0.78 1.00 0.91
## Volasertib 0.44 0.28 0.74 0.91 1.00
## Ganetespib 0.60 0.44 0.71 0.54 0.53
## Onalespib 0.50 0.33 0.68 0.46 0.47
## SCH772984 0.73 0.41 0.60 0.55 0.52
## Cobimetinib 0.61 0.36 0.65 0.68 0.59
## Trametinib 0.65 0.44 0.62 0.68 0.61
## JNK-IN-8 0.27 0.41 0.05 0.06 0.11
## Menin-MLL Inhibitor 0.19 0.32 0.19 0.15 0.25
## AZD6738 0.23 0.22 0.04 0.07 0.12
## KU-55933 0.32 0.07 0.16 0.30 0.30
## SGC 0946 0.41 0.17 0.08 0.06 0.16
## Ganetespib Onalespib SCH772984 Cobimetinib Trametinib
## BMS-509744 0.09 0.18 0.06 0.02 0.02
## Ceritinib 0.12 0.22 -0.02 -0.13 -0.15
## Fludarabine -0.15 -0.09 -0.09 -0.22 -0.17
## Selinexor -0.06 0.00 0.05 -0.09 -0.08
## Nutlin-3a -0.28 -0.14 -0.21 -0.37 -0.35
## Venetoclax -0.42 -0.31 -0.41 -0.58 -0.53
## Cytarabine 0.30 0.29 0.20 0.15 0.13
## RO5963 0.00 0.08 0.06 -0.02 -0.04
## A-1210477 0.19 0.23 0.25 0.17 0.16
## Panobinostat 0.34 0.37 0.28 0.19 0.22
## A-674563 0.24 0.33 0.22 0.08 0.14
## Palbociclib 0.47 0.53 0.35 0.27 0.30
## Dabrafenib -0.24 -0.31 -0.28 -0.17 -0.12
## ZM 336372 -0.16 -0.14 -0.25 -0.11 -0.09
## EPZ-6438 0.02 0.10 -0.05 -0.16 -0.08
## ONO-4059 0.17 0.25 0.10 0.06 0.05
## Midostaurin 0.02 0.01 -0.13 -0.14 -0.13
## Methotrexate 0.37 0.30 0.35 0.36 0.35
## Motolimod 0.22 0.17 0.17 0.34 0.31
## Olaparib 0.34 0.33 0.19 0.22 0.18
## Cisplatin 0.18 0.16 0.36 0.19 0.21
## BGJ398 0.48 0.42 0.46 0.47 0.43
## BML-277 0.08 0.10 0.09 0.07 0.04
## AMI-1 -0.06 -0.08 -0.07 -0.08 -0.04
## Vismodegib 0.14 0.16 0.10 0.00 0.02
## Selisistat 0.20 0.24 0.18 0.20 0.22
## TW-37 -0.02 -0.06 0.06 0.09 0.09
## D 4476 0.05 0.00 0.07 0.18 0.18
## Doxorubicine -0.26 -0.20 -0.01 0.04 0.00
## Dasatinib 0.57 0.54 0.52 0.52 0.48
## Duvelisib 0.62 0.63 0.58 0.60 0.60
## Idelalisib 0.47 0.53 0.50 0.40 0.42
## Ibrutinib 0.49 0.54 0.42 0.29 0.27
## PRT062607 0.60 0.64 0.57 0.45 0.44
## Afatinib 0.42 0.43 0.30 0.19 0.19
## SB 203580 0.16 0.24 0.17 -0.02 -0.03
## IRAK-1/4 Inhibitor I 0.47 0.55 0.45 0.23 0.25
## Quizartinib 0.14 0.25 -0.05 -0.16 -0.14
## MK-2206 0.44 0.46 0.16 0.24 0.24
## AZD1208 0.39 0.45 0.22 0.17 0.16
## AZD8055 0.57 0.62 0.39 0.46 0.44
## Rapamycin 0.48 0.50 0.37 0.43 0.43
## MI-503 0.40 0.35 0.44 0.38 0.38
## Imatinib 0.54 0.53 0.41 0.40 0.41
## Sunitinib 0.49 0.53 0.35 0.32 0.28
## Foretinib 0.47 0.50 0.34 0.27 0.25
## Tozasertib 0.72 0.71 0.59 0.54 0.52
## Ruxolitinib 0.60 0.50 0.73 0.61 0.65
## Tofacitinib 0.44 0.33 0.41 0.36 0.44
## PF-3758309 0.71 0.68 0.60 0.65 0.62
## OTX015 0.54 0.46 0.55 0.68 0.68
## Volasertib 0.53 0.47 0.52 0.59 0.61
## Ganetespib 1.00 0.95 0.73 0.76 0.75
## Onalespib 0.95 1.00 0.65 0.66 0.65
## SCH772984 0.73 0.65 1.00 0.88 0.91
## Cobimetinib 0.76 0.66 0.88 1.00 0.96
## Trametinib 0.75 0.65 0.91 0.96 1.00
## JNK-IN-8 0.20 0.19 0.05 -0.04 0.04
## Menin-MLL Inhibitor 0.26 0.29 0.16 0.05 0.14
## AZD6738 0.20 0.18 0.19 0.21 0.24
## KU-55933 0.22 0.18 0.35 0.29 0.33
## SGC 0946 0.26 0.27 0.36 0.21 0.31
## JNK-IN-8 Menin-MLL Inhibitor AZD6738 KU-55933 SGC 0946
## BMS-509744 0.10 0.05 0.45 0.30 0.26
## Ceritinib -0.05 0.03 0.17 0.08 0.18
## Fludarabine 0.17 0.14 0.03 0.07 0.24
## Selinexor 0.03 0.20 0.03 0.20 0.26
## Nutlin-3a 0.17 0.18 0.02 0.10 0.23
## Venetoclax 0.05 0.09 -0.06 0.04 0.23
## Cytarabine 0.29 0.24 0.19 0.08 0.23
## RO5963 0.22 0.05 0.23 0.15 0.09
## A-1210477 0.22 0.22 0.11 0.27 0.41
## Panobinostat 0.32 0.34 0.26 0.38 0.33
## A-674563 0.20 0.48 0.17 0.27 0.49
## Palbociclib 0.11 0.31 0.17 0.35 0.43
## Dabrafenib 0.11 -0.08 -0.10 -0.13 -0.18
## ZM 336372 -0.11 -0.28 0.11 -0.22 0.01
## EPZ-6438 0.35 -0.01 -0.11 -0.18 0.24
## ONO-4059 0.18 -0.14 0.02 0.22 0.35
## Midostaurin 0.10 0.19 -0.01 -0.03 -0.05
## Methotrexate 0.06 0.16 -0.01 0.17 -0.06
## Motolimod 0.00 0.09 0.03 0.11 -0.25
## Olaparib 0.28 0.20 0.25 0.13 0.00
## Cisplatin -0.03 0.13 0.16 0.15 0.25
## BGJ398 0.04 0.00 0.28 0.03 0.02
## BML-277 0.09 -0.13 0.02 -0.14 -0.01
## AMI-1 0.09 0.00 0.17 -0.25 -0.05
## Vismodegib 0.17 0.15 0.09 -0.10 -0.05
## Selisistat 0.09 -0.01 0.26 -0.05 0.12
## TW-37 0.01 -0.29 0.19 -0.11 0.05
## D 4476 0.29 0.05 0.19 0.09 -0.07
## Doxorubicine -0.20 0.13 0.03 0.35 -0.08
## Dasatinib 0.12 0.05 0.09 0.14 0.20
## Duvelisib 0.09 0.12 0.31 0.35 0.34
## Idelalisib 0.15 0.25 0.29 0.40 0.43
## Ibrutinib 0.28 0.24 0.04 0.17 0.37
## PRT062607 0.02 0.12 0.07 0.31 0.43
## Afatinib 0.16 0.23 0.02 0.19 0.26
## SB 203580 0.10 0.21 -0.10 0.19 0.24
## IRAK-1/4 Inhibitor I 0.22 0.42 0.17 0.16 0.40
## Quizartinib 0.08 0.25 -0.08 -0.08 0.16
## MK-2206 0.12 0.25 0.31 0.35 0.25
## AZD1208 0.06 0.29 0.20 0.29 0.39
## AZD8055 0.15 0.16 0.32 0.23 0.24
## Rapamycin 0.20 0.19 0.17 0.43 0.35
## MI-503 0.05 0.11 0.17 0.12 0.36
## Imatinib 0.14 0.35 0.17 0.20 0.31
## Sunitinib -0.06 0.26 0.15 0.09 0.26
## Foretinib 0.16 0.18 0.17 0.23 0.26
## Tozasertib 0.21 0.19 0.18 0.25 0.36
## Ruxolitinib 0.27 0.19 0.23 0.32 0.41
## Tofacitinib 0.41 0.32 0.22 0.07 0.17
## PF-3758309 0.05 0.19 0.04 0.16 0.08
## OTX015 0.06 0.15 0.07 0.30 0.06
## Volasertib 0.11 0.25 0.12 0.30 0.16
## Ganetespib 0.20 0.26 0.20 0.22 0.26
## Onalespib 0.19 0.29 0.18 0.18 0.27
## SCH772984 0.05 0.16 0.19 0.35 0.36
## Cobimetinib -0.04 0.05 0.21 0.29 0.21
## Trametinib 0.04 0.14 0.24 0.33 0.31
## JNK-IN-8 1.00 0.36 0.18 0.12 0.18
## Menin-MLL Inhibitor 0.36 1.00 0.10 0.35 0.20
## AZD6738 0.18 0.10 1.00 0.21 0.19
## KU-55933 0.12 0.35 0.21 1.00 0.44
## SGC 0946 0.18 0.20 0.19 0.44 1.00
##
## $corrPos
## xName yName x y corr
## 1 BMS-509744 BMS-509744 1 62 1.00
## 2 BMS-509744 Ceritinib 1 61 0.48
## 3 BMS-509744 Fludarabine 1 60 0.19
## 4 BMS-509744 Selinexor 1 59 0.22
## 5 BMS-509744 Nutlin-3a 1 58 0.38
## 6 BMS-509744 Venetoclax 1 57 0.16
## 7 BMS-509744 Cytarabine 1 56 0.17
## 8 BMS-509744 RO5963 1 55 0.44
## 9 BMS-509744 A-1210477 1 54 0.26
## 10 BMS-509744 Panobinostat 1 53 0.25
## 11 BMS-509744 A-674563 1 52 0.28
## 12 BMS-509744 Palbociclib 1 51 0.39
## 13 BMS-509744 Dabrafenib 1 50 -0.32
## 14 BMS-509744 ZM 336372 1 49 0.11
## 15 BMS-509744 EPZ-6438 1 48 -0.10
## 16 BMS-509744 ONO-4059 1 47 0.38
## 17 BMS-509744 Midostaurin 1 46 0.04
## 18 BMS-509744 Methotrexate 1 45 -0.07
## 19 BMS-509744 Motolimod 1 44 -0.04
## 20 BMS-509744 Olaparib 1 43 0.34
## 21 BMS-509744 Cisplatin 1 42 0.16
## 22 BMS-509744 BGJ398 1 41 0.18
## 23 BMS-509744 BML-277 1 40 0.13
## 24 BMS-509744 AMI-1 1 39 0.14
## 25 BMS-509744 Vismodegib 1 38 -0.04
## 26 BMS-509744 Selisistat 1 37 0.22
## 27 BMS-509744 TW-37 1 36 0.10
## 28 BMS-509744 D 4476 1 35 0.03
## 29 BMS-509744 Doxorubicine 1 34 0.11
## 30 BMS-509744 Dasatinib 1 33 0.15
## 31 BMS-509744 Duvelisib 1 32 0.40
## 32 BMS-509744 Idelalisib 1 31 0.39
## 33 BMS-509744 Ibrutinib 1 30 0.18
## 34 BMS-509744 PRT062607 1 29 0.28
## 35 BMS-509744 Afatinib 1 28 0.19
## 36 BMS-509744 SB 203580 1 27 0.10
## 37 BMS-509744 IRAK-1/4 Inhibitor I 1 26 0.20
## 38 BMS-509744 Quizartinib 1 25 0.21
## 39 BMS-509744 MK-2206 1 24 0.37
## 40 BMS-509744 AZD1208 1 23 0.39
## 41 BMS-509744 AZD8055 1 22 0.35
## 42 BMS-509744 Rapamycin 1 21 0.34
## 43 BMS-509744 MI-503 1 20 0.12
## 44 BMS-509744 Imatinib 1 19 0.30
## 45 BMS-509744 Sunitinib 1 18 0.30
## 46 BMS-509744 Foretinib 1 17 0.47
## 47 BMS-509744 Tozasertib 1 16 0.36
## 48 BMS-509744 Ruxolitinib 1 15 0.06
## 49 BMS-509744 Tofacitinib 1 14 -0.06
## 50 BMS-509744 PF-3758309 1 13 -0.10
## 51 BMS-509744 OTX015 1 12 -0.18
## 52 BMS-509744 Volasertib 1 11 -0.09
## 53 BMS-509744 Ganetespib 1 10 0.09
## 54 BMS-509744 Onalespib 1 9 0.18
## 55 BMS-509744 SCH772984 1 8 0.06
## 56 BMS-509744 Cobimetinib 1 7 0.02
## 57 BMS-509744 Trametinib 1 6 0.02
## 58 BMS-509744 JNK-IN-8 1 5 0.10
## 59 BMS-509744 Menin-MLL Inhibitor 1 4 0.05
## 60 BMS-509744 AZD6738 1 3 0.45
## 61 BMS-509744 KU-55933 1 2 0.30
## 62 BMS-509744 SGC 0946 1 1 0.26
## 63 Ceritinib Ceritinib 2 61 1.00
## 64 Ceritinib Fludarabine 2 60 0.14
## 65 Ceritinib Selinexor 2 59 0.33
## 66 Ceritinib Nutlin-3a 2 58 0.44
## 67 Ceritinib Venetoclax 2 57 0.48
## 68 Ceritinib Cytarabine 2 56 0.09
## 69 Ceritinib RO5963 2 55 0.24
## 70 Ceritinib A-1210477 2 54 0.30
## 71 Ceritinib Panobinostat 2 53 0.27
## 72 Ceritinib A-674563 2 52 0.34
## 73 Ceritinib Palbociclib 2 51 0.31
## 74 Ceritinib Dabrafenib 2 50 -0.31
## 75 Ceritinib ZM 336372 2 49 0.09
## 76 Ceritinib EPZ-6438 2 48 -0.10
## 77 Ceritinib ONO-4059 2 47 0.07
## 78 Ceritinib Midostaurin 2 46 -0.15
## 79 Ceritinib Methotrexate 2 45 -0.16
## 80 Ceritinib Motolimod 2 44 -0.27
## 81 Ceritinib Olaparib 2 43 0.25
## 82 Ceritinib Cisplatin 2 42 0.29
## 83 Ceritinib BGJ398 2 41 0.10
## 84 Ceritinib BML-277 2 40 0.28
## 85 Ceritinib AMI-1 2 39 0.14
## 86 Ceritinib Vismodegib 2 38 0.13
## 87 Ceritinib Selisistat 2 37 0.04
## 88 Ceritinib TW-37 2 36 -0.14
## 89 Ceritinib D 4476 2 35 -0.15
## 90 Ceritinib Doxorubicine 2 34 -0.10
## 91 Ceritinib Dasatinib 2 33 -0.07
## 92 Ceritinib Duvelisib 2 32 0.11
## 93 Ceritinib Idelalisib 2 31 0.17
## 94 Ceritinib Ibrutinib 2 30 0.17
## 95 Ceritinib PRT062607 2 29 0.12
## 96 Ceritinib Afatinib 2 28 0.41
## 97 Ceritinib SB 203580 2 27 0.24
## 98 Ceritinib IRAK-1/4 Inhibitor I 2 26 0.25
## 99 Ceritinib Quizartinib 2 25 0.23
## 100 Ceritinib MK-2206 2 24 0.25
## 101 Ceritinib AZD1208 2 23 0.44
## 102 Ceritinib AZD8055 2 22 0.27
## 103 Ceritinib Rapamycin 2 21 -0.01
## 104 Ceritinib MI-503 2 20 0.20
## 105 Ceritinib Imatinib 2 19 0.16
## 106 Ceritinib Sunitinib 2 18 0.29
## 107 Ceritinib Foretinib 2 17 0.19
## 108 Ceritinib Tozasertib 2 16 0.20
## 109 Ceritinib Ruxolitinib 2 15 -0.07
## 110 Ceritinib Tofacitinib 2 14 -0.14
## 111 Ceritinib PF-3758309 2 13 -0.05
## 112 Ceritinib OTX015 2 12 -0.18
## 113 Ceritinib Volasertib 2 11 0.00
## 114 Ceritinib Ganetespib 2 10 0.12
## 115 Ceritinib Onalespib 2 9 0.22
## 116 Ceritinib SCH772984 2 8 -0.02
## 117 Ceritinib Cobimetinib 2 7 -0.13
## 118 Ceritinib Trametinib 2 6 -0.15
## 119 Ceritinib JNK-IN-8 2 5 -0.05
## 120 Ceritinib Menin-MLL Inhibitor 2 4 0.03
## 121 Ceritinib AZD6738 2 3 0.17
## 122 Ceritinib KU-55933 2 2 0.08
## 123 Ceritinib SGC 0946 2 1 0.18
## 124 Fludarabine Fludarabine 3 60 1.00
## 125 Fludarabine Selinexor 3 59 0.59
## 126 Fludarabine Nutlin-3a 3 58 0.62
## 127 Fludarabine Venetoclax 3 57 0.60
## 128 Fludarabine Cytarabine 3 56 0.43
## 129 Fludarabine RO5963 3 55 0.51
## 130 Fludarabine A-1210477 3 54 0.47
## 131 Fludarabine Panobinostat 3 53 0.48
## 132 Fludarabine A-674563 3 52 0.54
## 133 Fludarabine Palbociclib 3 51 0.47
## 134 Fludarabine Dabrafenib 3 50 -0.06
## 135 Fludarabine ZM 336372 3 49 -0.04
## 136 Fludarabine EPZ-6438 3 48 0.06
## 137 Fludarabine ONO-4059 3 47 0.18
## 138 Fludarabine Midostaurin 3 46 0.03
## 139 Fludarabine Methotrexate 3 45 -0.36
## 140 Fludarabine Motolimod 3 44 -0.34
## 141 Fludarabine Olaparib 3 43 0.25
## 142 Fludarabine Cisplatin 3 42 0.22
## 143 Fludarabine BGJ398 3 41 -0.05
## 144 Fludarabine BML-277 3 40 0.05
## 145 Fludarabine AMI-1 3 39 0.04
## 146 Fludarabine Vismodegib 3 38 -0.06
## 147 Fludarabine Selisistat 3 37 -0.06
## 148 Fludarabine TW-37 3 36 -0.10
## 149 Fludarabine D 4476 3 35 0.02
## 150 Fludarabine Doxorubicine 3 34 0.26
## 151 Fludarabine Dasatinib 3 33 -0.10
## 152 Fludarabine Duvelisib 3 32 0.18
## 153 Fludarabine Idelalisib 3 31 0.30
## 154 Fludarabine Ibrutinib 3 30 0.20
## 155 Fludarabine PRT062607 3 29 0.01
## 156 Fludarabine Afatinib 3 28 0.31
## 157 Fludarabine SB 203580 3 27 0.36
## 158 Fludarabine IRAK-1/4 Inhibitor I 3 26 0.28
## 159 Fludarabine Quizartinib 3 25 0.22
## 160 Fludarabine MK-2206 3 24 0.02
## 161 Fludarabine AZD1208 3 23 0.35
## 162 Fludarabine AZD8055 3 22 0.24
## 163 Fludarabine Rapamycin 3 21 0.32
## 164 Fludarabine MI-503 3 20 0.16
## 165 Fludarabine Imatinib 3 19 0.05
## 166 Fludarabine Sunitinib 3 18 0.27
## 167 Fludarabine Foretinib 3 17 0.27
## 168 Fludarabine Tozasertib 3 16 0.04
## 169 Fludarabine Ruxolitinib 3 15 -0.08
## 170 Fludarabine Tofacitinib 3 14 -0.02
## 171 Fludarabine PF-3758309 3 13 0.13
## 172 Fludarabine OTX015 3 12 0.00
## 173 Fludarabine Volasertib 3 11 0.05
## 174 Fludarabine Ganetespib 3 10 -0.15
## 175 Fludarabine Onalespib 3 9 -0.09
## 176 Fludarabine SCH772984 3 8 -0.09
## 177 Fludarabine Cobimetinib 3 7 -0.22
## 178 Fludarabine Trametinib 3 6 -0.17
## 179 Fludarabine JNK-IN-8 3 5 0.17
## 180 Fludarabine Menin-MLL Inhibitor 3 4 0.14
## 181 Fludarabine AZD6738 3 3 0.03
## 182 Fludarabine KU-55933 3 2 0.07
## 183 Fludarabine SGC 0946 3 1 0.24
## 184 Selinexor Selinexor 4 59 1.00
## 185 Selinexor Nutlin-3a 4 58 0.69
## 186 Selinexor Venetoclax 4 57 0.64
## 187 Selinexor Cytarabine 4 56 0.29
## 188 Selinexor RO5963 4 55 0.46
## 189 Selinexor A-1210477 4 54 0.43
## 190 Selinexor Panobinostat 4 53 0.57
## 191 Selinexor A-674563 4 52 0.56
## 192 Selinexor Palbociclib 4 51 0.56
## 193 Selinexor Dabrafenib 4 50 -0.32
## 194 Selinexor ZM 336372 4 49 -0.08
## 195 Selinexor EPZ-6438 4 48 -0.06
## 196 Selinexor ONO-4059 4 47 0.01
## 197 Selinexor Midostaurin 4 46 -0.12
## 198 Selinexor Methotrexate 4 45 -0.30
## 199 Selinexor Motolimod 4 44 -0.25
## 200 Selinexor Olaparib 4 43 0.28
## 201 Selinexor Cisplatin 4 42 0.24
## 202 Selinexor BGJ398 4 41 -0.09
## 203 Selinexor BML-277 4 40 0.05
## 204 Selinexor AMI-1 4 39 -0.16
## 205 Selinexor Vismodegib 4 38 -0.01
## 206 Selinexor Selisistat 4 37 -0.01
## 207 Selinexor TW-37 4 36 -0.03
## 208 Selinexor D 4476 4 35 -0.10
## 209 Selinexor Doxorubicine 4 34 0.31
## 210 Selinexor Dasatinib 4 33 -0.07
## 211 Selinexor Duvelisib 4 32 0.12
## 212 Selinexor Idelalisib 4 31 0.28
## 213 Selinexor Ibrutinib 4 30 0.10
## 214 Selinexor PRT062607 4 29 0.03
## 215 Selinexor Afatinib 4 28 0.43
## 216 Selinexor SB 203580 4 27 0.36
## 217 Selinexor IRAK-1/4 Inhibitor I 4 26 0.27
## 218 Selinexor Quizartinib 4 25 0.23
## 219 Selinexor MK-2206 4 24 0.14
## 220 Selinexor AZD1208 4 23 0.48
## 221 Selinexor AZD8055 4 22 0.25
## 222 Selinexor Rapamycin 4 21 0.23
## 223 Selinexor MI-503 4 20 0.29
## 224 Selinexor Imatinib 4 19 0.03
## 225 Selinexor Sunitinib 4 18 0.29
## 226 Selinexor Foretinib 4 17 0.27
## 227 Selinexor Tozasertib 4 16 0.11
## 228 Selinexor Ruxolitinib 4 15 0.11
## 229 Selinexor Tofacitinib 4 14 0.00
## 230 Selinexor PF-3758309 4 13 0.09
## 231 Selinexor OTX015 4 12 0.05
## 232 Selinexor Volasertib 4 11 0.14
## 233 Selinexor Ganetespib 4 10 -0.06
## 234 Selinexor Onalespib 4 9 0.00
## 235 Selinexor SCH772984 4 8 0.05
## 236 Selinexor Cobimetinib 4 7 -0.09
## 237 Selinexor Trametinib 4 6 -0.08
## 238 Selinexor JNK-IN-8 4 5 0.03
## 239 Selinexor Menin-MLL Inhibitor 4 4 0.20
## 240 Selinexor AZD6738 4 3 0.03
## 241 Selinexor KU-55933 4 2 0.20
## 242 Selinexor SGC 0946 4 1 0.26
## 243 Nutlin-3a Nutlin-3a 5 58 1.00
## 244 Nutlin-3a Venetoclax 5 57 0.79
## 245 Nutlin-3a Cytarabine 5 56 0.35
## 246 Nutlin-3a RO5963 5 55 0.57
## 247 Nutlin-3a A-1210477 5 54 0.46
## 248 Nutlin-3a Panobinostat 5 53 0.40
## 249 Nutlin-3a A-674563 5 52 0.60
## 250 Nutlin-3a Palbociclib 5 51 0.44
## 251 Nutlin-3a Dabrafenib 5 50 -0.18
## 252 Nutlin-3a ZM 336372 5 49 0.01
## 253 Nutlin-3a EPZ-6438 5 48 0.06
## 254 Nutlin-3a ONO-4059 5 47 0.27
## 255 Nutlin-3a Midostaurin 5 46 -0.01
## 256 Nutlin-3a Methotrexate 5 45 -0.30
## 257 Nutlin-3a Motolimod 5 44 -0.44
## 258 Nutlin-3a Olaparib 5 43 0.32
## 259 Nutlin-3a Cisplatin 5 42 0.22
## 260 Nutlin-3a BGJ398 5 41 -0.22
## 261 Nutlin-3a BML-277 5 40 0.12
## 262 Nutlin-3a AMI-1 5 39 0.02
## 263 Nutlin-3a Vismodegib 5 38 0.07
## 264 Nutlin-3a Selisistat 5 37 0.11
## 265 Nutlin-3a TW-37 5 36 -0.06
## 266 Nutlin-3a D 4476 5 35 -0.21
## 267 Nutlin-3a Doxorubicine 5 34 0.11
## 268 Nutlin-3a Dasatinib 5 33 -0.22
## 269 Nutlin-3a Duvelisib 5 32 -0.05
## 270 Nutlin-3a Idelalisib 5 31 0.21
## 271 Nutlin-3a Ibrutinib 5 30 0.15
## 272 Nutlin-3a PRT062607 5 29 -0.03
## 273 Nutlin-3a Afatinib 5 28 0.41
## 274 Nutlin-3a SB 203580 5 27 0.38
## 275 Nutlin-3a IRAK-1/4 Inhibitor I 5 26 0.34
## 276 Nutlin-3a Quizartinib 5 25 0.33
## 277 Nutlin-3a MK-2206 5 24 0.07
## 278 Nutlin-3a AZD1208 5 23 0.35
## 279 Nutlin-3a AZD8055 5 22 0.08
## 280 Nutlin-3a Rapamycin 5 21 0.12
## 281 Nutlin-3a MI-503 5 20 0.12
## 282 Nutlin-3a Imatinib 5 19 0.03
## 283 Nutlin-3a Sunitinib 5 18 0.21
## 284 Nutlin-3a Foretinib 5 17 0.30
## 285 Nutlin-3a Tozasertib 5 16 0.03
## 286 Nutlin-3a Ruxolitinib 5 15 -0.17
## 287 Nutlin-3a Tofacitinib 5 14 -0.17
## 288 Nutlin-3a PF-3758309 5 13 -0.22
## 289 Nutlin-3a OTX015 5 12 -0.32
## 290 Nutlin-3a Volasertib 5 11 -0.14
## 291 Nutlin-3a Ganetespib 5 10 -0.28
## 292 Nutlin-3a Onalespib 5 9 -0.14
## 293 Nutlin-3a SCH772984 5 8 -0.21
## 294 Nutlin-3a Cobimetinib 5 7 -0.37
## 295 Nutlin-3a Trametinib 5 6 -0.35
## 296 Nutlin-3a JNK-IN-8 5 5 0.17
## 297 Nutlin-3a Menin-MLL Inhibitor 5 4 0.18
## 298 Nutlin-3a AZD6738 5 3 0.02
## 299 Nutlin-3a KU-55933 5 2 0.10
## 300 Nutlin-3a SGC 0946 5 1 0.23
## 301 Venetoclax Venetoclax 6 57 1.00
## 302 Venetoclax Cytarabine 6 56 0.14
## 303 Venetoclax RO5963 6 55 0.41
## 304 Venetoclax A-1210477 6 54 0.33
## 305 Venetoclax Panobinostat 6 53 0.33
## 306 Venetoclax A-674563 6 52 0.52
## 307 Venetoclax Palbociclib 6 51 0.30
## 308 Venetoclax Dabrafenib 6 50 -0.10
## 309 Venetoclax ZM 336372 6 49 0.04
## 310 Venetoclax EPZ-6438 6 48 0.02
## 311 Venetoclax ONO-4059 6 47 0.12
## 312 Venetoclax Midostaurin 6 46 -0.07
## 313 Venetoclax Methotrexate 6 45 -0.45
## 314 Venetoclax Motolimod 6 44 -0.52
## 315 Venetoclax Olaparib 6 43 0.07
## 316 Venetoclax Cisplatin 6 42 0.06
## 317 Venetoclax BGJ398 6 41 -0.33
## 318 Venetoclax BML-277 6 40 0.08
## 319 Venetoclax AMI-1 6 39 -0.03
## 320 Venetoclax Vismodegib 6 38 -0.11
## 321 Venetoclax Selisistat 6 37 -0.14
## 322 Venetoclax TW-37 6 36 -0.25
## 323 Venetoclax D 4476 6 35 -0.28
## 324 Venetoclax Doxorubicine 6 34 0.09
## 325 Venetoclax Dasatinib 6 33 -0.36
## 326 Venetoclax Duvelisib 6 32 -0.17
## 327 Venetoclax Idelalisib 6 31 0.05
## 328 Venetoclax Ibrutinib 6 30 0.06
## 329 Venetoclax PRT062607 6 29 -0.11
## 330 Venetoclax Afatinib 6 28 0.28
## 331 Venetoclax SB 203580 6 27 0.41
## 332 Venetoclax IRAK-1/4 Inhibitor I 6 26 0.15
## 333 Venetoclax Quizartinib 6 25 0.29
## 334 Venetoclax MK-2206 6 24 0.01
## 335 Venetoclax AZD1208 6 23 0.35
## 336 Venetoclax AZD8055 6 22 0.00
## 337 Venetoclax Rapamycin 6 21 -0.04
## 338 Venetoclax MI-503 6 20 0.04
## 339 Venetoclax Imatinib 6 19 -0.14
## 340 Venetoclax Sunitinib 6 18 0.07
## 341 Venetoclax Foretinib 6 17 0.02
## 342 Venetoclax Tozasertib 6 16 -0.17
## 343 Venetoclax Ruxolitinib 6 15 -0.21
## 344 Venetoclax Tofacitinib 6 14 -0.20
## 345 Venetoclax PF-3758309 6 13 -0.27
## 346 Venetoclax OTX015 6 12 -0.34
## 347 Venetoclax Volasertib 6 11 -0.18
## 348 Venetoclax Ganetespib 6 10 -0.42
## 349 Venetoclax Onalespib 6 9 -0.31
## 350 Venetoclax SCH772984 6 8 -0.41
## 351 Venetoclax Cobimetinib 6 7 -0.58
## 352 Venetoclax Trametinib 6 6 -0.53
## 353 Venetoclax JNK-IN-8 6 5 0.05
## 354 Venetoclax Menin-MLL Inhibitor 6 4 0.09
## 355 Venetoclax AZD6738 6 3 -0.06
## 356 Venetoclax KU-55933 6 2 0.04
## 357 Venetoclax SGC 0946 6 1 0.23
## 358 Cytarabine Cytarabine 7 56 1.00
## 359 Cytarabine RO5963 7 55 0.47
## 360 Cytarabine A-1210477 7 54 0.31
## 361 Cytarabine Panobinostat 7 53 0.40
## 362 Cytarabine A-674563 7 52 0.31
## 363 Cytarabine Palbociclib 7 51 0.32
## 364 Cytarabine Dabrafenib 7 50 -0.19
## 365 Cytarabine ZM 336372 7 49 -0.11
## 366 Cytarabine EPZ-6438 7 48 0.17
## 367 Cytarabine ONO-4059 7 47 0.19
## 368 Cytarabine Midostaurin 7 46 -0.11
## 369 Cytarabine Methotrexate 7 45 -0.12
## 370 Cytarabine Motolimod 7 44 -0.18
## 371 Cytarabine Olaparib 7 43 0.33
## 372 Cytarabine Cisplatin 7 42 0.34
## 373 Cytarabine BGJ398 7 41 0.32
## 374 Cytarabine BML-277 7 40 0.07
## 375 Cytarabine AMI-1 7 39 -0.03
## 376 Cytarabine Vismodegib 7 38 0.01
## 377 Cytarabine Selisistat 7 37 0.22
## 378 Cytarabine TW-37 7 36 0.25
## 379 Cytarabine D 4476 7 35 0.03
## 380 Cytarabine Doxorubicine 7 34 -0.01
## 381 Cytarabine Dasatinib 7 33 0.36
## 382 Cytarabine Duvelisib 7 32 0.34
## 383 Cytarabine Idelalisib 7 31 0.44
## 384 Cytarabine Ibrutinib 7 30 0.41
## 385 Cytarabine PRT062607 7 29 0.20
## 386 Cytarabine Afatinib 7 28 0.44
## 387 Cytarabine SB 203580 7 27 0.28
## 388 Cytarabine IRAK-1/4 Inhibitor I 7 26 0.45
## 389 Cytarabine Quizartinib 7 25 0.07
## 390 Cytarabine MK-2206 7 24 0.23
## 391 Cytarabine AZD1208 7 23 0.37
## 392 Cytarabine AZD8055 7 22 0.28
## 393 Cytarabine Rapamycin 7 21 0.34
## 394 Cytarabine MI-503 7 20 0.20
## 395 Cytarabine Imatinib 7 19 0.31
## 396 Cytarabine Sunitinib 7 18 0.45
## 397 Cytarabine Foretinib 7 17 0.46
## 398 Cytarabine Tozasertib 7 16 0.35
## 399 Cytarabine Ruxolitinib 7 15 0.22
## 400 Cytarabine Tofacitinib 7 14 0.17
## 401 Cytarabine PF-3758309 7 13 0.24
## 402 Cytarabine OTX015 7 12 0.09
## 403 Cytarabine Volasertib 7 11 0.13
## 404 Cytarabine Ganetespib 7 10 0.30
## 405 Cytarabine Onalespib 7 9 0.29
## 406 Cytarabine SCH772984 7 8 0.20
## 407 Cytarabine Cobimetinib 7 7 0.15
## 408 Cytarabine Trametinib 7 6 0.13
## 409 Cytarabine JNK-IN-8 7 5 0.29
## 410 Cytarabine Menin-MLL Inhibitor 7 4 0.24
## 411 Cytarabine AZD6738 7 3 0.19
## 412 Cytarabine KU-55933 7 2 0.08
## 413 Cytarabine SGC 0946 7 1 0.23
## 414 RO5963 RO5963 8 55 1.00
## 415 RO5963 A-1210477 8 54 0.36
## 416 RO5963 Panobinostat 8 53 0.38
## 417 RO5963 A-674563 8 52 0.38
## 418 RO5963 Palbociclib 8 51 0.38
## 419 RO5963 Dabrafenib 8 50 -0.41
## 420 RO5963 ZM 336372 8 49 0.02
## 421 RO5963 EPZ-6438 8 48 -0.07
## 422 RO5963 ONO-4059 8 47 0.47
## 423 RO5963 Midostaurin 8 46 -0.17
## 424 RO5963 Methotrexate 8 45 -0.30
## 425 RO5963 Motolimod 8 44 -0.32
## 426 RO5963 Olaparib 8 43 0.26
## 427 RO5963 Cisplatin 8 42 0.17
## 428 RO5963 BGJ398 8 41 0.10
## 429 RO5963 BML-277 8 40 0.06
## 430 RO5963 AMI-1 8 39 -0.04
## 431 RO5963 Vismodegib 8 38 -0.06
## 432 RO5963 Selisistat 8 37 0.20
## 433 RO5963 TW-37 8 36 0.14
## 434 RO5963 D 4476 8 35 0.15
## 435 RO5963 Doxorubicine 8 34 0.32
## 436 RO5963 Dasatinib 8 33 0.12
## 437 RO5963 Duvelisib 8 32 0.40
## 438 RO5963 Idelalisib 8 31 0.62
## 439 RO5963 Ibrutinib 8 30 0.44
## 440 RO5963 PRT062607 8 29 0.23
## 441 RO5963 Afatinib 8 28 0.25
## 442 RO5963 SB 203580 8 27 0.46
## 443 RO5963 IRAK-1/4 Inhibitor I 8 26 0.33
## 444 RO5963 Quizartinib 8 25 0.22
## 445 RO5963 MK-2206 8 24 0.15
## 446 RO5963 AZD1208 8 23 0.38
## 447 RO5963 AZD8055 8 22 0.30
## 448 RO5963 Rapamycin 8 21 0.41
## 449 RO5963 MI-503 8 20 0.29
## 450 RO5963 Imatinib 8 19 0.15
## 451 RO5963 Sunitinib 8 18 0.35
## 452 RO5963 Foretinib 8 17 0.46
## 453 RO5963 Tozasertib 8 16 0.27
## 454 RO5963 Ruxolitinib 8 15 0.14
## 455 RO5963 Tofacitinib 8 14 0.05
## 456 RO5963 PF-3758309 8 13 0.05
## 457 RO5963 OTX015 8 12 -0.06
## 458 RO5963 Volasertib 8 11 -0.04
## 459 RO5963 Ganetespib 8 10 0.00
## 460 RO5963 Onalespib 8 9 0.08
## 461 RO5963 SCH772984 8 8 0.06
## 462 RO5963 Cobimetinib 8 7 -0.02
## 463 RO5963 Trametinib 8 6 -0.04
## 464 RO5963 JNK-IN-8 8 5 0.22
## 465 RO5963 Menin-MLL Inhibitor 8 4 0.05
## 466 RO5963 AZD6738 8 3 0.23
## 467 RO5963 KU-55933 8 2 0.15
## 468 RO5963 SGC 0946 8 1 0.09
## 469 A-1210477 A-1210477 9 54 1.00
## 470 A-1210477 Panobinostat 9 53 0.52
## 471 A-1210477 A-674563 9 52 0.54
## 472 A-1210477 Palbociclib 9 51 0.46
## 473 A-1210477 Dabrafenib 9 50 -0.11
## 474 A-1210477 ZM 336372 9 49 -0.14
## 475 A-1210477 EPZ-6438 9 48 -0.02
## 476 A-1210477 ONO-4059 9 47 0.30
## 477 A-1210477 Midostaurin 9 46 -0.14
## 478 A-1210477 Methotrexate 9 45 0.02
## 479 A-1210477 Motolimod 9 44 -0.28
## 480 A-1210477 Olaparib 9 43 0.26
## 481 A-1210477 Cisplatin 9 42 0.22
## 482 A-1210477 BGJ398 9 41 0.05
## 483 A-1210477 BML-277 9 40 0.08
## 484 A-1210477 AMI-1 9 39 -0.09
## 485 A-1210477 Vismodegib 9 38 -0.04
## 486 A-1210477 Selisistat 9 37 0.06
## 487 A-1210477 TW-37 9 36 -0.21
## 488 A-1210477 D 4476 9 35 -0.03
## 489 A-1210477 Doxorubicine 9 34 0.06
## 490 A-1210477 Dasatinib 9 33 0.07
## 491 A-1210477 Duvelisib 9 32 0.29
## 492 A-1210477 Idelalisib 9 31 0.41
## 493 A-1210477 Ibrutinib 9 30 0.37
## 494 A-1210477 PRT062607 9 29 0.21
## 495 A-1210477 Afatinib 9 28 0.43
## 496 A-1210477 SB 203580 9 27 0.36
## 497 A-1210477 IRAK-1/4 Inhibitor I 9 26 0.34
## 498 A-1210477 Quizartinib 9 25 0.17
## 499 A-1210477 MK-2206 9 24 0.11
## 500 A-1210477 AZD1208 9 23 0.34
## 501 A-1210477 AZD8055 9 22 0.35
## 502 A-1210477 Rapamycin 9 21 0.32
## 503 A-1210477 MI-503 9 20 0.27
## 504 A-1210477 Imatinib 9 19 -0.01
## 505 A-1210477 Sunitinib 9 18 0.24
## 506 A-1210477 Foretinib 9 17 0.25
## 507 A-1210477 Tozasertib 9 16 0.23
## 508 A-1210477 Ruxolitinib 9 15 0.17
## 509 A-1210477 Tofacitinib 9 14 -0.02
## 510 A-1210477 PF-3758309 9 13 0.27
## 511 A-1210477 OTX015 9 12 0.19
## 512 A-1210477 Volasertib 9 11 0.31
## 513 A-1210477 Ganetespib 9 10 0.19
## 514 A-1210477 Onalespib 9 9 0.23
## 515 A-1210477 SCH772984 9 8 0.25
## 516 A-1210477 Cobimetinib 9 7 0.17
## 517 A-1210477 Trametinib 9 6 0.16
## 518 A-1210477 JNK-IN-8 9 5 0.22
## 519 A-1210477 Menin-MLL Inhibitor 9 4 0.22
## 520 A-1210477 AZD6738 9 3 0.11
## 521 A-1210477 KU-55933 9 2 0.27
## 522 A-1210477 SGC 0946 9 1 0.41
## 523 Panobinostat Panobinostat 10 53 1.00
## 524 Panobinostat A-674563 10 52 0.58
## 525 Panobinostat Palbociclib 10 51 0.57
## 526 Panobinostat Dabrafenib 10 50 -0.10
## 527 Panobinostat ZM 336372 10 49 -0.08
## 528 Panobinostat EPZ-6438 10 48 0.07
## 529 Panobinostat ONO-4059 10 47 0.06
## 530 Panobinostat Midostaurin 10 46 -0.11
## 531 Panobinostat Methotrexate 10 45 0.04
## 532 Panobinostat Motolimod 10 44 -0.09
## 533 Panobinostat Olaparib 10 43 0.38
## 534 Panobinostat Cisplatin 10 42 0.18
## 535 Panobinostat BGJ398 10 41 0.20
## 536 Panobinostat BML-277 10 40 0.05
## 537 Panobinostat AMI-1 10 39 -0.08
## 538 Panobinostat Vismodegib 10 38 0.06
## 539 Panobinostat Selisistat 10 37 0.00
## 540 Panobinostat TW-37 10 36 -0.20
## 541 Panobinostat D 4476 10 35 -0.07
## 542 Panobinostat Doxorubicine 10 34 0.21
## 543 Panobinostat Dasatinib 10 33 0.20
## 544 Panobinostat Duvelisib 10 32 0.42
## 545 Panobinostat Idelalisib 10 31 0.51
## 546 Panobinostat Ibrutinib 10 30 0.23
## 547 Panobinostat PRT062607 10 29 0.28
## 548 Panobinostat Afatinib 10 28 0.40
## 549 Panobinostat SB 203580 10 27 0.49
## 550 Panobinostat IRAK-1/4 Inhibitor I 10 26 0.41
## 551 Panobinostat Quizartinib 10 25 0.25
## 552 Panobinostat MK-2206 10 24 0.43
## 553 Panobinostat AZD1208 10 23 0.60
## 554 Panobinostat AZD8055 10 22 0.63
## 555 Panobinostat Rapamycin 10 21 0.49
## 556 Panobinostat MI-503 10 20 0.34
## 557 Panobinostat Imatinib 10 19 0.19
## 558 Panobinostat Sunitinib 10 18 0.35
## 559 Panobinostat Foretinib 10 17 0.37
## 560 Panobinostat Tozasertib 10 16 0.40
## 561 Panobinostat Ruxolitinib 10 15 0.41
## 562 Panobinostat Tofacitinib 10 14 0.31
## 563 Panobinostat PF-3758309 10 13 0.42
## 564 Panobinostat OTX015 10 12 0.35
## 565 Panobinostat Volasertib 10 11 0.40
## 566 Panobinostat Ganetespib 10 10 0.34
## 567 Panobinostat Onalespib 10 9 0.37
## 568 Panobinostat SCH772984 10 8 0.28
## 569 Panobinostat Cobimetinib 10 7 0.19
## 570 Panobinostat Trametinib 10 6 0.22
## 571 Panobinostat JNK-IN-8 10 5 0.32
## 572 Panobinostat Menin-MLL Inhibitor 10 4 0.34
## 573 Panobinostat AZD6738 10 3 0.26
## 574 Panobinostat KU-55933 10 2 0.38
## 575 Panobinostat SGC 0946 10 1 0.33
## 576 A-674563 A-674563 11 52 1.00
## 577 A-674563 Palbociclib 11 51 0.71
## 578 A-674563 Dabrafenib 11 50 -0.13
## 579 A-674563 ZM 336372 11 49 -0.14
## 580 A-674563 EPZ-6438 11 48 0.00
## 581 A-674563 ONO-4059 11 47 0.28
## 582 A-674563 Midostaurin 11 46 0.20
## 583 A-674563 Methotrexate 11 45 -0.16
## 584 A-674563 Motolimod 11 44 -0.36
## 585 A-674563 Olaparib 11 43 0.21
## 586 A-674563 Cisplatin 11 42 0.09
## 587 A-674563 BGJ398 11 41 -0.04
## 588 A-674563 BML-277 11 40 -0.03
## 589 A-674563 AMI-1 11 39 -0.02
## 590 A-674563 Vismodegib 11 38 0.08
## 591 A-674563 Selisistat 11 37 0.01
## 592 A-674563 TW-37 11 36 -0.34
## 593 A-674563 D 4476 11 35 -0.18
## 594 A-674563 Doxorubicine 11 34 0.03
## 595 A-674563 Dasatinib 11 33 0.05
## 596 A-674563 Duvelisib 11 32 0.42
## 597 A-674563 Idelalisib 11 31 0.54
## 598 A-674563 Ibrutinib 11 30 0.47
## 599 A-674563 PRT062607 11 29 0.42
## 600 A-674563 Afatinib 11 28 0.53
## 601 A-674563 SB 203580 11 27 0.48
## 602 A-674563 IRAK-1/4 Inhibitor I 11 26 0.58
## 603 A-674563 Quizartinib 11 25 0.53
## 604 A-674563 MK-2206 11 24 0.29
## 605 A-674563 AZD1208 11 23 0.67
## 606 A-674563 AZD8055 11 22 0.48
## 607 A-674563 Rapamycin 11 21 0.44
## 608 A-674563 MI-503 11 20 0.38
## 609 A-674563 Imatinib 11 19 0.32
## 610 A-674563 Sunitinib 11 18 0.59
## 611 A-674563 Foretinib 11 17 0.47
## 612 A-674563 Tozasertib 11 16 0.41
## 613 A-674563 Ruxolitinib 11 15 0.27
## 614 A-674563 Tofacitinib 11 14 0.25
## 615 A-674563 PF-3758309 11 13 0.36
## 616 A-674563 OTX015 11 12 0.15
## 617 A-674563 Volasertib 11 11 0.30
## 618 A-674563 Ganetespib 11 10 0.24
## 619 A-674563 Onalespib 11 9 0.33
## 620 A-674563 SCH772984 11 8 0.22
## 621 A-674563 Cobimetinib 11 7 0.08
## 622 A-674563 Trametinib 11 6 0.14
## 623 A-674563 JNK-IN-8 11 5 0.20
## 624 A-674563 Menin-MLL Inhibitor 11 4 0.48
## 625 A-674563 AZD6738 11 3 0.17
## 626 A-674563 KU-55933 11 2 0.27
## 627 A-674563 SGC 0946 11 1 0.49
## 628 Palbociclib Palbociclib 12 51 1.00
## 629 Palbociclib Dabrafenib 12 50 -0.24
## 630 Palbociclib ZM 336372 12 49 -0.07
## 631 Palbociclib EPZ-6438 12 48 -0.11
## 632 Palbociclib ONO-4059 12 47 0.32
## 633 Palbociclib Midostaurin 12 46 0.12
## 634 Palbociclib Methotrexate 12 45 -0.07
## 635 Palbociclib Motolimod 12 44 -0.14
## 636 Palbociclib Olaparib 12 43 0.39
## 637 Palbociclib Cisplatin 12 42 0.26
## 638 Palbociclib BGJ398 12 41 0.15
## 639 Palbociclib BML-277 12 40 0.10
## 640 Palbociclib AMI-1 12 39 -0.04
## 641 Palbociclib Vismodegib 12 38 0.01
## 642 Palbociclib Selisistat 12 37 0.16
## 643 Palbociclib TW-37 12 36 -0.07
## 644 Palbociclib D 4476 12 35 0.04
## 645 Palbociclib Doxorubicine 12 34 0.11
## 646 Palbociclib Dasatinib 12 33 0.20
## 647 Palbociclib Duvelisib 12 32 0.53
## 648 Palbociclib Idelalisib 12 31 0.58
## 649 Palbociclib Ibrutinib 12 30 0.39
## 650 Palbociclib PRT062607 12 29 0.47
## 651 Palbociclib Afatinib 12 28 0.57
## 652 Palbociclib SB 203580 12 27 0.31
## 653 Palbociclib IRAK-1/4 Inhibitor I 12 26 0.56
## 654 Palbociclib Quizartinib 12 25 0.40
## 655 Palbociclib MK-2206 12 24 0.44
## 656 Palbociclib AZD1208 12 23 0.55
## 657 Palbociclib AZD8055 12 22 0.56
## 658 Palbociclib Rapamycin 12 21 0.57
## 659 Palbociclib MI-503 12 20 0.51
## 660 Palbociclib Imatinib 12 19 0.46
## 661 Palbociclib Sunitinib 12 18 0.58
## 662 Palbociclib Foretinib 12 17 0.62
## 663 Palbociclib Tozasertib 12 16 0.57
## 664 Palbociclib Ruxolitinib 12 15 0.28
## 665 Palbociclib Tofacitinib 12 14 0.16
## 666 Palbociclib PF-3758309 12 13 0.51
## 667 Palbociclib OTX015 12 12 0.37
## 668 Palbociclib Volasertib 12 11 0.47
## 669 Palbociclib Ganetespib 12 10 0.47
## 670 Palbociclib Onalespib 12 9 0.53
## 671 Palbociclib SCH772984 12 8 0.35
## 672 Palbociclib Cobimetinib 12 7 0.27
## 673 Palbociclib Trametinib 12 6 0.30
## 674 Palbociclib JNK-IN-8 12 5 0.11
## 675 Palbociclib Menin-MLL Inhibitor 12 4 0.31
## 676 Palbociclib AZD6738 12 3 0.17
## 677 Palbociclib KU-55933 12 2 0.35
## 678 Palbociclib SGC 0946 12 1 0.43
## 679 Dabrafenib Dabrafenib 13 50 1.00
## 680 Dabrafenib ZM 336372 13 49 0.30
## 681 Dabrafenib EPZ-6438 13 48 0.14
## 682 Dabrafenib ONO-4059 13 47 -0.04
## 683 Dabrafenib Midostaurin 13 46 0.27
## 684 Dabrafenib Methotrexate 13 45 0.13
## 685 Dabrafenib Motolimod 13 44 0.18
## 686 Dabrafenib Olaparib 13 43 -0.21
## 687 Dabrafenib Cisplatin 13 42 -0.19
## 688 Dabrafenib BGJ398 13 41 -0.11
## 689 Dabrafenib BML-277 13 40 0.07
## 690 Dabrafenib AMI-1 13 39 0.12
## 691 Dabrafenib Vismodegib 13 38 0.09
## 692 Dabrafenib Selisistat 13 37 -0.11
## 693 Dabrafenib TW-37 13 36 -0.17
## 694 Dabrafenib D 4476 13 35 0.24
## 695 Dabrafenib Doxorubicine 13 34 -0.15
## 696 Dabrafenib Dasatinib 13 33 -0.12
## 697 Dabrafenib Duvelisib 13 32 -0.29
## 698 Dabrafenib Idelalisib 13 31 -0.28
## 699 Dabrafenib Ibrutinib 13 30 -0.25
## 700 Dabrafenib PRT062607 13 29 -0.30
## 701 Dabrafenib Afatinib 13 28 -0.18
## 702 Dabrafenib SB 203580 13 27 -0.21
## 703 Dabrafenib IRAK-1/4 Inhibitor I 13 26 -0.32
## 704 Dabrafenib Quizartinib 13 25 -0.03
## 705 Dabrafenib MK-2206 13 24 -0.16
## 706 Dabrafenib AZD1208 13 23 -0.27
## 707 Dabrafenib AZD8055 13 22 -0.23
## 708 Dabrafenib Rapamycin 13 21 -0.17
## 709 Dabrafenib MI-503 13 20 -0.15
## 710 Dabrafenib Imatinib 13 19 -0.24
## 711 Dabrafenib Sunitinib 13 18 -0.28
## 712 Dabrafenib Foretinib 13 17 -0.29
## 713 Dabrafenib Tozasertib 13 16 -0.35
## 714 Dabrafenib Ruxolitinib 13 15 -0.11
## 715 Dabrafenib Tofacitinib 13 14 0.09
## 716 Dabrafenib PF-3758309 13 13 -0.06
## 717 Dabrafenib OTX015 13 12 0.15
## 718 Dabrafenib Volasertib 13 11 0.11
## 719 Dabrafenib Ganetespib 13 10 -0.24
## 720 Dabrafenib Onalespib 13 9 -0.31
## 721 Dabrafenib SCH772984 13 8 -0.28
## 722 Dabrafenib Cobimetinib 13 7 -0.17
## 723 Dabrafenib Trametinib 13 6 -0.12
## 724 Dabrafenib JNK-IN-8 13 5 0.11
## 725 Dabrafenib Menin-MLL Inhibitor 13 4 -0.08
## 726 Dabrafenib AZD6738 13 3 -0.10
## 727 Dabrafenib KU-55933 13 2 -0.13
## 728 Dabrafenib SGC 0946 13 1 -0.18
## 729 ZM 336372 ZM 336372 14 49 1.00
## 730 ZM 336372 EPZ-6438 14 48 -0.01
## 731 ZM 336372 ONO-4059 14 47 0.14
## 732 ZM 336372 Midostaurin 14 46 -0.04
## 733 ZM 336372 Methotrexate 14 45 -0.15
## 734 ZM 336372 Motolimod 14 44 0.26
## 735 ZM 336372 Olaparib 14 43 -0.08
## 736 ZM 336372 Cisplatin 14 42 0.11
## 737 ZM 336372 BGJ398 14 41 0.04
## 738 ZM 336372 BML-277 14 40 0.16
## 739 ZM 336372 AMI-1 14 39 0.16
## 740 ZM 336372 Vismodegib 14 38 0.00
## 741 ZM 336372 Selisistat 14 37 0.23
## 742 ZM 336372 TW-37 14 36 0.15
## 743 ZM 336372 D 4476 14 35 0.18
## 744 ZM 336372 Doxorubicine 14 34 0.01
## 745 ZM 336372 Dasatinib 14 33 -0.12
## 746 ZM 336372 Duvelisib 14 32 -0.04
## 747 ZM 336372 Idelalisib 14 31 -0.08
## 748 ZM 336372 Ibrutinib 14 30 -0.24
## 749 ZM 336372 PRT062607 14 29 -0.24
## 750 ZM 336372 Afatinib 14 28 -0.19
## 751 ZM 336372 SB 203580 14 27 -0.18
## 752 ZM 336372 IRAK-1/4 Inhibitor I 14 26 -0.31
## 753 ZM 336372 Quizartinib 14 25 0.05
## 754 ZM 336372 MK-2206 14 24 0.02
## 755 ZM 336372 AZD1208 14 23 -0.07
## 756 ZM 336372 AZD8055 14 22 -0.05
## 757 ZM 336372 Rapamycin 14 21 -0.08
## 758 ZM 336372 MI-503 14 20 0.06
## 759 ZM 336372 Imatinib 14 19 -0.17
## 760 ZM 336372 Sunitinib 14 18 -0.14
## 761 ZM 336372 Foretinib 14 17 -0.16
## 762 ZM 336372 Tozasertib 14 16 -0.27
## 763 ZM 336372 Ruxolitinib 14 15 -0.19
## 764 ZM 336372 Tofacitinib 14 14 0.03
## 765 ZM 336372 PF-3758309 14 13 -0.22
## 766 ZM 336372 OTX015 14 12 -0.03
## 767 ZM 336372 Volasertib 14 11 -0.08
## 768 ZM 336372 Ganetespib 14 10 -0.16
## 769 ZM 336372 Onalespib 14 9 -0.14
## 770 ZM 336372 SCH772984 14 8 -0.25
## 771 ZM 336372 Cobimetinib 14 7 -0.11
## 772 ZM 336372 Trametinib 14 6 -0.09
## 773 ZM 336372 JNK-IN-8 14 5 -0.11
## 774 ZM 336372 Menin-MLL Inhibitor 14 4 -0.28
## 775 ZM 336372 AZD6738 14 3 0.11
## 776 ZM 336372 KU-55933 14 2 -0.22
## 777 ZM 336372 SGC 0946 14 1 0.01
## 778 EPZ-6438 EPZ-6438 15 48 1.00
## 779 EPZ-6438 ONO-4059 15 47 0.24
## 780 EPZ-6438 Midostaurin 15 46 -0.05
## 781 EPZ-6438 Methotrexate 15 45 -0.05
## 782 EPZ-6438 Motolimod 15 44 -0.08
## 783 EPZ-6438 Olaparib 15 43 -0.08
## 784 EPZ-6438 Cisplatin 15 42 -0.03
## 785 EPZ-6438 BGJ398 15 41 0.09
## 786 EPZ-6438 BML-277 15 40 0.20
## 787 EPZ-6438 AMI-1 15 39 0.14
## 788 EPZ-6438 Vismodegib 15 38 0.35
## 789 EPZ-6438 Selisistat 15 37 0.26
## 790 EPZ-6438 TW-37 15 36 0.18
## 791 EPZ-6438 D 4476 15 35 -0.06
## 792 EPZ-6438 Doxorubicine 15 34 -0.29
## 793 EPZ-6438 Dasatinib 15 33 0.03
## 794 EPZ-6438 Duvelisib 15 32 -0.09
## 795 EPZ-6438 Idelalisib 15 31 0.00
## 796 EPZ-6438 Ibrutinib 15 30 0.19
## 797 EPZ-6438 PRT062607 15 29 0.07
## 798 EPZ-6438 Afatinib 15 28 -0.06
## 799 EPZ-6438 SB 203580 15 27 0.10
## 800 EPZ-6438 IRAK-1/4 Inhibitor I 15 26 0.18
## 801 EPZ-6438 Quizartinib 15 25 0.02
## 802 EPZ-6438 MK-2206 15 24 -0.09
## 803 EPZ-6438 AZD1208 15 23 0.01
## 804 EPZ-6438 AZD8055 15 22 -0.04
## 805 EPZ-6438 Rapamycin 15 21 -0.02
## 806 EPZ-6438 MI-503 15 20 -0.14
## 807 EPZ-6438 Imatinib 15 19 -0.10
## 808 EPZ-6438 Sunitinib 15 18 -0.16
## 809 EPZ-6438 Foretinib 15 17 -0.13
## 810 EPZ-6438 Tozasertib 15 16 -0.03
## 811 EPZ-6438 Ruxolitinib 15 15 0.18
## 812 EPZ-6438 Tofacitinib 15 14 0.07
## 813 EPZ-6438 PF-3758309 15 13 0.01
## 814 EPZ-6438 OTX015 15 12 -0.04
## 815 EPZ-6438 Volasertib 15 11 0.00
## 816 EPZ-6438 Ganetespib 15 10 0.02
## 817 EPZ-6438 Onalespib 15 9 0.10
## 818 EPZ-6438 SCH772984 15 8 -0.05
## 819 EPZ-6438 Cobimetinib 15 7 -0.16
## 820 EPZ-6438 Trametinib 15 6 -0.08
## 821 EPZ-6438 JNK-IN-8 15 5 0.35
## 822 EPZ-6438 Menin-MLL Inhibitor 15 4 -0.01
## 823 EPZ-6438 AZD6738 15 3 -0.11
## 824 EPZ-6438 KU-55933 15 2 -0.18
## 825 EPZ-6438 SGC 0946 15 1 0.24
## 826 ONO-4059 ONO-4059 16 47 1.00
## 827 ONO-4059 Midostaurin 16 46 0.09
## 828 ONO-4059 Methotrexate 16 45 -0.16
## 829 ONO-4059 Motolimod 16 44 -0.19
## 830 ONO-4059 Olaparib 16 43 -0.03
## 831 ONO-4059 Cisplatin 16 42 -0.01
## 832 ONO-4059 BGJ398 16 41 0.01
## 833 ONO-4059 BML-277 16 40 0.08
## 834 ONO-4059 AMI-1 16 39 -0.09
## 835 ONO-4059 Vismodegib 16 38 0.02
## 836 ONO-4059 Selisistat 16 37 0.33
## 837 ONO-4059 TW-37 16 36 0.04
## 838 ONO-4059 D 4476 16 35 0.03
## 839 ONO-4059 Doxorubicine 16 34 -0.09
## 840 ONO-4059 Dasatinib 16 33 0.31
## 841 ONO-4059 Duvelisib 16 32 0.37
## 842 ONO-4059 Idelalisib 16 31 0.53
## 843 ONO-4059 Ibrutinib 16 30 0.60
## 844 ONO-4059 PRT062607 16 29 0.50
## 845 ONO-4059 Afatinib 16 28 0.17
## 846 ONO-4059 SB 203580 16 27 0.30
## 847 ONO-4059 IRAK-1/4 Inhibitor I 16 26 0.23
## 848 ONO-4059 Quizartinib 16 25 0.27
## 849 ONO-4059 MK-2206 16 24 0.09
## 850 ONO-4059 AZD1208 16 23 0.27
## 851 ONO-4059 AZD8055 16 22 0.18
## 852 ONO-4059 Rapamycin 16 21 0.44
## 853 ONO-4059 MI-503 16 20 0.20
## 854 ONO-4059 Imatinib 16 19 0.18
## 855 ONO-4059 Sunitinib 16 18 0.20
## 856 ONO-4059 Foretinib 16 17 0.45
## 857 ONO-4059 Tozasertib 16 16 0.32
## 858 ONO-4059 Ruxolitinib 16 15 0.22
## 859 ONO-4059 Tofacitinib 16 14 -0.02
## 860 ONO-4059 PF-3758309 16 13 0.08
## 861 ONO-4059 OTX015 16 12 -0.07
## 862 ONO-4059 Volasertib 16 11 -0.06
## 863 ONO-4059 Ganetespib 16 10 0.17
## 864 ONO-4059 Onalespib 16 9 0.25
## 865 ONO-4059 SCH772984 16 8 0.10
## 866 ONO-4059 Cobimetinib 16 7 0.06
## 867 ONO-4059 Trametinib 16 6 0.05
## 868 ONO-4059 JNK-IN-8 16 5 0.18
## 869 ONO-4059 Menin-MLL Inhibitor 16 4 -0.14
## 870 ONO-4059 AZD6738 16 3 0.02
## 871 ONO-4059 KU-55933 16 2 0.22
## 872 ONO-4059 SGC 0946 16 1 0.35
## 873 Midostaurin Midostaurin 17 46 1.00
## 874 Midostaurin Methotrexate 17 45 0.18
## 875 Midostaurin Motolimod 17 44 0.15
## 876 Midostaurin Olaparib 17 43 0.11
## 877 Midostaurin Cisplatin 17 42 -0.02
## 878 Midostaurin BGJ398 17 41 -0.05
## 879 Midostaurin BML-277 17 40 -0.03
## 880 Midostaurin AMI-1 17 39 0.20
## 881 Midostaurin Vismodegib 17 38 0.21
## 882 Midostaurin Selisistat 17 37 0.02
## 883 Midostaurin TW-37 17 36 0.00
## 884 Midostaurin D 4476 17 35 -0.02
## 885 Midostaurin Doxorubicine 17 34 -0.15
## 886 Midostaurin Dasatinib 17 33 -0.20
## 887 Midostaurin Duvelisib 17 32 -0.14
## 888 Midostaurin Idelalisib 17 31 -0.12
## 889 Midostaurin Ibrutinib 17 30 -0.04
## 890 Midostaurin PRT062607 17 29 0.03
## 891 Midostaurin Afatinib 17 28 -0.01
## 892 Midostaurin SB 203580 17 27 -0.21
## 893 Midostaurin IRAK-1/4 Inhibitor I 17 26 0.20
## 894 Midostaurin Quizartinib 17 25 0.48
## 895 Midostaurin MK-2206 17 24 0.13
## 896 Midostaurin AZD1208 17 23 -0.04
## 897 Midostaurin AZD8055 17 22 -0.02
## 898 Midostaurin Rapamycin 17 21 -0.04
## 899 Midostaurin MI-503 17 20 0.04
## 900 Midostaurin Imatinib 17 19 0.18
## 901 Midostaurin Sunitinib 17 18 0.27
## 902 Midostaurin Foretinib 17 17 0.28
## 903 Midostaurin Tozasertib 17 16 0.13
## 904 Midostaurin Ruxolitinib 17 15 -0.07
## 905 Midostaurin Tofacitinib 17 14 0.12
## 906 Midostaurin PF-3758309 17 13 -0.03
## 907 Midostaurin OTX015 17 12 -0.13
## 908 Midostaurin Volasertib 17 11 -0.10
## 909 Midostaurin Ganetespib 17 10 0.02
## 910 Midostaurin Onalespib 17 9 0.01
## 911 Midostaurin SCH772984 17 8 -0.13
## 912 Midostaurin Cobimetinib 17 7 -0.14
## 913 Midostaurin Trametinib 17 6 -0.13
## 914 Midostaurin JNK-IN-8 17 5 0.10
## 915 Midostaurin Menin-MLL Inhibitor 17 4 0.19
## 916 Midostaurin AZD6738 17 3 -0.01
## 917 Midostaurin KU-55933 17 2 -0.03
## 918 Midostaurin SGC 0946 17 1 -0.05
## 919 Methotrexate Methotrexate 18 45 1.00
## 920 Methotrexate Motolimod 18 44 0.35
## 921 Methotrexate Olaparib 18 43 0.13
## 922 Methotrexate Cisplatin 18 42 0.10
## 923 Methotrexate BGJ398 18 41 0.14
## 924 Methotrexate BML-277 18 40 -0.04
## 925 Methotrexate AMI-1 18 39 0.12
## 926 Methotrexate Vismodegib 18 38 0.14
## 927 Methotrexate Selisistat 18 37 -0.04
## 928 Methotrexate TW-37 18 36 -0.01
## 929 Methotrexate D 4476 18 35 0.03
## 930 Methotrexate Doxorubicine 18 34 -0.23
## 931 Methotrexate Dasatinib 18 33 0.15
## 932 Methotrexate Duvelisib 18 32 -0.04
## 933 Methotrexate Idelalisib 18 31 -0.10
## 934 Methotrexate Ibrutinib 18 30 -0.12
## 935 Methotrexate PRT062607 18 29 0.15
## 936 Methotrexate Afatinib 18 28 0.07
## 937 Methotrexate SB 203580 18 27 -0.16
## 938 Methotrexate IRAK-1/4 Inhibitor I 18 26 0.11
## 939 Methotrexate Quizartinib 18 25 -0.11
## 940 Methotrexate MK-2206 18 24 -0.02
## 941 Methotrexate AZD1208 18 23 -0.24
## 942 Methotrexate AZD8055 18 22 -0.07
## 943 Methotrexate Rapamycin 18 21 -0.14
## 944 Methotrexate MI-503 18 20 0.04
## 945 Methotrexate Imatinib 18 19 -0.01
## 946 Methotrexate Sunitinib 18 18 -0.06
## 947 Methotrexate Foretinib 18 17 -0.07
## 948 Methotrexate Tozasertib 18 16 0.11
## 949 Methotrexate Ruxolitinib 18 15 0.19
## 950 Methotrexate Tofacitinib 18 14 0.15
## 951 Methotrexate PF-3758309 18 13 0.18
## 952 Methotrexate OTX015 18 12 0.28
## 953 Methotrexate Volasertib 18 11 0.26
## 954 Methotrexate Ganetespib 18 10 0.37
## 955 Methotrexate Onalespib 18 9 0.30
## 956 Methotrexate SCH772984 18 8 0.35
## 957 Methotrexate Cobimetinib 18 7 0.36
## 958 Methotrexate Trametinib 18 6 0.35
## 959 Methotrexate JNK-IN-8 18 5 0.06
## 960 Methotrexate Menin-MLL Inhibitor 18 4 0.16
## 961 Methotrexate AZD6738 18 3 -0.01
## 962 Methotrexate KU-55933 18 2 0.17
## 963 Methotrexate SGC 0946 18 1 -0.06
## 964 Motolimod Motolimod 19 44 1.00
## 965 Motolimod Olaparib 19 43 0.20
## 966 Motolimod Cisplatin 19 42 0.12
## 967 Motolimod BGJ398 19 41 0.24
## 968 Motolimod BML-277 19 40 0.08
## 969 Motolimod AMI-1 19 39 0.02
## 970 Motolimod Vismodegib 19 38 0.04
## 971 Motolimod Selisistat 19 37 0.14
## 972 Motolimod TW-37 19 36 0.11
## 973 Motolimod D 4476 19 35 0.28
## 974 Motolimod Doxorubicine 19 34 0.22
## 975 Motolimod Dasatinib 19 33 0.06
## 976 Motolimod Duvelisib 19 32 0.07
## 977 Motolimod Idelalisib 19 31 -0.11
## 978 Motolimod Ibrutinib 19 30 -0.30
## 979 Motolimod PRT062607 19 29 -0.18
## 980 Motolimod Afatinib 19 28 -0.18
## 981 Motolimod SB 203580 19 27 -0.36
## 982 Motolimod IRAK-1/4 Inhibitor I 19 26 -0.20
## 983 Motolimod Quizartinib 19 25 -0.19
## 984 Motolimod MK-2206 19 24 0.14
## 985 Motolimod AZD1208 19 23 -0.27
## 986 Motolimod AZD8055 19 22 0.06
## 987 Motolimod Rapamycin 19 21 -0.03
## 988 Motolimod MI-503 19 20 -0.06
## 989 Motolimod Imatinib 19 19 0.01
## 990 Motolimod Sunitinib 19 18 -0.18
## 991 Motolimod Foretinib 19 17 -0.11
## 992 Motolimod Tozasertib 19 16 -0.02
## 993 Motolimod Ruxolitinib 19 15 0.00
## 994 Motolimod Tofacitinib 19 14 0.09
## 995 Motolimod PF-3758309 19 13 0.08
## 996 Motolimod OTX015 19 12 0.32
## 997 Motolimod Volasertib 19 11 0.18
## 998 Motolimod Ganetespib 19 10 0.22
## 999 Motolimod Onalespib 19 9 0.17
## 1000 Motolimod SCH772984 19 8 0.17
## 1001 Motolimod Cobimetinib 19 7 0.34
## 1002 Motolimod Trametinib 19 6 0.31
## 1003 Motolimod JNK-IN-8 19 5 0.00
## 1004 Motolimod Menin-MLL Inhibitor 19 4 0.09
## 1005 Motolimod AZD6738 19 3 0.03
## 1006 Motolimod KU-55933 19 2 0.11
## 1007 Motolimod SGC 0946 19 1 -0.25
## 1008 Olaparib Olaparib 20 43 1.00
## 1009 Olaparib Cisplatin 20 42 0.40
## 1010 Olaparib BGJ398 20 41 0.40
## 1011 Olaparib BML-277 20 40 0.28
## 1012 Olaparib AMI-1 20 39 0.25
## 1013 Olaparib Vismodegib 20 38 0.16
## 1014 Olaparib Selisistat 20 37 0.35
## 1015 Olaparib TW-37 20 36 0.28
## 1016 Olaparib D 4476 20 35 0.12
## 1017 Olaparib Doxorubicine 20 34 0.00
## 1018 Olaparib Dasatinib 20 33 0.02
## 1019 Olaparib Duvelisib 20 32 0.13
## 1020 Olaparib Idelalisib 20 31 0.09
## 1021 Olaparib Ibrutinib 20 30 -0.04
## 1022 Olaparib PRT062607 20 29 -0.09
## 1023 Olaparib Afatinib 20 28 0.32
## 1024 Olaparib SB 203580 20 27 -0.07
## 1025 Olaparib IRAK-1/4 Inhibitor I 20 26 0.32
## 1026 Olaparib Quizartinib 20 25 0.00
## 1027 Olaparib MK-2206 20 24 0.40
## 1028 Olaparib AZD1208 20 23 0.13
## 1029 Olaparib AZD8055 20 22 0.34
## 1030 Olaparib Rapamycin 20 21 0.17
## 1031 Olaparib MI-503 20 20 0.20
## 1032 Olaparib Imatinib 20 19 0.30
## 1033 Olaparib Sunitinib 20 18 0.23
## 1034 Olaparib Foretinib 20 17 0.38
## 1035 Olaparib Tozasertib 20 16 0.37
## 1036 Olaparib Ruxolitinib 20 15 0.07
## 1037 Olaparib Tofacitinib 20 14 0.04
## 1038 Olaparib PF-3758309 20 13 0.04
## 1039 Olaparib OTX015 20 12 0.12
## 1040 Olaparib Volasertib 20 11 0.19
## 1041 Olaparib Ganetespib 20 10 0.34
## 1042 Olaparib Onalespib 20 9 0.33
## 1043 Olaparib SCH772984 20 8 0.19
## 1044 Olaparib Cobimetinib 20 7 0.22
## 1045 Olaparib Trametinib 20 6 0.18
## 1046 Olaparib JNK-IN-8 20 5 0.28
## 1047 Olaparib Menin-MLL Inhibitor 20 4 0.20
## 1048 Olaparib AZD6738 20 3 0.25
## 1049 Olaparib KU-55933 20 2 0.13
## 1050 Olaparib SGC 0946 20 1 0.00
## 1051 Cisplatin Cisplatin 21 42 1.00
## 1052 Cisplatin BGJ398 21 41 0.46
## 1053 Cisplatin BML-277 21 40 0.41
## 1054 Cisplatin AMI-1 21 39 0.30
## 1055 Cisplatin Vismodegib 21 38 0.31
## 1056 Cisplatin Selisistat 21 37 0.34
## 1057 Cisplatin TW-37 21 36 0.31
## 1058 Cisplatin D 4476 21 35 0.23
## 1059 Cisplatin Doxorubicine 21 34 0.19
## 1060 Cisplatin Dasatinib 21 33 0.10
## 1061 Cisplatin Duvelisib 21 32 0.11
## 1062 Cisplatin Idelalisib 21 31 0.23
## 1063 Cisplatin Ibrutinib 21 30 0.12
## 1064 Cisplatin PRT062607 21 29 0.01
## 1065 Cisplatin Afatinib 21 28 0.30
## 1066 Cisplatin SB 203580 21 27 0.08
## 1067 Cisplatin IRAK-1/4 Inhibitor I 21 26 0.42
## 1068 Cisplatin Quizartinib 21 25 -0.02
## 1069 Cisplatin MK-2206 21 24 0.01
## 1070 Cisplatin AZD1208 21 23 0.03
## 1071 Cisplatin AZD8055 21 22 -0.01
## 1072 Cisplatin Rapamycin 21 21 -0.06
## 1073 Cisplatin MI-503 21 20 0.35
## 1074 Cisplatin Imatinib 21 19 0.21
## 1075 Cisplatin Sunitinib 21 18 0.29
## 1076 Cisplatin Foretinib 21 17 0.27
## 1077 Cisplatin Tozasertib 21 16 0.19
## 1078 Cisplatin Ruxolitinib 21 15 0.16
## 1079 Cisplatin Tofacitinib 21 14 0.03
## 1080 Cisplatin PF-3758309 21 13 0.00
## 1081 Cisplatin OTX015 21 12 0.08
## 1082 Cisplatin Volasertib 21 11 0.15
## 1083 Cisplatin Ganetespib 21 10 0.18
## 1084 Cisplatin Onalespib 21 9 0.16
## 1085 Cisplatin SCH772984 21 8 0.36
## 1086 Cisplatin Cobimetinib 21 7 0.19
## 1087 Cisplatin Trametinib 21 6 0.21
## 1088 Cisplatin JNK-IN-8 21 5 -0.03
## 1089 Cisplatin Menin-MLL Inhibitor 21 4 0.13
## 1090 Cisplatin AZD6738 21 3 0.16
## 1091 Cisplatin KU-55933 21 2 0.15
## 1092 Cisplatin SGC 0946 21 1 0.25
## 1093 BGJ398 BGJ398 22 41 1.00
## 1094 BGJ398 BML-277 22 40 0.50
## 1095 BGJ398 AMI-1 22 39 0.13
## 1096 BGJ398 Vismodegib 22 38 0.14
## 1097 BGJ398 Selisistat 22 37 0.34
## 1098 BGJ398 TW-37 22 36 0.30
## 1099 BGJ398 D 4476 22 35 0.26
## 1100 BGJ398 Doxorubicine 22 34 -0.05
## 1101 BGJ398 Dasatinib 22 33 0.39
## 1102 BGJ398 Duvelisib 22 32 0.36
## 1103 BGJ398 Idelalisib 22 31 0.25
## 1104 BGJ398 Ibrutinib 22 30 0.13
## 1105 BGJ398 PRT062607 22 29 0.21
## 1106 BGJ398 Afatinib 22 28 0.19
## 1107 BGJ398 SB 203580 22 27 0.06
## 1108 BGJ398 IRAK-1/4 Inhibitor I 22 26 0.33
## 1109 BGJ398 Quizartinib 22 25 0.01
## 1110 BGJ398 MK-2206 22 24 0.31
## 1111 BGJ398 AZD1208 22 23 0.18
## 1112 BGJ398 AZD8055 22 22 0.30
## 1113 BGJ398 Rapamycin 22 21 0.21
## 1114 BGJ398 MI-503 22 20 0.35
## 1115 BGJ398 Imatinib 22 19 0.38
## 1116 BGJ398 Sunitinib 22 18 0.37
## 1117 BGJ398 Foretinib 22 17 0.31
## 1118 BGJ398 Tozasertib 22 16 0.43
## 1119 BGJ398 Ruxolitinib 22 15 0.45
## 1120 BGJ398 Tofacitinib 22 14 0.17
## 1121 BGJ398 PF-3758309 22 13 0.39
## 1122 BGJ398 OTX015 22 12 0.39
## 1123 BGJ398 Volasertib 22 11 0.42
## 1124 BGJ398 Ganetespib 22 10 0.48
## 1125 BGJ398 Onalespib 22 9 0.42
## 1126 BGJ398 SCH772984 22 8 0.46
## 1127 BGJ398 Cobimetinib 22 7 0.47
## 1128 BGJ398 Trametinib 22 6 0.43
## 1129 BGJ398 JNK-IN-8 22 5 0.04
## 1130 BGJ398 Menin-MLL Inhibitor 22 4 0.00
## 1131 BGJ398 AZD6738 22 3 0.28
## 1132 BGJ398 KU-55933 22 2 0.03
## 1133 BGJ398 SGC 0946 22 1 0.02
## 1134 BML-277 BML-277 23 40 1.00
## 1135 BML-277 AMI-1 23 39 0.38
## 1136 BML-277 Vismodegib 23 38 0.31
## 1137 BML-277 Selisistat 23 37 0.34
## 1138 BML-277 TW-37 23 36 0.17
## 1139 BML-277 D 4476 23 35 0.18
## 1140 BML-277 Doxorubicine 23 34 0.05
## 1141 BML-277 Dasatinib 23 33 -0.01
## 1142 BML-277 Duvelisib 23 32 -0.08
## 1143 BML-277 Idelalisib 23 31 -0.09
## 1144 BML-277 Ibrutinib 23 30 -0.06
## 1145 BML-277 PRT062607 23 29 -0.13
## 1146 BML-277 Afatinib 23 28 0.14
## 1147 BML-277 SB 203580 23 27 0.04
## 1148 BML-277 IRAK-1/4 Inhibitor I 23 26 0.08
## 1149 BML-277 Quizartinib 23 25 0.01
## 1150 BML-277 MK-2206 23 24 -0.02
## 1151 BML-277 AZD1208 23 23 -0.07
## 1152 BML-277 AZD8055 23 22 -0.03
## 1153 BML-277 Rapamycin 23 21 -0.14
## 1154 BML-277 MI-503 23 20 0.15
## 1155 BML-277 Imatinib 23 19 0.10
## 1156 BML-277 Sunitinib 23 18 0.04
## 1157 BML-277 Foretinib 23 17 -0.01
## 1158 BML-277 Tozasertib 23 16 0.05
## 1159 BML-277 Ruxolitinib 23 15 0.14
## 1160 BML-277 Tofacitinib 23 14 -0.03
## 1161 BML-277 PF-3758309 23 13 0.01
## 1162 BML-277 OTX015 23 12 0.09
## 1163 BML-277 Volasertib 23 11 0.22
## 1164 BML-277 Ganetespib 23 10 0.08
## 1165 BML-277 Onalespib 23 9 0.10
## 1166 BML-277 SCH772984 23 8 0.09
## 1167 BML-277 Cobimetinib 23 7 0.07
## 1168 BML-277 Trametinib 23 6 0.04
## 1169 BML-277 JNK-IN-8 23 5 0.09
## 1170 BML-277 Menin-MLL Inhibitor 23 4 -0.13
## 1171 BML-277 AZD6738 23 3 0.02
## 1172 BML-277 KU-55933 23 2 -0.14
## 1173 BML-277 SGC 0946 23 1 -0.01
## 1174 AMI-1 AMI-1 24 39 1.00
## 1175 AMI-1 Vismodegib 24 38 0.57
## 1176 AMI-1 Selisistat 24 37 0.24
## 1177 AMI-1 TW-37 24 36 0.33
## 1178 AMI-1 D 4476 24 35 0.31
## 1179 AMI-1 Doxorubicine 24 34 -0.08
## 1180 AMI-1 Dasatinib 24 33 -0.11
## 1181 AMI-1 Duvelisib 24 32 -0.23
## 1182 AMI-1 Idelalisib 24 31 -0.19
## 1183 AMI-1 Ibrutinib 24 30 -0.09
## 1184 AMI-1 PRT062607 24 29 -0.19
## 1185 AMI-1 Afatinib 24 28 -0.01
## 1186 AMI-1 SB 203580 24 27 -0.20
## 1187 AMI-1 IRAK-1/4 Inhibitor I 24 26 -0.02
## 1188 AMI-1 Quizartinib 24 25 -0.12
## 1189 AMI-1 MK-2206 24 24 -0.28
## 1190 AMI-1 AZD1208 24 23 -0.22
## 1191 AMI-1 AZD8055 24 22 -0.22
## 1192 AMI-1 Rapamycin 24 21 -0.35
## 1193 AMI-1 MI-503 24 20 0.07
## 1194 AMI-1 Imatinib 24 19 0.04
## 1195 AMI-1 Sunitinib 24 18 0.01
## 1196 AMI-1 Foretinib 24 17 -0.10
## 1197 AMI-1 Tozasertib 24 16 0.03
## 1198 AMI-1 Ruxolitinib 24 15 0.02
## 1199 AMI-1 Tofacitinib 24 14 0.22
## 1200 AMI-1 PF-3758309 24 13 -0.14
## 1201 AMI-1 OTX015 24 12 -0.08
## 1202 AMI-1 Volasertib 24 11 0.07
## 1203 AMI-1 Ganetespib 24 10 -0.06
## 1204 AMI-1 Onalespib 24 9 -0.08
## 1205 AMI-1 SCH772984 24 8 -0.07
## 1206 AMI-1 Cobimetinib 24 7 -0.08
## 1207 AMI-1 Trametinib 24 6 -0.04
## 1208 AMI-1 JNK-IN-8 24 5 0.09
## 1209 AMI-1 Menin-MLL Inhibitor 24 4 0.00
## 1210 AMI-1 AZD6738 24 3 0.17
## 1211 AMI-1 KU-55933 24 2 -0.25
## 1212 AMI-1 SGC 0946 24 1 -0.05
## 1213 Vismodegib Vismodegib 25 38 1.00
## 1214 Vismodegib Selisistat 25 37 0.39
## 1215 Vismodegib TW-37 25 36 0.26
## 1216 Vismodegib D 4476 25 35 0.19
## 1217 Vismodegib Doxorubicine 25 34 -0.03
## 1218 Vismodegib Dasatinib 25 33 0.05
## 1219 Vismodegib Duvelisib 25 32 -0.18
## 1220 Vismodegib Idelalisib 25 31 0.00
## 1221 Vismodegib Ibrutinib 25 30 0.12
## 1222 Vismodegib PRT062607 25 29 0.03
## 1223 Vismodegib Afatinib 25 28 0.10
## 1224 Vismodegib SB 203580 25 27 0.05
## 1225 Vismodegib IRAK-1/4 Inhibitor I 25 26 0.20
## 1226 Vismodegib Quizartinib 25 25 -0.05
## 1227 Vismodegib MK-2206 25 24 -0.20
## 1228 Vismodegib AZD1208 25 23 -0.07
## 1229 Vismodegib AZD8055 25 22 -0.17
## 1230 Vismodegib Rapamycin 25 21 -0.22
## 1231 Vismodegib MI-503 25 20 0.02
## 1232 Vismodegib Imatinib 25 19 0.03
## 1233 Vismodegib Sunitinib 25 18 0.02
## 1234 Vismodegib Foretinib 25 17 -0.04
## 1235 Vismodegib Tozasertib 25 16 0.09
## 1236 Vismodegib Ruxolitinib 25 15 0.25
## 1237 Vismodegib Tofacitinib 25 14 0.34
## 1238 Vismodegib PF-3758309 25 13 0.03
## 1239 Vismodegib OTX015 25 12 0.01
## 1240 Vismodegib Volasertib 25 11 0.09
## 1241 Vismodegib Ganetespib 25 10 0.14
## 1242 Vismodegib Onalespib 25 9 0.16
## 1243 Vismodegib SCH772984 25 8 0.10
## 1244 Vismodegib Cobimetinib 25 7 0.00
## 1245 Vismodegib Trametinib 25 6 0.02
## 1246 Vismodegib JNK-IN-8 25 5 0.17
## 1247 Vismodegib Menin-MLL Inhibitor 25 4 0.15
## 1248 Vismodegib AZD6738 25 3 0.09
## 1249 Vismodegib KU-55933 25 2 -0.10
## 1250 Vismodegib SGC 0946 25 1 -0.05
## 1251 Selisistat Selisistat 26 37 1.00
## 1252 Selisistat TW-37 26 36 0.48
## 1253 Selisistat D 4476 26 35 0.19
## 1254 Selisistat Doxorubicine 26 34 0.04
## 1255 Selisistat Dasatinib 26 33 0.08
## 1256 Selisistat Duvelisib 26 32 0.11
## 1257 Selisistat Idelalisib 26 31 0.21
## 1258 Selisistat Ibrutinib 26 30 0.05
## 1259 Selisistat PRT062607 26 29 0.03
## 1260 Selisistat Afatinib 26 28 0.03
## 1261 Selisistat SB 203580 26 27 -0.11
## 1262 Selisistat IRAK-1/4 Inhibitor I 26 26 0.21
## 1263 Selisistat Quizartinib 26 25 -0.03
## 1264 Selisistat MK-2206 26 24 0.28
## 1265 Selisistat AZD1208 26 23 0.01
## 1266 Selisistat AZD8055 26 22 0.18
## 1267 Selisistat Rapamycin 26 21 0.19
## 1268 Selisistat MI-503 26 20 0.21
## 1269 Selisistat Imatinib 26 19 0.25
## 1270 Selisistat Sunitinib 26 18 0.11
## 1271 Selisistat Foretinib 26 17 0.26
## 1272 Selisistat Tozasertib 26 16 0.19
## 1273 Selisistat Ruxolitinib 26 15 0.15
## 1274 Selisistat Tofacitinib 26 14 0.01
## 1275 Selisistat PF-3758309 26 13 -0.02
## 1276 Selisistat OTX015 26 12 0.03
## 1277 Selisistat Volasertib 26 11 0.07
## 1278 Selisistat Ganetespib 26 10 0.20
## 1279 Selisistat Onalespib 26 9 0.24
## 1280 Selisistat SCH772984 26 8 0.18
## 1281 Selisistat Cobimetinib 26 7 0.20
## 1282 Selisistat Trametinib 26 6 0.22
## 1283 Selisistat JNK-IN-8 26 5 0.09
## 1284 Selisistat Menin-MLL Inhibitor 26 4 -0.01
## 1285 Selisistat AZD6738 26 3 0.26
## 1286 Selisistat KU-55933 26 2 -0.05
## 1287 Selisistat SGC 0946 26 1 0.12
## 1288 TW-37 TW-37 27 36 1.00
## 1289 TW-37 D 4476 27 35 0.32
## 1290 TW-37 Doxorubicine 27 34 0.02
## 1291 TW-37 Dasatinib 27 33 0.11
## 1292 TW-37 Duvelisib 27 32 -0.07
## 1293 TW-37 Idelalisib 27 31 -0.03
## 1294 TW-37 Ibrutinib 27 30 -0.19
## 1295 TW-37 PRT062607 27 29 -0.15
## 1296 TW-37 Afatinib 27 28 0.02
## 1297 TW-37 SB 203580 27 27 -0.29
## 1298 TW-37 IRAK-1/4 Inhibitor I 27 26 -0.03
## 1299 TW-37 Quizartinib 27 25 -0.37
## 1300 TW-37 MK-2206 27 24 -0.01
## 1301 TW-37 AZD1208 27 23 -0.32
## 1302 TW-37 AZD8055 27 22 -0.14
## 1303 TW-37 Rapamycin 27 21 -0.09
## 1304 TW-37 MI-503 27 20 0.02
## 1305 TW-37 Imatinib 27 19 0.05
## 1306 TW-37 Sunitinib 27 18 -0.05
## 1307 TW-37 Foretinib 27 17 0.10
## 1308 TW-37 Tozasertib 27 16 0.04
## 1309 TW-37 Ruxolitinib 27 15 0.09
## 1310 TW-37 Tofacitinib 27 14 0.10
## 1311 TW-37 PF-3758309 27 13 -0.24
## 1312 TW-37 OTX015 27 12 -0.06
## 1313 TW-37 Volasertib 27 11 -0.11
## 1314 TW-37 Ganetespib 27 10 -0.02
## 1315 TW-37 Onalespib 27 9 -0.06
## 1316 TW-37 SCH772984 27 8 0.06
## 1317 TW-37 Cobimetinib 27 7 0.09
## 1318 TW-37 Trametinib 27 6 0.09
## 1319 TW-37 JNK-IN-8 27 5 0.01
## 1320 TW-37 Menin-MLL Inhibitor 27 4 -0.29
## 1321 TW-37 AZD6738 27 3 0.19
## 1322 TW-37 KU-55933 27 2 -0.11
## 1323 TW-37 SGC 0946 27 1 0.05
## 1324 D 4476 D 4476 28 35 1.00
## 1325 D 4476 Doxorubicine 28 34 0.30
## 1326 D 4476 Dasatinib 28 33 0.18
## 1327 D 4476 Duvelisib 28 32 0.07
## 1328 D 4476 Idelalisib 28 31 0.16
## 1329 D 4476 Ibrutinib 28 30 0.06
## 1330 D 4476 PRT062607 28 29 -0.12
## 1331 D 4476 Afatinib 28 28 -0.01
## 1332 D 4476 SB 203580 28 27 -0.15
## 1333 D 4476 IRAK-1/4 Inhibitor I 28 26 -0.12
## 1334 D 4476 Quizartinib 28 25 -0.23
## 1335 D 4476 MK-2206 28 24 -0.12
## 1336 D 4476 AZD1208 28 23 -0.20
## 1337 D 4476 AZD8055 28 22 -0.09
## 1338 D 4476 Rapamycin 28 21 0.05
## 1339 D 4476 MI-503 28 20 0.20
## 1340 D 4476 Imatinib 28 19 0.13
## 1341 D 4476 Sunitinib 28 18 -0.06
## 1342 D 4476 Foretinib 28 17 0.02
## 1343 D 4476 Tozasertib 28 16 0.03
## 1344 D 4476 Ruxolitinib 28 15 0.11
## 1345 D 4476 Tofacitinib 28 14 0.19
## 1346 D 4476 PF-3758309 28 13 0.04
## 1347 D 4476 OTX015 28 12 0.31
## 1348 D 4476 Volasertib 28 11 0.25
## 1349 D 4476 Ganetespib 28 10 0.05
## 1350 D 4476 Onalespib 28 9 0.00
## 1351 D 4476 SCH772984 28 8 0.07
## 1352 D 4476 Cobimetinib 28 7 0.18
## 1353 D 4476 Trametinib 28 6 0.18
## 1354 D 4476 JNK-IN-8 28 5 0.29
## 1355 D 4476 Menin-MLL Inhibitor 28 4 0.05
## 1356 D 4476 AZD6738 28 3 0.19
## 1357 D 4476 KU-55933 28 2 0.09
## 1358 D 4476 SGC 0946 28 1 -0.07
## 1359 Doxorubicine Doxorubicine 29 34 1.00
## 1360 Doxorubicine Dasatinib 29 33 -0.09
## 1361 Doxorubicine Duvelisib 29 32 0.16
## 1362 Doxorubicine Idelalisib 29 31 0.24
## 1363 Doxorubicine Ibrutinib 29 30 -0.14
## 1364 Doxorubicine PRT062607 29 29 -0.15
## 1365 Doxorubicine Afatinib 29 28 -0.17
## 1366 Doxorubicine SB 203580 29 27 0.09
## 1367 Doxorubicine IRAK-1/4 Inhibitor I 29 26 -0.15
## 1368 Doxorubicine Quizartinib 29 25 -0.15
## 1369 Doxorubicine MK-2206 29 24 0.06
## 1370 Doxorubicine AZD1208 29 23 0.04
## 1371 Doxorubicine AZD8055 29 22 0.14
## 1372 Doxorubicine Rapamycin 29 21 0.20
## 1373 Doxorubicine MI-503 29 20 0.00
## 1374 Doxorubicine Imatinib 29 19 -0.04
## 1375 Doxorubicine Sunitinib 29 18 -0.01
## 1376 Doxorubicine Foretinib 29 17 -0.01
## 1377 Doxorubicine Tozasertib 29 16 -0.14
## 1378 Doxorubicine Ruxolitinib 29 15 -0.11
## 1379 Doxorubicine Tofacitinib 29 14 -0.15
## 1380 Doxorubicine PF-3758309 29 13 0.01
## 1381 Doxorubicine OTX015 29 12 0.20
## 1382 Doxorubicine Volasertib 29 11 0.08
## 1383 Doxorubicine Ganetespib 29 10 -0.26
## 1384 Doxorubicine Onalespib 29 9 -0.20
## 1385 Doxorubicine SCH772984 29 8 -0.01
## 1386 Doxorubicine Cobimetinib 29 7 0.04
## 1387 Doxorubicine Trametinib 29 6 0.00
## 1388 Doxorubicine JNK-IN-8 29 5 -0.20
## 1389 Doxorubicine Menin-MLL Inhibitor 29 4 0.13
## 1390 Doxorubicine AZD6738 29 3 0.03
## 1391 Doxorubicine KU-55933 29 2 0.35
## 1392 Doxorubicine SGC 0946 29 1 -0.08
## 1393 Dasatinib Dasatinib 30 33 1.00
## 1394 Dasatinib Duvelisib 30 32 0.55
## 1395 Dasatinib Idelalisib 30 31 0.50
## 1396 Dasatinib Ibrutinib 30 30 0.59
## 1397 Dasatinib PRT062607 30 29 0.66
## 1398 Dasatinib Afatinib 30 28 0.35
## 1399 Dasatinib SB 203580 30 27 0.34
## 1400 Dasatinib IRAK-1/4 Inhibitor I 30 26 0.25
## 1401 Dasatinib Quizartinib 30 25 0.01
## 1402 Dasatinib MK-2206 30 24 0.10
## 1403 Dasatinib AZD1208 30 23 0.34
## 1404 Dasatinib AZD8055 30 22 0.26
## 1405 Dasatinib Rapamycin 30 21 0.41
## 1406 Dasatinib MI-503 30 20 0.27
## 1407 Dasatinib Imatinib 30 19 0.52
## 1408 Dasatinib Sunitinib 30 18 0.40
## 1409 Dasatinib Foretinib 30 17 0.44
## 1410 Dasatinib Tozasertib 30 16 0.56
## 1411 Dasatinib Ruxolitinib 30 15 0.58
## 1412 Dasatinib Tofacitinib 30 14 0.43
## 1413 Dasatinib PF-3758309 30 13 0.45
## 1414 Dasatinib OTX015 30 12 0.25
## 1415 Dasatinib Volasertib 30 11 0.20
## 1416 Dasatinib Ganetespib 30 10 0.57
## 1417 Dasatinib Onalespib 30 9 0.54
## 1418 Dasatinib SCH772984 30 8 0.52
## 1419 Dasatinib Cobimetinib 30 7 0.52
## 1420 Dasatinib Trametinib 30 6 0.48
## 1421 Dasatinib JNK-IN-8 30 5 0.12
## 1422 Dasatinib Menin-MLL Inhibitor 30 4 0.05
## 1423 Dasatinib AZD6738 30 3 0.09
## 1424 Dasatinib KU-55933 30 2 0.14
## 1425 Dasatinib SGC 0946 30 1 0.20
## 1426 Duvelisib Duvelisib 31 32 1.00
## 1427 Duvelisib Idelalisib 31 31 0.83
## 1428 Duvelisib Ibrutinib 31 30 0.60
## 1429 Duvelisib PRT062607 31 29 0.67
## 1430 Duvelisib Afatinib 31 28 0.33
## 1431 Duvelisib SB 203580 31 27 0.34
## 1432 Duvelisib IRAK-1/4 Inhibitor I 31 26 0.44
## 1433 Duvelisib Quizartinib 31 25 0.27
## 1434 Duvelisib MK-2206 31 24 0.51
## 1435 Duvelisib AZD1208 31 23 0.58
## 1436 Duvelisib AZD8055 31 22 0.74
## 1437 Duvelisib Rapamycin 31 21 0.79
## 1438 Duvelisib MI-503 31 20 0.43
## 1439 Duvelisib Imatinib 31 19 0.47
## 1440 Duvelisib Sunitinib 31 18 0.60
## 1441 Duvelisib Foretinib 31 17 0.63
## 1442 Duvelisib Tozasertib 31 16 0.69
## 1443 Duvelisib Ruxolitinib 31 15 0.47
## 1444 Duvelisib Tofacitinib 31 14 0.31
## 1445 Duvelisib PF-3758309 31 13 0.65
## 1446 Duvelisib OTX015 31 12 0.43
## 1447 Duvelisib Volasertib 31 11 0.37
## 1448 Duvelisib Ganetespib 31 10 0.62
## 1449 Duvelisib Onalespib 31 9 0.63
## 1450 Duvelisib SCH772984 31 8 0.58
## 1451 Duvelisib Cobimetinib 31 7 0.60
## 1452 Duvelisib Trametinib 31 6 0.60
## 1453 Duvelisib JNK-IN-8 31 5 0.09
## 1454 Duvelisib Menin-MLL Inhibitor 31 4 0.12
## 1455 Duvelisib AZD6738 31 3 0.31
## 1456 Duvelisib KU-55933 31 2 0.35
## 1457 Duvelisib SGC 0946 31 1 0.34
## 1458 Idelalisib Idelalisib 32 31 1.00
## 1459 Idelalisib Ibrutinib 32 30 0.73
## 1460 Idelalisib PRT062607 32 29 0.66
## 1461 Idelalisib Afatinib 32 28 0.38
## 1462 Idelalisib SB 203580 32 27 0.55
## 1463 Idelalisib IRAK-1/4 Inhibitor I 32 26 0.56
## 1464 Idelalisib Quizartinib 32 25 0.31
## 1465 Idelalisib MK-2206 32 24 0.35
## 1466 Idelalisib AZD1208 32 23 0.60
## 1467 Idelalisib AZD8055 32 22 0.60
## 1468 Idelalisib Rapamycin 32 21 0.70
## 1469 Idelalisib MI-503 32 20 0.49
## 1470 Idelalisib Imatinib 32 19 0.42
## 1471 Idelalisib Sunitinib 32 18 0.56
## 1472 Idelalisib Foretinib 32 17 0.62
## 1473 Idelalisib Tozasertib 32 16 0.60
## 1474 Idelalisib Ruxolitinib 32 15 0.52
## 1475 Idelalisib Tofacitinib 32 14 0.31
## 1476 Idelalisib PF-3758309 32 13 0.48
## 1477 Idelalisib OTX015 32 12 0.27
## 1478 Idelalisib Volasertib 32 11 0.25
## 1479 Idelalisib Ganetespib 32 10 0.47
## 1480 Idelalisib Onalespib 32 9 0.53
## 1481 Idelalisib SCH772984 32 8 0.50
## 1482 Idelalisib Cobimetinib 32 7 0.40
## 1483 Idelalisib Trametinib 32 6 0.42
## 1484 Idelalisib JNK-IN-8 32 5 0.15
## 1485 Idelalisib Menin-MLL Inhibitor 32 4 0.25
## 1486 Idelalisib AZD6738 32 3 0.29
## 1487 Idelalisib KU-55933 32 2 0.40
## 1488 Idelalisib SGC 0946 32 1 0.43
## 1489 Ibrutinib Ibrutinib 33 30 1.00
## 1490 Ibrutinib PRT062607 33 29 0.75
## 1491 Ibrutinib Afatinib 33 28 0.44
## 1492 Ibrutinib SB 203580 33 27 0.57
## 1493 Ibrutinib IRAK-1/4 Inhibitor I 33 26 0.58
## 1494 Ibrutinib Quizartinib 33 25 0.33
## 1495 Ibrutinib MK-2206 33 24 0.04
## 1496 Ibrutinib AZD1208 33 23 0.54
## 1497 Ibrutinib AZD8055 33 22 0.30
## 1498 Ibrutinib Rapamycin 33 21 0.46
## 1499 Ibrutinib MI-503 33 20 0.34
## 1500 Ibrutinib Imatinib 33 19 0.39
## 1501 Ibrutinib Sunitinib 33 18 0.52
## 1502 Ibrutinib Foretinib 33 17 0.50
## 1503 Ibrutinib Tozasertib 33 16 0.57
## 1504 Ibrutinib Ruxolitinib 33 15 0.49
## 1505 Ibrutinib Tofacitinib 33 14 0.32
## 1506 Ibrutinib PF-3758309 33 13 0.46
## 1507 Ibrutinib OTX015 33 12 0.11
## 1508 Ibrutinib Volasertib 33 11 0.15
## 1509 Ibrutinib Ganetespib 33 10 0.49
## 1510 Ibrutinib Onalespib 33 9 0.54
## 1511 Ibrutinib SCH772984 33 8 0.42
## 1512 Ibrutinib Cobimetinib 33 7 0.29
## 1513 Ibrutinib Trametinib 33 6 0.27
## 1514 Ibrutinib JNK-IN-8 33 5 0.28
## 1515 Ibrutinib Menin-MLL Inhibitor 33 4 0.24
## 1516 Ibrutinib AZD6738 33 3 0.04
## 1517 Ibrutinib KU-55933 33 2 0.17
## 1518 Ibrutinib SGC 0946 33 1 0.37
## 1519 PRT062607 PRT062607 34 29 1.00
## 1520 PRT062607 Afatinib 34 28 0.46
## 1521 PRT062607 SB 203580 34 27 0.53
## 1522 PRT062607 IRAK-1/4 Inhibitor I 34 26 0.53
## 1523 PRT062607 Quizartinib 34 25 0.33
## 1524 PRT062607 MK-2206 34 24 0.26
## 1525 PRT062607 AZD1208 34 23 0.55
## 1526 PRT062607 AZD8055 34 22 0.39
## 1527 PRT062607 Rapamycin 34 21 0.53
## 1528 PRT062607 MI-503 34 20 0.39
## 1529 PRT062607 Imatinib 34 19 0.42
## 1530 PRT062607 Sunitinib 34 18 0.58
## 1531 PRT062607 Foretinib 34 17 0.57
## 1532 PRT062607 Tozasertib 34 16 0.70
## 1533 PRT062607 Ruxolitinib 34 15 0.60
## 1534 PRT062607 Tofacitinib 34 14 0.34
## 1535 PRT062607 PF-3758309 34 13 0.57
## 1536 PRT062607 OTX015 34 12 0.23
## 1537 PRT062607 Volasertib 34 11 0.21
## 1538 PRT062607 Ganetespib 34 10 0.60
## 1539 PRT062607 Onalespib 34 9 0.64
## 1540 PRT062607 SCH772984 34 8 0.57
## 1541 PRT062607 Cobimetinib 34 7 0.45
## 1542 PRT062607 Trametinib 34 6 0.44
## 1543 PRT062607 JNK-IN-8 34 5 0.02
## 1544 PRT062607 Menin-MLL Inhibitor 34 4 0.12
## 1545 PRT062607 AZD6738 34 3 0.07
## 1546 PRT062607 KU-55933 34 2 0.31
## 1547 PRT062607 SGC 0946 34 1 0.43
## 1548 Afatinib Afatinib 35 28 1.00
## 1549 Afatinib SB 203580 35 27 0.45
## 1550 Afatinib IRAK-1/4 Inhibitor I 35 26 0.46
## 1551 Afatinib Quizartinib 35 25 0.18
## 1552 Afatinib MK-2206 35 24 0.14
## 1553 Afatinib AZD1208 35 23 0.44
## 1554 Afatinib AZD8055 35 22 0.22
## 1555 Afatinib Rapamycin 35 21 0.22
## 1556 Afatinib MI-503 35 20 0.37
## 1557 Afatinib Imatinib 35 19 0.25
## 1558 Afatinib Sunitinib 35 18 0.50
## 1559 Afatinib Foretinib 35 17 0.49
## 1560 Afatinib Tozasertib 35 16 0.43
## 1561 Afatinib Ruxolitinib 35 15 0.33
## 1562 Afatinib Tofacitinib 35 14 0.30
## 1563 Afatinib PF-3758309 35 13 0.37
## 1564 Afatinib OTX015 35 12 0.16
## 1565 Afatinib Volasertib 35 11 0.26
## 1566 Afatinib Ganetespib 35 10 0.42
## 1567 Afatinib Onalespib 35 9 0.43
## 1568 Afatinib SCH772984 35 8 0.30
## 1569 Afatinib Cobimetinib 35 7 0.19
## 1570 Afatinib Trametinib 35 6 0.19
## 1571 Afatinib JNK-IN-8 35 5 0.16
## 1572 Afatinib Menin-MLL Inhibitor 35 4 0.23
## 1573 Afatinib AZD6738 35 3 0.02
## 1574 Afatinib KU-55933 35 2 0.19
## 1575 Afatinib SGC 0946 35 1 0.26
## 1576 SB 203580 SB 203580 36 27 1.00
## 1577 SB 203580 IRAK-1/4 Inhibitor I 36 26 0.40
## 1578 SB 203580 Quizartinib 36 25 0.32
## 1579 SB 203580 MK-2206 36 24 0.06
## 1580 SB 203580 AZD1208 36 23 0.57
## 1581 SB 203580 AZD8055 36 22 0.27
## 1582 SB 203580 Rapamycin 36 21 0.38
## 1583 SB 203580 MI-503 36 20 0.15
## 1584 SB 203580 Imatinib 36 19 0.09
## 1585 SB 203580 Sunitinib 36 18 0.36
## 1586 SB 203580 Foretinib 36 17 0.32
## 1587 SB 203580 Tozasertib 36 16 0.30
## 1588 SB 203580 Ruxolitinib 36 15 0.38
## 1589 SB 203580 Tofacitinib 36 14 0.24
## 1590 SB 203580 PF-3758309 36 13 0.31
## 1591 SB 203580 OTX015 36 12 0.02
## 1592 SB 203580 Volasertib 36 11 0.07
## 1593 SB 203580 Ganetespib 36 10 0.16
## 1594 SB 203580 Onalespib 36 9 0.24
## 1595 SB 203580 SCH772984 36 8 0.17
## 1596 SB 203580 Cobimetinib 36 7 -0.02
## 1597 SB 203580 Trametinib 36 6 -0.03
## 1598 SB 203580 JNK-IN-8 36 5 0.10
## 1599 SB 203580 Menin-MLL Inhibitor 36 4 0.21
## 1600 SB 203580 AZD6738 36 3 -0.10
## 1601 SB 203580 KU-55933 36 2 0.19
## 1602 SB 203580 SGC 0946 36 1 0.24
## 1603 IRAK-1/4 Inhibitor I IRAK-1/4 Inhibitor I 37 26 1.00
## 1604 IRAK-1/4 Inhibitor I Quizartinib 37 25 0.54
## 1605 IRAK-1/4 Inhibitor I MK-2206 37 24 0.30
## 1606 IRAK-1/4 Inhibitor I AZD1208 37 23 0.41
## 1607 IRAK-1/4 Inhibitor I AZD8055 37 22 0.36
## 1608 IRAK-1/4 Inhibitor I Rapamycin 37 21 0.30
## 1609 IRAK-1/4 Inhibitor I MI-503 37 20 0.34
## 1610 IRAK-1/4 Inhibitor I Imatinib 37 19 0.46
## 1611 IRAK-1/4 Inhibitor I Sunitinib 37 18 0.61
## 1612 IRAK-1/4 Inhibitor I Foretinib 37 17 0.59
## 1613 IRAK-1/4 Inhibitor I Tozasertib 37 16 0.58
## 1614 IRAK-1/4 Inhibitor I Ruxolitinib 37 15 0.42
## 1615 IRAK-1/4 Inhibitor I Tofacitinib 37 14 0.26
## 1616 IRAK-1/4 Inhibitor I PF-3758309 37 13 0.36
## 1617 IRAK-1/4 Inhibitor I OTX015 37 12 0.04
## 1618 IRAK-1/4 Inhibitor I Volasertib 37 11 0.19
## 1619 IRAK-1/4 Inhibitor I Ganetespib 37 10 0.47
## 1620 IRAK-1/4 Inhibitor I Onalespib 37 9 0.55
## 1621 IRAK-1/4 Inhibitor I SCH772984 37 8 0.45
## 1622 IRAK-1/4 Inhibitor I Cobimetinib 37 7 0.23
## 1623 IRAK-1/4 Inhibitor I Trametinib 37 6 0.25
## 1624 IRAK-1/4 Inhibitor I JNK-IN-8 37 5 0.22
## 1625 IRAK-1/4 Inhibitor I Menin-MLL Inhibitor 37 4 0.42
## 1626 IRAK-1/4 Inhibitor I AZD6738 37 3 0.17
## 1627 IRAK-1/4 Inhibitor I KU-55933 37 2 0.16
## 1628 IRAK-1/4 Inhibitor I SGC 0946 37 1 0.40
## 1629 Quizartinib Quizartinib 38 25 1.00
## 1630 Quizartinib MK-2206 38 24 0.34
## 1631 Quizartinib AZD1208 38 23 0.46
## 1632 Quizartinib AZD8055 38 22 0.32
## 1633 Quizartinib Rapamycin 38 21 0.30
## 1634 Quizartinib MI-503 38 20 0.24
## 1635 Quizartinib Imatinib 38 19 0.31
## 1636 Quizartinib Sunitinib 38 18 0.56
## 1637 Quizartinib Foretinib 38 17 0.56
## 1638 Quizartinib Tozasertib 38 16 0.38
## 1639 Quizartinib Ruxolitinib 38 15 0.01
## 1640 Quizartinib Tofacitinib 38 14 0.06
## 1641 Quizartinib PF-3758309 38 13 0.17
## 1642 Quizartinib OTX015 38 12 -0.20
## 1643 Quizartinib Volasertib 38 11 -0.08
## 1644 Quizartinib Ganetespib 38 10 0.14
## 1645 Quizartinib Onalespib 38 9 0.25
## 1646 Quizartinib SCH772984 38 8 -0.05
## 1647 Quizartinib Cobimetinib 38 7 -0.16
## 1648 Quizartinib Trametinib 38 6 -0.14
## 1649 Quizartinib JNK-IN-8 38 5 0.08
## 1650 Quizartinib Menin-MLL Inhibitor 38 4 0.25
## 1651 Quizartinib AZD6738 38 3 -0.08
## 1652 Quizartinib KU-55933 38 2 -0.08
## 1653 Quizartinib SGC 0946 38 1 0.16
## 1654 MK-2206 MK-2206 39 24 1.00
## 1655 MK-2206 AZD1208 39 23 0.51
## 1656 MK-2206 AZD8055 39 22 0.71
## 1657 MK-2206 Rapamycin 39 21 0.65
## 1658 MK-2206 MI-503 39 20 0.30
## 1659 MK-2206 Imatinib 39 19 0.47
## 1660 MK-2206 Sunitinib 39 18 0.46
## 1661 MK-2206 Foretinib 39 17 0.54
## 1662 MK-2206 Tozasertib 39 16 0.49
## 1663 MK-2206 Ruxolitinib 39 15 0.15
## 1664 MK-2206 Tofacitinib 39 14 -0.02
## 1665 MK-2206 PF-3758309 39 13 0.27
## 1666 MK-2206 OTX015 39 12 0.20
## 1667 MK-2206 Volasertib 39 11 0.18
## 1668 MK-2206 Ganetespib 39 10 0.44
## 1669 MK-2206 Onalespib 39 9 0.46
## 1670 MK-2206 SCH772984 39 8 0.16
## 1671 MK-2206 Cobimetinib 39 7 0.24
## 1672 MK-2206 Trametinib 39 6 0.24
## 1673 MK-2206 JNK-IN-8 39 5 0.12
## 1674 MK-2206 Menin-MLL Inhibitor 39 4 0.25
## 1675 MK-2206 AZD6738 39 3 0.31
## 1676 MK-2206 KU-55933 39 2 0.35
## 1677 MK-2206 SGC 0946 39 1 0.25
## 1678 AZD1208 AZD1208 40 23 1.00
## 1679 AZD1208 AZD8055 40 22 0.66
## 1680 AZD1208 Rapamycin 40 21 0.66
## 1681 AZD1208 MI-503 40 20 0.35
## 1682 AZD1208 Imatinib 40 19 0.40
## 1683 AZD1208 Sunitinib 40 18 0.66
## 1684 AZD1208 Foretinib 40 17 0.56
## 1685 AZD1208 Tozasertib 40 16 0.54
## 1686 AZD1208 Ruxolitinib 40 15 0.33
## 1687 AZD1208 Tofacitinib 40 14 0.12
## 1688 AZD1208 PF-3758309 40 13 0.49
## 1689 AZD1208 OTX015 40 12 0.19
## 1690 AZD1208 Volasertib 40 11 0.26
## 1691 AZD1208 Ganetespib 40 10 0.39
## 1692 AZD1208 Onalespib 40 9 0.45
## 1693 AZD1208 SCH772984 40 8 0.22
## 1694 AZD1208 Cobimetinib 40 7 0.17
## 1695 AZD1208 Trametinib 40 6 0.16
## 1696 AZD1208 JNK-IN-8 40 5 0.06
## 1697 AZD1208 Menin-MLL Inhibitor 40 4 0.29
## 1698 AZD1208 AZD6738 40 3 0.20
## 1699 AZD1208 KU-55933 40 2 0.29
## 1700 AZD1208 SGC 0946 40 1 0.39
## 1701 AZD8055 AZD8055 41 22 1.00
## 1702 AZD8055 Rapamycin 41 21 0.79
## 1703 AZD8055 MI-503 41 20 0.35
## 1704 AZD8055 Imatinib 41 19 0.42
## 1705 AZD8055 Sunitinib 41 18 0.52
## 1706 AZD8055 Foretinib 41 17 0.54
## 1707 AZD8055 Tozasertib 41 16 0.59
## 1708 AZD8055 Ruxolitinib 41 15 0.30
## 1709 AZD8055 Tofacitinib 41 14 0.16
## 1710 AZD8055 PF-3758309 41 13 0.62
## 1711 AZD8055 OTX015 41 12 0.43
## 1712 AZD8055 Volasertib 41 11 0.39
## 1713 AZD8055 Ganetespib 41 10 0.57
## 1714 AZD8055 Onalespib 41 9 0.62
## 1715 AZD8055 SCH772984 41 8 0.39
## 1716 AZD8055 Cobimetinib 41 7 0.46
## 1717 AZD8055 Trametinib 41 6 0.44
## 1718 AZD8055 JNK-IN-8 41 5 0.15
## 1719 AZD8055 Menin-MLL Inhibitor 41 4 0.16
## 1720 AZD8055 AZD6738 41 3 0.32
## 1721 AZD8055 KU-55933 41 2 0.23
## 1722 AZD8055 SGC 0946 41 1 0.24
## 1723 Rapamycin Rapamycin 42 21 1.00
## 1724 Rapamycin MI-503 42 20 0.37
## 1725 Rapamycin Imatinib 42 19 0.47
## 1726 Rapamycin Sunitinib 42 18 0.52
## 1727 Rapamycin Foretinib 42 17 0.66
## 1728 Rapamycin Tozasertib 42 16 0.60
## 1729 Rapamycin Ruxolitinib 42 15 0.37
## 1730 Rapamycin Tofacitinib 42 14 0.16
## 1731 Rapamycin PF-3758309 42 13 0.59
## 1732 Rapamycin OTX015 42 12 0.41
## 1733 Rapamycin Volasertib 42 11 0.34
## 1734 Rapamycin Ganetespib 42 10 0.48
## 1735 Rapamycin Onalespib 42 9 0.50
## 1736 Rapamycin SCH772984 42 8 0.37
## 1737 Rapamycin Cobimetinib 42 7 0.43
## 1738 Rapamycin Trametinib 42 6 0.43
## 1739 Rapamycin JNK-IN-8 42 5 0.20
## 1740 Rapamycin Menin-MLL Inhibitor 42 4 0.19
## 1741 Rapamycin AZD6738 42 3 0.17
## 1742 Rapamycin KU-55933 42 2 0.43
## 1743 Rapamycin SGC 0946 42 1 0.35
## 1744 MI-503 MI-503 43 20 1.00
## 1745 MI-503 Imatinib 43 19 0.44
## 1746 MI-503 Sunitinib 43 18 0.52
## 1747 MI-503 Foretinib 43 17 0.45
## 1748 MI-503 Tozasertib 43 16 0.48
## 1749 MI-503 Ruxolitinib 43 15 0.44
## 1750 MI-503 Tofacitinib 43 14 0.21
## 1751 MI-503 PF-3758309 43 13 0.39
## 1752 MI-503 OTX015 43 12 0.35
## 1753 MI-503 Volasertib 43 11 0.40
## 1754 MI-503 Ganetespib 43 10 0.40
## 1755 MI-503 Onalespib 43 9 0.35
## 1756 MI-503 SCH772984 43 8 0.44
## 1757 MI-503 Cobimetinib 43 7 0.38
## 1758 MI-503 Trametinib 43 6 0.38
## 1759 MI-503 JNK-IN-8 43 5 0.05
## 1760 MI-503 Menin-MLL Inhibitor 43 4 0.11
## 1761 MI-503 AZD6738 43 3 0.17
## 1762 MI-503 KU-55933 43 2 0.12
## 1763 MI-503 SGC 0946 43 1 0.36
## 1764 Imatinib Imatinib 44 19 1.00
## 1765 Imatinib Sunitinib 44 18 0.59
## 1766 Imatinib Foretinib 44 17 0.62
## 1767 Imatinib Tozasertib 44 16 0.65
## 1768 Imatinib Ruxolitinib 44 15 0.32
## 1769 Imatinib Tofacitinib 44 14 0.25
## 1770 Imatinib PF-3758309 44 13 0.33
## 1771 Imatinib OTX015 44 12 0.18
## 1772 Imatinib Volasertib 44 11 0.25
## 1773 Imatinib Ganetespib 44 10 0.54
## 1774 Imatinib Onalespib 44 9 0.53
## 1775 Imatinib SCH772984 44 8 0.41
## 1776 Imatinib Cobimetinib 44 7 0.40
## 1777 Imatinib Trametinib 44 6 0.41
## 1778 Imatinib JNK-IN-8 44 5 0.14
## 1779 Imatinib Menin-MLL Inhibitor 44 4 0.35
## 1780 Imatinib AZD6738 44 3 0.17
## 1781 Imatinib KU-55933 44 2 0.20
## 1782 Imatinib SGC 0946 44 1 0.31
## 1783 Sunitinib Sunitinib 45 18 1.00
## 1784 Sunitinib Foretinib 45 17 0.76
## 1785 Sunitinib Tozasertib 45 16 0.69
## 1786 Sunitinib Ruxolitinib 45 15 0.34
## 1787 Sunitinib Tofacitinib 45 14 0.20
## 1788 Sunitinib PF-3758309 45 13 0.54
## 1789 Sunitinib OTX015 45 12 0.18
## 1790 Sunitinib Volasertib 45 11 0.27
## 1791 Sunitinib Ganetespib 45 10 0.49
## 1792 Sunitinib Onalespib 45 9 0.53
## 1793 Sunitinib SCH772984 45 8 0.35
## 1794 Sunitinib Cobimetinib 45 7 0.32
## 1795 Sunitinib Trametinib 45 6 0.28
## 1796 Sunitinib JNK-IN-8 45 5 -0.06
## 1797 Sunitinib Menin-MLL Inhibitor 45 4 0.26
## 1798 Sunitinib AZD6738 45 3 0.15
## 1799 Sunitinib KU-55933 45 2 0.09
## 1800 Sunitinib SGC 0946 45 1 0.26
## 1801 Foretinib Foretinib 46 17 1.00
## 1802 Foretinib Tozasertib 46 16 0.79
## 1803 Foretinib Ruxolitinib 46 15 0.27
## 1804 Foretinib Tofacitinib 46 14 0.14
## 1805 Foretinib PF-3758309 46 13 0.36
## 1806 Foretinib OTX015 46 12 0.04
## 1807 Foretinib Volasertib 46 11 0.07
## 1808 Foretinib Ganetespib 46 10 0.47
## 1809 Foretinib Onalespib 46 9 0.50
## 1810 Foretinib SCH772984 46 8 0.34
## 1811 Foretinib Cobimetinib 46 7 0.27
## 1812 Foretinib Trametinib 46 6 0.25
## 1813 Foretinib JNK-IN-8 46 5 0.16
## 1814 Foretinib Menin-MLL Inhibitor 46 4 0.18
## 1815 Foretinib AZD6738 46 3 0.17
## 1816 Foretinib KU-55933 46 2 0.23
## 1817 Foretinib SGC 0946 46 1 0.26
## 1818 Tozasertib Tozasertib 47 16 1.00
## 1819 Tozasertib Ruxolitinib 47 15 0.52
## 1820 Tozasertib Tofacitinib 47 14 0.34
## 1821 Tozasertib PF-3758309 47 13 0.55
## 1822 Tozasertib OTX015 47 12 0.25
## 1823 Tozasertib Volasertib 47 11 0.30
## 1824 Tozasertib Ganetespib 47 10 0.72
## 1825 Tozasertib Onalespib 47 9 0.71
## 1826 Tozasertib SCH772984 47 8 0.59
## 1827 Tozasertib Cobimetinib 47 7 0.54
## 1828 Tozasertib Trametinib 47 6 0.52
## 1829 Tozasertib JNK-IN-8 47 5 0.21
## 1830 Tozasertib Menin-MLL Inhibitor 47 4 0.19
## 1831 Tozasertib AZD6738 47 3 0.18
## 1832 Tozasertib KU-55933 47 2 0.25
## 1833 Tozasertib SGC 0946 47 1 0.36
## 1834 Ruxolitinib Ruxolitinib 48 15 1.00
## 1835 Ruxolitinib Tofacitinib 48 14 0.69
## 1836 Ruxolitinib PF-3758309 48 13 0.52
## 1837 Ruxolitinib OTX015 48 12 0.43
## 1838 Ruxolitinib Volasertib 48 11 0.44
## 1839 Ruxolitinib Ganetespib 48 10 0.60
## 1840 Ruxolitinib Onalespib 48 9 0.50
## 1841 Ruxolitinib SCH772984 48 8 0.73
## 1842 Ruxolitinib Cobimetinib 48 7 0.61
## 1843 Ruxolitinib Trametinib 48 6 0.65
## 1844 Ruxolitinib JNK-IN-8 48 5 0.27
## 1845 Ruxolitinib Menin-MLL Inhibitor 48 4 0.19
## 1846 Ruxolitinib AZD6738 48 3 0.23
## 1847 Ruxolitinib KU-55933 48 2 0.32
## 1848 Ruxolitinib SGC 0946 48 1 0.41
## 1849 Tofacitinib Tofacitinib 49 14 1.00
## 1850 Tofacitinib PF-3758309 49 13 0.36
## 1851 Tofacitinib OTX015 49 12 0.30
## 1852 Tofacitinib Volasertib 49 11 0.28
## 1853 Tofacitinib Ganetespib 49 10 0.44
## 1854 Tofacitinib Onalespib 49 9 0.33
## 1855 Tofacitinib SCH772984 49 8 0.41
## 1856 Tofacitinib Cobimetinib 49 7 0.36
## 1857 Tofacitinib Trametinib 49 6 0.44
## 1858 Tofacitinib JNK-IN-8 49 5 0.41
## 1859 Tofacitinib Menin-MLL Inhibitor 49 4 0.32
## 1860 Tofacitinib AZD6738 49 3 0.22
## 1861 Tofacitinib KU-55933 49 2 0.07
## 1862 Tofacitinib SGC 0946 49 1 0.17
## 1863 PF-3758309 PF-3758309 50 13 1.00
## 1864 PF-3758309 OTX015 50 12 0.78
## 1865 PF-3758309 Volasertib 50 11 0.74
## 1866 PF-3758309 Ganetespib 50 10 0.71
## 1867 PF-3758309 Onalespib 50 9 0.68
## 1868 PF-3758309 SCH772984 50 8 0.60
## 1869 PF-3758309 Cobimetinib 50 7 0.65
## 1870 PF-3758309 Trametinib 50 6 0.62
## 1871 PF-3758309 JNK-IN-8 50 5 0.05
## 1872 PF-3758309 Menin-MLL Inhibitor 50 4 0.19
## 1873 PF-3758309 AZD6738 50 3 0.04
## 1874 PF-3758309 KU-55933 50 2 0.16
## 1875 PF-3758309 SGC 0946 50 1 0.08
## 1876 OTX015 OTX015 51 12 1.00
## 1877 OTX015 Volasertib 51 11 0.91
## 1878 OTX015 Ganetespib 51 10 0.54
## 1879 OTX015 Onalespib 51 9 0.46
## 1880 OTX015 SCH772984 51 8 0.55
## 1881 OTX015 Cobimetinib 51 7 0.68
## 1882 OTX015 Trametinib 51 6 0.68
## 1883 OTX015 JNK-IN-8 51 5 0.06
## 1884 OTX015 Menin-MLL Inhibitor 51 4 0.15
## 1885 OTX015 AZD6738 51 3 0.07
## 1886 OTX015 KU-55933 51 2 0.30
## 1887 OTX015 SGC 0946 51 1 0.06
## 1888 Volasertib Volasertib 52 11 1.00
## 1889 Volasertib Ganetespib 52 10 0.53
## 1890 Volasertib Onalespib 52 9 0.47
## 1891 Volasertib SCH772984 52 8 0.52
## 1892 Volasertib Cobimetinib 52 7 0.59
## 1893 Volasertib Trametinib 52 6 0.61
## 1894 Volasertib JNK-IN-8 52 5 0.11
## 1895 Volasertib Menin-MLL Inhibitor 52 4 0.25
## 1896 Volasertib AZD6738 52 3 0.12
## 1897 Volasertib KU-55933 52 2 0.30
## 1898 Volasertib SGC 0946 52 1 0.16
## 1899 Ganetespib Ganetespib 53 10 1.00
## 1900 Ganetespib Onalespib 53 9 0.95
## 1901 Ganetespib SCH772984 53 8 0.73
## 1902 Ganetespib Cobimetinib 53 7 0.76
## 1903 Ganetespib Trametinib 53 6 0.75
## 1904 Ganetespib JNK-IN-8 53 5 0.20
## 1905 Ganetespib Menin-MLL Inhibitor 53 4 0.26
## 1906 Ganetespib AZD6738 53 3 0.20
## 1907 Ganetespib KU-55933 53 2 0.22
## 1908 Ganetespib SGC 0946 53 1 0.26
## 1909 Onalespib Onalespib 54 9 1.00
## 1910 Onalespib SCH772984 54 8 0.65
## 1911 Onalespib Cobimetinib 54 7 0.66
## 1912 Onalespib Trametinib 54 6 0.65
## 1913 Onalespib JNK-IN-8 54 5 0.19
## 1914 Onalespib Menin-MLL Inhibitor 54 4 0.29
## 1915 Onalespib AZD6738 54 3 0.18
## 1916 Onalespib KU-55933 54 2 0.18
## 1917 Onalespib SGC 0946 54 1 0.27
## 1918 SCH772984 SCH772984 55 8 1.00
## 1919 SCH772984 Cobimetinib 55 7 0.88
## 1920 SCH772984 Trametinib 55 6 0.91
## 1921 SCH772984 JNK-IN-8 55 5 0.05
## 1922 SCH772984 Menin-MLL Inhibitor 55 4 0.16
## 1923 SCH772984 AZD6738 55 3 0.19
## 1924 SCH772984 KU-55933 55 2 0.35
## 1925 SCH772984 SGC 0946 55 1 0.36
## 1926 Cobimetinib Cobimetinib 56 7 1.00
## 1927 Cobimetinib Trametinib 56 6 0.96
## 1928 Cobimetinib JNK-IN-8 56 5 -0.04
## 1929 Cobimetinib Menin-MLL Inhibitor 56 4 0.05
## 1930 Cobimetinib AZD6738 56 3 0.21
## 1931 Cobimetinib KU-55933 56 2 0.29
## 1932 Cobimetinib SGC 0946 56 1 0.21
## 1933 Trametinib Trametinib 57 6 1.00
## 1934 Trametinib JNK-IN-8 57 5 0.04
## 1935 Trametinib Menin-MLL Inhibitor 57 4 0.14
## 1936 Trametinib AZD6738 57 3 0.24
## 1937 Trametinib KU-55933 57 2 0.33
## 1938 Trametinib SGC 0946 57 1 0.31
## 1939 JNK-IN-8 JNK-IN-8 58 5 1.00
## 1940 JNK-IN-8 Menin-MLL Inhibitor 58 4 0.36
## 1941 JNK-IN-8 AZD6738 58 3 0.18
## 1942 JNK-IN-8 KU-55933 58 2 0.12
## 1943 JNK-IN-8 SGC 0946 58 1 0.18
## 1944 Menin-MLL Inhibitor Menin-MLL Inhibitor 59 4 1.00
## 1945 Menin-MLL Inhibitor AZD6738 59 3 0.10
## 1946 Menin-MLL Inhibitor KU-55933 59 2 0.35
## 1947 Menin-MLL Inhibitor SGC 0946 59 1 0.20
## 1948 AZD6738 AZD6738 60 3 1.00
## 1949 AZD6738 KU-55933 60 2 0.21
## 1950 AZD6738 SGC 0946 60 1 0.19
## 1951 KU-55933 KU-55933 61 2 1.00
## 1952 KU-55933 SGC 0946 61 1 0.44
## 1953 SGC 0946 SGC 0946 62 1 1.00
##
## $arg
## $arg$type
## [1] "lower"grid.echo()
P2 <- grid.grab()
grid.draw(P2)
#Plot2
# save correlation matrix colors to a vector, then make coloured matrix grob transparent
matrix.colors2 <- getGrob(P2, gPath("square"), grep = TRUE)[["gp"]][["fill"]]
P2 <- editGrob(P2,
gPath("square"), grep = TRUE,
gp = gpar(col = NA,
fill = NA))
# apply the saved colours to the underlying matrix grob
P2 <- editGrob(P2,
gPath("symbols-rect-1"), grep = TRUE,
gp = gpar(fill = matrix.colors2))
# convert the background fill from white to transparent, while we are at it
P2 <- editGrob(P2,
gPath("background"), grep = TRUE,
gp = gpar(fill = NA))
#create a separate legend for pathways
colors_cor_heatmap <- df_pathway |>
filter(Pathway_mod %in% c("AKT/mTOR", "MAPK" , "B-cell receptor", "PI3K", "Stress pathway"))
colors_cor_heatmap$Pathway_mod[colors_cor_heatmap$Pathway_mod=="MAPK"] <- "MEK/ERK"
colors_cor_heatmap$random_value <- seq(1,nrow(colors_cor_heatmap),1)
legend_plot <- ggplot(colors_cor_heatmap, aes(x = Drug, y = random_value, fill = Pathway_mod)) +
geom_tile() +
scale_fill_manual(values = colors_cor_heatmap) +
labs(fill = "Pathway") +
theme_minimal() +
theme(
legend.title = element_text(size=8, face="bold"),
legend.text=element_text(size=8), legend.key.size = unit(0.3, 'cm'),
legend.direction="vertical")+
guides(fill = guide_legend(
title.position="top",
title.hjust = 0,
override.aes = list(shape = 1)))
legend <- get_legend(legend_plot) ## Warning: No shared levels found between `names(values)` of the manual scale and the
## data's fill values.## Warning: No shared levels found between `names(values)` of the manual scale and the
## data's fill values.#put all plots together
fig_corrplot <- grid.arrange(P1, P2, ncol = 2)
Fig4a <- plot_grid(P1, P2, ncol = 2, nrow = 1, align = "h", scale=1, rel_heights = c(1, 1), rel_widths = c(1, 1), greedy = TRUE)+
draw_plot(legend, x=0.82, y=0.4, height=0.25, width=0.25)+
theme(plot.margin = margin(t=1, unit = "cm"))## Warning in as_grob.default(plot): Cannot convert object of class NULL into a
## grob.Fig4a
ggsave(path=(paste0(filepath,"figures")), filename = "Fig4a_correlation_heatmap.svg", width=42, height=30, units = "cm")6.2 Scatter plots for drug-drug correlations (Fig. 4B)
#select drugs
drugs_show_corr <- c("SCH772984", "Cobimetinib", "Ibrutinib", "Idelalisib", "Cobimetinib", "Rapamycin")
#helper function for CLL
corr_drugs_cll <- screen_means |>
filter(diagnosis == c("CLL"), drug %in% drugs_show_corr) |>
pivot_wider(names_from = drug, values_from = mean_viab)
corr_drugs_aml <- screen_means |>
filter(diagnosis == c("AML"), drug %in% drugs_show_corr) |>
pivot_wider(names_from = drug, values_from = mean_viab)
corr_drugs <- rbind(corr_drugs_cll, corr_drugs_aml)
plot_corr <- function(data, x, y, xlab, ylab) {
corr_labels <- data |>
group_by(diagnosis) |>
summarize(corr=cor(.data[[x]], .data[[y]], use = "complete.obs"),
.groups = "drop")
ggplot(data, aes_string(x = x, y = y)) +
geom_point(aes(color = diagnosis), alpha = 0.5) +
geom_smooth(method = "lm", se = TRUE,
color = "black", fill = "lightgrey") +
labs(x = xlab, y = ylab, color="Diagnosis")+
facet_wrap(~diagnosis)+
theme_figures +
theme(strip.background = element_blank(),
strip.text.x = element_blank())+
geom_text(data = corr_labels, aes(x = 0.8, y = 1.1,
label = paste0("italic(R) == ", round(corr, 2))), size=3, parse = TRUE) +
xlim(0.4,1.2) + ylim(0.4,1.2) +
scale_color_manual(values = colors_diag)
}
#plot
p1 <- plot_corr(corr_drugs, "SCH772984", "Cobimetinib", xlab="SCH772984 (ERK)", ylab= "Cobimetinib (MEK)")## Warning: `aes_string()` was deprecated in ggplot2 3.0.0.
## ℹ Please use tidy evaluation idioms with `aes()`.
## ℹ See also `vignette("ggplot2-in-packages")` for more information.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.p2 <- plot_corr(corr_drugs, "Ibrutinib", "Idelalisib", xlab="Ibrutinib (BTK)", ylab= "Idelalisib (PI3K)")
p3 <- plot_corr(corr_drugs, "Ibrutinib", "Cobimetinib", xlab="Ibrutinib (BTK)", ylab= "Cobimetinib (MEK)")
p4 <- plot_corr(corr_drugs, "Rapamycin", "Idelalisib", xlab="Rapamycin (mTOR)", ylab= "Idelalisib (PI3K)")
Fig4b <- p1+plot_spacer()+p2+plot_spacer()+p3+plot_spacer()+p4+plot_layout(ncol=7, widths = c(4, 0.5, 4, 0.5, 4, 0.5, 4), guides = 'collect') & theme(legend.position='right', plot.margin = margin(t=1, l=0.5, unit = "cm"))## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'7 Genotype-phenotype associations in CLL
7.1 P value scatterplot
#prepare data
#pTab <- ... (adapt from Junyans script)
pTab <- read.csv(paste0(filepath,"data/pTable_drug_VS_gene.csv"), sep=";") |>
mutate(across(c(p, p.adj, diff), ~as.numeric(gsub(",", ".", as.character(.)))))
#number of significant associations per gene (10% FDR)
plotTab1 <- filter(pTab, p.adj <= 0.1) %>% group_by(gene) %>%
summarise(number = length(drug)) %>%
arrange(desc(number)) %>% mutate(gene = factor(gene, levels = gene))
#p value scatter plot (IGHV not shown)
top_genes <- as.vector(unlist(plotTab1[2:8,"gene"]))
showGenes <- sort(top_genes)
append(showGenes, "other")## [1] "DDX3X" "del11q" "del13q" "del17p" "gain19p" "TP53"
## [7] "trisomy12" "other"#define colors for each gene
library(RColorBrewer)
colorList <- c(colorRampPalette(brewer.pal(7, 'Set2'))(7),
"grey80", "grey90")
names(colorList) = c(showGenes, "other", "Below 10% FDR")
colorList["del17p"] <- "#FC8D62"
colorList["del11q"] <- "#E5C494"
colorList["trisomy12"] <- "#FFD92F"
colorList["DDX3X"] <- "#E78AC3"
colorList["TP53"] <- "#66C2A5"
#define shapes for viability
shapeList <- ifelse(names(colorList) %in% showGenes, 19,1)
names(shapeList) <- names(colorList)
shapeList["other"] <- 19
shapeList <- c(1, 25, 24)
names(shapeList) = c("Below 10% FDR", "Down", "Up")
#order drugs by their association similarity
pMat <- dplyr::select(pTab, drug, gene, p) %>%
filter(gene!="IGHV.status") %>%
spread(key = gene, value = p) %>%
column_to_rownames("drug") %>%
as.matrix()
hc <- hclust(dist(pMat), method = "ward.D2")
drugOrder <- rownames(pMat)[hc$order]
#order drugs by p value
pval_list <- pTab |>
filter(gene != "IGHV.status") |>
group_by(drug) |>
summarize(pval = min(p)) |>
arrange(pval, descending = FALSE)
drugOrder2 <- pval_list$drug
#prepare plot table
plotTab <- pTab %>% filter(gene != "IGHV.status") %>%
mutate(gene = ifelse(gene %in% showGenes, gene, "other")) %>%
mutate(gene_FDR = ifelse(p.adj < 0.1, gene, "Below 10% FDR"),
drug = factor(drug, levels = drugOrder2),
gene = factor(gene, levels = names(colorList)),
direction = ifelse(gene_FDR == "Below 10% FDR", "Below 10% FDR", ifelse(sign(diff)>0, "Down", "Up")))
#plot
Fig5a <- ggplot(plotTab, aes(x=drug, y = -log10(p), color = gene, shape = direction)) +
geom_point(size =2, alpha = 0.8, stroke = 1) + scale_color_manual(values = colorList) +
scale_shape_manual(values = shapeList, name = "Viability effect") + theme_bw() +
labs(x="", y = expression(-log[10]*italic(P)), color = "Genetic aberration")+
theme(axis.text.x = element_text(angle = 45, hjust =1, vjust=1,
color="black", size=8),
axis.text.y = element_text(color="black", size=8),
axis.title.y = element_text(size=8),
legend.title = element_text(size=8, face="bold"),
legend.text=element_text(size=8),
panel.grid.major.x = element_line(size=.1, color="grey50",
linetype = "dotted"),
panel.grid.major.y = element_blank(),
panel.grid.minor.y = element_blank(),
panel.border = element_rect(color = 'black',
fill = NA,
size = 1),
plot.margin = margin(t=1, l=1, unit = "cm"),
legend.position = c(.95, .95),
legend.justification = c("right", "top"),
legend.box.just = "right",
legend.box = "horizontal",
legend.margin = margin(6, 6, 6, 6))+
geom_hline(yintercept=-log10(0.004706046), linetype = "dashed", linewidth=0.3, color="black")+
annotate("text", label="FDR 10%", size=3, x=60, y=3)+
guides(shape = guide_legend(order = 1),
color = guide_legend(order = 2))## Warning: The `size` argument of `element_rect()` is deprecated as of ggplot2 3.4.0.
## ℹ Please use the `linewidth` argument instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.Fig5a
ggsave(path=(paste0(filepath,"figures")), filename = "Fig5a_pvalue_scatterplot.svg")## Saving 8 x 5 in image7.2 Volcano plots (for IGHV, trisomy12 and TP53)
7.3 Dose-response relationship in DDX3X-mutated U-CLL
7.3.1 BTK vs PI3K
7.4 Lasso model
7.5 del11q
7.6 trisomy(12) in M-CLL and U-CLL
7.7 Fludarabine and nutlin-3a in TP53-mutated CLL
8 DDX3X
8.1 Overview of mutations
8.1.1 Table
8.1.2 Lollipop plot
8.1.3 RNA-seq gene set signature
8.1.4 RNA seq volcano plot for single genes
8.1.5 Heatmaps
8.1.6 Genes of interest: NLRP3 and DDX3Y
9 Longitudinal analysis
9.1 Distribution
9.2 Treatment contexts
9.3 Longitudinal changes in drug response
9.3.1 P value heatmap
9.3.2 Drugs of interest
9.3.3 Absolute differences in mean viability
#Clinical correlation…
```