This R code includes the analyses and figures of the CPS1000 manuscript, written by Kevin D. Hofer and Junyan Lu.

1 Setup

library(knitr)
options(digits=3, width=80)
opts_chunk$set(echo=TRUE,tidy=FALSE,include=TRUE)

1.1 Load libraries

library(ggpmisc)
suppressMessages(library(RColorBrewer))
suppressMessages(library(ggrepel))
suppressMessages(library(cowplot))
suppressMessages(library(gridExtra))
suppressMessages(library(drc))
suppressMessages(library(tidyverse))
detach("package:dplyr") 
suppressMessages(library(dplyr))
library("survminer")
library("survival")
library("maxstat")
library("patchwork")
library("glmnet")
library("corrplot")
library("writexl")
library("ggplot2")
library("flextable")
library("ggpubr")
library("ComplexHeatmap")
library("circlize")
library("grid")
library("RColorBrewer")
library("ggplotify")
library("magrittr")
library("Rtsne")
library("paletteer")
library("ggtext")
library("ggh4x")
library("plotrix")
library("scales")
library("corrplot")
library("gridGraphics")
library("draw")
library("stringr")


#maintain function of specific R packages
rename <- dplyr::rename
count  <- dplyr::count
filter <- dplyr::filter

1.2 Define figure themes

theme_figures <- theme_classic()+
  theme(plot.title = element_text(size=8, hjust=0.5, face="bold"),
        axis.text = element_text(color="black", size=8), 
        axis.title = element_text(size=8), 
        axis.line = element_line(size=0.5), 
        legend.title = element_text(size=8, face="bold"), 
        legend.text = element_text(size=8), 
        legend.key.size = unit(0.5, 'cm'))
## Warning: The `size` argument of `element_line()` is deprecated as of ggplot2 3.4.0.
## ℹ Please use the `linewidth` argument instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
theme_figures_angle45_x <- theme_classic()+
  theme(plot.title=element_text(size=8, hjust=0.5, face="bold"),
        axis.text.x = element_text(color="black", angle = 45, hjust=1, vjust=1, size=8), 
        axis.text.y = element_text(size=8), 
        axis.title = element_text(size=8), 
        legend.title = element_text(size=8, face="bold"), 
        legend.text = element_text(size=8), 
        axis.line = element_line(size=0.5), 
        legend.key.size = unit(0.5, 'cm'))

theme_figures_facet <- theme_bw() +   
  theme(strip.text.y = element_text(size = 0), 
        strip.text.x = element_text(size=8),
        strip.background.y = element_rect(color=NA),
        axis.text = element_text(size=8, color="black"),
        axis.title = element_text(size=8, color="black"),
        panel.spacing = unit(0.15, "lines"), 
        legend.position = "none",
        panel.border = element_rect(color = "black", linewidth = 0.75, fill = NA),
        panel.grid = element_blank(),
        strip.background = element_rect(color = "black", linewidth = 0.75, fill = "grey90"),
        plot.title = element_text(hjust=0.5, size=8, face="bold"))

theme_figures_facet_angle60_x <- theme_bw() +   
  theme(strip.text.y = element_text(size = 0), 
        strip.text.x = element_text(size=8),
        strip.background.y = element_rect(color=NA),
        axis.text.y = element_text(size =8, color="black"),
        axis.text.x = element_text(angle = 60, hjust = 1, vjust = 1, size=8, color = "black"),
        panel.spacing = unit(0.15, "lines"), 
        legend.title = element_text(size = 8),
        panel.border = element_rect(color = "black", linewidth = 0.75, fill = NA),
        strip.background = element_rect(color = "black", linewidth = 0.75, fill = "grey90"),
        plot.title = element_text(hjust=0.5, size=8, face="bold"), 
        strip.text = element_text(size = 8))

#set colors
colors_diag <- setNames(c("#1F78B4", "#B2DF8A", "#A6CEE3", "grey", "#E31A1C", "#FB9A99", "#FF7F00", "#CAB2D6"), c("MCL", "CLL", "T-PLL", "other", "AML", "T-ALL", "B-ALL", "B-PLL"))

colors_diag_IGHV <- setNames(c("#1F78B4", "#B2DF8A", "#33A02C", "grey80", "#E31A1C", "#FB9A99", "#FF7F00", "#CAB2D6", "#A6CEE3"), c("MCL", "U-CLL", "M-CLL", "other", "AML", "T-ALL", "B-ALL", "B-PLL", "T-PLL"))

colors_pathways_mod <- setNames(c("lightgrey", "#BC80BD", "#FCCDE5", "#B3DE69", "#FDB462", "#80B1D3", "#FB8072", "#BEBADA", "#FFFFB3", "#8DD3C7"), c("other", "AKT/mTOR", "DNA damage response", "Chemotherapy" ,  "MAPK" , "B-cell receptor", "PI3K", "Stress pathway", "Bromodomain/PLK", "JAK/STAT"))

colors_cor_heatmap <- setNames(c("#BC80BD", "#FDB462", "#80B1D3", "#FB8072", "#BEBADA"), c("AKT/mTOR", "MEK/ERK" , "B-cell receptor", "PI3K", "Stress pathway"))

colors_drug_type <- c("Chemo" = "#9a6a3d", "Kinase" = "#6A3D9A", "Other" = "#3d9a6a")

1.3 Define functions

1.3.1 Functions for supplementary tables

stab_theme <- function(ft) {
  ft |>
    theme_alafoli() |>
    autofit() |> 
    fontsize(size = 8, part = "header") |> 
    fontsize(size = 8, part = "body") |> 
    padding(padding.top = 3, padding.bottom = 3, part = "all") |> 
    align(align = "left", part = "body") |>  
    align(align = "left", part = "header") |>
    bold(part = "header") |>
    width(j = 1, width = 1.25) |>
    width(j = 2, width = 3.5) |>
    width(j = 3, width = 0.75) |>
    line_spacing(space = 1, part = "all") |> 
    color(color = "black", part = "all")
}

1.3.2 Functions for analyses (???)

#function for t-test
tTest <- function(val, fac) {
  res <- t.test(val ~ fac, var.equal = TRUE)
  data.frame(p = res$p.value, 
             mean1 = res$estimate[[1]],
             mean2 = res$estimate[[2]],
             diff = res$estimate[[2]] - res$estimate[[1]])
}

#helper function for mean viability boxplots
create_boxplot <- function(data, diagnosis_filter, colors, title) {
  #order drugs by median viability
  drug_order <- data |> 
    filter(diagnosis == diagnosis_filter) |> 
    group_by(drug) |> 
    summarise(median = median(mean_viab)) |> 
    arrange(desc(median)) |> 
    pull(drug)
  
  #filter and reorder data
  plot_data <- data |> 
    filter(diagnosis == diagnosis_filter) |> 
    mutate(drug = factor(drug, levels = drug_order))
  
  #create plot
  plot_data |> 
    filter(diagnosis == diagnosis_filter) |> 
    ggplot(aes(x=mean_viab, y=drug, color=diagnosis))+ 
    geom_boxplot(alpha=0.8, outlier.shape=NA) +
    geom_jitter(alpha=0.2, size=0.2, width = 0.15)+
    scale_x_continuous(name ="Mean viability", breaks=seq(0,1.2, 0.2), limits=c(0,1.2))+
    theme_bw() +
    theme(
      axis.text = element_text(color = "black", size = 8),
      axis.title = element_text(size = 8),
      plot.title = element_text(size = 8, hjust = 0.5, face = "bold"),
      legend.position = "none",
      panel.border = element_rect(color = "black", linewidth = 1, fill = NA)) +
    labs(y = "", x = "Mean viability", title = title) +
    scale_color_manual(values = colors_diag_IGHV)
}

2 Load data

2.1 File path

# Modify according to directory

#filepath <-"../../"
filepath <- "~/Dropbox/Medizin/Forschung/Aktuelle Forschungsprojekte/CLL CPS1000/figures/github/"

2.2 Load processed CPS1000 data

load(paste0(filepath,"data/CPS1000_data.RData"))

Description of datasets:
- screen: processed DMSO-normalized ex vivo viability measurements for all patients and drugs - drugs: list of drugs used in the screen - patients: list of patients with corresponding diagnoses - metadata: annotation of genetic aberrations - treatments: treatment contexts for the longitudinal analysis of paired samples - survival: overall survival and time-to-treatment data

3 Drugs

3.1 Drug overview (Fig. 2A)

#prepare data
drugs <- drugs |> as.data.frame()
as.factor(drugs$Pathway)
##  [1] MYC                   Apoptosis             PI3K/AKT/mTOR        
##  [4] EGFR                  Histone methylation   JAK/STAT             
##  [7] DNA damage response   PI3K/AKT/mTOR         FGFR                 
## [10] DNA damage response   ITK                   ALK                  
## [13] Chemotherapy          MAPK                  Chemotherapy         
## [16] Wnt                   MAPK                  ABL (BCR)            
## [19] Chemotherapy          PI3K/AKT/mTOR         Histone methylation  
## [22] Chemotherapy          HGF                   Stress pathway       
## [25] B-cell receptor       PI3K/AKT/mTOR         ABL (BCR)            
## [28] TLR                   MAPK                  DNA damage response  
## [31] MEN1                  Chemotherapy          MEN1                 
## [34] PKC                   PI3K/AKT/mTOR         TLR                  
## [37] DNA damage response   DNA damage response   Stress pathway       
## [40] B-cell receptor       Bromodomain           Cell cycle control   
## [43] Histone deacetylation Cytoskeleton          B-cell receptor      
## [46] Cytokine receptor     PI3K/AKT/mTOR         DNA damage response  
## [49] JAK/STAT              MAPK                  MAPK                 
## [52] Nuclear export        DNA damage response   Histone methylation  
## [55] Cytokine receptor     JAK/STAT              Cell cycle control   
## [58] MAPK                  Apoptosis             Apoptosis            
## [61] Hedgehog              PLK                   MAPK                 
## 28 Levels: ABL (BCR) ALK Apoptosis B-cell receptor ... Wnt
Fig2a <- ggplot(drugs, aes(x = factor(Pathway))) + 
geom_bar(aes(fill = Type)) + 
scale_fill_brewer(palette = "PuRd",  direction = 1) +
labs(y="Number of drugs", x="", fill="Drug type") +
theme_figures_angle45_x +
scale_y_continuous(expand = c(0.01,0), breaks=c(1,2,3,4,5,6,7,8)) +
scale_x_discrete(expand = c(0.025,0)) +
theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig2a

ggsave(path=(paste0(filepath,"figures")), filename = "Fig2a_drug_compounds.svg")
## Saving 12 x 6 in image

3.2 Drug list

#prepare data
drugs$Drug <- drugs$Drug |> 
  gsub("\\.", "-", x = _) |>
  gsub("D4476", "D 4476", x = _) |>
  gsub("IRAK1/4 Inhibitor I", "IRAK-1/4 Inhibitor I", x = _) |> 
  gsub("SB-203580", "SB 203580", x = _)

drugs$Drug <- sort(drugs$Drug) 
drug_list <- drugs |> 
  dplyr::select(Drug, Target, Pathway) #add supplier

drugs$Drug
##  [1] "10058-F4"             "A-1210477"            "A-674563"            
##  [4] "Afatinib"             "AMI-1"                "AZD1208"             
##  [7] "AZD6738"              "AZD8055"              "BGJ398"              
## [10] "BML-277"              "BMS-509744"           "Ceritinib"           
## [13] "Cisplatin"            "Cobimetinib"          "Cytarabine"          
## [16] "D 4476"               "Dabrafenib"           "Dasatinib"           
## [19] "Doxorubicine"         "Duvelisib"            "EPZ-6438"            
## [22] "Fludarabine"          "Foretinib"            "Ganetespib"          
## [25] "Ibrutinib"            "Idelalisib"           "Imatinib"            
## [28] "IRAK-1/4 Inhibitor I" "JNK-IN-8"             "KU-55933"            
## [31] "Menin-MLL Inhibitor"  "Methotrexate"         "MI-503"              
## [34] "Midostaurin"          "MK-2206"              "Motolimod"           
## [37] "Nutlin-3a"            "Olaparib"             "Onalespib"           
## [40] "ONO-4059"             "OTX015"               "Palbociclib"         
## [43] "Panobinostat"         "PF-3758309"           "PRT062607"           
## [46] "Quizartinib"          "Rapamycin"            "RO5963"              
## [49] "Ruxolitinib"          "SB 203580"            "SCH772984"           
## [52] "Selinexor"            "Selisistat"           "SGC 0946"            
## [55] "Sunitinib"            "Tofacitinib"          "Tozasertib"          
## [58] "Trametinib"           "TW-37"                "Venetoclax"          
## [61] "Vismodegib"           "Volasertib"           "ZM 336372"
stab3 <- flextable(drug_list) # |> stab_theme()

ft_grob <- gen_grob(stab3, fit = "width", scaling = "min", hjust = 0)

STab3 <- ggplot() +
  annotation_custom(ft_grob) +
  theme_void() +
  theme(plot.margin = margin(t = 1, r = 1, b = 1, l = 1, unit = "cm"))

ggsave(width=21, height=29.7, units = "cm", path=(paste0(filepath,"tables")), filename = "STab3_drugs_and_targets.svg")

4 Patient characteristics

4.1 Diagnoses (Fig. 2C)

#prepare data
patients <- patients |> 
  filter(diagnosis != "") |> 
  as.data.frame()

patients$cohort <- patients$cohort |> 
  str_replace("IC50", "IC50 + CPS1000") |>
  as.factor()
  
Fig2c <- ggplot(patients, aes(x = forcats::fct_infreq(diagnosis))) +
  geom_bar(aes(fill = cohort)) + 
  geom_text(stat = "count", aes(label = after_stat(count)), vjust = -0.5, size=2.5) +
  scale_fill_brewer(palette = "Greens", direction =-1)+
  labs(y="Number of patients", x="", fill="Drug screen")+
  theme_figures_angle45_x +
  scale_y_continuous(expand = c(0.02,0), breaks=seq(0,300,50), limits = c(0,300))+
  scale_x_discrete(expand = c(0.04,0)) +
  theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig2c

ggsave(path=(paste0(filepath,"figures")), filename = "Fig2c_disease_distribution.svg")
## Saving 12 x 6 in image

4.2 Longitudinal data (Fig. 2D)

#prepare data
treatments$sample1 <- gsub("-[1234]$", "", treatments$sample1)
treatments$sample2 <- gsub("-[1234]$", "", treatments$sample2)

length(unique(treatments$patientID))
## [1] 110
#merge data
sample_date <- survival[,1:3]
merged_table <- merge(treatments, sample_date, by.x="sample1", by.y="sampleID", all.x=TRUE) |> 
  merge(patients[,c("patientID", "diagnosis")], by="patientID") |> 
  dplyr::rename(sampleDate1 = sampleDate)

#add date for 2. sampling and calculate time interval
merged_table <- merge(sample_date, merged_table, by.x="sampleID", by.y="sample2", ) |> 
  dplyr::rename(sample2 = sampleID, sampleDate2 = sampleDate) |> 
  dplyr::select(c(patientID, sample1, sample2, sampleDate1, sampleDate2, diagnosis)) |> 
  mutate(diff = sampleDate2-sampleDate1)

#plot
merged_table$diff <- as.numeric(merged_table$diff)
summary(merged_table$diff)
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       7     224     515     578     884    1757
Fig2d <- ggplot(merged_table, aes(x="", y=diff)) +
  geom_boxplot(color="black", linewidth=0.5, outliers = FALSE, width=0.4) +
  geom_jitter(width = 0.1, alpha = 0.75, size=1, color="#74c476")+ 
  theme_figures+
  labs(x = "", y = "Days between samples")+
  theme(axis.ticks.x = element_blank())+
  scale_y_continuous(expand = c(0.02,0), breaks=c(seq(0,1750,500))) +
  theme(plot.margin = margin(t=1, r=1, l=1, b=1, unit="cm"))
Fig2d

ggsave(path=(paste0(filepath,"figures")), filename = "Fig2d_interval_samples.svg")
## Saving 3 x 6 in image

4.3 Oncoprint of genetic alterations in the CLL cohort (Fig. 2E)

#prepare data
#remove del5IgH
oncoprint_data <- merge(patients, metadata, by.x="patientID", by.y="Patient.ID") |> 
  filter(diagnosis.x == "CLL") |> 
  dplyr::select(!del5IgH)

#remove the first two columns (IGHV.status and Methylation_Cluster)
matrix_data <- as.matrix(oncoprint_data[, -c(1:13)])
rownames(matrix_data) <- oncoprint_data$patientID 
genetic_variations <- t(matrix_data)

#exclude aberrations with less than 8 events
genetic_variations <- data.matrix(genetic_variations)

genetic_variations_num <- matrix(as.numeric(genetic_variations), ncol = 275)
## Warning in matrix(as.numeric(genetic_variations), ncol = 275): NAs introduced
## by coercion
rownames(genetic_variations_num) <- rownames(genetic_variations)
colnames(genetic_variations_num) <- colnames(genetic_variations)

genetic_variations_num <- as.data.frame(genetic_variations_num)
genetic_variations_num$count <- rowSums(!(is.na(genetic_variations_num) | genetic_variations_num == 0)) 

genetic_variations_num <- genetic_variations_num |> 
  filter(count >7)
  
#re-adjust matrix fĂĽr heatmap
genetic_variations_num[genetic_variations_num==0]<-""
genetic_variations_num[is.na(genetic_variations_num)]<-""

genetic_variations_red <- dplyr::select(genetic_variations_num, !count)
genetic_variations_red <- as.matrix(genetic_variations_red)

#annotations
#annotation for IGHV status
ighv_anno <- oncoprint_data[,"IGHV.status"]
ighv_anno <- ighv_anno %>% replace(is.na(.), "unknown")
ighv_colors <- colorRampPalette(brewer.pal(9, "Set1"))(length(unique(ighv_anno)))
annotation_colors <- setNames(ighv_colors, unique(ighv_anno))

#annotation for Methylation
meth_anno <- oncoprint_data[,"Methylation_Cluster"]
meth_anno <- factor(meth_anno, levels = c("HP", "IP","LP", "unknown"))
meth_anno <- meth_anno %>% replace(is.na(.), "unknown")
meth_colors <- colorRampPalette(brewer.pal(8, "Set2"))(length(unique(meth_anno)))
annotation_colors_meth <- setNames(meth_colors, unique(meth_anno))

#annotation for center
center_anno <- oncoprint_data[,"project"]
center_anno <- factor(center_anno, levels = c("HD", "HD-DNA", "H68", "MIR34a", "FB", "NOV", "MDACC", "MUN", "HCL_HD_Andrulis", "OX", "BARC", "ZCH_2"))
center_colors <- colorRampPalette(brewer.pal(3, "Paired"))(length(unique(center_anno)))

#change center label
center_anno <- fct_recode(center_anno,
"ZĂĽrich" = "ZCH_2",
"Barcelona" = "BARC",
"Heidelberg" = "HD")
annotation_colors_center <- setNames(center_colors, unique(center_anno))

#change IGHV label
ighv_anno <- fct_recode(ighv_anno,
"mutated" = "M",
"unmutated" = "U")
annotation_colors <- setNames(ighv_colors, unique(ighv_anno))

ha <- HeatmapAnnotation(Center = center_anno, IGHV = ighv_anno, Methylation = meth_anno, annotation_name_gp = gpar(fontsize = 8), col = list(Center =  annotation_colors_center, IGHV = annotation_colors, Methylation = annotation_colors_meth), annotation_legend_param = list(
    Center = list(
      title_gp = gpar(fontsize = 8, fontface = "bold"),
      labels_gp = gpar(fontsize = 8)
    ),
    IGHV = list(
      title_gp = gpar(fontsize = 8, fontface = "bold"),
      labels_gp = gpar(fontsize = 8)
    ),
    Methylation = list(
      title_gp = gpar(fontsize = 8, fontface = "bold"),
      labels_gp = gpar(fontsize = 8)
    )))

heatmap_legend_param = list(title="Alteration", at = c("1"), title_gp = gpar(fontsize = 8), labels_gp = gpar(fontsize = 8))

#create the oncoprint
oncoprint <- oncoPrint(
    genetic_variations_red,
    alter_fun = list(
      background = function(x, y, w, h) {
        grid.rect(x, y, w, h, gp = gpar(fill = "#F8F8F8", col = "white"))
      },
      "1" = function(x, y, w, h) grid.rect(x, y, w, h, gp = gpar(fill = "black", col = "white")), col = "white"),
    col = c("1" = "black"), na_col = "white",
    remove_empty_rows = FALSE,
    remove_empty_columns = FALSE,
    row_names_gp = gpar(fontsize = 8),
    column_names_gp = gpar(fontsize = 8), 
    row_names_side = "left", pct_side = "right", pct_digits = 1,
    right_annotation = rowAnnotation(row_barplot = anno_oncoprint_barplot(c("1"), border = FALSE, height = unit(4, "cm"), axis_param = list(side = "bottom", labels_rot = 0))), 
    pct_gp = gpar(fontsize = 8), top_annotation = ha, heatmap_legend_param = heatmap_legend_param)
## All mutation types: 1.
## `alter_fun` is assumed vectorizable. If it does not generate correct
## plot, please set `alter_fun_is_vectorized = FALSE` in `oncoPrint()`.
draw(oncoprint, heatmap_legend_side = "left", annotation_legend_side = "right", show_heatmap_legend = FALSE)

Fig2e <- grid.grabExpr(draw(oncoprint, heatmap_legend_side = "left", annotation_legend_side = "right", show_heatmap_legend = FALSE))

ggsave(Fig2e, path=(paste0(filepath,"figures")), filename = "Fig2e_CLL_genetic_landscape.svg")
## Saving 12 x 8 in image

5 Drug response

5.1 Comparison with previous data sets (Fig. 2B)

#prepare data
screen <- screen |> 
  as.data.frame()

colnames(screen) <- colnames(screen) |> 
  gsub("\\.", "-", x = _) |>
  gsub("X10058-F4", "10058-F4", x = _) |> 
  gsub("D4476", "D 4476", x = _) |>
  gsub("IRAK1-4-Inhibitor-I", "IRAK-1/4 Inhibitor I", x = _) |> 
  gsub("Menin-MLL-Inhibitor", "Menin-MLL Inhibitor", x = _) |> 
  gsub("SB-203580", "SB 203580", x = _) |> 
  gsub("SGC-0946", "SGC 0946", x = _) |> 
  gsub("ZM-336372", "ZM 336372", x = _)

screen_long <- patients |> 
  as.data.frame() |> 
  arrange(patientID) |> 
  dplyr::select (patientID, diagnosis)  |> 
  merge(screen) |>  
  pivot_longer(cols = c(4:318), names_to = "drug", values_to = "viability")

#merge with concentrations by drug group (see Table S1)
concentrations_A <- c(10, 2, 0.4, 0.08, 0.016)
concentrations_B <- c(2, 0.4, 0.08, 0.016, 0.0032)
concentrations_C <- c(0.4, 0.08, 0.016, 0.0032, 0.00064)

drug_list <- list(
  A = concentrations_A,
  B = concentrations_B,
  C = concentrations_C
)

#add concentrations
screen_long <- screen_long |> 
  mutate(
    conc_index = as.numeric(str_extract(drug, "\\d+$")),
    drug = str_replace(drug, "_\\d+$", "")
    ) |> 
  left_join(drugs |> 
              dplyr::select(Drug, Group), by = c("drug" = "Drug")) |> 
  rowwise() |> 
  mutate(concentration = drug_list[[Group]][conc_index]) |> 
  ungroup()

#load data from IC50 screen (Dietrich et al. 2018)
IC50 <- read.csv("~/Dropbox/Medizin/Forschung/Aktuelle Forschungsprojekte/CLL CPS1000/raw data/IC50_170823.csv") #adjust

#preparate data for IC50 screen, create bins         
IC50 <- IC50 |>   
mutate(bin = cut(Concentration, breaks=c(0.004, 0.033, 0.156, 0.625, 2.5, 10, 40))) |> 
  filter(!is.na(bin))

#plot
density_cps1000 <- ggplot(screen_long, aes(viability)) + 
  geom_density(aes(fill=factor(concentration)), alpha=0.3, linewidth=0.25) + 
  labs(y="Densitiy", x="Viability", title="CPS1000", fill = expression(bold(paste("Concentration (", mu, "M)"))))+
  theme_figures+
  scale_fill_brewer(palette = "Blues", direction = 1)+
  scale_y_continuous(expand = c(0.02,0))+
  scale_x_continuous(limits=c(0,1.25), expand = c(0.02,0))

density_ic50 <- ggplot(IC50, aes(normVal)) + 
  geom_density(aes(fill=factor(bin)), alpha=0.3, linewidth=0.25) + 
  labs(y="Densitiy", x="Viability", title="IC50 (Dietrich et al. 2018)", fill = expression(bold(paste("Concentration (", mu, "M)"))))+
  theme_figures+
  scale_fill_brewer(palette = "Reds", direction = 1, labels = c("0.004 to 0.033", "0.033 to 0.156", "0.156 to 0.625", "0.625 to 2.5", "2.5 to 10", "10 to 40"))+
  scale_y_continuous(expand = c(0.02,0))+
  scale_x_continuous(limits=c(0,1.25), expand = c(0.02,0))

Fig2b <- density_cps1000 + density_ic50 & theme(plot.margin = margin(r=1, l=0.5, t=0.5, b=0.5, unit="cm"))
Fig2b
## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).
## Warning: Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).

ggsave(path=(paste0(filepath,"figures")), filename = "Fig2c_density_plots.svg")
## Saving 12 x 4 in image
## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).
## Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).
## Warning: Removed 790 rows containing non-finite outside the scale range
## (`stat_density()`).
## Warning: Removed 1161 rows containing non-finite outside the scale range
## (`stat_density()`).

5.2 Drug response patterns (Fig. 3A)

#cap supravital viability results (cut-off <1.2)
screen_long$viability[screen_long$viability>1.2] <- 1.2
screen_long$viability[screen_long$viability<0] <- 0

#show diseases separately with at least 10 samples
pat_nr_per_disease <- patients |> 
  group_by(diagnosis) |> 
  summarize(n_pat = n()) |> 
  arrange(desc(n_pat))

diagnoses_show <- pat_nr_per_disease |> 
  filter(n_pat >=10) |> 
  pull(diagnosis)

df_tsne <- patients[,c("patientID", "diagnosis")] |> 
merge(screen, by="patientID") |> 
  dplyr::select(-patientID, -sampleID) |> 
  mutate(diagnosis= case_when(diagnosis %in% diagnoses_show ~ diagnosis,
                               TRUE ~ "other"))

#split dataframe in measures and subsetting
df_meas <- df_tsne[, !names(df_tsne) %in% "diagnosis"]
df_subset <- df_tsne[, names(df_tsne) %in% "diagnosis"]

#define order
order <- c("AML", "B-ALL", "B-PLL", "CLL", "MCL", "T-ALL", "T-PLL", "other")
df_subset <- factor(df_tsne$diagnosis, levels = order)

#t-sne
set.seed(12)
tsne_results <- Rtsne(df_meas, perplexity=25, check_duplicates = FALSE)

#plot
tsne_plot <- data.frame(
  x = tsne_results$Y[,1], 
  y = tsne_results$Y[,2],
  diagnosis = df_subset
)

Fig3a <- ggplot(tsne_plot) + 
  geom_point(aes(x=x, y=y, color=diagnosis), size=2, alpha=0.8) +
  theme_figures+
  labs(color="Diagnosis")+
  scale_color_manual(values=colors_diag)+
  theme(plot.margin = margin(t=2, b=2, r=1, l=1, unit="cm"))
Fig3a

ggsave(path=(paste0(filepath,"figures")), filename = "Fig3a_tsne.svg")
## Saving 6 x 6 in image

5.3 Mean viability by drug and disease

5.3.1 Overall Heatmap (Fig. 3B)

#prepare data
screen_long_topdiag <- screen_long |> 
  mutate(diagnosis = case_when(diagnosis %in% diagnoses_show ~ diagnosis, 
                               TRUE ~ "other"))

#calculate mean viability
screen_means <- screen_long_topdiag |> 
  group_by(patientID, diagnosis, drug) |> 
    summarize(mean_viab = mean(viability))
## `summarise()` has grouped output by 'patientID', 'diagnosis'. You can override
## using the `.groups` argument.
screen_means
## # A tibble: 28,665 Ă— 4
## # Groups:   patientID, diagnosis [455]
##    patientID diagnosis drug      mean_viab
##    <chr>     <chr>     <chr>         <dbl>
##  1 P0001     CLL       10058-F4      0.998
##  2 P0001     CLL       A-1210477     0.983
##  3 P0001     CLL       A-674563      0.898
##  4 P0001     CLL       AMI-1         1.00 
##  5 P0001     CLL       AZD1208       0.871
##  6 P0001     CLL       AZD6738       0.980
##  7 P0001     CLL       AZD8055       0.912
##  8 P0001     CLL       Afatinib      0.863
##  9 P0001     CLL       BGJ398        1.04 
## 10 P0001     CLL       BML-277       1.06 
## # ℹ 28,655 more rows
#merge with metadata for IGHV status in CLL, drop CLL without IGHV annotation
ighv <- metadata[, names(metadata) %in% c("Patient.ID", "IGHV.status")]

screen_means_ighv <- merge(screen_means, ighv, by.x = "patientID", by.y= "Patient.ID") |>     
  mutate(diagnosis = case_when(IGHV.status == "U" ~ "U-CLL",
                        IGHV.status == "M" ~ "M-CLL",
                        TRUE ~ diagnosis)) |> 
  filter (diagnosis != "CLL") |> 
  dplyr::select(-IGHV.status) 

#prepare for heatmap
df <- screen_means_ighv |> 
  dplyr::select(-diagnosis) |> 
  pivot_wider(names_from = patientID, values_from = mean_viab)

df_use <- df |> 
  dplyr::select(-drug) |> 
  colnames()

df_subset <- df |> 
  dplyr::select(-drug)

#diagnoses
df_diagnoses <- screen_means_ighv |> 
  filter(drug == "10058-F4") |> 
  dplyr::select(patientID, diagnosis)

#add pathways
df_pathway <- drugs[, names(drugs) %in% c("Drug", "Pathway_mod")]

df_combined <- merge(df_pathway, df, , by.x = "Drug", by.y = "drug")

#order pathways and diagnoses
df_combined$Pathway_mod <- factor(df_combined$Pathway_mod,
    levels = c("AKT/mTOR", "B-cell receptor", "Bromodomain/PLK", "Chemotherapy", 
               "DNA damage response", "JAK/STAT", "MAPK", "PI3K", "Stress pathway", "other"))
               
df_diagnoses$diagnosis <- factor(df_diagnoses$diagnosis,
    levels = c("AML", "B-ALL", "B-PLL", "M-CLL", "MCL", "T-ALL", "T-PLL", "U-CLL", "other"))

#scale
x <- data.frame(df_subset)
y <- data.frame(t(scale(t(x))))

#create matrix
rownames(y) = df$drug
colnames(y) = colnames(df_subset)
z <- as.matrix(y)

#annotations
color_fun_reversed <- colorRamp2(c(4, median(z), -4), c("red", "white", "blue"))

ha = HeatmapAnnotation(
  Diagnosis = df_diagnoses$diagnosis, 
  annotation_name_gp = gpar(fontsize = 8), 
  col = list(Diagnosis = colors_diag_IGHV),
  annotation_legend_param = list(
    Diagnosis = list(
      title_gp = gpar(fontsize = 8, fontface = "bold"),
      labels_gp = gpar(fontsize = 8),
      nrow = 2
    )
  )
)

pway <- as.data.frame(df_combined[,1:2])
pway_ordered = pway[match(rownames(z), pway$Drug), ]

ha2 = rowAnnotation(
  Pathway = pway_ordered$Pathway_mod, 
  annotation_name_gp = gpar(fontsize = 8), 
  col = list(Pathway = colors_pathways_mod),
  annotation_legend_param = list(
    Pathway = list(
      title_gp = gpar(fontsize = 8, fontface = "bold"),
      labels_gp = gpar(fontsize = 8),
      nrow = 2
    )
  )
)

#heatmap
h1 <- Heatmap(z, name = "Z-score", show_row_names = TRUE, show_column_names=FALSE, row_names_gp = gpar(fontsize = 8), width = ncol(z)*unit(0.25, "mm"), height = nrow(z)*unit(3.5, "mm"), col = color_fun_reversed, top_annotation = ha, left_annotation = ha2, show_column_dend = FALSE, row_km = 4, row_title = NULL, 
show_parent_dend_line = FALSE, heatmap_legend_param = list(direction = "horizontal", title_gp = gpar(fontsize = 8, fontface = "bold"), labels_gp = gpar(fontsize = 8)))

set.seed(1234)

#set spacing to legend
ht_opt(HEATMAP_LEGEND_PADDING = unit(1.5, "cm"))

Fig3b <- grid.grabExpr(draw(h1, merge_legends = TRUE, heatmap_legend_side = "bottom"))

# Reset options
ht_opt(RESET = TRUE)  

#save?

5.3.2 Drug-specific heatmaps (Fig. S2)

5.3.3 Overview of drug effects (Fig. 3C)

#create diagnosis-specific means
screen_mean_diag <- screen_long |> 
  group_by(diagnosis, drug) |> 
  summarize(mean_diag = mean(viability)) |> 
  filter(diagnosis %in% diagnoses_show) |> 
  pivot_wider(names_from = diagnosis, values_from = mean_diag)
## `summarise()` has grouped output by 'diagnosis'. You can override using the
## `.groups` argument.
#create heatmap
w <- screen_mean_diag[, names(screen_mean_diag) != "drug"]
rownames(w) = screen_mean_diag$drug
## Warning: Setting row names on a tibble is deprecated.
w <- as.matrix(t(w))

set.seed(123)
ha = rowAnnotation(foo = anno_text(rownames(w), gp = gpar(fontsize=8), just="right", offset=1))
## Warning: `offset` is deprecated, use `location` instead.
column_ha = HeatmapAnnotation(foo = anno_text(colnames(w), gp = gpar(fontsize=8), just = "left", offset =0))
## Warning: `offset` is deprecated, use `location` instead.
h2 <- Heatmap(w, name = "Mean viability", left_annotation = ha, 
top_annotation = column_ha, 
show_row_names = FALSE, show_column_names=FALSE, width = ncol(z)*unit(0.45, "mm"), height = nrow(z)*unit(0.4, "mm"), show_row_dend=TRUE, row_dend_side = "left", show_column_dend=FALSE,
row_dend_width = unit(7, "mm"), heatmap_legend_param = list(title_gp = gpar(fontsize = 8, fontface = "bold"), labels_gp = gpar(fontsize = 8)))

Fig3c_top <- draw(h2, heatmap_legend_side = "right", padding = unit(c(2, 2, 0, 2), "mm"))

#extract heatmap order
clustered_col_indices <- column_order(h2)
## Warning: The heatmap has not been initialized. You might have different results
## if you repeatedly execute this function, e.g. when row_km/column_km was
## set. It is more suggested to do as `ht = draw(ht); column_order(ht)`.
clustered_col_names <- colnames(w)[clustered_col_indices]

#create patient-specific means
screen_mean_pat <- screen_long |> 
  filter(diagnosis %in% diagnoses_show) |> 
  group_by(drug, patientID) |> 
  summarize(mean_pat = mean(viability)) |> 
  merge(drugs[,c("Drug", "Category")], by.x="drug", by.y="Drug") |> 
  mutate(drug = factor(drug, levels = clustered_col_names)) |> 
  arrange(drug)
## `summarise()` has grouped output by 'drug'. You can override using the
## `.groups` argument.
#add boxplots  
Fig3c_bottom <- ggplot(screen_mean_pat, aes(x=drug, y=mean_pat, color=Category))+ 
  geom_boxplot(alpha=0.6, outlier.shape=NA) +
  geom_jitter(alpha=0.1, size=0.2, width = 0.15)+
  theme_figures+
  theme(axis.text.x = element_text(color="black", size=8, angle=90, hjust=1, vjust=0.5), 
        legend.position = "bottom",
        panel.spacing = unit(0, "mm"),
        plot.margin = margin(t=0, b=2, r=33, l=21, unit = "mm"))+
  scale_y_continuous(name ="Mean viability", breaks=seq(0,1.2, 0.2), limits=c(0,1.2)) +
  scale_x_discrete(name="")+
  scale_color_manual(values=colors_drug_type, name =  "Drug type", labels=c("Chemotherapy", "Kinase inhibitor", "Other"))
Fig3c_bottom
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).

Fig3c_bottom_aligned <- ggdraw(Fig3c_bottom) +
  theme(plot.margin = margin(0, 0, 0, 0))
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_point()`).
Fig3c <- plot_grid(grid.grabExpr(draw(h2, heatmap_legend_side = "right")), Fig3c_bottom_aligned, ncol=1, rel_heights = c(0.5, 0.5))

#save?

5.3.4 Disease-specific drug effects

5.3.4.1 Overview (Fig. S3 and S4)

#create plots
aml <- create_boxplot(screen_means_ighv, "AML", colors_diag_IGHV, "AML")
ball <- create_boxplot(screen_means_ighv, "B-ALL", colors_diag_IGHV, "B-ALL")
tall <- create_boxplot(screen_means_ighv, "T-ALL", colors_diag_IGHV, "T-ALL")

SFig3 <- plot_grid(aml, ball, tall, NULL, NULL, ncol = 5, nrow = 1)
## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 31 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 21 rows containing missing values or values outside the scale range
## (`geom_point()`).
ggsave(path=(paste0(filepath,"figures")), filename = "SFig3_viab_leucemia.svg", width=42, height=20, units = "cm")


bpll <- create_boxplot(screen_means_ighv, "B-PLL", colors_diag_IGHV, "B-PLL")
mcll <- create_boxplot(screen_means_ighv, "M-CLL", colors_diag_IGHV, "M-CLL")
mcl <- create_boxplot(screen_means_ighv, "MCL", colors_diag_IGHV, "MCL")
ucll <- create_boxplot(screen_means_ighv, "U-CLL", colors_diag_IGHV, "U-CLL")
tpll <- create_boxplot(screen_means_ighv, "T-PLL", colors_diag_IGHV, "T-PLL")

SFig4 <- plot_grid(bpll, mcll, mcl, ucll, tpll, ncol = 5, nrow = 1)
## Warning: Removed 3 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 51 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 3 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 22 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 4 rows containing missing values or values outside the scale range
## (`geom_point()`).
ggsave(path=(paste0(filepath,"figures")), filename = "SFig4_viab_lymphoma.svg", width=42, height=20, units = "cm")

5.3.4.2 Heatmap (Fig. 3D)

#prepare data
diagnoses_show_ighv <- c(diagnoses_show, "U-CLL", "M-CLL")
diagnoses_show_ighv <- diagnoses_show_ighv[diagnoses_show_ighv != "CLL"]

viabTab.mean <- screen_means_ighv |> 
  filter(diagnosis %in% diagnoses_show_ighv)

#create p-values
allDiag <- unique(viabTab.mean$diagnosis)

pTabAll <- lapply(allDiag, function(diagBase) {
  #calculate p value matrix
  pTab <- lapply(allDiag[allDiag != diagBase], function(diagCompare) {
    testTab <- filter(viabTab.mean, diagnosis %in% c(diagBase, diagCompare))  |> 
      mutate(diagnosis = factor(diagnosis, levels = c(diagBase,diagCompare))) 
    res <- group_by(testTab, drug) |> do(tTest(.$mean_viab, .$diagnosis)) |>
      mutate(diagCompare = diagCompare, diagBase = diagBase)
    res
  }) |> bind_rows() |> ungroup() |> mutate(p.adj = p.adjust(p, method = "BH"))
}) |> bind_rows()

#prepare data table for plot 
plotTab <- pTabAll |> mutate(p = ifelse(p < 1e-12, 1e-12, p)) |>
  mutate(pSign = -log10(p)*sign(diff)) |>
  mutate(pSign = ifelse(p.adj < 0.1, pSign, 0)) |>
  ungroup()

#order drugs by their association similarity (hierarchical clustering)
pMat <- mutate(plotTab, diagPair = paste0(diagBase,"_",diagCompare)) |>
  dplyr::select(drug, pSign, diagPair) |>
  spread(key = diagPair, value = pSign) |> data.frame() |>
  column_to_rownames("drug") |> as.matrix()

#cut
set.seed(123)
nClust = 9
hcRes <- hclust(dist(pMat), method = "ward.D2")
drugOrder <- rownames(pMat)[hcRes$order]
clustMap <- cutree(hcRes,nClust)

diagOrder <- c("U-CLL", "M-CLL","MCL", "B-PLL", "T-PLL", "B-ALL", "T-ALL","AML")
plotTab <- mutate(plotTab, drug = factor(drug, levels = drugOrder), 
                  diagBase = factor(diagBase, levels= diagOrder), 
                  diagCompare = factor(diagCompare, levels = diagOrder)) |>
  arrange(drug) |> mutate(drugClust = paste0("",nClust-clustMap[as.character(drug)]+1))

#color strips in y-direction
strip <- strip_themed(background_y = elem_list_rect(fill = "white"))

#add pathway annotation
plotTab <- merge(plotTab, drugs[,c("Drug", "Pathway_mod")], by.x="drug", by.y="Drug")

#plot
main_plot <- ggplot(plotTab, aes(x=diagCompare, y = drug, fill = pSign)) + 
  geom_tile(size = 0.3, color = "white") +
  facet_grid2(rows = vars(drugClust), cols = vars(diagBase), scales = "free", space = "free_y", strip = strip) + 
  scale_fill_gradient2(
    high = "blue", mid = "white", low = "red", midpoint = 0)+
  theme_figures_facet_angle60_x+
  labs(fill = "**-log<sub>10</sub>*P*<br>with direction**") +
  theme(legend.title = ggtext::element_markdown())+
  ylab("") + xlab("")
## Warning: Using `size` aesthetic for lines was deprecated in ggplot2 3.4.0.
## ℹ Please use `linewidth` instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
main_plot

#add pathway annotation
anno_plot <- ggplot(plotTab, aes(x = diagCompare, y = drug, fill = Pathway_mod)) +
  geom_tile(size = 0.3) +
  facet_grid(rows = vars(drugClust), scales = "free", space = "free_y") +
  scale_fill_manual(values = colors_pathways_mod,
                    name = "Drug Class")+
  theme_minimal() +
  theme(axis.text = element_blank(),
        axis.title = element_blank(),
        panel.grid = element_blank(),
        panel.border = element_rect(linewidth = 0.75),
        panel.background = element_blank(),
        plot.background = element_blank(),
        strip.text.y = element_blank(),
        panel.spacing = unit(0.15, "lines"), 
        legend.position = "none")

Fig3d <- ggdraw() + 
  draw_plot(main_plot, x=0,y=0,width=1,height=1)+
  draw_plot(anno_plot,x=0.8612,y=0.0765,width=0.03,height=0.895) & 
  theme(plot.margin = margin(t=1, unit="cm"))

ggsave(path=(paste0(filepath,"figures")), filename = "Fig3d_pvalue_heatmap.svg", width=42, height=30, units = "cm")

5.3.4.3 Drug ranking

#prepare data
#rank drugs
rankTab <- screen_long |> 
  group_by(patientID, drug, diagnosis) |> 
  summarise(meanViab = mean(viability)) |> 
  dplyr::ungroup()
## `summarise()` has grouped output by 'patientID', 'drug'. You can override using
## the `.groups` argument.
medTab <- screen_long |> 
  group_by(drug) |> 
  summarise(medVal = median(viability))
rankTab <- left_join(rankTab, medTab, by = "drug") |>  
  mutate(score = meanViab - medVal)

#make rank plot
rank_score_tab <- rankTab |> 
  group_by(patientID, diagnosis) |> 
  arrange((score)) |> 
  mutate(rank_score=row_number(), l2fc = log2(meanViab)-log2(medVal)) |> 
  ungroup()

#show ranks for AML with venetoclax and cytarabine
aml_cyt <- rank_score_tab |> 
filter(diagnosis %in% c("AML")) |> 
mutate(drug_col = ifelse(drug %in% c("Cytarabine"), drug, "other")) |>
ggplot(aes(x=rank_score, y=score, alpha=drug_col, group=patientID))+
geom_hline(yintercept = 0, color="grey70")+
geom_line(alpha=0.25, color="black")+
geom_point(aes(alpha=drug_col, fill=drug_col, color=drug_col), size=1.5, shape=21)+
scale_alpha_manual(values=c(0.75,0))+
scale_fill_manual(name="Drug", breaks=c("Cytarabine"), values=c("#E31A1C", ""))+
scale_color_manual(name="Drug", breaks=c("Cytarabine"), values=c("#E31A1C", ""))+
  labs(title="Cytarabine", y="Score", x="Drug rank")+
  theme_bw()+
  theme(axis.text = element_text(color="black", size=8),
  legend.position = "none", axis.title = element_text(size=8), plot.title = element_text(hjust=0.5, size=8),
  panel.grid.major = element_blank(),
    panel.grid.minor = element_blank(),
    panel.border = element_rect(color = "black", linewidth = 1, fill = NA))

aml_ven <- rank_score_tab |> 
filter(diagnosis %in% c("AML")) |> 
mutate(drug_col = ifelse(drug %in% c("Venetoclax"), drug, "other")) |>
ggplot(aes(x=rank_score, y=score, alpha=drug_col, group=patientID))+
geom_hline(yintercept = 0, color="grey70")+
geom_line(alpha=0.25, color="black")+
geom_point(aes(alpha=drug_col, fill=drug_col, color=drug_col), size=1.5, shape=21)+
scale_alpha_manual(values=c(0, 0.75))+
scale_fill_manual(name="Drug", breaks=c("Venetoclax"), values=c("#E31A1C", ""))+
scale_color_manual(name="Drug", breaks=c("Venetoclax"), values=c("#E31A1C", ""))+
  labs(title="Venetoclax", y="Score", x="Drug rank")+
  theme_bw()+
  theme(axis.text = element_text(color="black", size=8),
  legend.position = "none", axis.title = element_text(size=8), plot.title = element_text(hjust=0.5, size=8),
  panel.grid.major = element_blank(),
    panel.grid.minor = element_blank(),
    panel.border = element_rect(color = "black", linewidth = 1, fill = NA))

SFig8c <- aml_cyt + aml_ven + plot_annotation(title = "AML", theme = theme(plot.title = element_text(hjust=0.5, size=8, face="bold"))) + theme(plot.margin = margin(t=1, unit = "cm"))
SFig8c

#combine with IGHV annotation
cll_meta <- metadata[, c("Patient.ID", "diagnosis", "IGHV.status")] |> 
  filter(diagnosis == "CLL")

rank_score_tab_mod <- merge(rank_score_tab, cll_meta[,c("Patient.ID", "IGHV.status")], by.x="patientID", by.y="Patient.ID", all.x = TRUE) |> 
  mutate(diagnosis = case_when(IGHV.status == "U" ~ "U-CLL",
                               IGHV.status == "M" ~ "M-CLL",
                               TRUE ~ diagnosis)) |> 
                               filter(diagnosis != "CLL")

drug_ranking_diag <- rank_score_tab_mod |> 
  group_by(drug, diagnosis) |> 
  summarize(median_score = median(score), score_sd = sd(score)) |> 
  arrange(median_score) |> 
  group_by(diagnosis) |>
  mutate(rank_median = row_number())
## `summarise()` has grouped output by 'drug'. You can override using the
## `.groups` argument.
# plot: aml
drug_order_aml <- drug_ranking_diag |> 
  filter(diagnosis == "AML") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_aml)  

rank_aml <- drug_ranking_diag |> 
  filter(diagnosis == "AML") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="Median score", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))
          
# plot: u-cll
drug_order_ucll <- drug_ranking_diag |> 
  filter(diagnosis == "U-CLL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_ucll)  

rank_ucll <- drug_ranking_diag |> 
  filter(diagnosis == "U-CLL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag_IGHV)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))    
          
# plot: m-cll
drug_order_mcll <- drug_ranking_diag |> 
  filter(diagnosis == "M-CLL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_mcll)  

rank_mcll <- drug_ranking_diag |> 
  filter(diagnosis == "M-CLL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag_IGHV)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))            
          
# plot: b-all
drug_order_ball <- drug_ranking_diag |> 
  filter(diagnosis == "B-ALL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_ball)  

rank_ball <- drug_ranking_diag |> 
  filter(diagnosis == "B-ALL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))      
          
# plot: t-all
drug_order_tall <- drug_ranking_diag |> 
  filter(diagnosis == "T-ALL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_tall)  

rank_tall <- drug_ranking_diag |> 
  filter(diagnosis == "T-ALL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="Median score", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))            

# plot: mcl
drug_order_mcl <- drug_ranking_diag |> 
  filter(diagnosis == "MCL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_mcl)  

rank_mcl <- drug_ranking_diag |> 
  filter(diagnosis == "MCL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="Median score", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))  

# plot: tpll
drug_order_tpll <- drug_ranking_diag |> 
  filter(diagnosis == "T-PLL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_tpll) 

rank_tpll <- drug_ranking_diag |> 
  filter(diagnosis == "T-PLL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))  
          

# plot: bpll
drug_order_bpll <- drug_ranking_diag |> 
  filter(diagnosis == "B-PLL") |> 
  arrange(median_score) |> 
  pull(drug)
  
drug_ranking_diag$drug <- factor(drug_ranking_diag$drug, levels=drug_order_bpll) 

rank_bpll <- drug_ranking_diag |> 
  filter(diagnosis == "B-PLL") |> 
  mutate(direction = sign(median_score)) |> 
  ggplot(aes(x=drug, y=median_score, fill=diagnosis))+
  geom_col(alpha=0.9) +
  geom_errorbar(aes(ymin = median_score-score_sd, ymax = median_score+score_sd), 
  color="black", alpha=0.75, width=0.5, linewidth=0.5)+
  facet_wrap(~diagnosis) +
  labs(title="", y="Median score", x="") +
  theme_bw() +
  guides(color="none")+
  scale_fill_manual(values=colors_diag)+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 90, hjust=1, vjust=0.5, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))          

SFig8b <- (rank_aml+plot_spacer()+rank_ball+plot_layout(widths = c(1, -0.1 ,1)))/(rank_bpll+plot_spacer()+rank_mcll+plot_layout(widths = c(1, -0.1 ,1)))/(rank_mcl+plot_spacer()+rank_ucll+plot_layout(widths = c(1, -0.1 ,1)))/(rank_tall+plot_spacer()+rank_tpll+plot_layout(widths = c(1, -0.1 ,1))) + theme(plot.margin = margin(t=1, unit = "cm"))

#calculate global ranks
#show all diseases
global_rank_tab <- rank_score_tab_mod |> 
group_by(patientID) |> 
mutate(global_score = sum(score)) |> 
arrange(global_score) |> 
group_by(drug) |> 
mutate(global_rank = row_number()) |> 
filter(drug == "Ibrutinib") |> 
#calculate median global rank per diagnosis
group_by(diagnosis) |> 
mutate(global_score_median_diag = median(global_score),
        global_rank_median_diag = median(global_rank))
        

#plot
diagSelected <- c("AML", "B-ALL", "T-ALL", "T-PLL", "B-PLL", "MCL", "U-CLL", "M-CLL")

global_rank_tab <- global_rank_tab |> 
  mutate(diag_col = ifelse(diagnosis %in% diagSelected, diagnosis, "other"))
  
global_rank_tab$diag_col <- factor(global_rank_tab$diag_col, levels = sort(diagSelected))

# Calculate the line for all data
reference_line <- global_rank_tab |>
  arrange(global_rank) |>
  dplyr::select(global_rank, global_score)
## Adding missing grouping variables: `diagnosis`
global_rank_tab <- global_rank_tab |> 
  filter(!is.na(diag_col)) 

score_ranking <- global_rank_tab |> 
  arrange(global_score_median_diag) |> 
  distinct(diag_col) |> 
  pull(diag_col)
  
global_rank_tab$diag_col <- factor(global_rank_tab$diag_col, levels = score_ranking)

# Now plot with facets
all_diag <- global_rank_tab |> 
  ggplot(aes(x=global_rank, y=global_score)) +
  geom_hline(data = global_rank_tab |> 
               distinct(diag_col, global_score_median_diag),
             aes(yintercept = global_score_median_diag), 
             color="grey90")+
  geom_line(data = reference_line, color="grey30", linewidth=0.5, inherit.aes=TRUE) +
  geom_hline(data = global_rank_tab |> 
               distinct(diag_col, global_score_median_diag),
             aes(yintercept = global_score_median_diag), 
             color="grey80")+
  geom_point(aes(color=diag_col), alpha=0.8, size=1.5) +
  #geom_point(aes(x=global_rank_median_diag, y=global_score_median_diag), color="grey80",size=1.5, shape=21) +
  facet_wrap(~diag_col, ncol=4) +
  scale_alpha_manual(values=c(rep(0.5, length(diagSelected)))) +
  scale_color_manual(values=colors_diag_IGHV)+
  labs(title="", y="Sum of drug scores", x="Sample rank") +
  theme_bw() +
  guides(alpha = "none", color="none")+
    theme(legend.position = "none", 
          axis.text.x = element_text(angle = 0, color="black", size=8), 
          panel.grid = element_line(colour = "white"), 
          axis.text.y = element_text(color="black", size=8), 
          axis.title.y = element_text(size=8), 
          axis.title.x = element_text(size=8), 
          panel.border = element_rect(color = "black", linewidth = 1, fill = NA),
          strip.background = element_rect(color = "black", linewidth = 1, fill = "grey90"),
          plot.title = element_text(hjust=0.5, size=8, face="bold"), 
          strip.text = element_text(size = 8), 
          plot.margin = margin(l = 0.5, r = 1, unit = "cm"))

SFig8a <- all_diag + theme(plot.margin = margin(t=1, l=1, r=1, unit = "cm"))

#multipanel
row3 <- plot_grid(SFig8c, NULL, ncol = 2, rel_widths = c(0.4, 0.6))

SFig.5 <- plot_grid(SFig8a, SFig8b, row3, rel_heights = c(0.2, 0.65, 0.15), ncol = 1, 
                   align = "v", axis = c("l", "r"), 
                   labels=c("A", "B", "C"), label_size=14) & theme(plot.margin=margin(r=1,l=1,t=1,b=1,unit="cm"))


ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.svg", width=42, height=59.4, units = "cm")
ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.pdf", width=42, height=59.4, units = "cm")
ggsave(path=(paste0(filepath,"figures")), filename = "FigS5.png", width=42, height=59.4, units = "cm", dpi=600) #remove later

5.3.4.4 Signature drugs at the single concentration level (multivariate binary logistic regression)

5.3.4.5 Specific drugs

#prepare data
drugs_show <- c("Ibrutinib", "PF-3758309", "AZD8055", "Venetoclax", "Duvelisib") 
drug_targets <- c("Ibrutinib" = "BTK", "PF-3758309" = "PAK", "AZD8055" = "mTOR", "Venetoclax" = "BCL2", "Duvelisib" = "PI3K")

screen_long_selected_drugs <- screen_long |> 
  filter(drug %in% drugs_show) |> 
  group_by(drug, diagnosis, conc_index) |>
    mutate(mean_viab=mean(viability), 
    std.error=std.error(viability))

screen_long_selected_drugs$concentration <- as.character(screen_long_selected_drugs$concentration)

#show drug-response for BTK, PAK and mTOR inhibitor
#helper function for plots
viab_plot_list <- list()

viab_plot_list <- map(drugs_show, ~{
  screen_long_selected_drugs |> 
    filter(drug == .x, diagnosis %in% diagnoses_show) |> 
    ggplot(aes(x=concentration, y=mean_viab, group=diagnosis, color=diagnosis)) +
      geom_errorbar(aes(ymin=mean_viab-std.error, ymax=mean_viab+std.error), 
                    width=.5, position=position_dodge(0.01)) +
      geom_line() +
      theme_figures_angle45_x +
      labs(title=paste0(.x, " (", drug_targets[.x], ")"), 
           y="Viability", x=bquote("Concentration ("*mu*"M)"), 
           color="Diagnosis") +
      scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1)) +
      scale_color_manual(values=colors_diag)
}) |> 
  set_names(drugs_show)

#combine plots
Fig3e <- viab_plot_list$Ibrutinib + viab_plot_list$`PF-3758309` + viab_plot_list$AZD8055 + 
  plot_layout(ncol=3, guides = 'collect') & 
  theme(legend.position='right', legend.title= element_text(size=8, face="bold"), 
        plot.margin = margin(t=0.5, b=1, l=0.5, r=0.5, unit = "cm")) &
  guides(
    color = guide_legend(ncol = 1),
    fill = guide_legend(ncol = 1),
    shape = guide_legend(ncol = 1),
    linetype = guide_legend(ncol = 1)
  )
Fig3e

ggsave(path=(paste0(filepath,"figures")), filename = "Fig3e_viab_btk_pak_mtor.svg")
## Saving 8 x 5 in image
#show drug-response for BCL2 inhibtor (venetoclax)
diagnoses_ven <- c("CLL", "AML", "B-ALL", "T-ALL", "MCL", "Sezary")

screen_long_ven <- screen_long_selected_drugs |> 
  filter(drug == "Venetoclax", diagnosis %in% diagnoses_ven) |> 
  group_by(diagnosis, concentration) |> 
  summarize(med_viab=median(viability))
## `summarise()` has grouped output by 'diagnosis'. You can override using the
## `.groups` argument.
#fit dose-response models
screen_long_ven$concentration <- as.numeric(screen_long_ven$concentration)

models_ven <- map(diagnoses_ven, function(dx) {
  data <- screen_long_ven |> filter(diagnosis == dx)
  drm(med_viab ~ concentration, 
      data = data, 
      fct = LL.4(names = c("hill", "min_value", "max_value", "ec_50")))
})
names(models_ven) <- tolower(diagnoses_ven)

#create predictions based on models
predictions_ven <- map(diagnoses_ven, function(dx) {
  data <- screen_long_ven |> filter(diagnosis == dx)
  model <- models_ven[[tolower(dx)]]
  
  new_data <- data.frame(
    concentration = seq(min(data$concentration), max(data$concentration), length.out = 100)
  )
  new_data$pred <- predict(model, newdata = new_data)
  new_data$diagnosis <- dx
  new_data
}) |> 
  bind_rows()

#calculate IC50 values for all diagnoses
ic50_ven <- do.call(rbind, lapply(diagnoses_ven, function(dx) {
  model <- models_ven[[tolower(dx)]]
  coefs <- setNames(model$coefficients, c("hill", "min_value", "max_value", "ec_50"))
  
  ic_50 <- with(as.list(coefs), 
                exp(log(ec_50) + (1 / hill) * log(max_value / (max_value - 2 * min_value))))
  
  data.frame(ic50 = ic_50, diagnosis = dx)
}))
## Warning in log(max_value/(max_value - 2 * min_value)): NaNs produced
#set colors
colors_ven <- c(setNames("darkgrey", "Sezary"), colors_diag)

#order of diagnoses
order_ven <- ic50_ven |> 
  arrange(ic50) |> 
  pull(diagnosis)

#plot
data_ven <- screen_long_selected_drugs |> 
  filter(drug == "Venetoclax", diagnosis %in% diagnoses_ven)
data_ven$diagnosis <- factor(data_ven$diagnosis, levels = order_ven)
data_ven$concentration <- as.numeric(data_ven$concentration)

predictions_ven$diagnosis <- factor(predictions_ven$diagnosis, levels = order_ven)
ic50_ven$diagnosis        <- factor(ic50_ven$diagnosis, levels = order_ven)

Fig3f <- data_ven |> 
  ggplot(aes(x=concentration, y=viability, group=diagnosis, color=diagnosis)) +
    geom_boxplot(aes(group=concentration), alpha = 0.8, outlier.shape = NA) +
    geom_jitter(aes(group=concentration), alpha=0.2, size=1, width = 0.15) +
    facet_wrap(~diagnosis, ncol=6) +
    geom_line(data = predictions_ven, aes(x = concentration, y = pred, color = diagnosis))+
    geom_vline(data = ic50_ven, aes(xintercept = ic50), 
               linetype = "dashed", color = "black", size = 0.4) +
    scale_x_log10(breaks = c(0.001, 0.01, 0.1, 1),
                  labels = trans_format("log10", math_format(10^.x)))+
    scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1)) +
    theme_figures_facet+
    labs(title="Venetoclax (BCL2)", x=bquote("Concentration ("*mu*"M)"), y = "Viability") +
    scale_color_manual(values=colors_ven)+
    theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig3f
## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).

ggsave(path=(paste0(filepath,"figures")), filename = "Fig3f_venetoclax.svg")
## Saving 8 x 5 in image
## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Warning: Removed 23 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).
#duvelisib
Fig3g <- screen_long_selected_drugs |> 
  filter(diagnosis %in% c("B-ALL", "T-ALL"), drug == "Duvelisib") |> 
  ggplot(aes(x=factor(concentration), y=viability, group=interaction(diagnosis, concentration), color=diagnosis)) +
  geom_boxplot(alpha = 0.8, outlier.shape = NA)+
  geom_jitter(alpha = 0.2, size=1, position = position_jitterdodge())+
  labs(title="Duvelisib (PI3K)", y="Viability", x=bquote("Concentration ("*mu*"M)"), color = "Diagnosis")+
  scale_y_continuous(breaks=seq(0,1.0, 0.2), limits=c(0,1.1))+
  theme_figures_angle45_x+
  scale_color_manual(values=colors_diag)+
  theme(plot.margin = margin(t=1, b=1, r=1, l=1, unit="cm"))
Fig3g 
## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

ggsave(path=(paste0(filepath,"figures")), filename = "Fig3g_duvelisib.svg")
## Saving 8 x 5 in image
## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).
#cobimetinib (...)

#quizartinib (...)
## Warning: Removed 22 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Warning: Removed 22 rows containing missing values or values outside the scale range
## (`geom_point()`).
## Warning: Removed 1 row containing missing values or values outside the scale range
## (`geom_vline()`).
## Warning: Removed 2 rows containing non-finite outside the scale range
## (`stat_boxplot()`).
## Warning: Removed 2 rows containing missing values or values outside the scale range
## (`geom_point()`).

6 Drug-drug correlations

6.1 Drug-drug correlation heatmap

#output not as desired in R Markdown !!! -> check with Junyan (output fine in R script)

#prepare data for CLL
cll_df <- screen_long |> 
  filter(diagnosis == "CLL") |> 
  group_by(patientID, drug) |> 
  summarize(mean_viab = mean(viability)) |> 
  pivot_wider(names_from = drug, values_from = mean_viab)
## `summarise()` has grouped output by 'patientID'. You can override using the
## `.groups` argument.
cll_corr_df <- scale(cll_df[3:length(cll_df)])

#calculate correlations
cll_corr <- round(cor(cll_corr_df), 2)

#set colors, make correlations between -0.2 and 0.2 white
colors_cor_heatmap <- colorRampPalette(c(
  colorRampPalette(brewer.pal(9, "Spectral")[1:4])(7),  #for correlations below -0.2
  rep("white", 6),  # For correlations between -0.2 and 0.2
  colorRampPalette(brewer.pal(9, "Spectral")[6:9])(7)   #for correlations above 0.2
))

#add colors for pathways (names not correct!)
all_labels <- colnames(cll_corr)
highlight_hsp <- c("AMI.1", "AZD1208")
highlight_bcr <- c("BMS.509744", "Ceritinib", "Cisplatin", "Cobimetinib")
highlight_pi3k <- c("BGJ398", "BML.277")
highlight_aktmtor <- c("A.1210477", "A.674563", "Fludarabine", "Ganetespib")
highlight_mapk <- c("Cytarabine", "D4476", "Dabrafenib")

label_colors <- setNames(rep("black", length(all_labels)), all_labels)
label_colors[highlight_hsp] <- "#BEBADA"
label_colors[highlight_bcr] <- "#80B1D3"
label_colors[highlight_pi3k] <- "#FB8072"
label_colors[highlight_aktmtor] <- "#BC80BD"
label_colors[highlight_mapk] <- "#FDB462"

#plot
cll_cor_heatmap <- corrplot(cll_corr, type="lower", order="hclust", method="color", 
         col = colors_cor_heatmap(20), sig.level = 0.05, addgrid.col = "grey",
         insig = "blank", tl.col = label_colors, tl.cex = 0.7, tl.pos = "ld",
         tl.offset = c(0.3), cl.ratio = 0.1, title="CLL", cex.main = 0.75, col.main = "black", mar = c(0,0,0.5,0), 
         cl.cex = 0.7, cl.col = "grey", asp=1)
## Warning in text.default(pos.xlabel[, 1], pos.xlabel[, 2], newcolnames, srt =
## tl.srt, : "cl.col" is not a graphical parameter
## Warning in text.default(pos.ylabel[, 1], pos.ylabel[, 2], newrownames, col =
## tl.col, : "cl.col" is not a graphical parameter
## Warning in title(title, ...): "cl.col" is not a graphical parameter

#prepare for multipanel figure
cll_cor_heatmap
## $corr
##                      AZD6738 Rapamycin Ganetespib Onalespib Palbociclib
## AZD6738                 1.00      0.30       0.28      0.25        0.41
## Rapamycin               0.30      1.00       0.33      0.34        0.49
## Ganetespib              0.28      0.33       1.00      0.96        0.69
## Onalespib               0.25      0.34       0.96      1.00        0.69
## Palbociclib             0.41      0.49       0.69      0.69        1.00
## Sunitinib               0.48      0.39       0.69      0.66        0.76
## Midostaurin             0.37      0.34       0.60      0.58        0.58
## Duvelisib               0.38      0.42       0.66      0.60        0.65
## Idelalisib              0.42      0.41       0.62      0.55        0.64
## Dasatinib               0.30      0.22       0.75      0.71        0.64
## PRT062607               0.29      0.25       0.70      0.67        0.69
## Ibrutinib               0.32      0.28       0.72      0.67        0.63
## ONO-4059                0.28      0.31       0.68      0.63        0.64
## Cobimetinib             0.27      0.26       0.47      0.40        0.38
## SCH772984               0.34      0.37       0.46      0.39        0.43
## Trametinib              0.33      0.37       0.54      0.47        0.46
## A-674563                0.44      0.34       0.41      0.41        0.65
## Tozasertib              0.31      0.25       0.51      0.46        0.54
## BMS-509744              0.34      0.03       0.07      0.01        0.17
## Ceritinib               0.26     -0.02       0.12      0.15        0.21
## MK-2206                 0.20      0.44       0.36      0.32        0.46
## AZD1208                 0.34      0.12       0.31      0.28        0.30
## AZD8055                 0.48      0.26       0.41      0.37        0.47
## Dabrafenib              0.10      0.10       0.24      0.17        0.27
## Imatinib                0.24      0.14       0.40      0.37        0.46
## KU-55933                0.08      0.29       0.33      0.29        0.29
## Quizartinib             0.10      0.05      -0.24     -0.22       -0.01
## Afatinib                0.05      0.20       0.04      0.13        0.21
## TW-37                   0.16      0.04      -0.11     -0.05        0.08
## ZM 336372               0.18      0.03      -0.11     -0.05       -0.04
## BML-277                -0.02     -0.08      -0.30     -0.25       -0.14
## EPZ-6438               -0.24     -0.06      -0.33     -0.30       -0.24
## PF-3758309              0.28      0.38       0.42      0.45        0.59
## Venetoclax              0.08      0.10       0.16      0.28        0.24
## Doxorubicine            0.00      0.06       0.14      0.11        0.29
## Panobinostat            0.23      0.24       0.32      0.31        0.33
## Selinexor               0.09      0.15       0.21      0.21        0.37
## OTX015                  0.22      0.35       0.42      0.42        0.46
## Volasertib              0.34      0.24       0.42      0.41        0.47
## Nutlin-3a               0.28      0.39       0.55      0.56        0.59
## RO5963                  0.33      0.37       0.44      0.46        0.47
## Cytarabine              0.16      0.20       0.45      0.44        0.47
## Fludarabine             0.22      0.26       0.32      0.32        0.37
## Ruxolitinib             0.25      0.11       0.13      0.11        0.20
## Tofacitinib             0.19      0.14       0.00      0.05        0.05
## Motolimod              -0.11      0.12      -0.06     -0.05        0.04
## Menin-MLL Inhibitor    -0.10      0.22       0.03      0.11        0.12
## MI-503                  0.01      0.06      -0.07     -0.03        0.10
## Olaparib                0.01     -0.13      -0.01      0.00       -0.06
## SB 203580               0.01      0.05       0.03      0.05       -0.01
## AMI-1                   0.36      0.09      -0.10     -0.07        0.05
## Vismodegib              0.25      0.12      -0.05     -0.03        0.17
## Methotrexate            0.29      0.08      -0.02     -0.04        0.09
## IRAK-1/4 Inhibitor I    0.22      0.28       0.14      0.20        0.39
## Selisistat              0.24      0.37       0.03      0.07        0.33
## Foretinib               0.01     -0.34       0.08      0.01       -0.10
## JNK-IN-8               -0.06     -0.22       0.10      0.06        0.15
## BGJ398                  0.17     -0.04       0.04      0.05        0.19
## SGC 0946                0.30      0.07      -0.02     -0.06        0.14
## D 4476                  0.10     -0.08      -0.10     -0.09        0.05
## A-1210477               0.34      0.33       0.17      0.18        0.47
## Cisplatin               0.28      0.08       0.14      0.10        0.29
##                      Sunitinib Midostaurin Duvelisib Idelalisib Dasatinib
## AZD6738                   0.48        0.37      0.38       0.42      0.30
## Rapamycin                 0.39        0.34      0.42       0.41      0.22
## Ganetespib                0.69        0.60      0.66       0.62      0.75
## Onalespib                 0.66        0.58      0.60       0.55      0.71
## Palbociclib               0.76        0.58      0.65       0.64      0.64
## Sunitinib                 1.00        0.55      0.61       0.58      0.60
## Midostaurin               0.55        1.00      0.63       0.66      0.63
## Duvelisib                 0.61        0.63      1.00       0.93      0.82
## Idelalisib                0.58        0.66      0.93       1.00      0.74
## Dasatinib                 0.60        0.63      0.82       0.74      1.00
## PRT062607                 0.65        0.58      0.85       0.78      0.84
## Ibrutinib                 0.61        0.62      0.89       0.84      0.87
## ONO-4059                  0.59        0.58      0.87       0.82      0.80
## Cobimetinib               0.46        0.35      0.62       0.57      0.63
## SCH772984                 0.52        0.41      0.59       0.58      0.55
## Trametinib                0.51        0.51      0.69       0.66      0.67
## A-674563                  0.64        0.27      0.45       0.46      0.40
## Tozasertib                0.61        0.36      0.58       0.57      0.52
## BMS-509744                0.23        0.19      0.30       0.33      0.25
## Ceritinib                 0.21        0.11      0.09       0.13      0.13
## MK-2206                   0.38        0.47      0.39       0.49      0.33
## AZD1208                   0.25        0.50      0.48       0.56      0.44
## AZD8055                   0.47        0.44      0.53       0.60      0.53
## Dabrafenib                0.23        0.28      0.35       0.39      0.38
## Imatinib                  0.48        0.48      0.50       0.52      0.60
## KU-55933                  0.25        0.47      0.41       0.46      0.34
## Quizartinib               0.02       -0.11     -0.30      -0.22     -0.37
## Afatinib                  0.18       -0.05     -0.21      -0.22     -0.14
## TW-37                     0.15       -0.21     -0.21      -0.18     -0.28
## ZM 336372                -0.11       -0.16     -0.25      -0.23     -0.24
## BML-277                  -0.21       -0.30     -0.43      -0.42     -0.40
## EPZ-6438                 -0.37       -0.23     -0.36      -0.37     -0.39
## PF-3758309                0.42        0.33      0.34       0.31      0.38
## Venetoclax                0.10        0.13      0.03       0.04      0.08
## Doxorubicine              0.22       -0.01      0.03       0.04     -0.02
## Panobinostat              0.38        0.24      0.16       0.16      0.06
## Selinexor                 0.29        0.07      0.16       0.12      0.11
## OTX015                    0.51        0.12      0.31       0.25      0.22
## Volasertib                0.59        0.09      0.30       0.25      0.23
## Nutlin-3a                 0.52        0.36      0.48       0.44      0.45
## RO5963                    0.45        0.32      0.42       0.39      0.36
## Cytarabine                0.43        0.20      0.32       0.29      0.30
## Fludarabine               0.33        0.16      0.21       0.19      0.11
## Ruxolitinib               0.30        0.22      0.22       0.22      0.33
## Tofacitinib               0.08        0.10     -0.10      -0.11      0.06
## Motolimod                 0.00       -0.01     -0.06      -0.06     -0.09
## Menin-MLL Inhibitor      -0.01        0.17     -0.08      -0.02     -0.03
## MI-503                    0.04        0.04     -0.21      -0.13     -0.10
## Olaparib                 -0.11        0.09     -0.07      -0.02      0.08
## SB 203580                 0.13       -0.14     -0.10      -0.10      0.02
## AMI-1                     0.09       -0.14     -0.17      -0.10     -0.15
## Vismodegib                0.16       -0.11     -0.11      -0.04     -0.07
## Methotrexate              0.23        0.11     -0.10      -0.02     -0.09
## IRAK-1/4 Inhibitor I      0.30        0.21      0.07       0.13      0.09
## Selisistat                0.24        0.03      0.02       0.06     -0.01
## Foretinib                 0.09       -0.16      0.02       0.07      0.11
## JNK-IN-8                  0.04        0.05     -0.04       0.09      0.09
## BGJ398                    0.24        0.04      0.02       0.00     -0.02
## SGC 0946                  0.22       -0.04      0.14       0.15      0.06
## D 4476                    0.05       -0.30     -0.17      -0.16     -0.18
## A-1210477                 0.38        0.11      0.32       0.34      0.19
## Cisplatin                 0.37        0.02      0.16       0.24      0.07
##                      PRT062607 Ibrutinib ONO-4059 Cobimetinib SCH772984
## AZD6738                   0.29      0.32     0.28        0.27      0.34
## Rapamycin                 0.25      0.28     0.31        0.26      0.37
## Ganetespib                0.70      0.72     0.68        0.47      0.46
## Onalespib                 0.67      0.67     0.63        0.40      0.39
## Palbociclib               0.69      0.63     0.64        0.38      0.43
## Sunitinib                 0.65      0.61     0.59        0.46      0.52
## Midostaurin               0.58      0.62     0.58        0.35      0.41
## Duvelisib                 0.85      0.89     0.87        0.62      0.59
## Idelalisib                0.78      0.84     0.82        0.57      0.58
## Dasatinib                 0.84      0.87     0.80        0.63      0.55
## PRT062607                 1.00      0.92     0.91        0.58      0.51
## Ibrutinib                 0.92      1.00     0.96        0.61      0.54
## ONO-4059                  0.91      0.96     1.00        0.56      0.51
## Cobimetinib               0.58      0.61     0.56        1.00      0.88
## SCH772984                 0.51      0.54     0.51        0.88      1.00
## Trametinib                0.61      0.66     0.61        0.90      0.92
## A-674563                  0.50      0.43     0.42        0.40      0.43
## Tozasertib                0.67      0.62     0.63        0.52      0.45
## BMS-509744                0.32      0.28     0.25        0.37      0.25
## Ceritinib                 0.19      0.13     0.09        0.08     -0.02
## MK-2206                   0.33      0.33     0.34        0.30      0.32
## AZD1208                   0.44      0.42     0.38        0.28      0.27
## AZD8055                   0.52      0.52     0.45        0.48      0.45
## Dabrafenib                0.34      0.36     0.38        0.33      0.29
## Imatinib                  0.55      0.54     0.51        0.46      0.40
## KU-55933                  0.43      0.47     0.49        0.31      0.31
## Quizartinib              -0.29     -0.35    -0.37       -0.32     -0.18
## Afatinib                 -0.15     -0.21    -0.23       -0.20     -0.11
## TW-37                    -0.15     -0.20    -0.16       -0.15     -0.06
## ZM 336372                -0.15     -0.25    -0.20       -0.30     -0.23
## BML-277                  -0.39     -0.46    -0.45       -0.27     -0.32
## EPZ-6438                 -0.37     -0.42    -0.39       -0.34     -0.30
## PF-3758309                0.34      0.29     0.23        0.15      0.27
## Venetoclax                0.12      0.04     0.06       -0.17     -0.11
## Doxorubicine              0.10      0.06     0.12       -0.03      0.05
## Panobinostat              0.04      0.07     0.09        0.05      0.19
## Selinexor                 0.23      0.14     0.18        0.17      0.25
## OTX015                    0.29      0.29     0.31        0.26      0.35
## Volasertib                0.34      0.30     0.32        0.31      0.38
## Nutlin-3a                 0.48      0.47     0.46        0.46      0.52
## RO5963                    0.41      0.40     0.38        0.42      0.50
## Cytarabine                0.34      0.34     0.31        0.29      0.33
## Fludarabine               0.12      0.14     0.13        0.17      0.29
## Ruxolitinib               0.29      0.30     0.25        0.52      0.57
## Tofacitinib              -0.01     -0.04    -0.12        0.16      0.23
## Motolimod                 0.00     -0.01     0.05       -0.08     -0.06
## Menin-MLL Inhibitor       0.00     -0.01    -0.04       -0.09     -0.06
## MI-503                   -0.15     -0.18    -0.18       -0.09     -0.12
## Olaparib                  0.07      0.04     0.01        0.14      0.05
## SB 203580                 0.08      0.04     0.01        0.20      0.20
## AMI-1                    -0.05     -0.14    -0.17       -0.01      0.02
## Vismodegib                0.01     -0.07    -0.09        0.09      0.12
## Methotrexate             -0.10     -0.09    -0.13        0.02      0.06
## IRAK-1/4 Inhibitor I      0.15      0.11     0.05        0.03      0.08
## Selisistat                0.13      0.05     0.05        0.09      0.09
## Foretinib                 0.16      0.15     0.12        0.20      0.05
## JNK-IN-8                  0.13      0.06     0.04       -0.11     -0.12
## BGJ398                    0.02      0.01     0.01        0.09      0.12
## SGC 0946                  0.20      0.16     0.21        0.25      0.29
## D 4476                   -0.05     -0.14    -0.12        0.07     -0.06
## A-1210477                 0.30      0.28     0.30        0.26      0.25
## Cisplatin                 0.23      0.24     0.21        0.27      0.24
##                      Trametinib A-674563 Tozasertib BMS-509744 Ceritinib
## AZD6738                    0.33     0.44       0.31       0.34      0.26
## Rapamycin                  0.37     0.34       0.25       0.03     -0.02
## Ganetespib                 0.54     0.41       0.51       0.07      0.12
## Onalespib                  0.47     0.41       0.46       0.01      0.15
## Palbociclib                0.46     0.65       0.54       0.17      0.21
## Sunitinib                  0.51     0.64       0.61       0.23      0.21
## Midostaurin                0.51     0.27       0.36       0.19      0.11
## Duvelisib                  0.69     0.45       0.58       0.30      0.09
## Idelalisib                 0.66     0.46       0.57       0.33      0.13
## Dasatinib                  0.67     0.40       0.52       0.25      0.13
## PRT062607                  0.61     0.50       0.67       0.32      0.19
## Ibrutinib                  0.66     0.43       0.62       0.28      0.13
## ONO-4059                   0.61     0.42       0.63       0.25      0.09
## Cobimetinib                0.90     0.40       0.52       0.37      0.08
## SCH772984                  0.92     0.43       0.45       0.25     -0.02
## Trametinib                 1.00     0.39       0.49       0.30      0.01
## A-674563                   0.39     1.00       0.56       0.23      0.27
## Tozasertib                 0.49     0.56       1.00       0.44      0.34
## BMS-509744                 0.30     0.23       0.44       1.00      0.56
## Ceritinib                  0.01     0.27       0.34       0.56      1.00
## MK-2206                    0.33     0.34       0.42       0.31      0.33
## AZD1208                    0.37     0.17       0.36       0.49      0.39
## AZD8055                    0.47     0.47       0.59       0.50      0.49
## Dabrafenib                 0.32     0.08       0.27       0.33      0.17
## Imatinib                   0.40     0.32       0.46       0.28      0.22
## KU-55933                   0.33     0.18       0.39       0.24      0.11
## Quizartinib               -0.25     0.17       0.00      -0.06      0.08
## Afatinib                  -0.15     0.18      -0.12      -0.12      0.13
## TW-37                     -0.17     0.27       0.04      -0.13      0.08
## ZM 336372                 -0.29     0.04      -0.01       0.02      0.16
## BML-277                   -0.43    -0.02      -0.13       0.09      0.24
## EPZ-6438                  -0.33    -0.30      -0.36      -0.12     -0.08
## PF-3758309                 0.28     0.50       0.26      -0.02      0.10
## Venetoclax                -0.08     0.18       0.04      -0.03      0.21
## Doxorubicine              -0.01     0.25       0.09      -0.16     -0.19
## Panobinostat               0.14     0.26       0.05      -0.07     -0.11
## Selinexor                  0.16     0.38       0.23      -0.03      0.02
## OTX015                     0.29     0.49       0.22      -0.08     -0.07
## Volasertib                 0.29     0.58       0.42       0.08      0.11
## Nutlin-3a                  0.51     0.46       0.37       0.02      0.07
## RO5963                     0.47     0.43       0.33       0.03      0.07
## Cytarabine                 0.33     0.39       0.25      -0.04      0.03
## Fludarabine                0.25     0.35       0.09      -0.10     -0.08
## Ruxolitinib                0.49     0.32       0.31       0.30      0.15
## Tofacitinib                0.17     0.22       0.02       0.12      0.10
## Motolimod                 -0.14    -0.10       0.00      -0.09     -0.05
## Menin-MLL Inhibitor       -0.11     0.02      -0.10      -0.08      0.10
## MI-503                    -0.18     0.12       0.09       0.05      0.31
## Olaparib                   0.02    -0.10       0.10       0.26      0.32
## SB 203580                  0.09     0.19       0.24       0.12      0.19
## AMI-1                     -0.13     0.28       0.19       0.29      0.42
## Vismodegib                -0.04     0.35       0.29       0.26      0.39
## Methotrexate              -0.05     0.11       0.12       0.05      0.08
## IRAK-1/4 Inhibitor I       0.00     0.36       0.22       0.10      0.29
## Selisistat                -0.01     0.34       0.28       0.16      0.29
## Foretinib                  0.03     0.08       0.45       0.29      0.30
## JNK-IN-8                  -0.10     0.13       0.14       0.12      0.27
## BGJ398                     0.06     0.23       0.22       0.15      0.30
## SGC 0946                   0.20     0.41       0.35       0.18      0.16
## D 4476                    -0.19     0.23       0.20       0.23      0.35
## A-1210477                  0.22     0.49       0.36       0.26      0.30
## Cisplatin                  0.16     0.39       0.43       0.20      0.20
##                      MK-2206 AZD1208 AZD8055 Dabrafenib Imatinib KU-55933
## AZD6738                 0.20    0.34    0.48       0.10     0.24     0.08
## Rapamycin               0.44    0.12    0.26       0.10     0.14     0.29
## Ganetespib              0.36    0.31    0.41       0.24     0.40     0.33
## Onalespib               0.32    0.28    0.37       0.17     0.37     0.29
## Palbociclib             0.46    0.30    0.47       0.27     0.46     0.29
## Sunitinib               0.38    0.25    0.47       0.23     0.48     0.25
## Midostaurin             0.47    0.50    0.44       0.28     0.48     0.47
## Duvelisib               0.39    0.48    0.53       0.35     0.50     0.41
## Idelalisib              0.49    0.56    0.60       0.39     0.52     0.46
## Dasatinib               0.33    0.44    0.53       0.38     0.60     0.34
## PRT062607               0.33    0.44    0.52       0.34     0.55     0.43
## Ibrutinib               0.33    0.42    0.52       0.36     0.54     0.47
## ONO-4059                0.34    0.38    0.45       0.38     0.51     0.49
## Cobimetinib             0.30    0.28    0.48       0.33     0.46     0.31
## SCH772984               0.32    0.27    0.45       0.29     0.40     0.31
## Trametinib              0.33    0.37    0.47       0.32     0.40     0.33
## A-674563                0.34    0.17    0.47       0.08     0.32     0.18
## Tozasertib              0.42    0.36    0.59       0.27     0.46     0.39
## BMS-509744              0.31    0.49    0.50       0.33     0.28     0.24
## Ceritinib               0.33    0.39    0.49       0.17     0.22     0.11
## MK-2206                 1.00    0.45    0.57       0.28     0.43     0.47
## AZD1208                 0.45    1.00    0.67       0.24     0.38     0.21
## AZD8055                 0.57    0.67    1.00       0.27     0.56     0.27
## Dabrafenib              0.28    0.24    0.27       1.00     0.19     0.22
## Imatinib                0.43    0.38    0.56       0.19     1.00     0.51
## KU-55933                0.47    0.21    0.27       0.22     0.51     1.00
## Quizartinib            -0.06   -0.09   -0.04      -0.16    -0.16    -0.11
## Afatinib               -0.05   -0.24   -0.19       0.02    -0.17    -0.13
## TW-37                  -0.05   -0.30   -0.10      -0.11    -0.19    -0.12
## ZM 336372               0.07    0.00    0.10      -0.11    -0.13    -0.12
## BML-277                -0.08   -0.13   -0.02      -0.16    -0.08    -0.17
## EPZ-6438               -0.13   -0.18   -0.33      -0.06    -0.30    -0.04
## PF-3758309              0.26    0.26    0.34      -0.10     0.16     0.04
## Venetoclax              0.08    0.17    0.08      -0.08    -0.11    -0.14
## Doxorubicine            0.04   -0.25   -0.16       0.09    -0.05     0.04
## Panobinostat            0.13    0.01    0.03       0.03    -0.01     0.03
## Selinexor               0.21   -0.01    0.19       0.04     0.12     0.03
## OTX015                  0.09   -0.22    0.02       0.10     0.00     0.11
## Volasertib              0.14   -0.13    0.21       0.12     0.07     0.10
## Nutlin-3a               0.27    0.05    0.30       0.22     0.20     0.17
## RO5963                  0.22    0.04    0.31       0.12     0.16     0.12
## Cytarabine              0.14   -0.07    0.07       0.17     0.08     0.08
## Fludarabine             0.10   -0.10    0.05       0.03    -0.11    -0.07
## Ruxolitinib             0.24    0.21    0.43       0.05     0.38     0.24
## Tofacitinib             0.11    0.10    0.23      -0.18     0.12     0.00
## Motolimod               0.05   -0.25   -0.11       0.13     0.04     0.21
## Menin-MLL Inhibitor     0.29   -0.02   -0.03       0.00     0.24     0.44
## MI-503                  0.31    0.10    0.22      -0.12     0.38     0.15
## Olaparib                0.25    0.28    0.30       0.10     0.39     0.30
## SB 203580               0.16   -0.13    0.24       0.09     0.20     0.20
## AMI-1                   0.11    0.01    0.30       0.02     0.11     0.05
## Vismodegib              0.21   -0.02    0.34       0.03     0.24     0.17
## Methotrexate            0.16   -0.06    0.16      -0.14     0.34     0.16
## IRAK-1/4 Inhibitor I    0.30    0.00    0.25       0.05     0.39     0.32
## Selisistat              0.29   -0.06    0.26       0.06     0.32     0.25
## Foretinib               0.06    0.14    0.36       0.01     0.33     0.06
## JNK-IN-8                0.13    0.19    0.19       0.17     0.18     0.11
## BGJ398                 -0.01    0.00    0.17       0.00     0.07    -0.04
## SGC 0946                0.11    0.01    0.30       0.15     0.13     0.13
## D 4476                 -0.06   -0.17    0.15       0.10    -0.04    -0.09
## A-1210477               0.24    0.05    0.28       0.34     0.12     0.10
## Cisplatin               0.14   -0.07    0.23       0.09     0.27     0.21
##                      Quizartinib Afatinib TW-37 ZM 336372 BML-277 EPZ-6438
## AZD6738                     0.10     0.05  0.16      0.18   -0.02    -0.24
## Rapamycin                   0.05     0.20  0.04      0.03   -0.08    -0.06
## Ganetespib                 -0.24     0.04 -0.11     -0.11   -0.30    -0.33
## Onalespib                  -0.22     0.13 -0.05     -0.05   -0.25    -0.30
## Palbociclib                -0.01     0.21  0.08     -0.04   -0.14    -0.24
## Sunitinib                   0.02     0.18  0.15     -0.11   -0.21    -0.37
## Midostaurin                -0.11    -0.05 -0.21     -0.16   -0.30    -0.23
## Duvelisib                  -0.30    -0.21 -0.21     -0.25   -0.43    -0.36
## Idelalisib                 -0.22    -0.22 -0.18     -0.23   -0.42    -0.37
## Dasatinib                  -0.37    -0.14 -0.28     -0.24   -0.40    -0.39
## PRT062607                  -0.29    -0.15 -0.15     -0.15   -0.39    -0.37
## Ibrutinib                  -0.35    -0.21 -0.20     -0.25   -0.46    -0.42
## ONO-4059                   -0.37    -0.23 -0.16     -0.20   -0.45    -0.39
## Cobimetinib                -0.32    -0.20 -0.15     -0.30   -0.27    -0.34
## SCH772984                  -0.18    -0.11 -0.06     -0.23   -0.32    -0.30
## Trametinib                 -0.25    -0.15 -0.17     -0.29   -0.43    -0.33
## A-674563                    0.17     0.18  0.27      0.04   -0.02    -0.30
## Tozasertib                  0.00    -0.12  0.04     -0.01   -0.13    -0.36
## BMS-509744                 -0.06    -0.12 -0.13      0.02    0.09    -0.12
## Ceritinib                   0.08     0.13  0.08      0.16    0.24    -0.08
## MK-2206                    -0.06    -0.05 -0.05      0.07   -0.08    -0.13
## AZD1208                    -0.09    -0.24 -0.30      0.00   -0.13    -0.18
## AZD8055                    -0.04    -0.19 -0.10      0.10   -0.02    -0.33
## Dabrafenib                 -0.16     0.02 -0.11     -0.11   -0.16    -0.06
## Imatinib                   -0.16    -0.17 -0.19     -0.13   -0.08    -0.30
## KU-55933                   -0.11    -0.13 -0.12     -0.12   -0.17    -0.04
## Quizartinib                 1.00     0.30  0.38      0.20    0.29     0.17
## Afatinib                    0.30     1.00  0.41      0.13    0.29     0.23
## TW-37                       0.38     0.41  1.00      0.25    0.31     0.13
## ZM 336372                   0.20     0.13  0.25      1.00    0.39     0.27
## BML-277                     0.29     0.29  0.31      0.39    1.00     0.48
## EPZ-6438                    0.17     0.23  0.13      0.27    0.48     1.00
## PF-3758309                  0.20     0.24 -0.03      0.08   -0.04    -0.13
## Venetoclax                 -0.01     0.34  0.12      0.21    0.11     0.01
## Doxorubicine                0.09     0.20  0.30     -0.15   -0.08    -0.02
## Panobinostat                0.10     0.17  0.23     -0.12   -0.06    -0.06
## Selinexor                   0.06     0.16  0.20      0.07   -0.03    -0.09
## OTX015                      0.01     0.23  0.37     -0.07   -0.09    -0.11
## Volasertib                  0.09     0.19  0.45      0.04    0.03    -0.15
## Nutlin-3a                  -0.04     0.22  0.14     -0.02   -0.09    -0.14
## RO5963                      0.00     0.14  0.14      0.04   -0.06    -0.14
## Cytarabine                  0.02     0.29  0.29     -0.06   -0.08    -0.06
## Fludarabine                 0.16     0.27  0.30     -0.02   -0.03    -0.05
## Ruxolitinib                 0.03    -0.02  0.08     -0.03   -0.01    -0.17
## Tofacitinib                 0.19     0.15  0.04      0.26    0.17     0.02
## Motolimod                   0.00     0.11  0.14      0.07    0.13     0.21
## Menin-MLL Inhibitor         0.05     0.25  0.03      0.10    0.16     0.24
## MI-503                      0.16     0.15  0.12      0.22    0.42     0.10
## Olaparib                   -0.17    -0.12 -0.08      0.07    0.19    -0.01
## SB 203580                   0.12     0.02  0.19      0.23    0.17    -0.08
## AMI-1                       0.29     0.19  0.34      0.41    0.45     0.05
## Vismodegib                  0.29     0.18  0.38      0.28    0.43    -0.03
## Methotrexate                0.33     0.07  0.22      0.07    0.25    -0.13
## IRAK-1/4 Inhibitor I        0.28     0.36  0.17      0.10    0.23    -0.01
## Selisistat                  0.26     0.24  0.33      0.21    0.31     0.01
## Foretinib                  -0.03    -0.30  0.00      0.12    0.16    -0.16
## JNK-IN-8                    0.25     0.15  0.06      0.19    0.17     0.14
## BGJ398                      0.08     0.23  0.22      0.03    0.31     0.05
## SGC 0946                    0.18    -0.07  0.25      0.27    0.04    -0.04
## D 4476                      0.18     0.19  0.36      0.26    0.47     0.11
## A-1210477                   0.03     0.32  0.28     -0.04    0.13    -0.13
## Cisplatin                   0.09     0.12  0.43      0.02    0.22    -0.08
##                      PF-3758309 Venetoclax Doxorubicine Panobinostat Selinexor
## AZD6738                    0.28       0.08         0.00         0.23      0.09
## Rapamycin                  0.38       0.10         0.06         0.24      0.15
## Ganetespib                 0.42       0.16         0.14         0.32      0.21
## Onalespib                  0.45       0.28         0.11         0.31      0.21
## Palbociclib                0.59       0.24         0.29         0.33      0.37
## Sunitinib                  0.42       0.10         0.22         0.38      0.29
## Midostaurin                0.33       0.13        -0.01         0.24      0.07
## Duvelisib                  0.34       0.03         0.03         0.16      0.16
## Idelalisib                 0.31       0.04         0.04         0.16      0.12
## Dasatinib                  0.38       0.08        -0.02         0.06      0.11
## PRT062607                  0.34       0.12         0.10         0.04      0.23
## Ibrutinib                  0.29       0.04         0.06         0.07      0.14
## ONO-4059                   0.23       0.06         0.12         0.09      0.18
## Cobimetinib                0.15      -0.17        -0.03         0.05      0.17
## SCH772984                  0.27      -0.11         0.05         0.19      0.25
## Trametinib                 0.28      -0.08        -0.01         0.14      0.16
## A-674563                   0.50       0.18         0.25         0.26      0.38
## Tozasertib                 0.26       0.04         0.09         0.05      0.23
## BMS-509744                -0.02      -0.03        -0.16        -0.07     -0.03
## Ceritinib                  0.10       0.21        -0.19        -0.11      0.02
## MK-2206                    0.26       0.08         0.04         0.13      0.21
## AZD1208                    0.26       0.17        -0.25         0.01     -0.01
## AZD8055                    0.34       0.08        -0.16         0.03      0.19
## Dabrafenib                -0.10      -0.08         0.09         0.03      0.04
## Imatinib                   0.16      -0.11        -0.05        -0.01      0.12
## KU-55933                   0.04      -0.14         0.04         0.03      0.03
## Quizartinib                0.20      -0.01         0.09         0.10      0.06
## Afatinib                   0.24       0.34         0.20         0.17      0.16
## TW-37                     -0.03       0.12         0.30         0.23      0.20
## ZM 336372                  0.08       0.21        -0.15        -0.12      0.07
## BML-277                   -0.04       0.11        -0.08        -0.06     -0.03
## EPZ-6438                  -0.13       0.01        -0.02        -0.06     -0.09
## PF-3758309                 1.00       0.39         0.12         0.26      0.32
## Venetoclax                 0.39       1.00         0.00         0.02      0.05
## Doxorubicine               0.12       0.00         1.00         0.44      0.44
## Panobinostat               0.26       0.02         0.44         1.00      0.31
## Selinexor                  0.32       0.05         0.44         0.31      1.00
## OTX015                     0.36       0.08         0.46         0.56      0.36
## Volasertib                 0.29       0.06         0.36         0.45      0.36
## Nutlin-3a                  0.36       0.20         0.22         0.31      0.37
## RO5963                     0.38       0.22         0.22         0.35      0.40
## Cytarabine                 0.36       0.18         0.42         0.32      0.35
## Fludarabine                0.41       0.15         0.37         0.52      0.42
## Ruxolitinib                0.16      -0.14        -0.04         0.04      0.23
## Tofacitinib                0.30       0.00        -0.17         0.05      0.15
## Motolimod                 -0.12      -0.06         0.25         0.05      0.17
## Menin-MLL Inhibitor        0.11       0.01         0.03        -0.01      0.04
## MI-503                     0.10       0.17        -0.16         0.07      0.06
## Olaparib                  -0.12      -0.03        -0.27        -0.17     -0.12
## SB 203580                 -0.05      -0.16        -0.04        -0.13      0.17
## AMI-1                      0.07       0.05        -0.08        -0.07      0.09
## Vismodegib                 0.10      -0.01         0.02        -0.08      0.15
## Methotrexate              -0.03      -0.18         0.03         0.04     -0.04
## IRAK-1/4 Inhibitor I       0.32       0.16         0.17         0.04      0.22
## Selisistat                 0.13       0.03         0.10         0.01      0.19
## Foretinib                 -0.14      -0.18        -0.17        -0.21     -0.01
## JNK-IN-8                   0.12       0.16         0.06        -0.18      0.05
## BGJ398                     0.11       0.11         0.05         0.13      0.13
## SGC 0946                   0.03      -0.09         0.10         0.03      0.22
## D 4476                    -0.08       0.02         0.11        -0.04      0.19
## A-1210477                  0.16       0.17         0.21         0.14      0.22
## Cisplatin                  0.04      -0.05         0.31         0.13      0.14
##                      OTX015 Volasertib Nutlin-3a RO5963 Cytarabine Fludarabine
## AZD6738                0.22       0.34      0.28   0.33       0.16        0.22
## Rapamycin              0.35       0.24      0.39   0.37       0.20        0.26
## Ganetespib             0.42       0.42      0.55   0.44       0.45        0.32
## Onalespib              0.42       0.41      0.56   0.46       0.44        0.32
## Palbociclib            0.46       0.47      0.59   0.47       0.47        0.37
## Sunitinib              0.51       0.59      0.52   0.45       0.43        0.33
## Midostaurin            0.12       0.09      0.36   0.32       0.20        0.16
## Duvelisib              0.31       0.30      0.48   0.42       0.32        0.21
## Idelalisib             0.25       0.25      0.44   0.39       0.29        0.19
## Dasatinib              0.22       0.23      0.45   0.36       0.30        0.11
## PRT062607              0.29       0.34      0.48   0.41       0.34        0.12
## Ibrutinib              0.29       0.30      0.47   0.40       0.34        0.14
## ONO-4059               0.31       0.32      0.46   0.38       0.31        0.13
## Cobimetinib            0.26       0.31      0.46   0.42       0.29        0.17
## SCH772984              0.35       0.38      0.52   0.50       0.33        0.29
## Trametinib             0.29       0.29      0.51   0.47       0.33        0.25
## A-674563               0.49       0.58      0.46   0.43       0.39        0.35
## Tozasertib             0.22       0.42      0.37   0.33       0.25        0.09
## BMS-509744            -0.08       0.08      0.02   0.03      -0.04       -0.10
## Ceritinib             -0.07       0.11      0.07   0.07       0.03       -0.08
## MK-2206                0.09       0.14      0.27   0.22       0.14        0.10
## AZD1208               -0.22      -0.13      0.05   0.04      -0.07       -0.10
## AZD8055                0.02       0.21      0.30   0.31       0.07        0.05
## Dabrafenib             0.10       0.12      0.22   0.12       0.17        0.03
## Imatinib               0.00       0.07      0.20   0.16       0.08       -0.11
## KU-55933               0.11       0.10      0.17   0.12       0.08       -0.07
## Quizartinib            0.01       0.09     -0.04   0.00       0.02        0.16
## Afatinib               0.23       0.19      0.22   0.14       0.29        0.27
## TW-37                  0.37       0.45      0.14   0.14       0.29        0.30
## ZM 336372             -0.07       0.04     -0.02   0.04      -0.06       -0.02
## BML-277               -0.09       0.03     -0.09  -0.06      -0.08       -0.03
## EPZ-6438              -0.11      -0.15     -0.14  -0.14      -0.06       -0.05
## PF-3758309             0.36       0.29      0.36   0.38       0.36        0.41
## Venetoclax             0.08       0.06      0.20   0.22       0.18        0.15
## Doxorubicine           0.46       0.36      0.22   0.22       0.42        0.37
## Panobinostat           0.56       0.45      0.31   0.35       0.32        0.52
## Selinexor              0.36       0.36      0.37   0.40       0.35        0.42
## OTX015                 1.00       0.85      0.54   0.49       0.52        0.56
## Volasertib             0.85       1.00      0.55   0.47       0.49        0.47
## Nutlin-3a              0.54       0.55      1.00   0.88       0.70        0.63
## RO5963                 0.49       0.47      0.88   1.00       0.59        0.59
## Cytarabine             0.52       0.49      0.70   0.59       1.00        0.73
## Fludarabine            0.56       0.47      0.63   0.59       0.73        1.00
## Ruxolitinib            0.08       0.22      0.16   0.16       0.06        0.03
## Tofacitinib           -0.03       0.03      0.09   0.16       0.01        0.06
## Motolimod              0.20       0.17      0.05   0.02       0.12        0.09
## Menin-MLL Inhibitor    0.04      -0.06      0.14   0.11       0.11        0.02
## MI-503                -0.16      -0.09     -0.03   0.00      -0.09       -0.10
## Olaparib              -0.28      -0.13      0.02   0.01      -0.11       -0.27
## SB 203580              0.10       0.28      0.19   0.20       0.08       -0.01
## AMI-1                 -0.01       0.22      0.08   0.16       0.05        0.01
## Vismodegib             0.07       0.29      0.21   0.22       0.11        0.04
## Methotrexate           0.01       0.13      0.08   0.06       0.03        0.03
## IRAK-1/4 Inhibitor I   0.20       0.20      0.31   0.28       0.25        0.15
## Selisistat             0.15       0.21      0.29   0.30       0.19        0.07
## Foretinib             -0.13       0.10     -0.06  -0.05      -0.09       -0.24
## JNK-IN-8              -0.08      -0.01      0.07  -0.01       0.10       -0.02
## BGJ398                 0.16       0.30      0.08   0.09       0.08        0.13
## SGC 0946               0.21       0.38      0.07   0.12       0.05        0.04
## D 4476                 0.15       0.33      0.10   0.10       0.09        0.05
## A-1210477              0.38       0.47      0.35   0.28       0.32        0.24
## Cisplatin              0.38       0.49      0.21   0.15       0.37        0.23
##                      Ruxolitinib Tofacitinib Motolimod Menin-MLL Inhibitor
## AZD6738                     0.25        0.19     -0.11               -0.10
## Rapamycin                   0.11        0.14      0.12                0.22
## Ganetespib                  0.13        0.00     -0.06                0.03
## Onalespib                   0.11        0.05     -0.05                0.11
## Palbociclib                 0.20        0.05      0.04                0.12
## Sunitinib                   0.30        0.08      0.00               -0.01
## Midostaurin                 0.22        0.10     -0.01                0.17
## Duvelisib                   0.22       -0.10     -0.06               -0.08
## Idelalisib                  0.22       -0.11     -0.06               -0.02
## Dasatinib                   0.33        0.06     -0.09               -0.03
## PRT062607                   0.29       -0.01      0.00                0.00
## Ibrutinib                   0.30       -0.04     -0.01               -0.01
## ONO-4059                    0.25       -0.12      0.05               -0.04
## Cobimetinib                 0.52        0.16     -0.08               -0.09
## SCH772984                   0.57        0.23     -0.06               -0.06
## Trametinib                  0.49        0.17     -0.14               -0.11
## A-674563                    0.32        0.22     -0.10                0.02
## Tozasertib                  0.31        0.02      0.00               -0.10
## BMS-509744                  0.30        0.12     -0.09               -0.08
## Ceritinib                   0.15        0.10     -0.05                0.10
## MK-2206                     0.24        0.11      0.05                0.29
## AZD1208                     0.21        0.10     -0.25               -0.02
## AZD8055                     0.43        0.23     -0.11               -0.03
## Dabrafenib                  0.05       -0.18      0.13                0.00
## Imatinib                    0.38        0.12      0.04                0.24
## KU-55933                    0.24        0.00      0.21                0.44
## Quizartinib                 0.03        0.19      0.00                0.05
## Afatinib                   -0.02        0.15      0.11                0.25
## TW-37                       0.08        0.04      0.14                0.03
## ZM 336372                  -0.03        0.26      0.07                0.10
## BML-277                    -0.01        0.17      0.13                0.16
## EPZ-6438                   -0.17        0.02      0.21                0.24
## PF-3758309                  0.16        0.30     -0.12                0.11
## Venetoclax                 -0.14        0.00     -0.06                0.01
## Doxorubicine               -0.04       -0.17      0.25                0.03
## Panobinostat                0.04        0.05      0.05               -0.01
## Selinexor                   0.23        0.15      0.17                0.04
## OTX015                      0.08       -0.03      0.20                0.04
## Volasertib                  0.22        0.03      0.17               -0.06
## Nutlin-3a                   0.16        0.09      0.05                0.14
## RO5963                      0.16        0.16      0.02                0.11
## Cytarabine                  0.06        0.01      0.12                0.11
## Fludarabine                 0.03        0.06      0.09                0.02
## Ruxolitinib                 1.00        0.59      0.06                0.07
## Tofacitinib                 0.59        1.00      0.03                0.21
## Motolimod                   0.06        0.03      1.00                0.30
## Menin-MLL Inhibitor         0.07        0.21      0.30                1.00
## MI-503                      0.14        0.23      0.16                0.32
## Olaparib                    0.25        0.30      0.12                0.31
## SB 203580                   0.37        0.35      0.22                0.21
## AMI-1                       0.21        0.38      0.12                0.22
## Vismodegib                  0.36        0.35      0.17                0.25
## Methotrexate                0.16        0.09      0.09                0.16
## IRAK-1/4 Inhibitor I        0.17        0.25      0.18                0.52
## Selisistat                  0.21        0.26      0.25                0.39
## Foretinib                   0.23        0.01     -0.03               -0.18
## JNK-IN-8                    0.03        0.00      0.05                0.17
## BGJ398                      0.14        0.03      0.04               -0.13
## SGC 0946                    0.36        0.13      0.17               -0.05
## D 4476                      0.09        0.04      0.20                0.02
## A-1210477                   0.10       -0.08      0.07               -0.04
## Cisplatin                   0.22       -0.05      0.17                0.02
##                      MI-503 Olaparib SB 203580 AMI-1 Vismodegib Methotrexate
## AZD6738                0.01     0.01      0.01  0.36       0.25         0.29
## Rapamycin              0.06    -0.13      0.05  0.09       0.12         0.08
## Ganetespib            -0.07    -0.01      0.03 -0.10      -0.05        -0.02
## Onalespib             -0.03     0.00      0.05 -0.07      -0.03        -0.04
## Palbociclib            0.10    -0.06     -0.01  0.05       0.17         0.09
## Sunitinib              0.04    -0.11      0.13  0.09       0.16         0.23
## Midostaurin            0.04     0.09     -0.14 -0.14      -0.11         0.11
## Duvelisib             -0.21    -0.07     -0.10 -0.17      -0.11        -0.10
## Idelalisib            -0.13    -0.02     -0.10 -0.10      -0.04        -0.02
## Dasatinib             -0.10     0.08      0.02 -0.15      -0.07        -0.09
## PRT062607             -0.15     0.07      0.08 -0.05       0.01        -0.10
## Ibrutinib             -0.18     0.04      0.04 -0.14      -0.07        -0.09
## ONO-4059              -0.18     0.01      0.01 -0.17      -0.09        -0.13
## Cobimetinib           -0.09     0.14      0.20 -0.01       0.09         0.02
## SCH772984             -0.12     0.05      0.20  0.02       0.12         0.06
## Trametinib            -0.18     0.02      0.09 -0.13      -0.04        -0.05
## A-674563               0.12    -0.10      0.19  0.28       0.35         0.11
## Tozasertib             0.09     0.10      0.24  0.19       0.29         0.12
## BMS-509744             0.05     0.26      0.12  0.29       0.26         0.05
## Ceritinib              0.31     0.32      0.19  0.42       0.39         0.08
## MK-2206                0.31     0.25      0.16  0.11       0.21         0.16
## AZD1208                0.10     0.28     -0.13  0.01      -0.02        -0.06
## AZD8055                0.22     0.30      0.24  0.30       0.34         0.16
## Dabrafenib            -0.12     0.10      0.09  0.02       0.03        -0.14
## Imatinib               0.38     0.39      0.20  0.11       0.24         0.34
## KU-55933               0.15     0.30      0.20  0.05       0.17         0.16
## Quizartinib            0.16    -0.17      0.12  0.29       0.29         0.33
## Afatinib               0.15    -0.12      0.02  0.19       0.18         0.07
## TW-37                  0.12    -0.08      0.19  0.34       0.38         0.22
## ZM 336372              0.22     0.07      0.23  0.41       0.28         0.07
## BML-277                0.42     0.19      0.17  0.45       0.43         0.25
## EPZ-6438               0.10    -0.01     -0.08  0.05      -0.03        -0.13
## PF-3758309             0.10    -0.12     -0.05  0.07       0.10        -0.03
## Venetoclax             0.17    -0.03     -0.16  0.05      -0.01        -0.18
## Doxorubicine          -0.16    -0.27     -0.04 -0.08       0.02         0.03
## Panobinostat           0.07    -0.17     -0.13 -0.07      -0.08         0.04
## Selinexor              0.06    -0.12      0.17  0.09       0.15        -0.04
## OTX015                -0.16    -0.28      0.10 -0.01       0.07         0.01
## Volasertib            -0.09    -0.13      0.28  0.22       0.29         0.13
## Nutlin-3a             -0.03     0.02      0.19  0.08       0.21         0.08
## RO5963                 0.00     0.01      0.20  0.16       0.22         0.06
## Cytarabine            -0.09    -0.11      0.08  0.05       0.11         0.03
## Fludarabine           -0.10    -0.27     -0.01  0.01       0.04         0.03
## Ruxolitinib            0.14     0.25      0.37  0.21       0.36         0.16
## Tofacitinib            0.23     0.30      0.35  0.38       0.35         0.09
## Motolimod              0.16     0.12      0.22  0.12       0.17         0.09
## Menin-MLL Inhibitor    0.32     0.31      0.21  0.22       0.25         0.16
## MI-503                 1.00     0.44      0.15  0.35       0.36         0.34
## Olaparib               0.44     1.00      0.33  0.38       0.40         0.25
## SB 203580              0.15     0.33      1.00  0.45       0.57         0.22
## AMI-1                  0.35     0.38      0.45  1.00       0.75         0.36
## Vismodegib             0.36     0.40      0.57  0.75       1.00         0.43
## Methotrexate           0.34     0.25      0.22  0.36       0.43         1.00
## IRAK-1/4 Inhibitor I   0.37     0.19      0.31  0.42       0.57         0.45
## Selisistat             0.39     0.33      0.47  0.61       0.72         0.45
## Foretinib              0.20     0.31      0.40  0.23       0.28         0.23
## JNK-IN-8               0.20     0.09      0.10  0.11       0.16         0.02
## BGJ398                 0.18    -0.02      0.00  0.23       0.17         0.05
## SGC 0946               0.03     0.01      0.38  0.41       0.31         0.08
## D 4476                 0.13     0.06      0.31  0.47       0.44         0.17
## A-1210477              0.04    -0.03      0.12  0.26       0.33         0.14
## Cisplatin              0.17     0.05      0.23  0.33       0.41         0.37
##                      IRAK-1/4 Inhibitor I Selisistat Foretinib JNK-IN-8 BGJ398
## AZD6738                              0.22       0.24      0.01    -0.06   0.17
## Rapamycin                            0.28       0.37     -0.34    -0.22  -0.04
## Ganetespib                           0.14       0.03      0.08     0.10   0.04
## Onalespib                            0.20       0.07      0.01     0.06   0.05
## Palbociclib                          0.39       0.33     -0.10     0.15   0.19
## Sunitinib                            0.30       0.24      0.09     0.04   0.24
## Midostaurin                          0.21       0.03     -0.16     0.05   0.04
## Duvelisib                            0.07       0.02      0.02    -0.04   0.02
## Idelalisib                           0.13       0.06      0.07     0.09   0.00
## Dasatinib                            0.09      -0.01      0.11     0.09  -0.02
## PRT062607                            0.15       0.13      0.16     0.13   0.02
## Ibrutinib                            0.11       0.05      0.15     0.06   0.01
## ONO-4059                             0.05       0.05      0.12     0.04   0.01
## Cobimetinib                          0.03       0.09      0.20    -0.11   0.09
## SCH772984                            0.08       0.09      0.05    -0.12   0.12
## Trametinib                           0.00      -0.01      0.03    -0.10   0.06
## A-674563                             0.36       0.34      0.08     0.13   0.23
## Tozasertib                           0.22       0.28      0.45     0.14   0.22
## BMS-509744                           0.10       0.16      0.29     0.12   0.15
## Ceritinib                            0.29       0.29      0.30     0.27   0.30
## MK-2206                              0.30       0.29      0.06     0.13  -0.01
## AZD1208                              0.00      -0.06      0.14     0.19   0.00
## AZD8055                              0.25       0.26      0.36     0.19   0.17
## Dabrafenib                           0.05       0.06      0.01     0.17   0.00
## Imatinib                             0.39       0.32      0.33     0.18   0.07
## KU-55933                             0.32       0.25      0.06     0.11  -0.04
## Quizartinib                          0.28       0.26     -0.03     0.25   0.08
## Afatinib                             0.36       0.24     -0.30     0.15   0.23
## TW-37                                0.17       0.33      0.00     0.06   0.22
## ZM 336372                            0.10       0.21      0.12     0.19   0.03
## BML-277                              0.23       0.31      0.16     0.17   0.31
## EPZ-6438                            -0.01       0.01     -0.16     0.14   0.05
## PF-3758309                           0.32       0.13     -0.14     0.12   0.11
## Venetoclax                           0.16       0.03     -0.18     0.16   0.11
## Doxorubicine                         0.17       0.10     -0.17     0.06   0.05
## Panobinostat                         0.04       0.01     -0.21    -0.18   0.13
## Selinexor                            0.22       0.19     -0.01     0.05   0.13
## OTX015                               0.20       0.15     -0.13    -0.08   0.16
## Volasertib                           0.20       0.21      0.10    -0.01   0.30
## Nutlin-3a                            0.31       0.29     -0.06     0.07   0.08
## RO5963                               0.28       0.30     -0.05    -0.01   0.09
## Cytarabine                           0.25       0.19     -0.09     0.10   0.08
## Fludarabine                          0.15       0.07     -0.24    -0.02   0.13
## Ruxolitinib                          0.17       0.21      0.23     0.03   0.14
## Tofacitinib                          0.25       0.26      0.01     0.00   0.03
## Motolimod                            0.18       0.25     -0.03     0.05   0.04
## Menin-MLL Inhibitor                  0.52       0.39     -0.18     0.17  -0.13
## MI-503                               0.37       0.39      0.20     0.20   0.18
## Olaparib                             0.19       0.33      0.31     0.09  -0.02
## SB 203580                            0.31       0.47      0.40     0.10   0.00
## AMI-1                                0.42       0.61      0.23     0.11   0.23
## Vismodegib                           0.57       0.72      0.28     0.16   0.17
## Methotrexate                         0.45       0.45      0.23     0.02   0.05
## IRAK-1/4 Inhibitor I                 1.00       0.65     -0.02     0.26   0.08
## Selisistat                           0.65       1.00      0.09     0.06  -0.01
## Foretinib                           -0.02       0.09      1.00     0.29   0.15
## JNK-IN-8                             0.26       0.06      0.29     1.00   0.07
## BGJ398                               0.08      -0.01      0.15     0.07   1.00
## SGC 0946                             0.09       0.28      0.30     0.04   0.27
## D 4476                               0.21       0.37      0.31     0.17   0.29
## A-1210477                            0.32       0.36      0.02     0.03   0.31
## Cisplatin                            0.35       0.39      0.36     0.12   0.38
##                      SGC 0946 D 4476 A-1210477 Cisplatin
## AZD6738                  0.30   0.10      0.34      0.28
## Rapamycin                0.07  -0.08      0.33      0.08
## Ganetespib              -0.02  -0.10      0.17      0.14
## Onalespib               -0.06  -0.09      0.18      0.10
## Palbociclib              0.14   0.05      0.47      0.29
## Sunitinib                0.22   0.05      0.38      0.37
## Midostaurin             -0.04  -0.30      0.11      0.02
## Duvelisib                0.14  -0.17      0.32      0.16
## Idelalisib               0.15  -0.16      0.34      0.24
## Dasatinib                0.06  -0.18      0.19      0.07
## PRT062607                0.20  -0.05      0.30      0.23
## Ibrutinib                0.16  -0.14      0.28      0.24
## ONO-4059                 0.21  -0.12      0.30      0.21
## Cobimetinib              0.25   0.07      0.26      0.27
## SCH772984                0.29  -0.06      0.25      0.24
## Trametinib               0.20  -0.19      0.22      0.16
## A-674563                 0.41   0.23      0.49      0.39
## Tozasertib               0.35   0.20      0.36      0.43
## BMS-509744               0.18   0.23      0.26      0.20
## Ceritinib                0.16   0.35      0.30      0.20
## MK-2206                  0.11  -0.06      0.24      0.14
## AZD1208                  0.01  -0.17      0.05     -0.07
## AZD8055                  0.30   0.15      0.28      0.23
## Dabrafenib               0.15   0.10      0.34      0.09
## Imatinib                 0.13  -0.04      0.12      0.27
## KU-55933                 0.13  -0.09      0.10      0.21
## Quizartinib              0.18   0.18      0.03      0.09
## Afatinib                -0.07   0.19      0.32      0.12
## TW-37                    0.25   0.36      0.28      0.43
## ZM 336372                0.27   0.26     -0.04      0.02
## BML-277                  0.04   0.47      0.13      0.22
## EPZ-6438                -0.04   0.11     -0.13     -0.08
## PF-3758309               0.03  -0.08      0.16      0.04
## Venetoclax              -0.09   0.02      0.17     -0.05
## Doxorubicine             0.10   0.11      0.21      0.31
## Panobinostat             0.03  -0.04      0.14      0.13
## Selinexor                0.22   0.19      0.22      0.14
## OTX015                   0.21   0.15      0.38      0.38
## Volasertib               0.38   0.33      0.47      0.49
## Nutlin-3a                0.07   0.10      0.35      0.21
## RO5963                   0.12   0.10      0.28      0.15
## Cytarabine               0.05   0.09      0.32      0.37
## Fludarabine              0.04   0.05      0.24      0.23
## Ruxolitinib              0.36   0.09      0.10      0.22
## Tofacitinib              0.13   0.04     -0.08     -0.05
## Motolimod                0.17   0.20      0.07      0.17
## Menin-MLL Inhibitor     -0.05   0.02     -0.04      0.02
## MI-503                   0.03   0.13      0.04      0.17
## Olaparib                 0.01   0.06     -0.03      0.05
## SB 203580                0.38   0.31      0.12      0.23
## AMI-1                    0.41   0.47      0.26      0.33
## Vismodegib               0.31   0.44      0.33      0.41
## Methotrexate             0.08   0.17      0.14      0.37
## IRAK-1/4 Inhibitor I     0.09   0.21      0.32      0.35
## Selisistat               0.28   0.37      0.36      0.39
## Foretinib                0.30   0.31      0.02      0.36
## JNK-IN-8                 0.04   0.17      0.03      0.12
## BGJ398                   0.27   0.29      0.31      0.38
## SGC 0946                 1.00   0.35      0.31      0.37
## D 4476                   0.35   1.00      0.36      0.41
## A-1210477                0.31   0.36      1.00      0.48
## Cisplatin                0.37   0.41      0.48      1.00
## 
## $corrPos
##                     xName                yName  x  y  corr
## 1                 AZD6738              AZD6738  1 62  1.00
## 2                 AZD6738            Rapamycin  1 61  0.30
## 3                 AZD6738           Ganetespib  1 60  0.28
## 4                 AZD6738            Onalespib  1 59  0.25
## 5                 AZD6738          Palbociclib  1 58  0.41
## 6                 AZD6738            Sunitinib  1 57  0.48
## 7                 AZD6738          Midostaurin  1 56  0.37
## 8                 AZD6738            Duvelisib  1 55  0.38
## 9                 AZD6738           Idelalisib  1 54  0.42
## 10                AZD6738            Dasatinib  1 53  0.30
## 11                AZD6738            PRT062607  1 52  0.29
## 12                AZD6738            Ibrutinib  1 51  0.32
## 13                AZD6738             ONO-4059  1 50  0.28
## 14                AZD6738          Cobimetinib  1 49  0.27
## 15                AZD6738            SCH772984  1 48  0.34
## 16                AZD6738           Trametinib  1 47  0.33
## 17                AZD6738             A-674563  1 46  0.44
## 18                AZD6738           Tozasertib  1 45  0.31
## 19                AZD6738           BMS-509744  1 44  0.34
## 20                AZD6738            Ceritinib  1 43  0.26
## 21                AZD6738              MK-2206  1 42  0.20
## 22                AZD6738              AZD1208  1 41  0.34
## 23                AZD6738              AZD8055  1 40  0.48
## 24                AZD6738           Dabrafenib  1 39  0.10
## 25                AZD6738             Imatinib  1 38  0.24
## 26                AZD6738             KU-55933  1 37  0.08
## 27                AZD6738          Quizartinib  1 36  0.10
## 28                AZD6738             Afatinib  1 35  0.05
## 29                AZD6738                TW-37  1 34  0.16
## 30                AZD6738            ZM 336372  1 33  0.18
## 31                AZD6738              BML-277  1 32 -0.02
## 32                AZD6738             EPZ-6438  1 31 -0.24
## 33                AZD6738           PF-3758309  1 30  0.28
## 34                AZD6738           Venetoclax  1 29  0.08
## 35                AZD6738         Doxorubicine  1 28  0.00
## 36                AZD6738         Panobinostat  1 27  0.23
## 37                AZD6738            Selinexor  1 26  0.09
## 38                AZD6738               OTX015  1 25  0.22
## 39                AZD6738           Volasertib  1 24  0.34
## 40                AZD6738            Nutlin-3a  1 23  0.28
## 41                AZD6738               RO5963  1 22  0.33
## 42                AZD6738           Cytarabine  1 21  0.16
## 43                AZD6738          Fludarabine  1 20  0.22
## 44                AZD6738          Ruxolitinib  1 19  0.25
## 45                AZD6738          Tofacitinib  1 18  0.19
## 46                AZD6738            Motolimod  1 17 -0.11
## 47                AZD6738  Menin-MLL Inhibitor  1 16 -0.10
## 48                AZD6738               MI-503  1 15  0.01
## 49                AZD6738             Olaparib  1 14  0.01
## 50                AZD6738            SB 203580  1 13  0.01
## 51                AZD6738                AMI-1  1 12  0.36
## 52                AZD6738           Vismodegib  1 11  0.25
## 53                AZD6738         Methotrexate  1 10  0.29
## 54                AZD6738 IRAK-1/4 Inhibitor I  1  9  0.22
## 55                AZD6738           Selisistat  1  8  0.24
## 56                AZD6738            Foretinib  1  7  0.01
## 57                AZD6738             JNK-IN-8  1  6 -0.06
## 58                AZD6738               BGJ398  1  5  0.17
## 59                AZD6738             SGC 0946  1  4  0.30
## 60                AZD6738               D 4476  1  3  0.10
## 61                AZD6738            A-1210477  1  2  0.34
## 62                AZD6738            Cisplatin  1  1  0.28
## 63              Rapamycin            Rapamycin  2 61  1.00
## 64              Rapamycin           Ganetespib  2 60  0.33
## 65              Rapamycin            Onalespib  2 59  0.34
## 66              Rapamycin          Palbociclib  2 58  0.49
## 67              Rapamycin            Sunitinib  2 57  0.39
## 68              Rapamycin          Midostaurin  2 56  0.34
## 69              Rapamycin            Duvelisib  2 55  0.42
## 70              Rapamycin           Idelalisib  2 54  0.41
## 71              Rapamycin            Dasatinib  2 53  0.22
## 72              Rapamycin            PRT062607  2 52  0.25
## 73              Rapamycin            Ibrutinib  2 51  0.28
## 74              Rapamycin             ONO-4059  2 50  0.31
## 75              Rapamycin          Cobimetinib  2 49  0.26
## 76              Rapamycin            SCH772984  2 48  0.37
## 77              Rapamycin           Trametinib  2 47  0.37
## 78              Rapamycin             A-674563  2 46  0.34
## 79              Rapamycin           Tozasertib  2 45  0.25
## 80              Rapamycin           BMS-509744  2 44  0.03
## 81              Rapamycin            Ceritinib  2 43 -0.02
## 82              Rapamycin              MK-2206  2 42  0.44
## 83              Rapamycin              AZD1208  2 41  0.12
## 84              Rapamycin              AZD8055  2 40  0.26
## 85              Rapamycin           Dabrafenib  2 39  0.10
## 86              Rapamycin             Imatinib  2 38  0.14
## 87              Rapamycin             KU-55933  2 37  0.29
## 88              Rapamycin          Quizartinib  2 36  0.05
## 89              Rapamycin             Afatinib  2 35  0.20
## 90              Rapamycin                TW-37  2 34  0.04
## 91              Rapamycin            ZM 336372  2 33  0.03
## 92              Rapamycin              BML-277  2 32 -0.08
## 93              Rapamycin             EPZ-6438  2 31 -0.06
## 94              Rapamycin           PF-3758309  2 30  0.38
## 95              Rapamycin           Venetoclax  2 29  0.10
## 96              Rapamycin         Doxorubicine  2 28  0.06
## 97              Rapamycin         Panobinostat  2 27  0.24
## 98              Rapamycin            Selinexor  2 26  0.15
## 99              Rapamycin               OTX015  2 25  0.35
## 100             Rapamycin           Volasertib  2 24  0.24
## 101             Rapamycin            Nutlin-3a  2 23  0.39
## 102             Rapamycin               RO5963  2 22  0.37
## 103             Rapamycin           Cytarabine  2 21  0.20
## 104             Rapamycin          Fludarabine  2 20  0.26
## 105             Rapamycin          Ruxolitinib  2 19  0.11
## 106             Rapamycin          Tofacitinib  2 18  0.14
## 107             Rapamycin            Motolimod  2 17  0.12
## 108             Rapamycin  Menin-MLL Inhibitor  2 16  0.22
## 109             Rapamycin               MI-503  2 15  0.06
## 110             Rapamycin             Olaparib  2 14 -0.13
## 111             Rapamycin            SB 203580  2 13  0.05
## 112             Rapamycin                AMI-1  2 12  0.09
## 113             Rapamycin           Vismodegib  2 11  0.12
## 114             Rapamycin         Methotrexate  2 10  0.08
## 115             Rapamycin IRAK-1/4 Inhibitor I  2  9  0.28
## 116             Rapamycin           Selisistat  2  8  0.37
## 117             Rapamycin            Foretinib  2  7 -0.34
## 118             Rapamycin             JNK-IN-8  2  6 -0.22
## 119             Rapamycin               BGJ398  2  5 -0.04
## 120             Rapamycin             SGC 0946  2  4  0.07
## 121             Rapamycin               D 4476  2  3 -0.08
## 122             Rapamycin            A-1210477  2  2  0.33
## 123             Rapamycin            Cisplatin  2  1  0.08
## 124            Ganetespib           Ganetespib  3 60  1.00
## 125            Ganetespib            Onalespib  3 59  0.96
## 126            Ganetespib          Palbociclib  3 58  0.69
## 127            Ganetespib            Sunitinib  3 57  0.69
## 128            Ganetespib          Midostaurin  3 56  0.60
## 129            Ganetespib            Duvelisib  3 55  0.66
## 130            Ganetespib           Idelalisib  3 54  0.62
## 131            Ganetespib            Dasatinib  3 53  0.75
## 132            Ganetespib            PRT062607  3 52  0.70
## 133            Ganetespib            Ibrutinib  3 51  0.72
## 134            Ganetespib             ONO-4059  3 50  0.68
## 135            Ganetespib          Cobimetinib  3 49  0.47
## 136            Ganetespib            SCH772984  3 48  0.46
## 137            Ganetespib           Trametinib  3 47  0.54
## 138            Ganetespib             A-674563  3 46  0.41
## 139            Ganetespib           Tozasertib  3 45  0.51
## 140            Ganetespib           BMS-509744  3 44  0.07
## 141            Ganetespib            Ceritinib  3 43  0.12
## 142            Ganetespib              MK-2206  3 42  0.36
## 143            Ganetespib              AZD1208  3 41  0.31
## 144            Ganetespib              AZD8055  3 40  0.41
## 145            Ganetespib           Dabrafenib  3 39  0.24
## 146            Ganetespib             Imatinib  3 38  0.40
## 147            Ganetespib             KU-55933  3 37  0.33
## 148            Ganetespib          Quizartinib  3 36 -0.24
## 149            Ganetespib             Afatinib  3 35  0.04
## 150            Ganetespib                TW-37  3 34 -0.11
## 151            Ganetespib            ZM 336372  3 33 -0.11
## 152            Ganetespib              BML-277  3 32 -0.30
## 153            Ganetespib             EPZ-6438  3 31 -0.33
## 154            Ganetespib           PF-3758309  3 30  0.42
## 155            Ganetespib           Venetoclax  3 29  0.16
## 156            Ganetespib         Doxorubicine  3 28  0.14
## 157            Ganetespib         Panobinostat  3 27  0.32
## 158            Ganetespib            Selinexor  3 26  0.21
## 159            Ganetespib               OTX015  3 25  0.42
## 160            Ganetespib           Volasertib  3 24  0.42
## 161            Ganetespib            Nutlin-3a  3 23  0.55
## 162            Ganetespib               RO5963  3 22  0.44
## 163            Ganetespib           Cytarabine  3 21  0.45
## 164            Ganetespib          Fludarabine  3 20  0.32
## 165            Ganetespib          Ruxolitinib  3 19  0.13
## 166            Ganetespib          Tofacitinib  3 18  0.00
## 167            Ganetespib            Motolimod  3 17 -0.06
## 168            Ganetespib  Menin-MLL Inhibitor  3 16  0.03
## 169            Ganetespib               MI-503  3 15 -0.07
## 170            Ganetespib             Olaparib  3 14 -0.01
## 171            Ganetespib            SB 203580  3 13  0.03
## 172            Ganetespib                AMI-1  3 12 -0.10
## 173            Ganetespib           Vismodegib  3 11 -0.05
## 174            Ganetespib         Methotrexate  3 10 -0.02
## 175            Ganetespib IRAK-1/4 Inhibitor I  3  9  0.14
## 176            Ganetespib           Selisistat  3  8  0.03
## 177            Ganetespib            Foretinib  3  7  0.08
## 178            Ganetespib             JNK-IN-8  3  6  0.10
## 179            Ganetespib               BGJ398  3  5  0.04
## 180            Ganetespib             SGC 0946  3  4 -0.02
## 181            Ganetespib               D 4476  3  3 -0.10
## 182            Ganetespib            A-1210477  3  2  0.17
## 183            Ganetespib            Cisplatin  3  1  0.14
## 184             Onalespib            Onalespib  4 59  1.00
## 185             Onalespib          Palbociclib  4 58  0.69
## 186             Onalespib            Sunitinib  4 57  0.66
## 187             Onalespib          Midostaurin  4 56  0.58
## 188             Onalespib            Duvelisib  4 55  0.60
## 189             Onalespib           Idelalisib  4 54  0.55
## 190             Onalespib            Dasatinib  4 53  0.71
## 191             Onalespib            PRT062607  4 52  0.67
## 192             Onalespib            Ibrutinib  4 51  0.67
## 193             Onalespib             ONO-4059  4 50  0.63
## 194             Onalespib          Cobimetinib  4 49  0.40
## 195             Onalespib            SCH772984  4 48  0.39
## 196             Onalespib           Trametinib  4 47  0.47
## 197             Onalespib             A-674563  4 46  0.41
## 198             Onalespib           Tozasertib  4 45  0.46
## 199             Onalespib           BMS-509744  4 44  0.01
## 200             Onalespib            Ceritinib  4 43  0.15
## 201             Onalespib              MK-2206  4 42  0.32
## 202             Onalespib              AZD1208  4 41  0.28
## 203             Onalespib              AZD8055  4 40  0.37
## 204             Onalespib           Dabrafenib  4 39  0.17
## 205             Onalespib             Imatinib  4 38  0.37
## 206             Onalespib             KU-55933  4 37  0.29
## 207             Onalespib          Quizartinib  4 36 -0.22
## 208             Onalespib             Afatinib  4 35  0.13
## 209             Onalespib                TW-37  4 34 -0.05
## 210             Onalespib            ZM 336372  4 33 -0.05
## 211             Onalespib              BML-277  4 32 -0.25
## 212             Onalespib             EPZ-6438  4 31 -0.30
## 213             Onalespib           PF-3758309  4 30  0.45
## 214             Onalespib           Venetoclax  4 29  0.28
## 215             Onalespib         Doxorubicine  4 28  0.11
## 216             Onalespib         Panobinostat  4 27  0.31
## 217             Onalespib            Selinexor  4 26  0.21
## 218             Onalespib               OTX015  4 25  0.42
## 219             Onalespib           Volasertib  4 24  0.41
## 220             Onalespib            Nutlin-3a  4 23  0.56
## 221             Onalespib               RO5963  4 22  0.46
## 222             Onalespib           Cytarabine  4 21  0.44
## 223             Onalespib          Fludarabine  4 20  0.32
## 224             Onalespib          Ruxolitinib  4 19  0.11
## 225             Onalespib          Tofacitinib  4 18  0.05
## 226             Onalespib            Motolimod  4 17 -0.05
## 227             Onalespib  Menin-MLL Inhibitor  4 16  0.11
## 228             Onalespib               MI-503  4 15 -0.03
## 229             Onalespib             Olaparib  4 14  0.00
## 230             Onalespib            SB 203580  4 13  0.05
## 231             Onalespib                AMI-1  4 12 -0.07
## 232             Onalespib           Vismodegib  4 11 -0.03
## 233             Onalespib         Methotrexate  4 10 -0.04
## 234             Onalespib IRAK-1/4 Inhibitor I  4  9  0.20
## 235             Onalespib           Selisistat  4  8  0.07
## 236             Onalespib            Foretinib  4  7  0.01
## 237             Onalespib             JNK-IN-8  4  6  0.06
## 238             Onalespib               BGJ398  4  5  0.05
## 239             Onalespib             SGC 0946  4  4 -0.06
## 240             Onalespib               D 4476  4  3 -0.09
## 241             Onalespib            A-1210477  4  2  0.18
## 242             Onalespib            Cisplatin  4  1  0.10
## 243           Palbociclib          Palbociclib  5 58  1.00
## 244           Palbociclib            Sunitinib  5 57  0.76
## 245           Palbociclib          Midostaurin  5 56  0.58
## 246           Palbociclib            Duvelisib  5 55  0.65
## 247           Palbociclib           Idelalisib  5 54  0.64
## 248           Palbociclib            Dasatinib  5 53  0.64
## 249           Palbociclib            PRT062607  5 52  0.69
## 250           Palbociclib            Ibrutinib  5 51  0.63
## 251           Palbociclib             ONO-4059  5 50  0.64
## 252           Palbociclib          Cobimetinib  5 49  0.38
## 253           Palbociclib            SCH772984  5 48  0.43
## 254           Palbociclib           Trametinib  5 47  0.46
## 255           Palbociclib             A-674563  5 46  0.65
## 256           Palbociclib           Tozasertib  5 45  0.54
## 257           Palbociclib           BMS-509744  5 44  0.17
## 258           Palbociclib            Ceritinib  5 43  0.21
## 259           Palbociclib              MK-2206  5 42  0.46
## 260           Palbociclib              AZD1208  5 41  0.30
## 261           Palbociclib              AZD8055  5 40  0.47
## 262           Palbociclib           Dabrafenib  5 39  0.27
## 263           Palbociclib             Imatinib  5 38  0.46
## 264           Palbociclib             KU-55933  5 37  0.29
## 265           Palbociclib          Quizartinib  5 36 -0.01
## 266           Palbociclib             Afatinib  5 35  0.21
## 267           Palbociclib                TW-37  5 34  0.08
## 268           Palbociclib            ZM 336372  5 33 -0.04
## 269           Palbociclib              BML-277  5 32 -0.14
## 270           Palbociclib             EPZ-6438  5 31 -0.24
## 271           Palbociclib           PF-3758309  5 30  0.59
## 272           Palbociclib           Venetoclax  5 29  0.24
## 273           Palbociclib         Doxorubicine  5 28  0.29
## 274           Palbociclib         Panobinostat  5 27  0.33
## 275           Palbociclib            Selinexor  5 26  0.37
## 276           Palbociclib               OTX015  5 25  0.46
## 277           Palbociclib           Volasertib  5 24  0.47
## 278           Palbociclib            Nutlin-3a  5 23  0.59
## 279           Palbociclib               RO5963  5 22  0.47
## 280           Palbociclib           Cytarabine  5 21  0.47
## 281           Palbociclib          Fludarabine  5 20  0.37
## 282           Palbociclib          Ruxolitinib  5 19  0.20
## 283           Palbociclib          Tofacitinib  5 18  0.05
## 284           Palbociclib            Motolimod  5 17  0.04
## 285           Palbociclib  Menin-MLL Inhibitor  5 16  0.12
## 286           Palbociclib               MI-503  5 15  0.10
## 287           Palbociclib             Olaparib  5 14 -0.06
## 288           Palbociclib            SB 203580  5 13 -0.01
## 289           Palbociclib                AMI-1  5 12  0.05
## 290           Palbociclib           Vismodegib  5 11  0.17
## 291           Palbociclib         Methotrexate  5 10  0.09
## 292           Palbociclib IRAK-1/4 Inhibitor I  5  9  0.39
## 293           Palbociclib           Selisistat  5  8  0.33
## 294           Palbociclib            Foretinib  5  7 -0.10
## 295           Palbociclib             JNK-IN-8  5  6  0.15
## 296           Palbociclib               BGJ398  5  5  0.19
## 297           Palbociclib             SGC 0946  5  4  0.14
## 298           Palbociclib               D 4476  5  3  0.05
## 299           Palbociclib            A-1210477  5  2  0.47
## 300           Palbociclib            Cisplatin  5  1  0.29
## 301             Sunitinib            Sunitinib  6 57  1.00
## 302             Sunitinib          Midostaurin  6 56  0.55
## 303             Sunitinib            Duvelisib  6 55  0.61
## 304             Sunitinib           Idelalisib  6 54  0.58
## 305             Sunitinib            Dasatinib  6 53  0.60
## 306             Sunitinib            PRT062607  6 52  0.65
## 307             Sunitinib            Ibrutinib  6 51  0.61
## 308             Sunitinib             ONO-4059  6 50  0.59
## 309             Sunitinib          Cobimetinib  6 49  0.46
## 310             Sunitinib            SCH772984  6 48  0.52
## 311             Sunitinib           Trametinib  6 47  0.51
## 312             Sunitinib             A-674563  6 46  0.64
## 313             Sunitinib           Tozasertib  6 45  0.61
## 314             Sunitinib           BMS-509744  6 44  0.23
## 315             Sunitinib            Ceritinib  6 43  0.21
## 316             Sunitinib              MK-2206  6 42  0.38
## 317             Sunitinib              AZD1208  6 41  0.25
## 318             Sunitinib              AZD8055  6 40  0.47
## 319             Sunitinib           Dabrafenib  6 39  0.23
## 320             Sunitinib             Imatinib  6 38  0.48
## 321             Sunitinib             KU-55933  6 37  0.25
## 322             Sunitinib          Quizartinib  6 36  0.02
## 323             Sunitinib             Afatinib  6 35  0.18
## 324             Sunitinib                TW-37  6 34  0.15
## 325             Sunitinib            ZM 336372  6 33 -0.11
## 326             Sunitinib              BML-277  6 32 -0.21
## 327             Sunitinib             EPZ-6438  6 31 -0.37
## 328             Sunitinib           PF-3758309  6 30  0.42
## 329             Sunitinib           Venetoclax  6 29  0.10
## 330             Sunitinib         Doxorubicine  6 28  0.22
## 331             Sunitinib         Panobinostat  6 27  0.38
## 332             Sunitinib            Selinexor  6 26  0.29
## 333             Sunitinib               OTX015  6 25  0.51
## 334             Sunitinib           Volasertib  6 24  0.59
## 335             Sunitinib            Nutlin-3a  6 23  0.52
## 336             Sunitinib               RO5963  6 22  0.45
## 337             Sunitinib           Cytarabine  6 21  0.43
## 338             Sunitinib          Fludarabine  6 20  0.33
## 339             Sunitinib          Ruxolitinib  6 19  0.30
## 340             Sunitinib          Tofacitinib  6 18  0.08
## 341             Sunitinib            Motolimod  6 17  0.00
## 342             Sunitinib  Menin-MLL Inhibitor  6 16 -0.01
## 343             Sunitinib               MI-503  6 15  0.04
## 344             Sunitinib             Olaparib  6 14 -0.11
## 345             Sunitinib            SB 203580  6 13  0.13
## 346             Sunitinib                AMI-1  6 12  0.09
## 347             Sunitinib           Vismodegib  6 11  0.16
## 348             Sunitinib         Methotrexate  6 10  0.23
## 349             Sunitinib IRAK-1/4 Inhibitor I  6  9  0.30
## 350             Sunitinib           Selisistat  6  8  0.24
## 351             Sunitinib            Foretinib  6  7  0.09
## 352             Sunitinib             JNK-IN-8  6  6  0.04
## 353             Sunitinib               BGJ398  6  5  0.24
## 354             Sunitinib             SGC 0946  6  4  0.22
## 355             Sunitinib               D 4476  6  3  0.05
## 356             Sunitinib            A-1210477  6  2  0.38
## 357             Sunitinib            Cisplatin  6  1  0.37
## 358           Midostaurin          Midostaurin  7 56  1.00
## 359           Midostaurin            Duvelisib  7 55  0.63
## 360           Midostaurin           Idelalisib  7 54  0.66
## 361           Midostaurin            Dasatinib  7 53  0.63
## 362           Midostaurin            PRT062607  7 52  0.58
## 363           Midostaurin            Ibrutinib  7 51  0.62
## 364           Midostaurin             ONO-4059  7 50  0.58
## 365           Midostaurin          Cobimetinib  7 49  0.35
## 366           Midostaurin            SCH772984  7 48  0.41
## 367           Midostaurin           Trametinib  7 47  0.51
## 368           Midostaurin             A-674563  7 46  0.27
## 369           Midostaurin           Tozasertib  7 45  0.36
## 370           Midostaurin           BMS-509744  7 44  0.19
## 371           Midostaurin            Ceritinib  7 43  0.11
## 372           Midostaurin              MK-2206  7 42  0.47
## 373           Midostaurin              AZD1208  7 41  0.50
## 374           Midostaurin              AZD8055  7 40  0.44
## 375           Midostaurin           Dabrafenib  7 39  0.28
## 376           Midostaurin             Imatinib  7 38  0.48
## 377           Midostaurin             KU-55933  7 37  0.47
## 378           Midostaurin          Quizartinib  7 36 -0.11
## 379           Midostaurin             Afatinib  7 35 -0.05
## 380           Midostaurin                TW-37  7 34 -0.21
## 381           Midostaurin            ZM 336372  7 33 -0.16
## 382           Midostaurin              BML-277  7 32 -0.30
## 383           Midostaurin             EPZ-6438  7 31 -0.23
## 384           Midostaurin           PF-3758309  7 30  0.33
## 385           Midostaurin           Venetoclax  7 29  0.13
## 386           Midostaurin         Doxorubicine  7 28 -0.01
## 387           Midostaurin         Panobinostat  7 27  0.24
## 388           Midostaurin            Selinexor  7 26  0.07
## 389           Midostaurin               OTX015  7 25  0.12
## 390           Midostaurin           Volasertib  7 24  0.09
## 391           Midostaurin            Nutlin-3a  7 23  0.36
## 392           Midostaurin               RO5963  7 22  0.32
## 393           Midostaurin           Cytarabine  7 21  0.20
## 394           Midostaurin          Fludarabine  7 20  0.16
## 395           Midostaurin          Ruxolitinib  7 19  0.22
## 396           Midostaurin          Tofacitinib  7 18  0.10
## 397           Midostaurin            Motolimod  7 17 -0.01
## 398           Midostaurin  Menin-MLL Inhibitor  7 16  0.17
## 399           Midostaurin               MI-503  7 15  0.04
## 400           Midostaurin             Olaparib  7 14  0.09
## 401           Midostaurin            SB 203580  7 13 -0.14
## 402           Midostaurin                AMI-1  7 12 -0.14
## 403           Midostaurin           Vismodegib  7 11 -0.11
## 404           Midostaurin         Methotrexate  7 10  0.11
## 405           Midostaurin IRAK-1/4 Inhibitor I  7  9  0.21
## 406           Midostaurin           Selisistat  7  8  0.03
## 407           Midostaurin            Foretinib  7  7 -0.16
## 408           Midostaurin             JNK-IN-8  7  6  0.05
## 409           Midostaurin               BGJ398  7  5  0.04
## 410           Midostaurin             SGC 0946  7  4 -0.04
## 411           Midostaurin               D 4476  7  3 -0.30
## 412           Midostaurin            A-1210477  7  2  0.11
## 413           Midostaurin            Cisplatin  7  1  0.02
## 414             Duvelisib            Duvelisib  8 55  1.00
## 415             Duvelisib           Idelalisib  8 54  0.93
## 416             Duvelisib            Dasatinib  8 53  0.82
## 417             Duvelisib            PRT062607  8 52  0.85
## 418             Duvelisib            Ibrutinib  8 51  0.89
## 419             Duvelisib             ONO-4059  8 50  0.87
## 420             Duvelisib          Cobimetinib  8 49  0.62
## 421             Duvelisib            SCH772984  8 48  0.59
## 422             Duvelisib           Trametinib  8 47  0.69
## 423             Duvelisib             A-674563  8 46  0.45
## 424             Duvelisib           Tozasertib  8 45  0.58
## 425             Duvelisib           BMS-509744  8 44  0.30
## 426             Duvelisib            Ceritinib  8 43  0.09
## 427             Duvelisib              MK-2206  8 42  0.39
## 428             Duvelisib              AZD1208  8 41  0.48
## 429             Duvelisib              AZD8055  8 40  0.53
## 430             Duvelisib           Dabrafenib  8 39  0.35
## 431             Duvelisib             Imatinib  8 38  0.50
## 432             Duvelisib             KU-55933  8 37  0.41
## 433             Duvelisib          Quizartinib  8 36 -0.30
## 434             Duvelisib             Afatinib  8 35 -0.21
## 435             Duvelisib                TW-37  8 34 -0.21
## 436             Duvelisib            ZM 336372  8 33 -0.25
## 437             Duvelisib              BML-277  8 32 -0.43
## 438             Duvelisib             EPZ-6438  8 31 -0.36
## 439             Duvelisib           PF-3758309  8 30  0.34
## 440             Duvelisib           Venetoclax  8 29  0.03
## 441             Duvelisib         Doxorubicine  8 28  0.03
## 442             Duvelisib         Panobinostat  8 27  0.16
## 443             Duvelisib            Selinexor  8 26  0.16
## 444             Duvelisib               OTX015  8 25  0.31
## 445             Duvelisib           Volasertib  8 24  0.30
## 446             Duvelisib            Nutlin-3a  8 23  0.48
## 447             Duvelisib               RO5963  8 22  0.42
## 448             Duvelisib           Cytarabine  8 21  0.32
## 449             Duvelisib          Fludarabine  8 20  0.21
## 450             Duvelisib          Ruxolitinib  8 19  0.22
## 451             Duvelisib          Tofacitinib  8 18 -0.10
## 452             Duvelisib            Motolimod  8 17 -0.06
## 453             Duvelisib  Menin-MLL Inhibitor  8 16 -0.08
## 454             Duvelisib               MI-503  8 15 -0.21
## 455             Duvelisib             Olaparib  8 14 -0.07
## 456             Duvelisib            SB 203580  8 13 -0.10
## 457             Duvelisib                AMI-1  8 12 -0.17
## 458             Duvelisib           Vismodegib  8 11 -0.11
## 459             Duvelisib         Methotrexate  8 10 -0.10
## 460             Duvelisib IRAK-1/4 Inhibitor I  8  9  0.07
## 461             Duvelisib           Selisistat  8  8  0.02
## 462             Duvelisib            Foretinib  8  7  0.02
## 463             Duvelisib             JNK-IN-8  8  6 -0.04
## 464             Duvelisib               BGJ398  8  5  0.02
## 465             Duvelisib             SGC 0946  8  4  0.14
## 466             Duvelisib               D 4476  8  3 -0.17
## 467             Duvelisib            A-1210477  8  2  0.32
## 468             Duvelisib            Cisplatin  8  1  0.16
## 469            Idelalisib           Idelalisib  9 54  1.00
## 470            Idelalisib            Dasatinib  9 53  0.74
## 471            Idelalisib            PRT062607  9 52  0.78
## 472            Idelalisib            Ibrutinib  9 51  0.84
## 473            Idelalisib             ONO-4059  9 50  0.82
## 474            Idelalisib          Cobimetinib  9 49  0.57
## 475            Idelalisib            SCH772984  9 48  0.58
## 476            Idelalisib           Trametinib  9 47  0.66
## 477            Idelalisib             A-674563  9 46  0.46
## 478            Idelalisib           Tozasertib  9 45  0.57
## 479            Idelalisib           BMS-509744  9 44  0.33
## 480            Idelalisib            Ceritinib  9 43  0.13
## 481            Idelalisib              MK-2206  9 42  0.49
## 482            Idelalisib              AZD1208  9 41  0.56
## 483            Idelalisib              AZD8055  9 40  0.60
## 484            Idelalisib           Dabrafenib  9 39  0.39
## 485            Idelalisib             Imatinib  9 38  0.52
## 486            Idelalisib             KU-55933  9 37  0.46
## 487            Idelalisib          Quizartinib  9 36 -0.22
## 488            Idelalisib             Afatinib  9 35 -0.22
## 489            Idelalisib                TW-37  9 34 -0.18
## 490            Idelalisib            ZM 336372  9 33 -0.23
## 491            Idelalisib              BML-277  9 32 -0.42
## 492            Idelalisib             EPZ-6438  9 31 -0.37
## 493            Idelalisib           PF-3758309  9 30  0.31
## 494            Idelalisib           Venetoclax  9 29  0.04
## 495            Idelalisib         Doxorubicine  9 28  0.04
## 496            Idelalisib         Panobinostat  9 27  0.16
## 497            Idelalisib            Selinexor  9 26  0.12
## 498            Idelalisib               OTX015  9 25  0.25
## 499            Idelalisib           Volasertib  9 24  0.25
## 500            Idelalisib            Nutlin-3a  9 23  0.44
## 501            Idelalisib               RO5963  9 22  0.39
## 502            Idelalisib           Cytarabine  9 21  0.29
## 503            Idelalisib          Fludarabine  9 20  0.19
## 504            Idelalisib          Ruxolitinib  9 19  0.22
## 505            Idelalisib          Tofacitinib  9 18 -0.11
## 506            Idelalisib            Motolimod  9 17 -0.06
## 507            Idelalisib  Menin-MLL Inhibitor  9 16 -0.02
## 508            Idelalisib               MI-503  9 15 -0.13
## 509            Idelalisib             Olaparib  9 14 -0.02
## 510            Idelalisib            SB 203580  9 13 -0.10
## 511            Idelalisib                AMI-1  9 12 -0.10
## 512            Idelalisib           Vismodegib  9 11 -0.04
## 513            Idelalisib         Methotrexate  9 10 -0.02
## 514            Idelalisib IRAK-1/4 Inhibitor I  9  9  0.13
## 515            Idelalisib           Selisistat  9  8  0.06
## 516            Idelalisib            Foretinib  9  7  0.07
## 517            Idelalisib             JNK-IN-8  9  6  0.09
## 518            Idelalisib               BGJ398  9  5  0.00
## 519            Idelalisib             SGC 0946  9  4  0.15
## 520            Idelalisib               D 4476  9  3 -0.16
## 521            Idelalisib            A-1210477  9  2  0.34
## 522            Idelalisib            Cisplatin  9  1  0.24
## 523             Dasatinib            Dasatinib 10 53  1.00
## 524             Dasatinib            PRT062607 10 52  0.84
## 525             Dasatinib            Ibrutinib 10 51  0.87
## 526             Dasatinib             ONO-4059 10 50  0.80
## 527             Dasatinib          Cobimetinib 10 49  0.63
## 528             Dasatinib            SCH772984 10 48  0.55
## 529             Dasatinib           Trametinib 10 47  0.67
## 530             Dasatinib             A-674563 10 46  0.40
## 531             Dasatinib           Tozasertib 10 45  0.52
## 532             Dasatinib           BMS-509744 10 44  0.25
## 533             Dasatinib            Ceritinib 10 43  0.13
## 534             Dasatinib              MK-2206 10 42  0.33
## 535             Dasatinib              AZD1208 10 41  0.44
## 536             Dasatinib              AZD8055 10 40  0.53
## 537             Dasatinib           Dabrafenib 10 39  0.38
## 538             Dasatinib             Imatinib 10 38  0.60
## 539             Dasatinib             KU-55933 10 37  0.34
## 540             Dasatinib          Quizartinib 10 36 -0.37
## 541             Dasatinib             Afatinib 10 35 -0.14
## 542             Dasatinib                TW-37 10 34 -0.28
## 543             Dasatinib            ZM 336372 10 33 -0.24
## 544             Dasatinib              BML-277 10 32 -0.40
## 545             Dasatinib             EPZ-6438 10 31 -0.39
## 546             Dasatinib           PF-3758309 10 30  0.38
## 547             Dasatinib           Venetoclax 10 29  0.08
## 548             Dasatinib         Doxorubicine 10 28 -0.02
## 549             Dasatinib         Panobinostat 10 27  0.06
## 550             Dasatinib            Selinexor 10 26  0.11
## 551             Dasatinib               OTX015 10 25  0.22
## 552             Dasatinib           Volasertib 10 24  0.23
## 553             Dasatinib            Nutlin-3a 10 23  0.45
## 554             Dasatinib               RO5963 10 22  0.36
## 555             Dasatinib           Cytarabine 10 21  0.30
## 556             Dasatinib          Fludarabine 10 20  0.11
## 557             Dasatinib          Ruxolitinib 10 19  0.33
## 558             Dasatinib          Tofacitinib 10 18  0.06
## 559             Dasatinib            Motolimod 10 17 -0.09
## 560             Dasatinib  Menin-MLL Inhibitor 10 16 -0.03
## 561             Dasatinib               MI-503 10 15 -0.10
## 562             Dasatinib             Olaparib 10 14  0.08
## 563             Dasatinib            SB 203580 10 13  0.02
## 564             Dasatinib                AMI-1 10 12 -0.15
## 565             Dasatinib           Vismodegib 10 11 -0.07
## 566             Dasatinib         Methotrexate 10 10 -0.09
## 567             Dasatinib IRAK-1/4 Inhibitor I 10  9  0.09
## 568             Dasatinib           Selisistat 10  8 -0.01
## 569             Dasatinib            Foretinib 10  7  0.11
## 570             Dasatinib             JNK-IN-8 10  6  0.09
## 571             Dasatinib               BGJ398 10  5 -0.02
## 572             Dasatinib             SGC 0946 10  4  0.06
## 573             Dasatinib               D 4476 10  3 -0.18
## 574             Dasatinib            A-1210477 10  2  0.19
## 575             Dasatinib            Cisplatin 10  1  0.07
## 576             PRT062607            PRT062607 11 52  1.00
## 577             PRT062607            Ibrutinib 11 51  0.92
## 578             PRT062607             ONO-4059 11 50  0.91
## 579             PRT062607          Cobimetinib 11 49  0.58
## 580             PRT062607            SCH772984 11 48  0.51
## 581             PRT062607           Trametinib 11 47  0.61
## 582             PRT062607             A-674563 11 46  0.50
## 583             PRT062607           Tozasertib 11 45  0.67
## 584             PRT062607           BMS-509744 11 44  0.32
## 585             PRT062607            Ceritinib 11 43  0.19
## 586             PRT062607              MK-2206 11 42  0.33
## 587             PRT062607              AZD1208 11 41  0.44
## 588             PRT062607              AZD8055 11 40  0.52
## 589             PRT062607           Dabrafenib 11 39  0.34
## 590             PRT062607             Imatinib 11 38  0.55
## 591             PRT062607             KU-55933 11 37  0.43
## 592             PRT062607          Quizartinib 11 36 -0.29
## 593             PRT062607             Afatinib 11 35 -0.15
## 594             PRT062607                TW-37 11 34 -0.15
## 595             PRT062607            ZM 336372 11 33 -0.15
## 596             PRT062607              BML-277 11 32 -0.39
## 597             PRT062607             EPZ-6438 11 31 -0.37
## 598             PRT062607           PF-3758309 11 30  0.34
## 599             PRT062607           Venetoclax 11 29  0.12
## 600             PRT062607         Doxorubicine 11 28  0.10
## 601             PRT062607         Panobinostat 11 27  0.04
## 602             PRT062607            Selinexor 11 26  0.23
## 603             PRT062607               OTX015 11 25  0.29
## 604             PRT062607           Volasertib 11 24  0.34
## 605             PRT062607            Nutlin-3a 11 23  0.48
## 606             PRT062607               RO5963 11 22  0.41
## 607             PRT062607           Cytarabine 11 21  0.34
## 608             PRT062607          Fludarabine 11 20  0.12
## 609             PRT062607          Ruxolitinib 11 19  0.29
## 610             PRT062607          Tofacitinib 11 18 -0.01
## 611             PRT062607            Motolimod 11 17  0.00
## 612             PRT062607  Menin-MLL Inhibitor 11 16  0.00
## 613             PRT062607               MI-503 11 15 -0.15
## 614             PRT062607             Olaparib 11 14  0.07
## 615             PRT062607            SB 203580 11 13  0.08
## 616             PRT062607                AMI-1 11 12 -0.05
## 617             PRT062607           Vismodegib 11 11  0.01
## 618             PRT062607         Methotrexate 11 10 -0.10
## 619             PRT062607 IRAK-1/4 Inhibitor I 11  9  0.15
## 620             PRT062607           Selisistat 11  8  0.13
## 621             PRT062607            Foretinib 11  7  0.16
## 622             PRT062607             JNK-IN-8 11  6  0.13
## 623             PRT062607               BGJ398 11  5  0.02
## 624             PRT062607             SGC 0946 11  4  0.20
## 625             PRT062607               D 4476 11  3 -0.05
## 626             PRT062607            A-1210477 11  2  0.30
## 627             PRT062607            Cisplatin 11  1  0.23
## 628             Ibrutinib            Ibrutinib 12 51  1.00
## 629             Ibrutinib             ONO-4059 12 50  0.96
## 630             Ibrutinib          Cobimetinib 12 49  0.61
## 631             Ibrutinib            SCH772984 12 48  0.54
## 632             Ibrutinib           Trametinib 12 47  0.66
## 633             Ibrutinib             A-674563 12 46  0.43
## 634             Ibrutinib           Tozasertib 12 45  0.62
## 635             Ibrutinib           BMS-509744 12 44  0.28
## 636             Ibrutinib            Ceritinib 12 43  0.13
## 637             Ibrutinib              MK-2206 12 42  0.33
## 638             Ibrutinib              AZD1208 12 41  0.42
## 639             Ibrutinib              AZD8055 12 40  0.52
## 640             Ibrutinib           Dabrafenib 12 39  0.36
## 641             Ibrutinib             Imatinib 12 38  0.54
## 642             Ibrutinib             KU-55933 12 37  0.47
## 643             Ibrutinib          Quizartinib 12 36 -0.35
## 644             Ibrutinib             Afatinib 12 35 -0.21
## 645             Ibrutinib                TW-37 12 34 -0.20
## 646             Ibrutinib            ZM 336372 12 33 -0.25
## 647             Ibrutinib              BML-277 12 32 -0.46
## 648             Ibrutinib             EPZ-6438 12 31 -0.42
## 649             Ibrutinib           PF-3758309 12 30  0.29
## 650             Ibrutinib           Venetoclax 12 29  0.04
## 651             Ibrutinib         Doxorubicine 12 28  0.06
## 652             Ibrutinib         Panobinostat 12 27  0.07
## 653             Ibrutinib            Selinexor 12 26  0.14
## 654             Ibrutinib               OTX015 12 25  0.29
## 655             Ibrutinib           Volasertib 12 24  0.30
## 656             Ibrutinib            Nutlin-3a 12 23  0.47
## 657             Ibrutinib               RO5963 12 22  0.40
## 658             Ibrutinib           Cytarabine 12 21  0.34
## 659             Ibrutinib          Fludarabine 12 20  0.14
## 660             Ibrutinib          Ruxolitinib 12 19  0.30
## 661             Ibrutinib          Tofacitinib 12 18 -0.04
## 662             Ibrutinib            Motolimod 12 17 -0.01
## 663             Ibrutinib  Menin-MLL Inhibitor 12 16 -0.01
## 664             Ibrutinib               MI-503 12 15 -0.18
## 665             Ibrutinib             Olaparib 12 14  0.04
## 666             Ibrutinib            SB 203580 12 13  0.04
## 667             Ibrutinib                AMI-1 12 12 -0.14
## 668             Ibrutinib           Vismodegib 12 11 -0.07
## 669             Ibrutinib         Methotrexate 12 10 -0.09
## 670             Ibrutinib IRAK-1/4 Inhibitor I 12  9  0.11
## 671             Ibrutinib           Selisistat 12  8  0.05
## 672             Ibrutinib            Foretinib 12  7  0.15
## 673             Ibrutinib             JNK-IN-8 12  6  0.06
## 674             Ibrutinib               BGJ398 12  5  0.01
## 675             Ibrutinib             SGC 0946 12  4  0.16
## 676             Ibrutinib               D 4476 12  3 -0.14
## 677             Ibrutinib            A-1210477 12  2  0.28
## 678             Ibrutinib            Cisplatin 12  1  0.24
## 679              ONO-4059             ONO-4059 13 50  1.00
## 680              ONO-4059          Cobimetinib 13 49  0.56
## 681              ONO-4059            SCH772984 13 48  0.51
## 682              ONO-4059           Trametinib 13 47  0.61
## 683              ONO-4059             A-674563 13 46  0.42
## 684              ONO-4059           Tozasertib 13 45  0.63
## 685              ONO-4059           BMS-509744 13 44  0.25
## 686              ONO-4059            Ceritinib 13 43  0.09
## 687              ONO-4059              MK-2206 13 42  0.34
## 688              ONO-4059              AZD1208 13 41  0.38
## 689              ONO-4059              AZD8055 13 40  0.45
## 690              ONO-4059           Dabrafenib 13 39  0.38
## 691              ONO-4059             Imatinib 13 38  0.51
## 692              ONO-4059             KU-55933 13 37  0.49
## 693              ONO-4059          Quizartinib 13 36 -0.37
## 694              ONO-4059             Afatinib 13 35 -0.23
## 695              ONO-4059                TW-37 13 34 -0.16
## 696              ONO-4059            ZM 336372 13 33 -0.20
## 697              ONO-4059              BML-277 13 32 -0.45
## 698              ONO-4059             EPZ-6438 13 31 -0.39
## 699              ONO-4059           PF-3758309 13 30  0.23
## 700              ONO-4059           Venetoclax 13 29  0.06
## 701              ONO-4059         Doxorubicine 13 28  0.12
## 702              ONO-4059         Panobinostat 13 27  0.09
## 703              ONO-4059            Selinexor 13 26  0.18
## 704              ONO-4059               OTX015 13 25  0.31
## 705              ONO-4059           Volasertib 13 24  0.32
## 706              ONO-4059            Nutlin-3a 13 23  0.46
## 707              ONO-4059               RO5963 13 22  0.38
## 708              ONO-4059           Cytarabine 13 21  0.31
## 709              ONO-4059          Fludarabine 13 20  0.13
## 710              ONO-4059          Ruxolitinib 13 19  0.25
## 711              ONO-4059          Tofacitinib 13 18 -0.12
## 712              ONO-4059            Motolimod 13 17  0.05
## 713              ONO-4059  Menin-MLL Inhibitor 13 16 -0.04
## 714              ONO-4059               MI-503 13 15 -0.18
## 715              ONO-4059             Olaparib 13 14  0.01
## 716              ONO-4059            SB 203580 13 13  0.01
## 717              ONO-4059                AMI-1 13 12 -0.17
## 718              ONO-4059           Vismodegib 13 11 -0.09
## 719              ONO-4059         Methotrexate 13 10 -0.13
## 720              ONO-4059 IRAK-1/4 Inhibitor I 13  9  0.05
## 721              ONO-4059           Selisistat 13  8  0.05
## 722              ONO-4059            Foretinib 13  7  0.12
## 723              ONO-4059             JNK-IN-8 13  6  0.04
## 724              ONO-4059               BGJ398 13  5  0.01
## 725              ONO-4059             SGC 0946 13  4  0.21
## 726              ONO-4059               D 4476 13  3 -0.12
## 727              ONO-4059            A-1210477 13  2  0.30
## 728              ONO-4059            Cisplatin 13  1  0.21
## 729           Cobimetinib          Cobimetinib 14 49  1.00
## 730           Cobimetinib            SCH772984 14 48  0.88
## 731           Cobimetinib           Trametinib 14 47  0.90
## 732           Cobimetinib             A-674563 14 46  0.40
## 733           Cobimetinib           Tozasertib 14 45  0.52
## 734           Cobimetinib           BMS-509744 14 44  0.37
## 735           Cobimetinib            Ceritinib 14 43  0.08
## 736           Cobimetinib              MK-2206 14 42  0.30
## 737           Cobimetinib              AZD1208 14 41  0.28
## 738           Cobimetinib              AZD8055 14 40  0.48
## 739           Cobimetinib           Dabrafenib 14 39  0.33
## 740           Cobimetinib             Imatinib 14 38  0.46
## 741           Cobimetinib             KU-55933 14 37  0.31
## 742           Cobimetinib          Quizartinib 14 36 -0.32
## 743           Cobimetinib             Afatinib 14 35 -0.20
## 744           Cobimetinib                TW-37 14 34 -0.15
## 745           Cobimetinib            ZM 336372 14 33 -0.30
## 746           Cobimetinib              BML-277 14 32 -0.27
## 747           Cobimetinib             EPZ-6438 14 31 -0.34
## 748           Cobimetinib           PF-3758309 14 30  0.15
## 749           Cobimetinib           Venetoclax 14 29 -0.17
## 750           Cobimetinib         Doxorubicine 14 28 -0.03
## 751           Cobimetinib         Panobinostat 14 27  0.05
## 752           Cobimetinib            Selinexor 14 26  0.17
## 753           Cobimetinib               OTX015 14 25  0.26
## 754           Cobimetinib           Volasertib 14 24  0.31
## 755           Cobimetinib            Nutlin-3a 14 23  0.46
## 756           Cobimetinib               RO5963 14 22  0.42
## 757           Cobimetinib           Cytarabine 14 21  0.29
## 758           Cobimetinib          Fludarabine 14 20  0.17
## 759           Cobimetinib          Ruxolitinib 14 19  0.52
## 760           Cobimetinib          Tofacitinib 14 18  0.16
## 761           Cobimetinib            Motolimod 14 17 -0.08
## 762           Cobimetinib  Menin-MLL Inhibitor 14 16 -0.09
## 763           Cobimetinib               MI-503 14 15 -0.09
## 764           Cobimetinib             Olaparib 14 14  0.14
## 765           Cobimetinib            SB 203580 14 13  0.20
## 766           Cobimetinib                AMI-1 14 12 -0.01
## 767           Cobimetinib           Vismodegib 14 11  0.09
## 768           Cobimetinib         Methotrexate 14 10  0.02
## 769           Cobimetinib IRAK-1/4 Inhibitor I 14  9  0.03
## 770           Cobimetinib           Selisistat 14  8  0.09
## 771           Cobimetinib            Foretinib 14  7  0.20
## 772           Cobimetinib             JNK-IN-8 14  6 -0.11
## 773           Cobimetinib               BGJ398 14  5  0.09
## 774           Cobimetinib             SGC 0946 14  4  0.25
## 775           Cobimetinib               D 4476 14  3  0.07
## 776           Cobimetinib            A-1210477 14  2  0.26
## 777           Cobimetinib            Cisplatin 14  1  0.27
## 778             SCH772984            SCH772984 15 48  1.00
## 779             SCH772984           Trametinib 15 47  0.92
## 780             SCH772984             A-674563 15 46  0.43
## 781             SCH772984           Tozasertib 15 45  0.45
## 782             SCH772984           BMS-509744 15 44  0.25
## 783             SCH772984            Ceritinib 15 43 -0.02
## 784             SCH772984              MK-2206 15 42  0.32
## 785             SCH772984              AZD1208 15 41  0.27
## 786             SCH772984              AZD8055 15 40  0.45
## 787             SCH772984           Dabrafenib 15 39  0.29
## 788             SCH772984             Imatinib 15 38  0.40
## 789             SCH772984             KU-55933 15 37  0.31
## 790             SCH772984          Quizartinib 15 36 -0.18
## 791             SCH772984             Afatinib 15 35 -0.11
## 792             SCH772984                TW-37 15 34 -0.06
## 793             SCH772984            ZM 336372 15 33 -0.23
## 794             SCH772984              BML-277 15 32 -0.32
## 795             SCH772984             EPZ-6438 15 31 -0.30
## 796             SCH772984           PF-3758309 15 30  0.27
## 797             SCH772984           Venetoclax 15 29 -0.11
## 798             SCH772984         Doxorubicine 15 28  0.05
## 799             SCH772984         Panobinostat 15 27  0.19
## 800             SCH772984            Selinexor 15 26  0.25
## 801             SCH772984               OTX015 15 25  0.35
## 802             SCH772984           Volasertib 15 24  0.38
## 803             SCH772984            Nutlin-3a 15 23  0.52
## 804             SCH772984               RO5963 15 22  0.50
## 805             SCH772984           Cytarabine 15 21  0.33
## 806             SCH772984          Fludarabine 15 20  0.29
## 807             SCH772984          Ruxolitinib 15 19  0.57
## 808             SCH772984          Tofacitinib 15 18  0.23
## 809             SCH772984            Motolimod 15 17 -0.06
## 810             SCH772984  Menin-MLL Inhibitor 15 16 -0.06
## 811             SCH772984               MI-503 15 15 -0.12
## 812             SCH772984             Olaparib 15 14  0.05
## 813             SCH772984            SB 203580 15 13  0.20
## 814             SCH772984                AMI-1 15 12  0.02
## 815             SCH772984           Vismodegib 15 11  0.12
## 816             SCH772984         Methotrexate 15 10  0.06
## 817             SCH772984 IRAK-1/4 Inhibitor I 15  9  0.08
## 818             SCH772984           Selisistat 15  8  0.09
## 819             SCH772984            Foretinib 15  7  0.05
## 820             SCH772984             JNK-IN-8 15  6 -0.12
## 821             SCH772984               BGJ398 15  5  0.12
## 822             SCH772984             SGC 0946 15  4  0.29
## 823             SCH772984               D 4476 15  3 -0.06
## 824             SCH772984            A-1210477 15  2  0.25
## 825             SCH772984            Cisplatin 15  1  0.24
## 826            Trametinib           Trametinib 16 47  1.00
## 827            Trametinib             A-674563 16 46  0.39
## 828            Trametinib           Tozasertib 16 45  0.49
## 829            Trametinib           BMS-509744 16 44  0.30
## 830            Trametinib            Ceritinib 16 43  0.01
## 831            Trametinib              MK-2206 16 42  0.33
## 832            Trametinib              AZD1208 16 41  0.37
## 833            Trametinib              AZD8055 16 40  0.47
## 834            Trametinib           Dabrafenib 16 39  0.32
## 835            Trametinib             Imatinib 16 38  0.40
## 836            Trametinib             KU-55933 16 37  0.33
## 837            Trametinib          Quizartinib 16 36 -0.25
## 838            Trametinib             Afatinib 16 35 -0.15
## 839            Trametinib                TW-37 16 34 -0.17
## 840            Trametinib            ZM 336372 16 33 -0.29
## 841            Trametinib              BML-277 16 32 -0.43
## 842            Trametinib             EPZ-6438 16 31 -0.33
## 843            Trametinib           PF-3758309 16 30  0.28
## 844            Trametinib           Venetoclax 16 29 -0.08
## 845            Trametinib         Doxorubicine 16 28 -0.01
## 846            Trametinib         Panobinostat 16 27  0.14
## 847            Trametinib            Selinexor 16 26  0.16
## 848            Trametinib               OTX015 16 25  0.29
## 849            Trametinib           Volasertib 16 24  0.29
## 850            Trametinib            Nutlin-3a 16 23  0.51
## 851            Trametinib               RO5963 16 22  0.47
## 852            Trametinib           Cytarabine 16 21  0.33
## 853            Trametinib          Fludarabine 16 20  0.25
## 854            Trametinib          Ruxolitinib 16 19  0.49
## 855            Trametinib          Tofacitinib 16 18  0.17
## 856            Trametinib            Motolimod 16 17 -0.14
## 857            Trametinib  Menin-MLL Inhibitor 16 16 -0.11
## 858            Trametinib               MI-503 16 15 -0.18
## 859            Trametinib             Olaparib 16 14  0.02
## 860            Trametinib            SB 203580 16 13  0.09
## 861            Trametinib                AMI-1 16 12 -0.13
## 862            Trametinib           Vismodegib 16 11 -0.04
## 863            Trametinib         Methotrexate 16 10 -0.05
## 864            Trametinib IRAK-1/4 Inhibitor I 16  9  0.00
## 865            Trametinib           Selisistat 16  8 -0.01
## 866            Trametinib            Foretinib 16  7  0.03
## 867            Trametinib             JNK-IN-8 16  6 -0.10
## 868            Trametinib               BGJ398 16  5  0.06
## 869            Trametinib             SGC 0946 16  4  0.20
## 870            Trametinib               D 4476 16  3 -0.19
## 871            Trametinib            A-1210477 16  2  0.22
## 872            Trametinib            Cisplatin 16  1  0.16
## 873              A-674563             A-674563 17 46  1.00
## 874              A-674563           Tozasertib 17 45  0.56
## 875              A-674563           BMS-509744 17 44  0.23
## 876              A-674563            Ceritinib 17 43  0.27
## 877              A-674563              MK-2206 17 42  0.34
## 878              A-674563              AZD1208 17 41  0.17
## 879              A-674563              AZD8055 17 40  0.47
## 880              A-674563           Dabrafenib 17 39  0.08
## 881              A-674563             Imatinib 17 38  0.32
## 882              A-674563             KU-55933 17 37  0.18
## 883              A-674563          Quizartinib 17 36  0.17
## 884              A-674563             Afatinib 17 35  0.18
## 885              A-674563                TW-37 17 34  0.27
## 886              A-674563            ZM 336372 17 33  0.04
## 887              A-674563              BML-277 17 32 -0.02
## 888              A-674563             EPZ-6438 17 31 -0.30
## 889              A-674563           PF-3758309 17 30  0.50
## 890              A-674563           Venetoclax 17 29  0.18
## 891              A-674563         Doxorubicine 17 28  0.25
## 892              A-674563         Panobinostat 17 27  0.26
## 893              A-674563            Selinexor 17 26  0.38
## 894              A-674563               OTX015 17 25  0.49
## 895              A-674563           Volasertib 17 24  0.58
## 896              A-674563            Nutlin-3a 17 23  0.46
## 897              A-674563               RO5963 17 22  0.43
## 898              A-674563           Cytarabine 17 21  0.39
## 899              A-674563          Fludarabine 17 20  0.35
## 900              A-674563          Ruxolitinib 17 19  0.32
## 901              A-674563          Tofacitinib 17 18  0.22
## 902              A-674563            Motolimod 17 17 -0.10
## 903              A-674563  Menin-MLL Inhibitor 17 16  0.02
## 904              A-674563               MI-503 17 15  0.12
## 905              A-674563             Olaparib 17 14 -0.10
## 906              A-674563            SB 203580 17 13  0.19
## 907              A-674563                AMI-1 17 12  0.28
## 908              A-674563           Vismodegib 17 11  0.35
## 909              A-674563         Methotrexate 17 10  0.11
## 910              A-674563 IRAK-1/4 Inhibitor I 17  9  0.36
## 911              A-674563           Selisistat 17  8  0.34
## 912              A-674563            Foretinib 17  7  0.08
## 913              A-674563             JNK-IN-8 17  6  0.13
## 914              A-674563               BGJ398 17  5  0.23
## 915              A-674563             SGC 0946 17  4  0.41
## 916              A-674563               D 4476 17  3  0.23
## 917              A-674563            A-1210477 17  2  0.49
## 918              A-674563            Cisplatin 17  1  0.39
## 919            Tozasertib           Tozasertib 18 45  1.00
## 920            Tozasertib           BMS-509744 18 44  0.44
## 921            Tozasertib            Ceritinib 18 43  0.34
## 922            Tozasertib              MK-2206 18 42  0.42
## 923            Tozasertib              AZD1208 18 41  0.36
## 924            Tozasertib              AZD8055 18 40  0.59
## 925            Tozasertib           Dabrafenib 18 39  0.27
## 926            Tozasertib             Imatinib 18 38  0.46
## 927            Tozasertib             KU-55933 18 37  0.39
## 928            Tozasertib          Quizartinib 18 36  0.00
## 929            Tozasertib             Afatinib 18 35 -0.12
## 930            Tozasertib                TW-37 18 34  0.04
## 931            Tozasertib            ZM 336372 18 33 -0.01
## 932            Tozasertib              BML-277 18 32 -0.13
## 933            Tozasertib             EPZ-6438 18 31 -0.36
## 934            Tozasertib           PF-3758309 18 30  0.26
## 935            Tozasertib           Venetoclax 18 29  0.04
## 936            Tozasertib         Doxorubicine 18 28  0.09
## 937            Tozasertib         Panobinostat 18 27  0.05
## 938            Tozasertib            Selinexor 18 26  0.23
## 939            Tozasertib               OTX015 18 25  0.22
## 940            Tozasertib           Volasertib 18 24  0.42
## 941            Tozasertib            Nutlin-3a 18 23  0.37
## 942            Tozasertib               RO5963 18 22  0.33
## 943            Tozasertib           Cytarabine 18 21  0.25
## 944            Tozasertib          Fludarabine 18 20  0.09
## 945            Tozasertib          Ruxolitinib 18 19  0.31
## 946            Tozasertib          Tofacitinib 18 18  0.02
## 947            Tozasertib            Motolimod 18 17  0.00
## 948            Tozasertib  Menin-MLL Inhibitor 18 16 -0.10
## 949            Tozasertib               MI-503 18 15  0.09
## 950            Tozasertib             Olaparib 18 14  0.10
## 951            Tozasertib            SB 203580 18 13  0.24
## 952            Tozasertib                AMI-1 18 12  0.19
## 953            Tozasertib           Vismodegib 18 11  0.29
## 954            Tozasertib         Methotrexate 18 10  0.12
## 955            Tozasertib IRAK-1/4 Inhibitor I 18  9  0.22
## 956            Tozasertib           Selisistat 18  8  0.28
## 957            Tozasertib            Foretinib 18  7  0.45
## 958            Tozasertib             JNK-IN-8 18  6  0.14
## 959            Tozasertib               BGJ398 18  5  0.22
## 960            Tozasertib             SGC 0946 18  4  0.35
## 961            Tozasertib               D 4476 18  3  0.20
## 962            Tozasertib            A-1210477 18  2  0.36
## 963            Tozasertib            Cisplatin 18  1  0.43
## 964            BMS-509744           BMS-509744 19 44  1.00
## 965            BMS-509744            Ceritinib 19 43  0.56
## 966            BMS-509744              MK-2206 19 42  0.31
## 967            BMS-509744              AZD1208 19 41  0.49
## 968            BMS-509744              AZD8055 19 40  0.50
## 969            BMS-509744           Dabrafenib 19 39  0.33
## 970            BMS-509744             Imatinib 19 38  0.28
## 971            BMS-509744             KU-55933 19 37  0.24
## 972            BMS-509744          Quizartinib 19 36 -0.06
## 973            BMS-509744             Afatinib 19 35 -0.12
## 974            BMS-509744                TW-37 19 34 -0.13
## 975            BMS-509744            ZM 336372 19 33  0.02
## 976            BMS-509744              BML-277 19 32  0.09
## 977            BMS-509744             EPZ-6438 19 31 -0.12
## 978            BMS-509744           PF-3758309 19 30 -0.02
## 979            BMS-509744           Venetoclax 19 29 -0.03
## 980            BMS-509744         Doxorubicine 19 28 -0.16
## 981            BMS-509744         Panobinostat 19 27 -0.07
## 982            BMS-509744            Selinexor 19 26 -0.03
## 983            BMS-509744               OTX015 19 25 -0.08
## 984            BMS-509744           Volasertib 19 24  0.08
## 985            BMS-509744            Nutlin-3a 19 23  0.02
## 986            BMS-509744               RO5963 19 22  0.03
## 987            BMS-509744           Cytarabine 19 21 -0.04
## 988            BMS-509744          Fludarabine 19 20 -0.10
## 989            BMS-509744          Ruxolitinib 19 19  0.30
## 990            BMS-509744          Tofacitinib 19 18  0.12
## 991            BMS-509744            Motolimod 19 17 -0.09
## 992            BMS-509744  Menin-MLL Inhibitor 19 16 -0.08
## 993            BMS-509744               MI-503 19 15  0.05
## 994            BMS-509744             Olaparib 19 14  0.26
## 995            BMS-509744            SB 203580 19 13  0.12
## 996            BMS-509744                AMI-1 19 12  0.29
## 997            BMS-509744           Vismodegib 19 11  0.26
## 998            BMS-509744         Methotrexate 19 10  0.05
## 999            BMS-509744 IRAK-1/4 Inhibitor I 19  9  0.10
## 1000           BMS-509744           Selisistat 19  8  0.16
## 1001           BMS-509744            Foretinib 19  7  0.29
## 1002           BMS-509744             JNK-IN-8 19  6  0.12
## 1003           BMS-509744               BGJ398 19  5  0.15
## 1004           BMS-509744             SGC 0946 19  4  0.18
## 1005           BMS-509744               D 4476 19  3  0.23
## 1006           BMS-509744            A-1210477 19  2  0.26
## 1007           BMS-509744            Cisplatin 19  1  0.20
## 1008            Ceritinib            Ceritinib 20 43  1.00
## 1009            Ceritinib              MK-2206 20 42  0.33
## 1010            Ceritinib              AZD1208 20 41  0.39
## 1011            Ceritinib              AZD8055 20 40  0.49
## 1012            Ceritinib           Dabrafenib 20 39  0.17
## 1013            Ceritinib             Imatinib 20 38  0.22
## 1014            Ceritinib             KU-55933 20 37  0.11
## 1015            Ceritinib          Quizartinib 20 36  0.08
## 1016            Ceritinib             Afatinib 20 35  0.13
## 1017            Ceritinib                TW-37 20 34  0.08
## 1018            Ceritinib            ZM 336372 20 33  0.16
## 1019            Ceritinib              BML-277 20 32  0.24
## 1020            Ceritinib             EPZ-6438 20 31 -0.08
## 1021            Ceritinib           PF-3758309 20 30  0.10
## 1022            Ceritinib           Venetoclax 20 29  0.21
## 1023            Ceritinib         Doxorubicine 20 28 -0.19
## 1024            Ceritinib         Panobinostat 20 27 -0.11
## 1025            Ceritinib            Selinexor 20 26  0.02
## 1026            Ceritinib               OTX015 20 25 -0.07
## 1027            Ceritinib           Volasertib 20 24  0.11
## 1028            Ceritinib            Nutlin-3a 20 23  0.07
## 1029            Ceritinib               RO5963 20 22  0.07
## 1030            Ceritinib           Cytarabine 20 21  0.03
## 1031            Ceritinib          Fludarabine 20 20 -0.08
## 1032            Ceritinib          Ruxolitinib 20 19  0.15
## 1033            Ceritinib          Tofacitinib 20 18  0.10
## 1034            Ceritinib            Motolimod 20 17 -0.05
## 1035            Ceritinib  Menin-MLL Inhibitor 20 16  0.10
## 1036            Ceritinib               MI-503 20 15  0.31
## 1037            Ceritinib             Olaparib 20 14  0.32
## 1038            Ceritinib            SB 203580 20 13  0.19
## 1039            Ceritinib                AMI-1 20 12  0.42
## 1040            Ceritinib           Vismodegib 20 11  0.39
## 1041            Ceritinib         Methotrexate 20 10  0.08
## 1042            Ceritinib IRAK-1/4 Inhibitor I 20  9  0.29
## 1043            Ceritinib           Selisistat 20  8  0.29
## 1044            Ceritinib            Foretinib 20  7  0.30
## 1045            Ceritinib             JNK-IN-8 20  6  0.27
## 1046            Ceritinib               BGJ398 20  5  0.30
## 1047            Ceritinib             SGC 0946 20  4  0.16
## 1048            Ceritinib               D 4476 20  3  0.35
## 1049            Ceritinib            A-1210477 20  2  0.30
## 1050            Ceritinib            Cisplatin 20  1  0.20
## 1051              MK-2206              MK-2206 21 42  1.00
## 1052              MK-2206              AZD1208 21 41  0.45
## 1053              MK-2206              AZD8055 21 40  0.57
## 1054              MK-2206           Dabrafenib 21 39  0.28
## 1055              MK-2206             Imatinib 21 38  0.43
## 1056              MK-2206             KU-55933 21 37  0.47
## 1057              MK-2206          Quizartinib 21 36 -0.06
## 1058              MK-2206             Afatinib 21 35 -0.05
## 1059              MK-2206                TW-37 21 34 -0.05
## 1060              MK-2206            ZM 336372 21 33  0.07
## 1061              MK-2206              BML-277 21 32 -0.08
## 1062              MK-2206             EPZ-6438 21 31 -0.13
## 1063              MK-2206           PF-3758309 21 30  0.26
## 1064              MK-2206           Venetoclax 21 29  0.08
## 1065              MK-2206         Doxorubicine 21 28  0.04
## 1066              MK-2206         Panobinostat 21 27  0.13
## 1067              MK-2206            Selinexor 21 26  0.21
## 1068              MK-2206               OTX015 21 25  0.09
## 1069              MK-2206           Volasertib 21 24  0.14
## 1070              MK-2206            Nutlin-3a 21 23  0.27
## 1071              MK-2206               RO5963 21 22  0.22
## 1072              MK-2206           Cytarabine 21 21  0.14
## 1073              MK-2206          Fludarabine 21 20  0.10
## 1074              MK-2206          Ruxolitinib 21 19  0.24
## 1075              MK-2206          Tofacitinib 21 18  0.11
## 1076              MK-2206            Motolimod 21 17  0.05
## 1077              MK-2206  Menin-MLL Inhibitor 21 16  0.29
## 1078              MK-2206               MI-503 21 15  0.31
## 1079              MK-2206             Olaparib 21 14  0.25
## 1080              MK-2206            SB 203580 21 13  0.16
## 1081              MK-2206                AMI-1 21 12  0.11
## 1082              MK-2206           Vismodegib 21 11  0.21
## 1083              MK-2206         Methotrexate 21 10  0.16
## 1084              MK-2206 IRAK-1/4 Inhibitor I 21  9  0.30
## 1085              MK-2206           Selisistat 21  8  0.29
## 1086              MK-2206            Foretinib 21  7  0.06
## 1087              MK-2206             JNK-IN-8 21  6  0.13
## 1088              MK-2206               BGJ398 21  5 -0.01
## 1089              MK-2206             SGC 0946 21  4  0.11
## 1090              MK-2206               D 4476 21  3 -0.06
## 1091              MK-2206            A-1210477 21  2  0.24
## 1092              MK-2206            Cisplatin 21  1  0.14
## 1093              AZD1208              AZD1208 22 41  1.00
## 1094              AZD1208              AZD8055 22 40  0.67
## 1095              AZD1208           Dabrafenib 22 39  0.24
## 1096              AZD1208             Imatinib 22 38  0.38
## 1097              AZD1208             KU-55933 22 37  0.21
## 1098              AZD1208          Quizartinib 22 36 -0.09
## 1099              AZD1208             Afatinib 22 35 -0.24
## 1100              AZD1208                TW-37 22 34 -0.30
## 1101              AZD1208            ZM 336372 22 33  0.00
## 1102              AZD1208              BML-277 22 32 -0.13
## 1103              AZD1208             EPZ-6438 22 31 -0.18
## 1104              AZD1208           PF-3758309 22 30  0.26
## 1105              AZD1208           Venetoclax 22 29  0.17
## 1106              AZD1208         Doxorubicine 22 28 -0.25
## 1107              AZD1208         Panobinostat 22 27  0.01
## 1108              AZD1208            Selinexor 22 26 -0.01
## 1109              AZD1208               OTX015 22 25 -0.22
## 1110              AZD1208           Volasertib 22 24 -0.13
## 1111              AZD1208            Nutlin-3a 22 23  0.05
## 1112              AZD1208               RO5963 22 22  0.04
## 1113              AZD1208           Cytarabine 22 21 -0.07
## 1114              AZD1208          Fludarabine 22 20 -0.10
## 1115              AZD1208          Ruxolitinib 22 19  0.21
## 1116              AZD1208          Tofacitinib 22 18  0.10
## 1117              AZD1208            Motolimod 22 17 -0.25
## 1118              AZD1208  Menin-MLL Inhibitor 22 16 -0.02
## 1119              AZD1208               MI-503 22 15  0.10
## 1120              AZD1208             Olaparib 22 14  0.28
## 1121              AZD1208            SB 203580 22 13 -0.13
## 1122              AZD1208                AMI-1 22 12  0.01
## 1123              AZD1208           Vismodegib 22 11 -0.02
## 1124              AZD1208         Methotrexate 22 10 -0.06
## 1125              AZD1208 IRAK-1/4 Inhibitor I 22  9  0.00
## 1126              AZD1208           Selisistat 22  8 -0.06
## 1127              AZD1208            Foretinib 22  7  0.14
## 1128              AZD1208             JNK-IN-8 22  6  0.19
## 1129              AZD1208               BGJ398 22  5  0.00
## 1130              AZD1208             SGC 0946 22  4  0.01
## 1131              AZD1208               D 4476 22  3 -0.17
## 1132              AZD1208            A-1210477 22  2  0.05
## 1133              AZD1208            Cisplatin 22  1 -0.07
## 1134              AZD8055              AZD8055 23 40  1.00
## 1135              AZD8055           Dabrafenib 23 39  0.27
## 1136              AZD8055             Imatinib 23 38  0.56
## 1137              AZD8055             KU-55933 23 37  0.27
## 1138              AZD8055          Quizartinib 23 36 -0.04
## 1139              AZD8055             Afatinib 23 35 -0.19
## 1140              AZD8055                TW-37 23 34 -0.10
## 1141              AZD8055            ZM 336372 23 33  0.10
## 1142              AZD8055              BML-277 23 32 -0.02
## 1143              AZD8055             EPZ-6438 23 31 -0.33
## 1144              AZD8055           PF-3758309 23 30  0.34
## 1145              AZD8055           Venetoclax 23 29  0.08
## 1146              AZD8055         Doxorubicine 23 28 -0.16
## 1147              AZD8055         Panobinostat 23 27  0.03
## 1148              AZD8055            Selinexor 23 26  0.19
## 1149              AZD8055               OTX015 23 25  0.02
## 1150              AZD8055           Volasertib 23 24  0.21
## 1151              AZD8055            Nutlin-3a 23 23  0.30
## 1152              AZD8055               RO5963 23 22  0.31
## 1153              AZD8055           Cytarabine 23 21  0.07
## 1154              AZD8055          Fludarabine 23 20  0.05
## 1155              AZD8055          Ruxolitinib 23 19  0.43
## 1156              AZD8055          Tofacitinib 23 18  0.23
## 1157              AZD8055            Motolimod 23 17 -0.11
## 1158              AZD8055  Menin-MLL Inhibitor 23 16 -0.03
## 1159              AZD8055               MI-503 23 15  0.22
## 1160              AZD8055             Olaparib 23 14  0.30
## 1161              AZD8055            SB 203580 23 13  0.24
## 1162              AZD8055                AMI-1 23 12  0.30
## 1163              AZD8055           Vismodegib 23 11  0.34
## 1164              AZD8055         Methotrexate 23 10  0.16
## 1165              AZD8055 IRAK-1/4 Inhibitor I 23  9  0.25
## 1166              AZD8055           Selisistat 23  8  0.26
## 1167              AZD8055            Foretinib 23  7  0.36
## 1168              AZD8055             JNK-IN-8 23  6  0.19
## 1169              AZD8055               BGJ398 23  5  0.17
## 1170              AZD8055             SGC 0946 23  4  0.30
## 1171              AZD8055               D 4476 23  3  0.15
## 1172              AZD8055            A-1210477 23  2  0.28
## 1173              AZD8055            Cisplatin 23  1  0.23
## 1174           Dabrafenib           Dabrafenib 24 39  1.00
## 1175           Dabrafenib             Imatinib 24 38  0.19
## 1176           Dabrafenib             KU-55933 24 37  0.22
## 1177           Dabrafenib          Quizartinib 24 36 -0.16
## 1178           Dabrafenib             Afatinib 24 35  0.02
## 1179           Dabrafenib                TW-37 24 34 -0.11
## 1180           Dabrafenib            ZM 336372 24 33 -0.11
## 1181           Dabrafenib              BML-277 24 32 -0.16
## 1182           Dabrafenib             EPZ-6438 24 31 -0.06
## 1183           Dabrafenib           PF-3758309 24 30 -0.10
## 1184           Dabrafenib           Venetoclax 24 29 -0.08
## 1185           Dabrafenib         Doxorubicine 24 28  0.09
## 1186           Dabrafenib         Panobinostat 24 27  0.03
## 1187           Dabrafenib            Selinexor 24 26  0.04
## 1188           Dabrafenib               OTX015 24 25  0.10
## 1189           Dabrafenib           Volasertib 24 24  0.12
## 1190           Dabrafenib            Nutlin-3a 24 23  0.22
## 1191           Dabrafenib               RO5963 24 22  0.12
## 1192           Dabrafenib           Cytarabine 24 21  0.17
## 1193           Dabrafenib          Fludarabine 24 20  0.03
## 1194           Dabrafenib          Ruxolitinib 24 19  0.05
## 1195           Dabrafenib          Tofacitinib 24 18 -0.18
## 1196           Dabrafenib            Motolimod 24 17  0.13
## 1197           Dabrafenib  Menin-MLL Inhibitor 24 16  0.00
## 1198           Dabrafenib               MI-503 24 15 -0.12
## 1199           Dabrafenib             Olaparib 24 14  0.10
## 1200           Dabrafenib            SB 203580 24 13  0.09
## 1201           Dabrafenib                AMI-1 24 12  0.02
## 1202           Dabrafenib           Vismodegib 24 11  0.03
## 1203           Dabrafenib         Methotrexate 24 10 -0.14
## 1204           Dabrafenib IRAK-1/4 Inhibitor I 24  9  0.05
## 1205           Dabrafenib           Selisistat 24  8  0.06
## 1206           Dabrafenib            Foretinib 24  7  0.01
## 1207           Dabrafenib             JNK-IN-8 24  6  0.17
## 1208           Dabrafenib               BGJ398 24  5  0.00
## 1209           Dabrafenib             SGC 0946 24  4  0.15
## 1210           Dabrafenib               D 4476 24  3  0.10
## 1211           Dabrafenib            A-1210477 24  2  0.34
## 1212           Dabrafenib            Cisplatin 24  1  0.09
## 1213             Imatinib             Imatinib 25 38  1.00
## 1214             Imatinib             KU-55933 25 37  0.51
## 1215             Imatinib          Quizartinib 25 36 -0.16
## 1216             Imatinib             Afatinib 25 35 -0.17
## 1217             Imatinib                TW-37 25 34 -0.19
## 1218             Imatinib            ZM 336372 25 33 -0.13
## 1219             Imatinib              BML-277 25 32 -0.08
## 1220             Imatinib             EPZ-6438 25 31 -0.30
## 1221             Imatinib           PF-3758309 25 30  0.16
## 1222             Imatinib           Venetoclax 25 29 -0.11
## 1223             Imatinib         Doxorubicine 25 28 -0.05
## 1224             Imatinib         Panobinostat 25 27 -0.01
## 1225             Imatinib            Selinexor 25 26  0.12
## 1226             Imatinib               OTX015 25 25  0.00
## 1227             Imatinib           Volasertib 25 24  0.07
## 1228             Imatinib            Nutlin-3a 25 23  0.20
## 1229             Imatinib               RO5963 25 22  0.16
## 1230             Imatinib           Cytarabine 25 21  0.08
## 1231             Imatinib          Fludarabine 25 20 -0.11
## 1232             Imatinib          Ruxolitinib 25 19  0.38
## 1233             Imatinib          Tofacitinib 25 18  0.12
## 1234             Imatinib            Motolimod 25 17  0.04
## 1235             Imatinib  Menin-MLL Inhibitor 25 16  0.24
## 1236             Imatinib               MI-503 25 15  0.38
## 1237             Imatinib             Olaparib 25 14  0.39
## 1238             Imatinib            SB 203580 25 13  0.20
## 1239             Imatinib                AMI-1 25 12  0.11
## 1240             Imatinib           Vismodegib 25 11  0.24
## 1241             Imatinib         Methotrexate 25 10  0.34
## 1242             Imatinib IRAK-1/4 Inhibitor I 25  9  0.39
## 1243             Imatinib           Selisistat 25  8  0.32
## 1244             Imatinib            Foretinib 25  7  0.33
## 1245             Imatinib             JNK-IN-8 25  6  0.18
## 1246             Imatinib               BGJ398 25  5  0.07
## 1247             Imatinib             SGC 0946 25  4  0.13
## 1248             Imatinib               D 4476 25  3 -0.04
## 1249             Imatinib            A-1210477 25  2  0.12
## 1250             Imatinib            Cisplatin 25  1  0.27
## 1251             KU-55933             KU-55933 26 37  1.00
## 1252             KU-55933          Quizartinib 26 36 -0.11
## 1253             KU-55933             Afatinib 26 35 -0.13
## 1254             KU-55933                TW-37 26 34 -0.12
## 1255             KU-55933            ZM 336372 26 33 -0.12
## 1256             KU-55933              BML-277 26 32 -0.17
## 1257             KU-55933             EPZ-6438 26 31 -0.04
## 1258             KU-55933           PF-3758309 26 30  0.04
## 1259             KU-55933           Venetoclax 26 29 -0.14
## 1260             KU-55933         Doxorubicine 26 28  0.04
## 1261             KU-55933         Panobinostat 26 27  0.03
## 1262             KU-55933            Selinexor 26 26  0.03
## 1263             KU-55933               OTX015 26 25  0.11
## 1264             KU-55933           Volasertib 26 24  0.10
## 1265             KU-55933            Nutlin-3a 26 23  0.17
## 1266             KU-55933               RO5963 26 22  0.12
## 1267             KU-55933           Cytarabine 26 21  0.08
## 1268             KU-55933          Fludarabine 26 20 -0.07
## 1269             KU-55933          Ruxolitinib 26 19  0.24
## 1270             KU-55933          Tofacitinib 26 18  0.00
## 1271             KU-55933            Motolimod 26 17  0.21
## 1272             KU-55933  Menin-MLL Inhibitor 26 16  0.44
## 1273             KU-55933               MI-503 26 15  0.15
## 1274             KU-55933             Olaparib 26 14  0.30
## 1275             KU-55933            SB 203580 26 13  0.20
## 1276             KU-55933                AMI-1 26 12  0.05
## 1277             KU-55933           Vismodegib 26 11  0.17
## 1278             KU-55933         Methotrexate 26 10  0.16
## 1279             KU-55933 IRAK-1/4 Inhibitor I 26  9  0.32
## 1280             KU-55933           Selisistat 26  8  0.25
## 1281             KU-55933            Foretinib 26  7  0.06
## 1282             KU-55933             JNK-IN-8 26  6  0.11
## 1283             KU-55933               BGJ398 26  5 -0.04
## 1284             KU-55933             SGC 0946 26  4  0.13
## 1285             KU-55933               D 4476 26  3 -0.09
## 1286             KU-55933            A-1210477 26  2  0.10
## 1287             KU-55933            Cisplatin 26  1  0.21
## 1288          Quizartinib          Quizartinib 27 36  1.00
## 1289          Quizartinib             Afatinib 27 35  0.30
## 1290          Quizartinib                TW-37 27 34  0.38
## 1291          Quizartinib            ZM 336372 27 33  0.20
## 1292          Quizartinib              BML-277 27 32  0.29
## 1293          Quizartinib             EPZ-6438 27 31  0.17
## 1294          Quizartinib           PF-3758309 27 30  0.20
## 1295          Quizartinib           Venetoclax 27 29 -0.01
## 1296          Quizartinib         Doxorubicine 27 28  0.09
## 1297          Quizartinib         Panobinostat 27 27  0.10
## 1298          Quizartinib            Selinexor 27 26  0.06
## 1299          Quizartinib               OTX015 27 25  0.01
## 1300          Quizartinib           Volasertib 27 24  0.09
## 1301          Quizartinib            Nutlin-3a 27 23 -0.04
## 1302          Quizartinib               RO5963 27 22  0.00
## 1303          Quizartinib           Cytarabine 27 21  0.02
## 1304          Quizartinib          Fludarabine 27 20  0.16
## 1305          Quizartinib          Ruxolitinib 27 19  0.03
## 1306          Quizartinib          Tofacitinib 27 18  0.19
## 1307          Quizartinib            Motolimod 27 17  0.00
## 1308          Quizartinib  Menin-MLL Inhibitor 27 16  0.05
## 1309          Quizartinib               MI-503 27 15  0.16
## 1310          Quizartinib             Olaparib 27 14 -0.17
## 1311          Quizartinib            SB 203580 27 13  0.12
## 1312          Quizartinib                AMI-1 27 12  0.29
## 1313          Quizartinib           Vismodegib 27 11  0.29
## 1314          Quizartinib         Methotrexate 27 10  0.33
## 1315          Quizartinib IRAK-1/4 Inhibitor I 27  9  0.28
## 1316          Quizartinib           Selisistat 27  8  0.26
## 1317          Quizartinib            Foretinib 27  7 -0.03
## 1318          Quizartinib             JNK-IN-8 27  6  0.25
## 1319          Quizartinib               BGJ398 27  5  0.08
## 1320          Quizartinib             SGC 0946 27  4  0.18
## 1321          Quizartinib               D 4476 27  3  0.18
## 1322          Quizartinib            A-1210477 27  2  0.03
## 1323          Quizartinib            Cisplatin 27  1  0.09
## 1324             Afatinib             Afatinib 28 35  1.00
## 1325             Afatinib                TW-37 28 34  0.41
## 1326             Afatinib            ZM 336372 28 33  0.13
## 1327             Afatinib              BML-277 28 32  0.29
## 1328             Afatinib             EPZ-6438 28 31  0.23
## 1329             Afatinib           PF-3758309 28 30  0.24
## 1330             Afatinib           Venetoclax 28 29  0.34
## 1331             Afatinib         Doxorubicine 28 28  0.20
## 1332             Afatinib         Panobinostat 28 27  0.17
## 1333             Afatinib            Selinexor 28 26  0.16
## 1334             Afatinib               OTX015 28 25  0.23
## 1335             Afatinib           Volasertib 28 24  0.19
## 1336             Afatinib            Nutlin-3a 28 23  0.22
## 1337             Afatinib               RO5963 28 22  0.14
## 1338             Afatinib           Cytarabine 28 21  0.29
## 1339             Afatinib          Fludarabine 28 20  0.27
## 1340             Afatinib          Ruxolitinib 28 19 -0.02
## 1341             Afatinib          Tofacitinib 28 18  0.15
## 1342             Afatinib            Motolimod 28 17  0.11
## 1343             Afatinib  Menin-MLL Inhibitor 28 16  0.25
## 1344             Afatinib               MI-503 28 15  0.15
## 1345             Afatinib             Olaparib 28 14 -0.12
## 1346             Afatinib            SB 203580 28 13  0.02
## 1347             Afatinib                AMI-1 28 12  0.19
## 1348             Afatinib           Vismodegib 28 11  0.18
## 1349             Afatinib         Methotrexate 28 10  0.07
## 1350             Afatinib IRAK-1/4 Inhibitor I 28  9  0.36
## 1351             Afatinib           Selisistat 28  8  0.24
## 1352             Afatinib            Foretinib 28  7 -0.30
## 1353             Afatinib             JNK-IN-8 28  6  0.15
## 1354             Afatinib               BGJ398 28  5  0.23
## 1355             Afatinib             SGC 0946 28  4 -0.07
## 1356             Afatinib               D 4476 28  3  0.19
## 1357             Afatinib            A-1210477 28  2  0.32
## 1358             Afatinib            Cisplatin 28  1  0.12
## 1359                TW-37                TW-37 29 34  1.00
## 1360                TW-37            ZM 336372 29 33  0.25
## 1361                TW-37              BML-277 29 32  0.31
## 1362                TW-37             EPZ-6438 29 31  0.13
## 1363                TW-37           PF-3758309 29 30 -0.03
## 1364                TW-37           Venetoclax 29 29  0.12
## 1365                TW-37         Doxorubicine 29 28  0.30
## 1366                TW-37         Panobinostat 29 27  0.23
## 1367                TW-37            Selinexor 29 26  0.20
## 1368                TW-37               OTX015 29 25  0.37
## 1369                TW-37           Volasertib 29 24  0.45
## 1370                TW-37            Nutlin-3a 29 23  0.14
## 1371                TW-37               RO5963 29 22  0.14
## 1372                TW-37           Cytarabine 29 21  0.29
## 1373                TW-37          Fludarabine 29 20  0.30
## 1374                TW-37          Ruxolitinib 29 19  0.08
## 1375                TW-37          Tofacitinib 29 18  0.04
## 1376                TW-37            Motolimod 29 17  0.14
## 1377                TW-37  Menin-MLL Inhibitor 29 16  0.03
## 1378                TW-37               MI-503 29 15  0.12
## 1379                TW-37             Olaparib 29 14 -0.08
## 1380                TW-37            SB 203580 29 13  0.19
## 1381                TW-37                AMI-1 29 12  0.34
## 1382                TW-37           Vismodegib 29 11  0.38
## 1383                TW-37         Methotrexate 29 10  0.22
## 1384                TW-37 IRAK-1/4 Inhibitor I 29  9  0.17
## 1385                TW-37           Selisistat 29  8  0.33
## 1386                TW-37            Foretinib 29  7  0.00
## 1387                TW-37             JNK-IN-8 29  6  0.06
## 1388                TW-37               BGJ398 29  5  0.22
## 1389                TW-37             SGC 0946 29  4  0.25
## 1390                TW-37               D 4476 29  3  0.36
## 1391                TW-37            A-1210477 29  2  0.28
## 1392                TW-37            Cisplatin 29  1  0.43
## 1393            ZM 336372            ZM 336372 30 33  1.00
## 1394            ZM 336372              BML-277 30 32  0.39
## 1395            ZM 336372             EPZ-6438 30 31  0.27
## 1396            ZM 336372           PF-3758309 30 30  0.08
## 1397            ZM 336372           Venetoclax 30 29  0.21
## 1398            ZM 336372         Doxorubicine 30 28 -0.15
## 1399            ZM 336372         Panobinostat 30 27 -0.12
## 1400            ZM 336372            Selinexor 30 26  0.07
## 1401            ZM 336372               OTX015 30 25 -0.07
## 1402            ZM 336372           Volasertib 30 24  0.04
## 1403            ZM 336372            Nutlin-3a 30 23 -0.02
## 1404            ZM 336372               RO5963 30 22  0.04
## 1405            ZM 336372           Cytarabine 30 21 -0.06
## 1406            ZM 336372          Fludarabine 30 20 -0.02
## 1407            ZM 336372          Ruxolitinib 30 19 -0.03
## 1408            ZM 336372          Tofacitinib 30 18  0.26
## 1409            ZM 336372            Motolimod 30 17  0.07
## 1410            ZM 336372  Menin-MLL Inhibitor 30 16  0.10
## 1411            ZM 336372               MI-503 30 15  0.22
## 1412            ZM 336372             Olaparib 30 14  0.07
## 1413            ZM 336372            SB 203580 30 13  0.23
## 1414            ZM 336372                AMI-1 30 12  0.41
## 1415            ZM 336372           Vismodegib 30 11  0.28
## 1416            ZM 336372         Methotrexate 30 10  0.07
## 1417            ZM 336372 IRAK-1/4 Inhibitor I 30  9  0.10
## 1418            ZM 336372           Selisistat 30  8  0.21
## 1419            ZM 336372            Foretinib 30  7  0.12
## 1420            ZM 336372             JNK-IN-8 30  6  0.19
## 1421            ZM 336372               BGJ398 30  5  0.03
## 1422            ZM 336372             SGC 0946 30  4  0.27
## 1423            ZM 336372               D 4476 30  3  0.26
## 1424            ZM 336372            A-1210477 30  2 -0.04
## 1425            ZM 336372            Cisplatin 30  1  0.02
## 1426              BML-277              BML-277 31 32  1.00
## 1427              BML-277             EPZ-6438 31 31  0.48
## 1428              BML-277           PF-3758309 31 30 -0.04
## 1429              BML-277           Venetoclax 31 29  0.11
## 1430              BML-277         Doxorubicine 31 28 -0.08
## 1431              BML-277         Panobinostat 31 27 -0.06
## 1432              BML-277            Selinexor 31 26 -0.03
## 1433              BML-277               OTX015 31 25 -0.09
## 1434              BML-277           Volasertib 31 24  0.03
## 1435              BML-277            Nutlin-3a 31 23 -0.09
## 1436              BML-277               RO5963 31 22 -0.06
## 1437              BML-277           Cytarabine 31 21 -0.08
## 1438              BML-277          Fludarabine 31 20 -0.03
## 1439              BML-277          Ruxolitinib 31 19 -0.01
## 1440              BML-277          Tofacitinib 31 18  0.17
## 1441              BML-277            Motolimod 31 17  0.13
## 1442              BML-277  Menin-MLL Inhibitor 31 16  0.16
## 1443              BML-277               MI-503 31 15  0.42
## 1444              BML-277             Olaparib 31 14  0.19
## 1445              BML-277            SB 203580 31 13  0.17
## 1446              BML-277                AMI-1 31 12  0.45
## 1447              BML-277           Vismodegib 31 11  0.43
## 1448              BML-277         Methotrexate 31 10  0.25
## 1449              BML-277 IRAK-1/4 Inhibitor I 31  9  0.23
## 1450              BML-277           Selisistat 31  8  0.31
## 1451              BML-277            Foretinib 31  7  0.16
## 1452              BML-277             JNK-IN-8 31  6  0.17
## 1453              BML-277               BGJ398 31  5  0.31
## 1454              BML-277             SGC 0946 31  4  0.04
## 1455              BML-277               D 4476 31  3  0.47
## 1456              BML-277            A-1210477 31  2  0.13
## 1457              BML-277            Cisplatin 31  1  0.22
## 1458             EPZ-6438             EPZ-6438 32 31  1.00
## 1459             EPZ-6438           PF-3758309 32 30 -0.13
## 1460             EPZ-6438           Venetoclax 32 29  0.01
## 1461             EPZ-6438         Doxorubicine 32 28 -0.02
## 1462             EPZ-6438         Panobinostat 32 27 -0.06
## 1463             EPZ-6438            Selinexor 32 26 -0.09
## 1464             EPZ-6438               OTX015 32 25 -0.11
## 1465             EPZ-6438           Volasertib 32 24 -0.15
## 1466             EPZ-6438            Nutlin-3a 32 23 -0.14
## 1467             EPZ-6438               RO5963 32 22 -0.14
## 1468             EPZ-6438           Cytarabine 32 21 -0.06
## 1469             EPZ-6438          Fludarabine 32 20 -0.05
## 1470             EPZ-6438          Ruxolitinib 32 19 -0.17
## 1471             EPZ-6438          Tofacitinib 32 18  0.02
## 1472             EPZ-6438            Motolimod 32 17  0.21
## 1473             EPZ-6438  Menin-MLL Inhibitor 32 16  0.24
## 1474             EPZ-6438               MI-503 32 15  0.10
## 1475             EPZ-6438             Olaparib 32 14 -0.01
## 1476             EPZ-6438            SB 203580 32 13 -0.08
## 1477             EPZ-6438                AMI-1 32 12  0.05
## 1478             EPZ-6438           Vismodegib 32 11 -0.03
## 1479             EPZ-6438         Methotrexate 32 10 -0.13
## 1480             EPZ-6438 IRAK-1/4 Inhibitor I 32  9 -0.01
## 1481             EPZ-6438           Selisistat 32  8  0.01
## 1482             EPZ-6438            Foretinib 32  7 -0.16
## 1483             EPZ-6438             JNK-IN-8 32  6  0.14
## 1484             EPZ-6438               BGJ398 32  5  0.05
## 1485             EPZ-6438             SGC 0946 32  4 -0.04
## 1486             EPZ-6438               D 4476 32  3  0.11
## 1487             EPZ-6438            A-1210477 32  2 -0.13
## 1488             EPZ-6438            Cisplatin 32  1 -0.08
## 1489           PF-3758309           PF-3758309 33 30  1.00
## 1490           PF-3758309           Venetoclax 33 29  0.39
## 1491           PF-3758309         Doxorubicine 33 28  0.12
## 1492           PF-3758309         Panobinostat 33 27  0.26
## 1493           PF-3758309            Selinexor 33 26  0.32
## 1494           PF-3758309               OTX015 33 25  0.36
## 1495           PF-3758309           Volasertib 33 24  0.29
## 1496           PF-3758309            Nutlin-3a 33 23  0.36
## 1497           PF-3758309               RO5963 33 22  0.38
## 1498           PF-3758309           Cytarabine 33 21  0.36
## 1499           PF-3758309          Fludarabine 33 20  0.41
## 1500           PF-3758309          Ruxolitinib 33 19  0.16
## 1501           PF-3758309          Tofacitinib 33 18  0.30
## 1502           PF-3758309            Motolimod 33 17 -0.12
## 1503           PF-3758309  Menin-MLL Inhibitor 33 16  0.11
## 1504           PF-3758309               MI-503 33 15  0.10
## 1505           PF-3758309             Olaparib 33 14 -0.12
## 1506           PF-3758309            SB 203580 33 13 -0.05
## 1507           PF-3758309                AMI-1 33 12  0.07
## 1508           PF-3758309           Vismodegib 33 11  0.10
## 1509           PF-3758309         Methotrexate 33 10 -0.03
## 1510           PF-3758309 IRAK-1/4 Inhibitor I 33  9  0.32
## 1511           PF-3758309           Selisistat 33  8  0.13
## 1512           PF-3758309            Foretinib 33  7 -0.14
## 1513           PF-3758309             JNK-IN-8 33  6  0.12
## 1514           PF-3758309               BGJ398 33  5  0.11
## 1515           PF-3758309             SGC 0946 33  4  0.03
## 1516           PF-3758309               D 4476 33  3 -0.08
## 1517           PF-3758309            A-1210477 33  2  0.16
## 1518           PF-3758309            Cisplatin 33  1  0.04
## 1519           Venetoclax           Venetoclax 34 29  1.00
## 1520           Venetoclax         Doxorubicine 34 28  0.00
## 1521           Venetoclax         Panobinostat 34 27  0.02
## 1522           Venetoclax            Selinexor 34 26  0.05
## 1523           Venetoclax               OTX015 34 25  0.08
## 1524           Venetoclax           Volasertib 34 24  0.06
## 1525           Venetoclax            Nutlin-3a 34 23  0.20
## 1526           Venetoclax               RO5963 34 22  0.22
## 1527           Venetoclax           Cytarabine 34 21  0.18
## 1528           Venetoclax          Fludarabine 34 20  0.15
## 1529           Venetoclax          Ruxolitinib 34 19 -0.14
## 1530           Venetoclax          Tofacitinib 34 18  0.00
## 1531           Venetoclax            Motolimod 34 17 -0.06
## 1532           Venetoclax  Menin-MLL Inhibitor 34 16  0.01
## 1533           Venetoclax               MI-503 34 15  0.17
## 1534           Venetoclax             Olaparib 34 14 -0.03
## 1535           Venetoclax            SB 203580 34 13 -0.16
## 1536           Venetoclax                AMI-1 34 12  0.05
## 1537           Venetoclax           Vismodegib 34 11 -0.01
## 1538           Venetoclax         Methotrexate 34 10 -0.18
## 1539           Venetoclax IRAK-1/4 Inhibitor I 34  9  0.16
## 1540           Venetoclax           Selisistat 34  8  0.03
## 1541           Venetoclax            Foretinib 34  7 -0.18
## 1542           Venetoclax             JNK-IN-8 34  6  0.16
## 1543           Venetoclax               BGJ398 34  5  0.11
## 1544           Venetoclax             SGC 0946 34  4 -0.09
## 1545           Venetoclax               D 4476 34  3  0.02
## 1546           Venetoclax            A-1210477 34  2  0.17
## 1547           Venetoclax            Cisplatin 34  1 -0.05
## 1548         Doxorubicine         Doxorubicine 35 28  1.00
## 1549         Doxorubicine         Panobinostat 35 27  0.44
## 1550         Doxorubicine            Selinexor 35 26  0.44
## 1551         Doxorubicine               OTX015 35 25  0.46
## 1552         Doxorubicine           Volasertib 35 24  0.36
## 1553         Doxorubicine            Nutlin-3a 35 23  0.22
## 1554         Doxorubicine               RO5963 35 22  0.22
## 1555         Doxorubicine           Cytarabine 35 21  0.42
## 1556         Doxorubicine          Fludarabine 35 20  0.37
## 1557         Doxorubicine          Ruxolitinib 35 19 -0.04
## 1558         Doxorubicine          Tofacitinib 35 18 -0.17
## 1559         Doxorubicine            Motolimod 35 17  0.25
## 1560         Doxorubicine  Menin-MLL Inhibitor 35 16  0.03
## 1561         Doxorubicine               MI-503 35 15 -0.16
## 1562         Doxorubicine             Olaparib 35 14 -0.27
## 1563         Doxorubicine            SB 203580 35 13 -0.04
## 1564         Doxorubicine                AMI-1 35 12 -0.08
## 1565         Doxorubicine           Vismodegib 35 11  0.02
## 1566         Doxorubicine         Methotrexate 35 10  0.03
## 1567         Doxorubicine IRAK-1/4 Inhibitor I 35  9  0.17
## 1568         Doxorubicine           Selisistat 35  8  0.10
## 1569         Doxorubicine            Foretinib 35  7 -0.17
## 1570         Doxorubicine             JNK-IN-8 35  6  0.06
## 1571         Doxorubicine               BGJ398 35  5  0.05
## 1572         Doxorubicine             SGC 0946 35  4  0.10
## 1573         Doxorubicine               D 4476 35  3  0.11
## 1574         Doxorubicine            A-1210477 35  2  0.21
## 1575         Doxorubicine            Cisplatin 35  1  0.31
## 1576         Panobinostat         Panobinostat 36 27  1.00
## 1577         Panobinostat            Selinexor 36 26  0.31
## 1578         Panobinostat               OTX015 36 25  0.56
## 1579         Panobinostat           Volasertib 36 24  0.45
## 1580         Panobinostat            Nutlin-3a 36 23  0.31
## 1581         Panobinostat               RO5963 36 22  0.35
## 1582         Panobinostat           Cytarabine 36 21  0.32
## 1583         Panobinostat          Fludarabine 36 20  0.52
## 1584         Panobinostat          Ruxolitinib 36 19  0.04
## 1585         Panobinostat          Tofacitinib 36 18  0.05
## 1586         Panobinostat            Motolimod 36 17  0.05
## 1587         Panobinostat  Menin-MLL Inhibitor 36 16 -0.01
## 1588         Panobinostat               MI-503 36 15  0.07
## 1589         Panobinostat             Olaparib 36 14 -0.17
## 1590         Panobinostat            SB 203580 36 13 -0.13
## 1591         Panobinostat                AMI-1 36 12 -0.07
## 1592         Panobinostat           Vismodegib 36 11 -0.08
## 1593         Panobinostat         Methotrexate 36 10  0.04
## 1594         Panobinostat IRAK-1/4 Inhibitor I 36  9  0.04
## 1595         Panobinostat           Selisistat 36  8  0.01
## 1596         Panobinostat            Foretinib 36  7 -0.21
## 1597         Panobinostat             JNK-IN-8 36  6 -0.18
## 1598         Panobinostat               BGJ398 36  5  0.13
## 1599         Panobinostat             SGC 0946 36  4  0.03
## 1600         Panobinostat               D 4476 36  3 -0.04
## 1601         Panobinostat            A-1210477 36  2  0.14
## 1602         Panobinostat            Cisplatin 36  1  0.13
## 1603            Selinexor            Selinexor 37 26  1.00
## 1604            Selinexor               OTX015 37 25  0.36
## 1605            Selinexor           Volasertib 37 24  0.36
## 1606            Selinexor            Nutlin-3a 37 23  0.37
## 1607            Selinexor               RO5963 37 22  0.40
## 1608            Selinexor           Cytarabine 37 21  0.35
## 1609            Selinexor          Fludarabine 37 20  0.42
## 1610            Selinexor          Ruxolitinib 37 19  0.23
## 1611            Selinexor          Tofacitinib 37 18  0.15
## 1612            Selinexor            Motolimod 37 17  0.17
## 1613            Selinexor  Menin-MLL Inhibitor 37 16  0.04
## 1614            Selinexor               MI-503 37 15  0.06
## 1615            Selinexor             Olaparib 37 14 -0.12
## 1616            Selinexor            SB 203580 37 13  0.17
## 1617            Selinexor                AMI-1 37 12  0.09
## 1618            Selinexor           Vismodegib 37 11  0.15
## 1619            Selinexor         Methotrexate 37 10 -0.04
## 1620            Selinexor IRAK-1/4 Inhibitor I 37  9  0.22
## 1621            Selinexor           Selisistat 37  8  0.19
## 1622            Selinexor            Foretinib 37  7 -0.01
## 1623            Selinexor             JNK-IN-8 37  6  0.05
## 1624            Selinexor               BGJ398 37  5  0.13
## 1625            Selinexor             SGC 0946 37  4  0.22
## 1626            Selinexor               D 4476 37  3  0.19
## 1627            Selinexor            A-1210477 37  2  0.22
## 1628            Selinexor            Cisplatin 37  1  0.14
## 1629               OTX015               OTX015 38 25  1.00
## 1630               OTX015           Volasertib 38 24  0.85
## 1631               OTX015            Nutlin-3a 38 23  0.54
## 1632               OTX015               RO5963 38 22  0.49
## 1633               OTX015           Cytarabine 38 21  0.52
## 1634               OTX015          Fludarabine 38 20  0.56
## 1635               OTX015          Ruxolitinib 38 19  0.08
## 1636               OTX015          Tofacitinib 38 18 -0.03
## 1637               OTX015            Motolimod 38 17  0.20
## 1638               OTX015  Menin-MLL Inhibitor 38 16  0.04
## 1639               OTX015               MI-503 38 15 -0.16
## 1640               OTX015             Olaparib 38 14 -0.28
## 1641               OTX015            SB 203580 38 13  0.10
## 1642               OTX015                AMI-1 38 12 -0.01
## 1643               OTX015           Vismodegib 38 11  0.07
## 1644               OTX015         Methotrexate 38 10  0.01
## 1645               OTX015 IRAK-1/4 Inhibitor I 38  9  0.20
## 1646               OTX015           Selisistat 38  8  0.15
## 1647               OTX015            Foretinib 38  7 -0.13
## 1648               OTX015             JNK-IN-8 38  6 -0.08
## 1649               OTX015               BGJ398 38  5  0.16
## 1650               OTX015             SGC 0946 38  4  0.21
## 1651               OTX015               D 4476 38  3  0.15
## 1652               OTX015            A-1210477 38  2  0.38
## 1653               OTX015            Cisplatin 38  1  0.38
## 1654           Volasertib           Volasertib 39 24  1.00
## 1655           Volasertib            Nutlin-3a 39 23  0.55
## 1656           Volasertib               RO5963 39 22  0.47
## 1657           Volasertib           Cytarabine 39 21  0.49
## 1658           Volasertib          Fludarabine 39 20  0.47
## 1659           Volasertib          Ruxolitinib 39 19  0.22
## 1660           Volasertib          Tofacitinib 39 18  0.03
## 1661           Volasertib            Motolimod 39 17  0.17
## 1662           Volasertib  Menin-MLL Inhibitor 39 16 -0.06
## 1663           Volasertib               MI-503 39 15 -0.09
## 1664           Volasertib             Olaparib 39 14 -0.13
## 1665           Volasertib            SB 203580 39 13  0.28
## 1666           Volasertib                AMI-1 39 12  0.22
## 1667           Volasertib           Vismodegib 39 11  0.29
## 1668           Volasertib         Methotrexate 39 10  0.13
## 1669           Volasertib IRAK-1/4 Inhibitor I 39  9  0.20
## 1670           Volasertib           Selisistat 39  8  0.21
## 1671           Volasertib            Foretinib 39  7  0.10
## 1672           Volasertib             JNK-IN-8 39  6 -0.01
## 1673           Volasertib               BGJ398 39  5  0.30
## 1674           Volasertib             SGC 0946 39  4  0.38
## 1675           Volasertib               D 4476 39  3  0.33
## 1676           Volasertib            A-1210477 39  2  0.47
## 1677           Volasertib            Cisplatin 39  1  0.49
## 1678            Nutlin-3a            Nutlin-3a 40 23  1.00
## 1679            Nutlin-3a               RO5963 40 22  0.88
## 1680            Nutlin-3a           Cytarabine 40 21  0.70
## 1681            Nutlin-3a          Fludarabine 40 20  0.63
## 1682            Nutlin-3a          Ruxolitinib 40 19  0.16
## 1683            Nutlin-3a          Tofacitinib 40 18  0.09
## 1684            Nutlin-3a            Motolimod 40 17  0.05
## 1685            Nutlin-3a  Menin-MLL Inhibitor 40 16  0.14
## 1686            Nutlin-3a               MI-503 40 15 -0.03
## 1687            Nutlin-3a             Olaparib 40 14  0.02
## 1688            Nutlin-3a            SB 203580 40 13  0.19
## 1689            Nutlin-3a                AMI-1 40 12  0.08
## 1690            Nutlin-3a           Vismodegib 40 11  0.21
## 1691            Nutlin-3a         Methotrexate 40 10  0.08
## 1692            Nutlin-3a IRAK-1/4 Inhibitor I 40  9  0.31
## 1693            Nutlin-3a           Selisistat 40  8  0.29
## 1694            Nutlin-3a            Foretinib 40  7 -0.06
## 1695            Nutlin-3a             JNK-IN-8 40  6  0.07
## 1696            Nutlin-3a               BGJ398 40  5  0.08
## 1697            Nutlin-3a             SGC 0946 40  4  0.07
## 1698            Nutlin-3a               D 4476 40  3  0.10
## 1699            Nutlin-3a            A-1210477 40  2  0.35
## 1700            Nutlin-3a            Cisplatin 40  1  0.21
## 1701               RO5963               RO5963 41 22  1.00
## 1702               RO5963           Cytarabine 41 21  0.59
## 1703               RO5963          Fludarabine 41 20  0.59
## 1704               RO5963          Ruxolitinib 41 19  0.16
## 1705               RO5963          Tofacitinib 41 18  0.16
## 1706               RO5963            Motolimod 41 17  0.02
## 1707               RO5963  Menin-MLL Inhibitor 41 16  0.11
## 1708               RO5963               MI-503 41 15  0.00
## 1709               RO5963             Olaparib 41 14  0.01
## 1710               RO5963            SB 203580 41 13  0.20
## 1711               RO5963                AMI-1 41 12  0.16
## 1712               RO5963           Vismodegib 41 11  0.22
## 1713               RO5963         Methotrexate 41 10  0.06
## 1714               RO5963 IRAK-1/4 Inhibitor I 41  9  0.28
## 1715               RO5963           Selisistat 41  8  0.30
## 1716               RO5963            Foretinib 41  7 -0.05
## 1717               RO5963             JNK-IN-8 41  6 -0.01
## 1718               RO5963               BGJ398 41  5  0.09
## 1719               RO5963             SGC 0946 41  4  0.12
## 1720               RO5963               D 4476 41  3  0.10
## 1721               RO5963            A-1210477 41  2  0.28
## 1722               RO5963            Cisplatin 41  1  0.15
## 1723           Cytarabine           Cytarabine 42 21  1.00
## 1724           Cytarabine          Fludarabine 42 20  0.73
## 1725           Cytarabine          Ruxolitinib 42 19  0.06
## 1726           Cytarabine          Tofacitinib 42 18  0.01
## 1727           Cytarabine            Motolimod 42 17  0.12
## 1728           Cytarabine  Menin-MLL Inhibitor 42 16  0.11
## 1729           Cytarabine               MI-503 42 15 -0.09
## 1730           Cytarabine             Olaparib 42 14 -0.11
## 1731           Cytarabine            SB 203580 42 13  0.08
## 1732           Cytarabine                AMI-1 42 12  0.05
## 1733           Cytarabine           Vismodegib 42 11  0.11
## 1734           Cytarabine         Methotrexate 42 10  0.03
## 1735           Cytarabine IRAK-1/4 Inhibitor I 42  9  0.25
## 1736           Cytarabine           Selisistat 42  8  0.19
## 1737           Cytarabine            Foretinib 42  7 -0.09
## 1738           Cytarabine             JNK-IN-8 42  6  0.10
## 1739           Cytarabine               BGJ398 42  5  0.08
## 1740           Cytarabine             SGC 0946 42  4  0.05
## 1741           Cytarabine               D 4476 42  3  0.09
## 1742           Cytarabine            A-1210477 42  2  0.32
## 1743           Cytarabine            Cisplatin 42  1  0.37
## 1744          Fludarabine          Fludarabine 43 20  1.00
## 1745          Fludarabine          Ruxolitinib 43 19  0.03
## 1746          Fludarabine          Tofacitinib 43 18  0.06
## 1747          Fludarabine            Motolimod 43 17  0.09
## 1748          Fludarabine  Menin-MLL Inhibitor 43 16  0.02
## 1749          Fludarabine               MI-503 43 15 -0.10
## 1750          Fludarabine             Olaparib 43 14 -0.27
## 1751          Fludarabine            SB 203580 43 13 -0.01
## 1752          Fludarabine                AMI-1 43 12  0.01
## 1753          Fludarabine           Vismodegib 43 11  0.04
## 1754          Fludarabine         Methotrexate 43 10  0.03
## 1755          Fludarabine IRAK-1/4 Inhibitor I 43  9  0.15
## 1756          Fludarabine           Selisistat 43  8  0.07
## 1757          Fludarabine            Foretinib 43  7 -0.24
## 1758          Fludarabine             JNK-IN-8 43  6 -0.02
## 1759          Fludarabine               BGJ398 43  5  0.13
## 1760          Fludarabine             SGC 0946 43  4  0.04
## 1761          Fludarabine               D 4476 43  3  0.05
## 1762          Fludarabine            A-1210477 43  2  0.24
## 1763          Fludarabine            Cisplatin 43  1  0.23
## 1764          Ruxolitinib          Ruxolitinib 44 19  1.00
## 1765          Ruxolitinib          Tofacitinib 44 18  0.59
## 1766          Ruxolitinib            Motolimod 44 17  0.06
## 1767          Ruxolitinib  Menin-MLL Inhibitor 44 16  0.07
## 1768          Ruxolitinib               MI-503 44 15  0.14
## 1769          Ruxolitinib             Olaparib 44 14  0.25
## 1770          Ruxolitinib            SB 203580 44 13  0.37
## 1771          Ruxolitinib                AMI-1 44 12  0.21
## 1772          Ruxolitinib           Vismodegib 44 11  0.36
## 1773          Ruxolitinib         Methotrexate 44 10  0.16
## 1774          Ruxolitinib IRAK-1/4 Inhibitor I 44  9  0.17
## 1775          Ruxolitinib           Selisistat 44  8  0.21
## 1776          Ruxolitinib            Foretinib 44  7  0.23
## 1777          Ruxolitinib             JNK-IN-8 44  6  0.03
## 1778          Ruxolitinib               BGJ398 44  5  0.14
## 1779          Ruxolitinib             SGC 0946 44  4  0.36
## 1780          Ruxolitinib               D 4476 44  3  0.09
## 1781          Ruxolitinib            A-1210477 44  2  0.10
## 1782          Ruxolitinib            Cisplatin 44  1  0.22
## 1783          Tofacitinib          Tofacitinib 45 18  1.00
## 1784          Tofacitinib            Motolimod 45 17  0.03
## 1785          Tofacitinib  Menin-MLL Inhibitor 45 16  0.21
## 1786          Tofacitinib               MI-503 45 15  0.23
## 1787          Tofacitinib             Olaparib 45 14  0.30
## 1788          Tofacitinib            SB 203580 45 13  0.35
## 1789          Tofacitinib                AMI-1 45 12  0.38
## 1790          Tofacitinib           Vismodegib 45 11  0.35
## 1791          Tofacitinib         Methotrexate 45 10  0.09
## 1792          Tofacitinib IRAK-1/4 Inhibitor I 45  9  0.25
## 1793          Tofacitinib           Selisistat 45  8  0.26
## 1794          Tofacitinib            Foretinib 45  7  0.01
## 1795          Tofacitinib             JNK-IN-8 45  6  0.00
## 1796          Tofacitinib               BGJ398 45  5  0.03
## 1797          Tofacitinib             SGC 0946 45  4  0.13
## 1798          Tofacitinib               D 4476 45  3  0.04
## 1799          Tofacitinib            A-1210477 45  2 -0.08
## 1800          Tofacitinib            Cisplatin 45  1 -0.05
## 1801            Motolimod            Motolimod 46 17  1.00
## 1802            Motolimod  Menin-MLL Inhibitor 46 16  0.30
## 1803            Motolimod               MI-503 46 15  0.16
## 1804            Motolimod             Olaparib 46 14  0.12
## 1805            Motolimod            SB 203580 46 13  0.22
## 1806            Motolimod                AMI-1 46 12  0.12
## 1807            Motolimod           Vismodegib 46 11  0.17
## 1808            Motolimod         Methotrexate 46 10  0.09
## 1809            Motolimod IRAK-1/4 Inhibitor I 46  9  0.18
## 1810            Motolimod           Selisistat 46  8  0.25
## 1811            Motolimod            Foretinib 46  7 -0.03
## 1812            Motolimod             JNK-IN-8 46  6  0.05
## 1813            Motolimod               BGJ398 46  5  0.04
## 1814            Motolimod             SGC 0946 46  4  0.17
## 1815            Motolimod               D 4476 46  3  0.20
## 1816            Motolimod            A-1210477 46  2  0.07
## 1817            Motolimod            Cisplatin 46  1  0.17
## 1818  Menin-MLL Inhibitor  Menin-MLL Inhibitor 47 16  1.00
## 1819  Menin-MLL Inhibitor               MI-503 47 15  0.32
## 1820  Menin-MLL Inhibitor             Olaparib 47 14  0.31
## 1821  Menin-MLL Inhibitor            SB 203580 47 13  0.21
## 1822  Menin-MLL Inhibitor                AMI-1 47 12  0.22
## 1823  Menin-MLL Inhibitor           Vismodegib 47 11  0.25
## 1824  Menin-MLL Inhibitor         Methotrexate 47 10  0.16
## 1825  Menin-MLL Inhibitor IRAK-1/4 Inhibitor I 47  9  0.52
## 1826  Menin-MLL Inhibitor           Selisistat 47  8  0.39
## 1827  Menin-MLL Inhibitor            Foretinib 47  7 -0.18
## 1828  Menin-MLL Inhibitor             JNK-IN-8 47  6  0.17
## 1829  Menin-MLL Inhibitor               BGJ398 47  5 -0.13
## 1830  Menin-MLL Inhibitor             SGC 0946 47  4 -0.05
## 1831  Menin-MLL Inhibitor               D 4476 47  3  0.02
## 1832  Menin-MLL Inhibitor            A-1210477 47  2 -0.04
## 1833  Menin-MLL Inhibitor            Cisplatin 47  1  0.02
## 1834               MI-503               MI-503 48 15  1.00
## 1835               MI-503             Olaparib 48 14  0.44
## 1836               MI-503            SB 203580 48 13  0.15
## 1837               MI-503                AMI-1 48 12  0.35
## 1838               MI-503           Vismodegib 48 11  0.36
## 1839               MI-503         Methotrexate 48 10  0.34
## 1840               MI-503 IRAK-1/4 Inhibitor I 48  9  0.37
## 1841               MI-503           Selisistat 48  8  0.39
## 1842               MI-503            Foretinib 48  7  0.20
## 1843               MI-503             JNK-IN-8 48  6  0.20
## 1844               MI-503               BGJ398 48  5  0.18
## 1845               MI-503             SGC 0946 48  4  0.03
## 1846               MI-503               D 4476 48  3  0.13
## 1847               MI-503            A-1210477 48  2  0.04
## 1848               MI-503            Cisplatin 48  1  0.17
## 1849             Olaparib             Olaparib 49 14  1.00
## 1850             Olaparib            SB 203580 49 13  0.33
## 1851             Olaparib                AMI-1 49 12  0.38
## 1852             Olaparib           Vismodegib 49 11  0.40
## 1853             Olaparib         Methotrexate 49 10  0.25
## 1854             Olaparib IRAK-1/4 Inhibitor I 49  9  0.19
## 1855             Olaparib           Selisistat 49  8  0.33
## 1856             Olaparib            Foretinib 49  7  0.31
## 1857             Olaparib             JNK-IN-8 49  6  0.09
## 1858             Olaparib               BGJ398 49  5 -0.02
## 1859             Olaparib             SGC 0946 49  4  0.01
## 1860             Olaparib               D 4476 49  3  0.06
## 1861             Olaparib            A-1210477 49  2 -0.03
## 1862             Olaparib            Cisplatin 49  1  0.05
## 1863            SB 203580            SB 203580 50 13  1.00
## 1864            SB 203580                AMI-1 50 12  0.45
## 1865            SB 203580           Vismodegib 50 11  0.57
## 1866            SB 203580         Methotrexate 50 10  0.22
## 1867            SB 203580 IRAK-1/4 Inhibitor I 50  9  0.31
## 1868            SB 203580           Selisistat 50  8  0.47
## 1869            SB 203580            Foretinib 50  7  0.40
## 1870            SB 203580             JNK-IN-8 50  6  0.10
## 1871            SB 203580               BGJ398 50  5  0.00
## 1872            SB 203580             SGC 0946 50  4  0.38
## 1873            SB 203580               D 4476 50  3  0.31
## 1874            SB 203580            A-1210477 50  2  0.12
## 1875            SB 203580            Cisplatin 50  1  0.23
## 1876                AMI-1                AMI-1 51 12  1.00
## 1877                AMI-1           Vismodegib 51 11  0.75
## 1878                AMI-1         Methotrexate 51 10  0.36
## 1879                AMI-1 IRAK-1/4 Inhibitor I 51  9  0.42
## 1880                AMI-1           Selisistat 51  8  0.61
## 1881                AMI-1            Foretinib 51  7  0.23
## 1882                AMI-1             JNK-IN-8 51  6  0.11
## 1883                AMI-1               BGJ398 51  5  0.23
## 1884                AMI-1             SGC 0946 51  4  0.41
## 1885                AMI-1               D 4476 51  3  0.47
## 1886                AMI-1            A-1210477 51  2  0.26
## 1887                AMI-1            Cisplatin 51  1  0.33
## 1888           Vismodegib           Vismodegib 52 11  1.00
## 1889           Vismodegib         Methotrexate 52 10  0.43
## 1890           Vismodegib IRAK-1/4 Inhibitor I 52  9  0.57
## 1891           Vismodegib           Selisistat 52  8  0.72
## 1892           Vismodegib            Foretinib 52  7  0.28
## 1893           Vismodegib             JNK-IN-8 52  6  0.16
## 1894           Vismodegib               BGJ398 52  5  0.17
## 1895           Vismodegib             SGC 0946 52  4  0.31
## 1896           Vismodegib               D 4476 52  3  0.44
## 1897           Vismodegib            A-1210477 52  2  0.33
## 1898           Vismodegib            Cisplatin 52  1  0.41
## 1899         Methotrexate         Methotrexate 53 10  1.00
## 1900         Methotrexate IRAK-1/4 Inhibitor I 53  9  0.45
## 1901         Methotrexate           Selisistat 53  8  0.45
## 1902         Methotrexate            Foretinib 53  7  0.23
## 1903         Methotrexate             JNK-IN-8 53  6  0.02
## 1904         Methotrexate               BGJ398 53  5  0.05
## 1905         Methotrexate             SGC 0946 53  4  0.08
## 1906         Methotrexate               D 4476 53  3  0.17
## 1907         Methotrexate            A-1210477 53  2  0.14
## 1908         Methotrexate            Cisplatin 53  1  0.37
## 1909 IRAK-1/4 Inhibitor I IRAK-1/4 Inhibitor I 54  9  1.00
## 1910 IRAK-1/4 Inhibitor I           Selisistat 54  8  0.65
## 1911 IRAK-1/4 Inhibitor I            Foretinib 54  7 -0.02
## 1912 IRAK-1/4 Inhibitor I             JNK-IN-8 54  6  0.26
## 1913 IRAK-1/4 Inhibitor I               BGJ398 54  5  0.08
## 1914 IRAK-1/4 Inhibitor I             SGC 0946 54  4  0.09
## 1915 IRAK-1/4 Inhibitor I               D 4476 54  3  0.21
## 1916 IRAK-1/4 Inhibitor I            A-1210477 54  2  0.32
## 1917 IRAK-1/4 Inhibitor I            Cisplatin 54  1  0.35
## 1918           Selisistat           Selisistat 55  8  1.00
## 1919           Selisistat            Foretinib 55  7  0.09
## 1920           Selisistat             JNK-IN-8 55  6  0.06
## 1921           Selisistat               BGJ398 55  5 -0.01
## 1922           Selisistat             SGC 0946 55  4  0.28
## 1923           Selisistat               D 4476 55  3  0.37
## 1924           Selisistat            A-1210477 55  2  0.36
## 1925           Selisistat            Cisplatin 55  1  0.39
## 1926            Foretinib            Foretinib 56  7  1.00
## 1927            Foretinib             JNK-IN-8 56  6  0.29
## 1928            Foretinib               BGJ398 56  5  0.15
## 1929            Foretinib             SGC 0946 56  4  0.30
## 1930            Foretinib               D 4476 56  3  0.31
## 1931            Foretinib            A-1210477 56  2  0.02
## 1932            Foretinib            Cisplatin 56  1  0.36
## 1933             JNK-IN-8             JNK-IN-8 57  6  1.00
## 1934             JNK-IN-8               BGJ398 57  5  0.07
## 1935             JNK-IN-8             SGC 0946 57  4  0.04
## 1936             JNK-IN-8               D 4476 57  3  0.17
## 1937             JNK-IN-8            A-1210477 57  2  0.03
## 1938             JNK-IN-8            Cisplatin 57  1  0.12
## 1939               BGJ398               BGJ398 58  5  1.00
## 1940               BGJ398             SGC 0946 58  4  0.27
## 1941               BGJ398               D 4476 58  3  0.29
## 1942               BGJ398            A-1210477 58  2  0.31
## 1943               BGJ398            Cisplatin 58  1  0.38
## 1944             SGC 0946             SGC 0946 59  4  1.00
## 1945             SGC 0946               D 4476 59  3  0.35
## 1946             SGC 0946            A-1210477 59  2  0.31
## 1947             SGC 0946            Cisplatin 59  1  0.37
## 1948               D 4476               D 4476 60  3  1.00
## 1949               D 4476            A-1210477 60  2  0.36
## 1950               D 4476            Cisplatin 60  1  0.41
## 1951            A-1210477            A-1210477 61  2  1.00
## 1952            A-1210477            Cisplatin 61  1  0.48
## 1953            Cisplatin            Cisplatin 62  1  1.00
## 
## $arg
## $arg$type
## [1] "lower"
grid.echo()

P1 <- grid.grab()
grid.draw(P1)

#Plot1
matrix.colors1 <- getGrob(P1, gPath("square"), grep = TRUE)[["gp"]][["fill"]]
P1 <- editGrob(P1,
               gPath("square"), grep = TRUE,
               gp = gpar(col = NA,
                         fill = NA))

# apply the saved colours to the underlying matrix grob
P1 <- editGrob(P1,
               gPath("symbols-rect-1"), grep = TRUE,
               gp = gpar(fill = matrix.colors1))

# convert the background fill from white to transparent, while we are at it
P1 <- editGrob(P1,
               gPath("background"), grep = TRUE,
               gp = gpar(fill = NA))               
               

#prepare data for AML
aml_df <- screen_long |> 
  filter(diagnosis == "AML") |> 
  group_by(patientID, drug) |> 
  summarize(mean_viab = mean(viability)) |> 
  pivot_wider(names_from = drug, values_from = mean_viab)
## `summarise()` has grouped output by 'patientID'. You can override using the
## `.groups` argument.
aml_corr_df <- scale(aml_df[3:length(aml_df)])

#calculate correlations
aml_corr <- round(cor(aml_corr_df), 2)

#add colors for pathways (names not correct!)
all_labels <- colnames(aml_corr)
highlight_hsp <- c("Onalespib", "PF.3758309") # verify order
highlight_bcr <- c("KU.55933", "MI.503", "MK.2206", "Menin.MLL.Inhibitor")
highlight_pi3k <- c("SCH772984", "SGC.0946")
highlight_aktmtor <- c("Selisistat", "Sunitinib","Afatinib", "X10058.F4")
highlight_mapk <- c("PRT062607", "Palbociclib", "Panobinostat")

label_colors <- setNames(rep("black", length(all_labels)), all_labels)
label_colors[highlight_hsp] <- "#BEBADA"
label_colors[highlight_bcr] <- "#80B1D3"
label_colors[highlight_pi3k] <- "#FB8072"
label_colors[highlight_aktmtor] <- "#BC80BD"
label_colors[highlight_mapk] <- "#FDB462"

aml_cor_heatmap <- corrplot(aml_corr, type="lower", order="hclust", method="color", 
         col = colors_cor_heatmap(20), sig.level = 0.05, addgrid.col = "grey", 
         insig = "blank", tl.col = label_colors, tl.cex = 0.7, tl.pos = NULL,
         tl.offset = c(0.3), title="AML", cex.main = 0.75, col.main = "black", mar = c(0,0,0.5,0), 
         cl.ratio = 0.1, , cl.cex = 0.7, cl.col = "grey", asp=1)
## Warning in text.default(pos.xlabel[, 1], pos.xlabel[, 2], newcolnames, srt =
## tl.srt, : "cl.col" is not a graphical parameter
## Warning in text.default(pos.ylabel[, 1], pos.ylabel[, 2], newrownames, col =
## tl.col, : "cl.col" is not a graphical parameter
## Warning in title(title, ...): "cl.col" is not a graphical parameter

#prepare for multipanel figure
aml_cor_heatmap
## $corr
##                      BMS-509744 Ceritinib Fludarabine Selinexor Nutlin-3a
## BMS-509744                 1.00      0.48        0.19      0.22      0.38
## Ceritinib                  0.48      1.00        0.14      0.33      0.44
## Fludarabine                0.19      0.14        1.00      0.59      0.62
## Selinexor                  0.22      0.33        0.59      1.00      0.69
## Nutlin-3a                  0.38      0.44        0.62      0.69      1.00
## Venetoclax                 0.16      0.48        0.60      0.64      0.79
## Cytarabine                 0.17      0.09        0.43      0.29      0.35
## RO5963                     0.44      0.24        0.51      0.46      0.57
## A-1210477                  0.26      0.30        0.47      0.43      0.46
## Panobinostat               0.25      0.27        0.48      0.57      0.40
## A-674563                   0.28      0.34        0.54      0.56      0.60
## Palbociclib                0.39      0.31        0.47      0.56      0.44
## Dabrafenib                -0.32     -0.31       -0.06     -0.32     -0.18
## ZM 336372                  0.11      0.09       -0.04     -0.08      0.01
## EPZ-6438                  -0.10     -0.10        0.06     -0.06      0.06
## ONO-4059                   0.38      0.07        0.18      0.01      0.27
## Midostaurin                0.04     -0.15        0.03     -0.12     -0.01
## Methotrexate              -0.07     -0.16       -0.36     -0.30     -0.30
## Motolimod                 -0.04     -0.27       -0.34     -0.25     -0.44
## Olaparib                   0.34      0.25        0.25      0.28      0.32
## Cisplatin                  0.16      0.29        0.22      0.24      0.22
## BGJ398                     0.18      0.10       -0.05     -0.09     -0.22
## BML-277                    0.13      0.28        0.05      0.05      0.12
## AMI-1                      0.14      0.14        0.04     -0.16      0.02
## Vismodegib                -0.04      0.13       -0.06     -0.01      0.07
## Selisistat                 0.22      0.04       -0.06     -0.01      0.11
## TW-37                      0.10     -0.14       -0.10     -0.03     -0.06
## D 4476                     0.03     -0.15        0.02     -0.10     -0.21
## Doxorubicine               0.11     -0.10        0.26      0.31      0.11
## Dasatinib                  0.15     -0.07       -0.10     -0.07     -0.22
## Duvelisib                  0.40      0.11        0.18      0.12     -0.05
## Idelalisib                 0.39      0.17        0.30      0.28      0.21
## Ibrutinib                  0.18      0.17        0.20      0.10      0.15
## PRT062607                  0.28      0.12        0.01      0.03     -0.03
## Afatinib                   0.19      0.41        0.31      0.43      0.41
## SB 203580                  0.10      0.24        0.36      0.36      0.38
## IRAK-1/4 Inhibitor I       0.20      0.25        0.28      0.27      0.34
## Quizartinib                0.21      0.23        0.22      0.23      0.33
## MK-2206                    0.37      0.25        0.02      0.14      0.07
## AZD1208                    0.39      0.44        0.35      0.48      0.35
## AZD8055                    0.35      0.27        0.24      0.25      0.08
## Rapamycin                  0.34     -0.01        0.32      0.23      0.12
## MI-503                     0.12      0.20        0.16      0.29      0.12
## Imatinib                   0.30      0.16        0.05      0.03      0.03
## Sunitinib                  0.30      0.29        0.27      0.29      0.21
## Foretinib                  0.47      0.19        0.27      0.27      0.30
## Tozasertib                 0.36      0.20        0.04      0.11      0.03
## Ruxolitinib                0.06     -0.07       -0.08      0.11     -0.17
## Tofacitinib               -0.06     -0.14       -0.02      0.00     -0.17
## PF-3758309                -0.10     -0.05        0.13      0.09     -0.22
## OTX015                    -0.18     -0.18        0.00      0.05     -0.32
## Volasertib                -0.09      0.00        0.05      0.14     -0.14
## Ganetespib                 0.09      0.12       -0.15     -0.06     -0.28
## Onalespib                  0.18      0.22       -0.09      0.00     -0.14
## SCH772984                  0.06     -0.02       -0.09      0.05     -0.21
## Cobimetinib                0.02     -0.13       -0.22     -0.09     -0.37
## Trametinib                 0.02     -0.15       -0.17     -0.08     -0.35
## JNK-IN-8                   0.10     -0.05        0.17      0.03      0.17
## Menin-MLL Inhibitor        0.05      0.03        0.14      0.20      0.18
## AZD6738                    0.45      0.17        0.03      0.03      0.02
## KU-55933                   0.30      0.08        0.07      0.20      0.10
## SGC 0946                   0.26      0.18        0.24      0.26      0.23
##                      Venetoclax Cytarabine RO5963 A-1210477 Panobinostat
## BMS-509744                 0.16       0.17   0.44      0.26         0.25
## Ceritinib                  0.48       0.09   0.24      0.30         0.27
## Fludarabine                0.60       0.43   0.51      0.47         0.48
## Selinexor                  0.64       0.29   0.46      0.43         0.57
## Nutlin-3a                  0.79       0.35   0.57      0.46         0.40
## Venetoclax                 1.00       0.14   0.41      0.33         0.33
## Cytarabine                 0.14       1.00   0.47      0.31         0.40
## RO5963                     0.41       0.47   1.00      0.36         0.38
## A-1210477                  0.33       0.31   0.36      1.00         0.52
## Panobinostat               0.33       0.40   0.38      0.52         1.00
## A-674563                   0.52       0.31   0.38      0.54         0.58
## Palbociclib                0.30       0.32   0.38      0.46         0.57
## Dabrafenib                -0.10      -0.19  -0.41     -0.11        -0.10
## ZM 336372                  0.04      -0.11   0.02     -0.14        -0.08
## EPZ-6438                   0.02       0.17  -0.07     -0.02         0.07
## ONO-4059                   0.12       0.19   0.47      0.30         0.06
## Midostaurin               -0.07      -0.11  -0.17     -0.14        -0.11
## Methotrexate              -0.45      -0.12  -0.30      0.02         0.04
## Motolimod                 -0.52      -0.18  -0.32     -0.28        -0.09
## Olaparib                   0.07       0.33   0.26      0.26         0.38
## Cisplatin                  0.06       0.34   0.17      0.22         0.18
## BGJ398                    -0.33       0.32   0.10      0.05         0.20
## BML-277                    0.08       0.07   0.06      0.08         0.05
## AMI-1                     -0.03      -0.03  -0.04     -0.09        -0.08
## Vismodegib                -0.11       0.01  -0.06     -0.04         0.06
## Selisistat                -0.14       0.22   0.20      0.06         0.00
## TW-37                     -0.25       0.25   0.14     -0.21        -0.20
## D 4476                    -0.28       0.03   0.15     -0.03        -0.07
## Doxorubicine               0.09      -0.01   0.32      0.06         0.21
## Dasatinib                 -0.36       0.36   0.12      0.07         0.20
## Duvelisib                 -0.17       0.34   0.40      0.29         0.42
## Idelalisib                 0.05       0.44   0.62      0.41         0.51
## Ibrutinib                  0.06       0.41   0.44      0.37         0.23
## PRT062607                 -0.11       0.20   0.23      0.21         0.28
## Afatinib                   0.28       0.44   0.25      0.43         0.40
## SB 203580                  0.41       0.28   0.46      0.36         0.49
## IRAK-1/4 Inhibitor I       0.15       0.45   0.33      0.34         0.41
## Quizartinib                0.29       0.07   0.22      0.17         0.25
## MK-2206                    0.01       0.23   0.15      0.11         0.43
## AZD1208                    0.35       0.37   0.38      0.34         0.60
## AZD8055                    0.00       0.28   0.30      0.35         0.63
## Rapamycin                 -0.04       0.34   0.41      0.32         0.49
## MI-503                     0.04       0.20   0.29      0.27         0.34
## Imatinib                  -0.14       0.31   0.15     -0.01         0.19
## Sunitinib                  0.07       0.45   0.35      0.24         0.35
## Foretinib                  0.02       0.46   0.46      0.25         0.37
## Tozasertib                -0.17       0.35   0.27      0.23         0.40
## Ruxolitinib               -0.21       0.22   0.14      0.17         0.41
## Tofacitinib               -0.20       0.17   0.05     -0.02         0.31
## PF-3758309                -0.27       0.24   0.05      0.27         0.42
## OTX015                    -0.34       0.09  -0.06      0.19         0.35
## Volasertib                -0.18       0.13  -0.04      0.31         0.40
## Ganetespib                -0.42       0.30   0.00      0.19         0.34
## Onalespib                 -0.31       0.29   0.08      0.23         0.37
## SCH772984                 -0.41       0.20   0.06      0.25         0.28
## Cobimetinib               -0.58       0.15  -0.02      0.17         0.19
## Trametinib                -0.53       0.13  -0.04      0.16         0.22
## JNK-IN-8                   0.05       0.29   0.22      0.22         0.32
## Menin-MLL Inhibitor        0.09       0.24   0.05      0.22         0.34
## AZD6738                   -0.06       0.19   0.23      0.11         0.26
## KU-55933                   0.04       0.08   0.15      0.27         0.38
## SGC 0946                   0.23       0.23   0.09      0.41         0.33
##                      A-674563 Palbociclib Dabrafenib ZM 336372 EPZ-6438
## BMS-509744               0.28        0.39      -0.32      0.11    -0.10
## Ceritinib                0.34        0.31      -0.31      0.09    -0.10
## Fludarabine              0.54        0.47      -0.06     -0.04     0.06
## Selinexor                0.56        0.56      -0.32     -0.08    -0.06
## Nutlin-3a                0.60        0.44      -0.18      0.01     0.06
## Venetoclax               0.52        0.30      -0.10      0.04     0.02
## Cytarabine               0.31        0.32      -0.19     -0.11     0.17
## RO5963                   0.38        0.38      -0.41      0.02    -0.07
## A-1210477                0.54        0.46      -0.11     -0.14    -0.02
## Panobinostat             0.58        0.57      -0.10     -0.08     0.07
## A-674563                 1.00        0.71      -0.13     -0.14     0.00
## Palbociclib              0.71        1.00      -0.24     -0.07    -0.11
## Dabrafenib              -0.13       -0.24       1.00      0.30     0.14
## ZM 336372               -0.14       -0.07       0.30      1.00    -0.01
## EPZ-6438                 0.00       -0.11       0.14     -0.01     1.00
## ONO-4059                 0.28        0.32      -0.04      0.14     0.24
## Midostaurin              0.20        0.12       0.27     -0.04    -0.05
## Methotrexate            -0.16       -0.07       0.13     -0.15    -0.05
## Motolimod               -0.36       -0.14       0.18      0.26    -0.08
## Olaparib                 0.21        0.39      -0.21     -0.08    -0.08
## Cisplatin                0.09        0.26      -0.19      0.11    -0.03
## BGJ398                  -0.04        0.15      -0.11      0.04     0.09
## BML-277                 -0.03        0.10       0.07      0.16     0.20
## AMI-1                   -0.02       -0.04       0.12      0.16     0.14
## Vismodegib               0.08        0.01       0.09      0.00     0.35
## Selisistat               0.01        0.16      -0.11      0.23     0.26
## TW-37                   -0.34       -0.07      -0.17      0.15     0.18
## D 4476                  -0.18        0.04       0.24      0.18    -0.06
## Doxorubicine             0.03        0.11      -0.15      0.01    -0.29
## Dasatinib                0.05        0.20      -0.12     -0.12     0.03
## Duvelisib                0.42        0.53      -0.29     -0.04    -0.09
## Idelalisib               0.54        0.58      -0.28     -0.08     0.00
## Ibrutinib                0.47        0.39      -0.25     -0.24     0.19
## PRT062607                0.42        0.47      -0.30     -0.24     0.07
## Afatinib                 0.53        0.57      -0.18     -0.19    -0.06
## SB 203580                0.48        0.31      -0.21     -0.18     0.10
## IRAK-1/4 Inhibitor I     0.58        0.56      -0.32     -0.31     0.18
## Quizartinib              0.53        0.40      -0.03      0.05     0.02
## MK-2206                  0.29        0.44      -0.16      0.02    -0.09
## AZD1208                  0.67        0.55      -0.27     -0.07     0.01
## AZD8055                  0.48        0.56      -0.23     -0.05    -0.04
## Rapamycin                0.44        0.57      -0.17     -0.08    -0.02
## MI-503                   0.38        0.51      -0.15      0.06    -0.14
## Imatinib                 0.32        0.46      -0.24     -0.17    -0.10
## Sunitinib                0.59        0.58      -0.28     -0.14    -0.16
## Foretinib                0.47        0.62      -0.29     -0.16    -0.13
## Tozasertib               0.41        0.57      -0.35     -0.27    -0.03
## Ruxolitinib              0.27        0.28      -0.11     -0.19     0.18
## Tofacitinib              0.25        0.16       0.09      0.03     0.07
## PF-3758309               0.36        0.51      -0.06     -0.22     0.01
## OTX015                   0.15        0.37       0.15     -0.03    -0.04
## Volasertib               0.30        0.47       0.11     -0.08     0.00
## Ganetespib               0.24        0.47      -0.24     -0.16     0.02
## Onalespib                0.33        0.53      -0.31     -0.14     0.10
## SCH772984                0.22        0.35      -0.28     -0.25    -0.05
## Cobimetinib              0.08        0.27      -0.17     -0.11    -0.16
## Trametinib               0.14        0.30      -0.12     -0.09    -0.08
## JNK-IN-8                 0.20        0.11       0.11     -0.11     0.35
## Menin-MLL Inhibitor      0.48        0.31      -0.08     -0.28    -0.01
## AZD6738                  0.17        0.17      -0.10      0.11    -0.11
## KU-55933                 0.27        0.35      -0.13     -0.22    -0.18
## SGC 0946                 0.49        0.43      -0.18      0.01     0.24
##                      ONO-4059 Midostaurin Methotrexate Motolimod Olaparib
## BMS-509744               0.38        0.04        -0.07     -0.04     0.34
## Ceritinib                0.07       -0.15        -0.16     -0.27     0.25
## Fludarabine              0.18        0.03        -0.36     -0.34     0.25
## Selinexor                0.01       -0.12        -0.30     -0.25     0.28
## Nutlin-3a                0.27       -0.01        -0.30     -0.44     0.32
## Venetoclax               0.12       -0.07        -0.45     -0.52     0.07
## Cytarabine               0.19       -0.11        -0.12     -0.18     0.33
## RO5963                   0.47       -0.17        -0.30     -0.32     0.26
## A-1210477                0.30       -0.14         0.02     -0.28     0.26
## Panobinostat             0.06       -0.11         0.04     -0.09     0.38
## A-674563                 0.28        0.20        -0.16     -0.36     0.21
## Palbociclib              0.32        0.12        -0.07     -0.14     0.39
## Dabrafenib              -0.04        0.27         0.13      0.18    -0.21
## ZM 336372                0.14       -0.04        -0.15      0.26    -0.08
## EPZ-6438                 0.24       -0.05        -0.05     -0.08    -0.08
## ONO-4059                 1.00        0.09        -0.16     -0.19    -0.03
## Midostaurin              0.09        1.00         0.18      0.15     0.11
## Methotrexate            -0.16        0.18         1.00      0.35     0.13
## Motolimod               -0.19        0.15         0.35      1.00     0.20
## Olaparib                -0.03        0.11         0.13      0.20     1.00
## Cisplatin               -0.01       -0.02         0.10      0.12     0.40
## BGJ398                   0.01       -0.05         0.14      0.24     0.40
## BML-277                  0.08       -0.03        -0.04      0.08     0.28
## AMI-1                   -0.09        0.20         0.12      0.02     0.25
## Vismodegib               0.02        0.21         0.14      0.04     0.16
## Selisistat               0.33        0.02        -0.04      0.14     0.35
## TW-37                    0.04        0.00        -0.01      0.11     0.28
## D 4476                   0.03       -0.02         0.03      0.28     0.12
## Doxorubicine            -0.09       -0.15        -0.23      0.22     0.00
## Dasatinib                0.31       -0.20         0.15      0.06     0.02
## Duvelisib                0.37       -0.14        -0.04      0.07     0.13
## Idelalisib               0.53       -0.12        -0.10     -0.11     0.09
## Ibrutinib                0.60       -0.04        -0.12     -0.30    -0.04
## PRT062607                0.50        0.03         0.15     -0.18    -0.09
## Afatinib                 0.17       -0.01         0.07     -0.18     0.32
## SB 203580                0.30       -0.21        -0.16     -0.36    -0.07
## IRAK-1/4 Inhibitor I     0.23        0.20         0.11     -0.20     0.32
## Quizartinib              0.27        0.48        -0.11     -0.19     0.00
## MK-2206                  0.09        0.13        -0.02      0.14     0.40
## AZD1208                  0.27       -0.04        -0.24     -0.27     0.13
## AZD8055                  0.18       -0.02        -0.07      0.06     0.34
## Rapamycin                0.44       -0.04        -0.14     -0.03     0.17
## MI-503                   0.20        0.04         0.04     -0.06     0.20
## Imatinib                 0.18        0.18        -0.01      0.01     0.30
## Sunitinib                0.20        0.27        -0.06     -0.18     0.23
## Foretinib                0.45        0.28        -0.07     -0.11     0.38
## Tozasertib               0.32        0.13         0.11     -0.02     0.37
## Ruxolitinib              0.22       -0.07         0.19      0.00     0.07
## Tofacitinib             -0.02        0.12         0.15      0.09     0.04
## PF-3758309               0.08       -0.03         0.18      0.08     0.04
## OTX015                  -0.07       -0.13         0.28      0.32     0.12
## Volasertib              -0.06       -0.10         0.26      0.18     0.19
## Ganetespib               0.17        0.02         0.37      0.22     0.34
## Onalespib                0.25        0.01         0.30      0.17     0.33
## SCH772984                0.10       -0.13         0.35      0.17     0.19
## Cobimetinib              0.06       -0.14         0.36      0.34     0.22
## Trametinib               0.05       -0.13         0.35      0.31     0.18
## JNK-IN-8                 0.18        0.10         0.06      0.00     0.28
## Menin-MLL Inhibitor     -0.14        0.19         0.16      0.09     0.20
## AZD6738                  0.02       -0.01        -0.01      0.03     0.25
## KU-55933                 0.22       -0.03         0.17      0.11     0.13
## SGC 0946                 0.35       -0.05        -0.06     -0.25     0.00
##                      Cisplatin BGJ398 BML-277 AMI-1 Vismodegib Selisistat TW-37
## BMS-509744                0.16   0.18    0.13  0.14      -0.04       0.22  0.10
## Ceritinib                 0.29   0.10    0.28  0.14       0.13       0.04 -0.14
## Fludarabine               0.22  -0.05    0.05  0.04      -0.06      -0.06 -0.10
## Selinexor                 0.24  -0.09    0.05 -0.16      -0.01      -0.01 -0.03
## Nutlin-3a                 0.22  -0.22    0.12  0.02       0.07       0.11 -0.06
## Venetoclax                0.06  -0.33    0.08 -0.03      -0.11      -0.14 -0.25
## Cytarabine                0.34   0.32    0.07 -0.03       0.01       0.22  0.25
## RO5963                    0.17   0.10    0.06 -0.04      -0.06       0.20  0.14
## A-1210477                 0.22   0.05    0.08 -0.09      -0.04       0.06 -0.21
## Panobinostat              0.18   0.20    0.05 -0.08       0.06       0.00 -0.20
## A-674563                  0.09  -0.04   -0.03 -0.02       0.08       0.01 -0.34
## Palbociclib               0.26   0.15    0.10 -0.04       0.01       0.16 -0.07
## Dabrafenib               -0.19  -0.11    0.07  0.12       0.09      -0.11 -0.17
## ZM 336372                 0.11   0.04    0.16  0.16       0.00       0.23  0.15
## EPZ-6438                 -0.03   0.09    0.20  0.14       0.35       0.26  0.18
## ONO-4059                 -0.01   0.01    0.08 -0.09       0.02       0.33  0.04
## Midostaurin              -0.02  -0.05   -0.03  0.20       0.21       0.02  0.00
## Methotrexate              0.10   0.14   -0.04  0.12       0.14      -0.04 -0.01
## Motolimod                 0.12   0.24    0.08  0.02       0.04       0.14  0.11
## Olaparib                  0.40   0.40    0.28  0.25       0.16       0.35  0.28
## Cisplatin                 1.00   0.46    0.41  0.30       0.31       0.34  0.31
## BGJ398                    0.46   1.00    0.50  0.13       0.14       0.34  0.30
## BML-277                   0.41   0.50    1.00  0.38       0.31       0.34  0.17
## AMI-1                     0.30   0.13    0.38  1.00       0.57       0.24  0.33
## Vismodegib                0.31   0.14    0.31  0.57       1.00       0.39  0.26
## Selisistat                0.34   0.34    0.34  0.24       0.39       1.00  0.48
## TW-37                     0.31   0.30    0.17  0.33       0.26       0.48  1.00
## D 4476                    0.23   0.26    0.18  0.31       0.19       0.19  0.32
## Doxorubicine              0.19  -0.05    0.05 -0.08      -0.03       0.04  0.02
## Dasatinib                 0.10   0.39   -0.01 -0.11       0.05       0.08  0.11
## Duvelisib                 0.11   0.36   -0.08 -0.23      -0.18       0.11 -0.07
## Idelalisib                0.23   0.25   -0.09 -0.19       0.00       0.21 -0.03
## Ibrutinib                 0.12   0.13   -0.06 -0.09       0.12       0.05 -0.19
## PRT062607                 0.01   0.21   -0.13 -0.19       0.03       0.03 -0.15
## Afatinib                  0.30   0.19    0.14 -0.01       0.10       0.03  0.02
## SB 203580                 0.08   0.06    0.04 -0.20       0.05      -0.11 -0.29
## IRAK-1/4 Inhibitor I      0.42   0.33    0.08 -0.02       0.20       0.21 -0.03
## Quizartinib              -0.02   0.01    0.01 -0.12      -0.05      -0.03 -0.37
## MK-2206                   0.01   0.31   -0.02 -0.28      -0.20       0.28 -0.01
## AZD1208                   0.03   0.18   -0.07 -0.22      -0.07       0.01 -0.32
## AZD8055                  -0.01   0.30   -0.03 -0.22      -0.17       0.18 -0.14
## Rapamycin                -0.06   0.21   -0.14 -0.35      -0.22       0.19 -0.09
## MI-503                    0.35   0.35    0.15  0.07       0.02       0.21  0.02
## Imatinib                  0.21   0.38    0.10  0.04       0.03       0.25  0.05
## Sunitinib                 0.29   0.37    0.04  0.01       0.02       0.11 -0.05
## Foretinib                 0.27   0.31   -0.01 -0.10      -0.04       0.26  0.10
## Tozasertib                0.19   0.43    0.05  0.03       0.09       0.19  0.04
## Ruxolitinib               0.16   0.45    0.14  0.02       0.25       0.15  0.09
## Tofacitinib               0.03   0.17   -0.03  0.22       0.34       0.01  0.10
## PF-3758309                0.00   0.39    0.01 -0.14       0.03      -0.02 -0.24
## OTX015                    0.08   0.39    0.09 -0.08       0.01       0.03 -0.06
## Volasertib                0.15   0.42    0.22  0.07       0.09       0.07 -0.11
## Ganetespib                0.18   0.48    0.08 -0.06       0.14       0.20 -0.02
## Onalespib                 0.16   0.42    0.10 -0.08       0.16       0.24 -0.06
## SCH772984                 0.36   0.46    0.09 -0.07       0.10       0.18  0.06
## Cobimetinib               0.19   0.47    0.07 -0.08       0.00       0.20  0.09
## Trametinib                0.21   0.43    0.04 -0.04       0.02       0.22  0.09
## JNK-IN-8                 -0.03   0.04    0.09  0.09       0.17       0.09  0.01
## Menin-MLL Inhibitor       0.13   0.00   -0.13  0.00       0.15      -0.01 -0.29
## AZD6738                   0.16   0.28    0.02  0.17       0.09       0.26  0.19
## KU-55933                  0.15   0.03   -0.14 -0.25      -0.10      -0.05 -0.11
## SGC 0946                  0.25   0.02   -0.01 -0.05      -0.05       0.12  0.05
##                      D 4476 Doxorubicine Dasatinib Duvelisib Idelalisib
## BMS-509744             0.03         0.11      0.15      0.40       0.39
## Ceritinib             -0.15        -0.10     -0.07      0.11       0.17
## Fludarabine            0.02         0.26     -0.10      0.18       0.30
## Selinexor             -0.10         0.31     -0.07      0.12       0.28
## Nutlin-3a             -0.21         0.11     -0.22     -0.05       0.21
## Venetoclax            -0.28         0.09     -0.36     -0.17       0.05
## Cytarabine             0.03        -0.01      0.36      0.34       0.44
## RO5963                 0.15         0.32      0.12      0.40       0.62
## A-1210477             -0.03         0.06      0.07      0.29       0.41
## Panobinostat          -0.07         0.21      0.20      0.42       0.51
## A-674563              -0.18         0.03      0.05      0.42       0.54
## Palbociclib            0.04         0.11      0.20      0.53       0.58
## Dabrafenib             0.24        -0.15     -0.12     -0.29      -0.28
## ZM 336372              0.18         0.01     -0.12     -0.04      -0.08
## EPZ-6438              -0.06        -0.29      0.03     -0.09       0.00
## ONO-4059               0.03        -0.09      0.31      0.37       0.53
## Midostaurin           -0.02        -0.15     -0.20     -0.14      -0.12
## Methotrexate           0.03        -0.23      0.15     -0.04      -0.10
## Motolimod              0.28         0.22      0.06      0.07      -0.11
## Olaparib               0.12         0.00      0.02      0.13       0.09
## Cisplatin              0.23         0.19      0.10      0.11       0.23
## BGJ398                 0.26        -0.05      0.39      0.36       0.25
## BML-277                0.18         0.05     -0.01     -0.08      -0.09
## AMI-1                  0.31        -0.08     -0.11     -0.23      -0.19
## Vismodegib             0.19        -0.03      0.05     -0.18       0.00
## Selisistat             0.19         0.04      0.08      0.11       0.21
## TW-37                  0.32         0.02      0.11     -0.07      -0.03
## D 4476                 1.00         0.30      0.18      0.07       0.16
## Doxorubicine           0.30         1.00     -0.09      0.16       0.24
## Dasatinib              0.18        -0.09      1.00      0.55       0.50
## Duvelisib              0.07         0.16      0.55      1.00       0.83
## Idelalisib             0.16         0.24      0.50      0.83       1.00
## Ibrutinib              0.06        -0.14      0.59      0.60       0.73
## PRT062607             -0.12        -0.15      0.66      0.67       0.66
## Afatinib              -0.01        -0.17      0.35      0.33       0.38
## SB 203580             -0.15         0.09      0.34      0.34       0.55
## IRAK-1/4 Inhibitor I  -0.12        -0.15      0.25      0.44       0.56
## Quizartinib           -0.23        -0.15      0.01      0.27       0.31
## MK-2206               -0.12         0.06      0.10      0.51       0.35
## AZD1208               -0.20         0.04      0.34      0.58       0.60
## AZD8055               -0.09         0.14      0.26      0.74       0.60
## Rapamycin              0.05         0.20      0.41      0.79       0.70
## MI-503                 0.20         0.00      0.27      0.43       0.49
## Imatinib               0.13        -0.04      0.52      0.47       0.42
## Sunitinib             -0.06        -0.01      0.40      0.60       0.56
## Foretinib              0.02        -0.01      0.44      0.63       0.62
## Tozasertib             0.03        -0.14      0.56      0.69       0.60
## Ruxolitinib            0.11        -0.11      0.58      0.47       0.52
## Tofacitinib            0.19        -0.15      0.43      0.31       0.31
## PF-3758309             0.04         0.01      0.45      0.65       0.48
## OTX015                 0.31         0.20      0.25      0.43       0.27
## Volasertib             0.25         0.08      0.20      0.37       0.25
## Ganetespib             0.05        -0.26      0.57      0.62       0.47
## Onalespib              0.00        -0.20      0.54      0.63       0.53
## SCH772984              0.07        -0.01      0.52      0.58       0.50
## Cobimetinib            0.18         0.04      0.52      0.60       0.40
## Trametinib             0.18         0.00      0.48      0.60       0.42
## JNK-IN-8               0.29        -0.20      0.12      0.09       0.15
## Menin-MLL Inhibitor    0.05         0.13      0.05      0.12       0.25
## AZD6738                0.19         0.03      0.09      0.31       0.29
## KU-55933               0.09         0.35      0.14      0.35       0.40
## SGC 0946              -0.07        -0.08      0.20      0.34       0.43
##                      Ibrutinib PRT062607 Afatinib SB 203580
## BMS-509744                0.18      0.28     0.19      0.10
## Ceritinib                 0.17      0.12     0.41      0.24
## Fludarabine               0.20      0.01     0.31      0.36
## Selinexor                 0.10      0.03     0.43      0.36
## Nutlin-3a                 0.15     -0.03     0.41      0.38
## Venetoclax                0.06     -0.11     0.28      0.41
## Cytarabine                0.41      0.20     0.44      0.28
## RO5963                    0.44      0.23     0.25      0.46
## A-1210477                 0.37      0.21     0.43      0.36
## Panobinostat              0.23      0.28     0.40      0.49
## A-674563                  0.47      0.42     0.53      0.48
## Palbociclib               0.39      0.47     0.57      0.31
## Dabrafenib               -0.25     -0.30    -0.18     -0.21
## ZM 336372                -0.24     -0.24    -0.19     -0.18
## EPZ-6438                  0.19      0.07    -0.06      0.10
## ONO-4059                  0.60      0.50     0.17      0.30
## Midostaurin              -0.04      0.03    -0.01     -0.21
## Methotrexate             -0.12      0.15     0.07     -0.16
## Motolimod                -0.30     -0.18    -0.18     -0.36
## Olaparib                 -0.04     -0.09     0.32     -0.07
## Cisplatin                 0.12      0.01     0.30      0.08
## BGJ398                    0.13      0.21     0.19      0.06
## BML-277                  -0.06     -0.13     0.14      0.04
## AMI-1                    -0.09     -0.19    -0.01     -0.20
## Vismodegib                0.12      0.03     0.10      0.05
## Selisistat                0.05      0.03     0.03     -0.11
## TW-37                    -0.19     -0.15     0.02     -0.29
## D 4476                    0.06     -0.12    -0.01     -0.15
## Doxorubicine             -0.14     -0.15    -0.17      0.09
## Dasatinib                 0.59      0.66     0.35      0.34
## Duvelisib                 0.60      0.67     0.33      0.34
## Idelalisib                0.73      0.66     0.38      0.55
## Ibrutinib                 1.00      0.75     0.44      0.57
## PRT062607                 0.75      1.00     0.46      0.53
## Afatinib                  0.44      0.46     1.00      0.45
## SB 203580                 0.57      0.53     0.45      1.00
## IRAK-1/4 Inhibitor I      0.58      0.53     0.46      0.40
## Quizartinib               0.33      0.33     0.18      0.32
## MK-2206                   0.04      0.26     0.14      0.06
## AZD1208                   0.54      0.55     0.44      0.57
## AZD8055                   0.30      0.39     0.22      0.27
## Rapamycin                 0.46      0.53     0.22      0.38
## MI-503                    0.34      0.39     0.37      0.15
## Imatinib                  0.39      0.42     0.25      0.09
## Sunitinib                 0.52      0.58     0.50      0.36
## Foretinib                 0.50      0.57     0.49      0.32
## Tozasertib                0.57      0.70     0.43      0.30
## Ruxolitinib               0.49      0.60     0.33      0.38
## Tofacitinib               0.32      0.34     0.30      0.24
## PF-3758309                0.46      0.57     0.37      0.31
## OTX015                    0.11      0.23     0.16      0.02
## Volasertib                0.15      0.21     0.26      0.07
## Ganetespib                0.49      0.60     0.42      0.16
## Onalespib                 0.54      0.64     0.43      0.24
## SCH772984                 0.42      0.57     0.30      0.17
## Cobimetinib               0.29      0.45     0.19     -0.02
## Trametinib                0.27      0.44     0.19     -0.03
## JNK-IN-8                  0.28      0.02     0.16      0.10
## Menin-MLL Inhibitor       0.24      0.12     0.23      0.21
## AZD6738                   0.04      0.07     0.02     -0.10
## KU-55933                  0.17      0.31     0.19      0.19
## SGC 0946                  0.37      0.43     0.26      0.24
##                      IRAK-1/4 Inhibitor I Quizartinib MK-2206 AZD1208 AZD8055
## BMS-509744                           0.20        0.21    0.37    0.39    0.35
## Ceritinib                            0.25        0.23    0.25    0.44    0.27
## Fludarabine                          0.28        0.22    0.02    0.35    0.24
## Selinexor                            0.27        0.23    0.14    0.48    0.25
## Nutlin-3a                            0.34        0.33    0.07    0.35    0.08
## Venetoclax                           0.15        0.29    0.01    0.35    0.00
## Cytarabine                           0.45        0.07    0.23    0.37    0.28
## RO5963                               0.33        0.22    0.15    0.38    0.30
## A-1210477                            0.34        0.17    0.11    0.34    0.35
## Panobinostat                         0.41        0.25    0.43    0.60    0.63
## A-674563                             0.58        0.53    0.29    0.67    0.48
## Palbociclib                          0.56        0.40    0.44    0.55    0.56
## Dabrafenib                          -0.32       -0.03   -0.16   -0.27   -0.23
## ZM 336372                           -0.31        0.05    0.02   -0.07   -0.05
## EPZ-6438                             0.18        0.02   -0.09    0.01   -0.04
## ONO-4059                             0.23        0.27    0.09    0.27    0.18
## Midostaurin                          0.20        0.48    0.13   -0.04   -0.02
## Methotrexate                         0.11       -0.11   -0.02   -0.24   -0.07
## Motolimod                           -0.20       -0.19    0.14   -0.27    0.06
## Olaparib                             0.32        0.00    0.40    0.13    0.34
## Cisplatin                            0.42       -0.02    0.01    0.03   -0.01
## BGJ398                               0.33        0.01    0.31    0.18    0.30
## BML-277                              0.08        0.01   -0.02   -0.07   -0.03
## AMI-1                               -0.02       -0.12   -0.28   -0.22   -0.22
## Vismodegib                           0.20       -0.05   -0.20   -0.07   -0.17
## Selisistat                           0.21       -0.03    0.28    0.01    0.18
## TW-37                               -0.03       -0.37   -0.01   -0.32   -0.14
## D 4476                              -0.12       -0.23   -0.12   -0.20   -0.09
## Doxorubicine                        -0.15       -0.15    0.06    0.04    0.14
## Dasatinib                            0.25        0.01    0.10    0.34    0.26
## Duvelisib                            0.44        0.27    0.51    0.58    0.74
## Idelalisib                           0.56        0.31    0.35    0.60    0.60
## Ibrutinib                            0.58        0.33    0.04    0.54    0.30
## PRT062607                            0.53        0.33    0.26    0.55    0.39
## Afatinib                             0.46        0.18    0.14    0.44    0.22
## SB 203580                            0.40        0.32    0.06    0.57    0.27
## IRAK-1/4 Inhibitor I                 1.00        0.54    0.30    0.41    0.36
## Quizartinib                          0.54        1.00    0.34    0.46    0.32
## MK-2206                              0.30        0.34    1.00    0.51    0.71
## AZD1208                              0.41        0.46    0.51    1.00    0.66
## AZD8055                              0.36        0.32    0.71    0.66    1.00
## Rapamycin                            0.30        0.30    0.65    0.66    0.79
## MI-503                               0.34        0.24    0.30    0.35    0.35
## Imatinib                             0.46        0.31    0.47    0.40    0.42
## Sunitinib                            0.61        0.56    0.46    0.66    0.52
## Foretinib                            0.59        0.56    0.54    0.56    0.54
## Tozasertib                           0.58        0.38    0.49    0.54    0.59
## Ruxolitinib                          0.42        0.01    0.15    0.33    0.30
## Tofacitinib                          0.26        0.06   -0.02    0.12    0.16
## PF-3758309                           0.36        0.17    0.27    0.49    0.62
## OTX015                               0.04       -0.20    0.20    0.19    0.43
## Volasertib                           0.19       -0.08    0.18    0.26    0.39
## Ganetespib                           0.47        0.14    0.44    0.39    0.57
## Onalespib                            0.55        0.25    0.46    0.45    0.62
## SCH772984                            0.45       -0.05    0.16    0.22    0.39
## Cobimetinib                          0.23       -0.16    0.24    0.17    0.46
## Trametinib                           0.25       -0.14    0.24    0.16    0.44
## JNK-IN-8                             0.22        0.08    0.12    0.06    0.15
## Menin-MLL Inhibitor                  0.42        0.25    0.25    0.29    0.16
## AZD6738                              0.17       -0.08    0.31    0.20    0.32
## KU-55933                             0.16       -0.08    0.35    0.29    0.23
## SGC 0946                             0.40        0.16    0.25    0.39    0.24
##                      Rapamycin MI-503 Imatinib Sunitinib Foretinib Tozasertib
## BMS-509744                0.34   0.12     0.30      0.30      0.47       0.36
## Ceritinib                -0.01   0.20     0.16      0.29      0.19       0.20
## Fludarabine               0.32   0.16     0.05      0.27      0.27       0.04
## Selinexor                 0.23   0.29     0.03      0.29      0.27       0.11
## Nutlin-3a                 0.12   0.12     0.03      0.21      0.30       0.03
## Venetoclax               -0.04   0.04    -0.14      0.07      0.02      -0.17
## Cytarabine                0.34   0.20     0.31      0.45      0.46       0.35
## RO5963                    0.41   0.29     0.15      0.35      0.46       0.27
## A-1210477                 0.32   0.27    -0.01      0.24      0.25       0.23
## Panobinostat              0.49   0.34     0.19      0.35      0.37       0.40
## A-674563                  0.44   0.38     0.32      0.59      0.47       0.41
## Palbociclib               0.57   0.51     0.46      0.58      0.62       0.57
## Dabrafenib               -0.17  -0.15    -0.24     -0.28     -0.29      -0.35
## ZM 336372                -0.08   0.06    -0.17     -0.14     -0.16      -0.27
## EPZ-6438                 -0.02  -0.14    -0.10     -0.16     -0.13      -0.03
## ONO-4059                  0.44   0.20     0.18      0.20      0.45       0.32
## Midostaurin              -0.04   0.04     0.18      0.27      0.28       0.13
## Methotrexate             -0.14   0.04    -0.01     -0.06     -0.07       0.11
## Motolimod                -0.03  -0.06     0.01     -0.18     -0.11      -0.02
## Olaparib                  0.17   0.20     0.30      0.23      0.38       0.37
## Cisplatin                -0.06   0.35     0.21      0.29      0.27       0.19
## BGJ398                    0.21   0.35     0.38      0.37      0.31       0.43
## BML-277                  -0.14   0.15     0.10      0.04     -0.01       0.05
## AMI-1                    -0.35   0.07     0.04      0.01     -0.10       0.03
## Vismodegib               -0.22   0.02     0.03      0.02     -0.04       0.09
## Selisistat                0.19   0.21     0.25      0.11      0.26       0.19
## TW-37                    -0.09   0.02     0.05     -0.05      0.10       0.04
## D 4476                    0.05   0.20     0.13     -0.06      0.02       0.03
## Doxorubicine              0.20   0.00    -0.04     -0.01     -0.01      -0.14
## Dasatinib                 0.41   0.27     0.52      0.40      0.44       0.56
## Duvelisib                 0.79   0.43     0.47      0.60      0.63       0.69
## Idelalisib                0.70   0.49     0.42      0.56      0.62       0.60
## Ibrutinib                 0.46   0.34     0.39      0.52      0.50       0.57
## PRT062607                 0.53   0.39     0.42      0.58      0.57       0.70
## Afatinib                  0.22   0.37     0.25      0.50      0.49       0.43
## SB 203580                 0.38   0.15     0.09      0.36      0.32       0.30
## IRAK-1/4 Inhibitor I      0.30   0.34     0.46      0.61      0.59       0.58
## Quizartinib               0.30   0.24     0.31      0.56      0.56       0.38
## MK-2206                   0.65   0.30     0.47      0.46      0.54       0.49
## AZD1208                   0.66   0.35     0.40      0.66      0.56       0.54
## AZD8055                   0.79   0.35     0.42      0.52      0.54       0.59
## Rapamycin                 1.00   0.37     0.47      0.52      0.66       0.60
## MI-503                    0.37   1.00     0.44      0.52      0.45       0.48
## Imatinib                  0.47   0.44     1.00      0.59      0.62       0.65
## Sunitinib                 0.52   0.52     0.59      1.00      0.76       0.69
## Foretinib                 0.66   0.45     0.62      0.76      1.00       0.79
## Tozasertib                0.60   0.48     0.65      0.69      0.79       1.00
## Ruxolitinib               0.37   0.44     0.32      0.34      0.27       0.52
## Tofacitinib               0.16   0.21     0.25      0.20      0.14       0.34
## PF-3758309                0.59   0.39     0.33      0.54      0.36       0.55
## OTX015                    0.41   0.35     0.18      0.18      0.04       0.25
## Volasertib                0.34   0.40     0.25      0.27      0.07       0.30
## Ganetespib                0.48   0.40     0.54      0.49      0.47       0.72
## Onalespib                 0.50   0.35     0.53      0.53      0.50       0.71
## SCH772984                 0.37   0.44     0.41      0.35      0.34       0.59
## Cobimetinib               0.43   0.38     0.40      0.32      0.27       0.54
## Trametinib                0.43   0.38     0.41      0.28      0.25       0.52
## JNK-IN-8                  0.20   0.05     0.14     -0.06      0.16       0.21
## Menin-MLL Inhibitor       0.19   0.11     0.35      0.26      0.18       0.19
## AZD6738                   0.17   0.17     0.17      0.15      0.17       0.18
## KU-55933                  0.43   0.12     0.20      0.09      0.23       0.25
## SGC 0946                  0.35   0.36     0.31      0.26      0.26       0.36
##                      Ruxolitinib Tofacitinib PF-3758309 OTX015 Volasertib
## BMS-509744                  0.06       -0.06      -0.10  -0.18      -0.09
## Ceritinib                  -0.07       -0.14      -0.05  -0.18       0.00
## Fludarabine                -0.08       -0.02       0.13   0.00       0.05
## Selinexor                   0.11        0.00       0.09   0.05       0.14
## Nutlin-3a                  -0.17       -0.17      -0.22  -0.32      -0.14
## Venetoclax                 -0.21       -0.20      -0.27  -0.34      -0.18
## Cytarabine                  0.22        0.17       0.24   0.09       0.13
## RO5963                      0.14        0.05       0.05  -0.06      -0.04
## A-1210477                   0.17       -0.02       0.27   0.19       0.31
## Panobinostat                0.41        0.31       0.42   0.35       0.40
## A-674563                    0.27        0.25       0.36   0.15       0.30
## Palbociclib                 0.28        0.16       0.51   0.37       0.47
## Dabrafenib                 -0.11        0.09      -0.06   0.15       0.11
## ZM 336372                  -0.19        0.03      -0.22  -0.03      -0.08
## EPZ-6438                    0.18        0.07       0.01  -0.04       0.00
## ONO-4059                    0.22       -0.02       0.08  -0.07      -0.06
## Midostaurin                -0.07        0.12      -0.03  -0.13      -0.10
## Methotrexate                0.19        0.15       0.18   0.28       0.26
## Motolimod                   0.00        0.09       0.08   0.32       0.18
## Olaparib                    0.07        0.04       0.04   0.12       0.19
## Cisplatin                   0.16        0.03       0.00   0.08       0.15
## BGJ398                      0.45        0.17       0.39   0.39       0.42
## BML-277                     0.14       -0.03       0.01   0.09       0.22
## AMI-1                       0.02        0.22      -0.14  -0.08       0.07
## Vismodegib                  0.25        0.34       0.03   0.01       0.09
## Selisistat                  0.15        0.01      -0.02   0.03       0.07
## TW-37                       0.09        0.10      -0.24  -0.06      -0.11
## D 4476                      0.11        0.19       0.04   0.31       0.25
## Doxorubicine               -0.11       -0.15       0.01   0.20       0.08
## Dasatinib                   0.58        0.43       0.45   0.25       0.20
## Duvelisib                   0.47        0.31       0.65   0.43       0.37
## Idelalisib                  0.52        0.31       0.48   0.27       0.25
## Ibrutinib                   0.49        0.32       0.46   0.11       0.15
## PRT062607                   0.60        0.34       0.57   0.23       0.21
## Afatinib                    0.33        0.30       0.37   0.16       0.26
## SB 203580                   0.38        0.24       0.31   0.02       0.07
## IRAK-1/4 Inhibitor I        0.42        0.26       0.36   0.04       0.19
## Quizartinib                 0.01        0.06       0.17  -0.20      -0.08
## MK-2206                     0.15       -0.02       0.27   0.20       0.18
## AZD1208                     0.33        0.12       0.49   0.19       0.26
## AZD8055                     0.30        0.16       0.62   0.43       0.39
## Rapamycin                   0.37        0.16       0.59   0.41       0.34
## MI-503                      0.44        0.21       0.39   0.35       0.40
## Imatinib                    0.32        0.25       0.33   0.18       0.25
## Sunitinib                   0.34        0.20       0.54   0.18       0.27
## Foretinib                   0.27        0.14       0.36   0.04       0.07
## Tozasertib                  0.52        0.34       0.55   0.25       0.30
## Ruxolitinib                 1.00        0.69       0.52   0.43       0.44
## Tofacitinib                 0.69        1.00       0.36   0.30       0.28
## PF-3758309                  0.52        0.36       1.00   0.78       0.74
## OTX015                      0.43        0.30       0.78   1.00       0.91
## Volasertib                  0.44        0.28       0.74   0.91       1.00
## Ganetespib                  0.60        0.44       0.71   0.54       0.53
## Onalespib                   0.50        0.33       0.68   0.46       0.47
## SCH772984                   0.73        0.41       0.60   0.55       0.52
## Cobimetinib                 0.61        0.36       0.65   0.68       0.59
## Trametinib                  0.65        0.44       0.62   0.68       0.61
## JNK-IN-8                    0.27        0.41       0.05   0.06       0.11
## Menin-MLL Inhibitor         0.19        0.32       0.19   0.15       0.25
## AZD6738                     0.23        0.22       0.04   0.07       0.12
## KU-55933                    0.32        0.07       0.16   0.30       0.30
## SGC 0946                    0.41        0.17       0.08   0.06       0.16
##                      Ganetespib Onalespib SCH772984 Cobimetinib Trametinib
## BMS-509744                 0.09      0.18      0.06        0.02       0.02
## Ceritinib                  0.12      0.22     -0.02       -0.13      -0.15
## Fludarabine               -0.15     -0.09     -0.09       -0.22      -0.17
## Selinexor                 -0.06      0.00      0.05       -0.09      -0.08
## Nutlin-3a                 -0.28     -0.14     -0.21       -0.37      -0.35
## Venetoclax                -0.42     -0.31     -0.41       -0.58      -0.53
## Cytarabine                 0.30      0.29      0.20        0.15       0.13
## RO5963                     0.00      0.08      0.06       -0.02      -0.04
## A-1210477                  0.19      0.23      0.25        0.17       0.16
## Panobinostat               0.34      0.37      0.28        0.19       0.22
## A-674563                   0.24      0.33      0.22        0.08       0.14
## Palbociclib                0.47      0.53      0.35        0.27       0.30
## Dabrafenib                -0.24     -0.31     -0.28       -0.17      -0.12
## ZM 336372                 -0.16     -0.14     -0.25       -0.11      -0.09
## EPZ-6438                   0.02      0.10     -0.05       -0.16      -0.08
## ONO-4059                   0.17      0.25      0.10        0.06       0.05
## Midostaurin                0.02      0.01     -0.13       -0.14      -0.13
## Methotrexate               0.37      0.30      0.35        0.36       0.35
## Motolimod                  0.22      0.17      0.17        0.34       0.31
## Olaparib                   0.34      0.33      0.19        0.22       0.18
## Cisplatin                  0.18      0.16      0.36        0.19       0.21
## BGJ398                     0.48      0.42      0.46        0.47       0.43
## BML-277                    0.08      0.10      0.09        0.07       0.04
## AMI-1                     -0.06     -0.08     -0.07       -0.08      -0.04
## Vismodegib                 0.14      0.16      0.10        0.00       0.02
## Selisistat                 0.20      0.24      0.18        0.20       0.22
## TW-37                     -0.02     -0.06      0.06        0.09       0.09
## D 4476                     0.05      0.00      0.07        0.18       0.18
## Doxorubicine              -0.26     -0.20     -0.01        0.04       0.00
## Dasatinib                  0.57      0.54      0.52        0.52       0.48
## Duvelisib                  0.62      0.63      0.58        0.60       0.60
## Idelalisib                 0.47      0.53      0.50        0.40       0.42
## Ibrutinib                  0.49      0.54      0.42        0.29       0.27
## PRT062607                  0.60      0.64      0.57        0.45       0.44
## Afatinib                   0.42      0.43      0.30        0.19       0.19
## SB 203580                  0.16      0.24      0.17       -0.02      -0.03
## IRAK-1/4 Inhibitor I       0.47      0.55      0.45        0.23       0.25
## Quizartinib                0.14      0.25     -0.05       -0.16      -0.14
## MK-2206                    0.44      0.46      0.16        0.24       0.24
## AZD1208                    0.39      0.45      0.22        0.17       0.16
## AZD8055                    0.57      0.62      0.39        0.46       0.44
## Rapamycin                  0.48      0.50      0.37        0.43       0.43
## MI-503                     0.40      0.35      0.44        0.38       0.38
## Imatinib                   0.54      0.53      0.41        0.40       0.41
## Sunitinib                  0.49      0.53      0.35        0.32       0.28
## Foretinib                  0.47      0.50      0.34        0.27       0.25
## Tozasertib                 0.72      0.71      0.59        0.54       0.52
## Ruxolitinib                0.60      0.50      0.73        0.61       0.65
## Tofacitinib                0.44      0.33      0.41        0.36       0.44
## PF-3758309                 0.71      0.68      0.60        0.65       0.62
## OTX015                     0.54      0.46      0.55        0.68       0.68
## Volasertib                 0.53      0.47      0.52        0.59       0.61
## Ganetespib                 1.00      0.95      0.73        0.76       0.75
## Onalespib                  0.95      1.00      0.65        0.66       0.65
## SCH772984                  0.73      0.65      1.00        0.88       0.91
## Cobimetinib                0.76      0.66      0.88        1.00       0.96
## Trametinib                 0.75      0.65      0.91        0.96       1.00
## JNK-IN-8                   0.20      0.19      0.05       -0.04       0.04
## Menin-MLL Inhibitor        0.26      0.29      0.16        0.05       0.14
## AZD6738                    0.20      0.18      0.19        0.21       0.24
## KU-55933                   0.22      0.18      0.35        0.29       0.33
## SGC 0946                   0.26      0.27      0.36        0.21       0.31
##                      JNK-IN-8 Menin-MLL Inhibitor AZD6738 KU-55933 SGC 0946
## BMS-509744               0.10                0.05    0.45     0.30     0.26
## Ceritinib               -0.05                0.03    0.17     0.08     0.18
## Fludarabine              0.17                0.14    0.03     0.07     0.24
## Selinexor                0.03                0.20    0.03     0.20     0.26
## Nutlin-3a                0.17                0.18    0.02     0.10     0.23
## Venetoclax               0.05                0.09   -0.06     0.04     0.23
## Cytarabine               0.29                0.24    0.19     0.08     0.23
## RO5963                   0.22                0.05    0.23     0.15     0.09
## A-1210477                0.22                0.22    0.11     0.27     0.41
## Panobinostat             0.32                0.34    0.26     0.38     0.33
## A-674563                 0.20                0.48    0.17     0.27     0.49
## Palbociclib              0.11                0.31    0.17     0.35     0.43
## Dabrafenib               0.11               -0.08   -0.10    -0.13    -0.18
## ZM 336372               -0.11               -0.28    0.11    -0.22     0.01
## EPZ-6438                 0.35               -0.01   -0.11    -0.18     0.24
## ONO-4059                 0.18               -0.14    0.02     0.22     0.35
## Midostaurin              0.10                0.19   -0.01    -0.03    -0.05
## Methotrexate             0.06                0.16   -0.01     0.17    -0.06
## Motolimod                0.00                0.09    0.03     0.11    -0.25
## Olaparib                 0.28                0.20    0.25     0.13     0.00
## Cisplatin               -0.03                0.13    0.16     0.15     0.25
## BGJ398                   0.04                0.00    0.28     0.03     0.02
## BML-277                  0.09               -0.13    0.02    -0.14    -0.01
## AMI-1                    0.09                0.00    0.17    -0.25    -0.05
## Vismodegib               0.17                0.15    0.09    -0.10    -0.05
## Selisistat               0.09               -0.01    0.26    -0.05     0.12
## TW-37                    0.01               -0.29    0.19    -0.11     0.05
## D 4476                   0.29                0.05    0.19     0.09    -0.07
## Doxorubicine            -0.20                0.13    0.03     0.35    -0.08
## Dasatinib                0.12                0.05    0.09     0.14     0.20
## Duvelisib                0.09                0.12    0.31     0.35     0.34
## Idelalisib               0.15                0.25    0.29     0.40     0.43
## Ibrutinib                0.28                0.24    0.04     0.17     0.37
## PRT062607                0.02                0.12    0.07     0.31     0.43
## Afatinib                 0.16                0.23    0.02     0.19     0.26
## SB 203580                0.10                0.21   -0.10     0.19     0.24
## IRAK-1/4 Inhibitor I     0.22                0.42    0.17     0.16     0.40
## Quizartinib              0.08                0.25   -0.08    -0.08     0.16
## MK-2206                  0.12                0.25    0.31     0.35     0.25
## AZD1208                  0.06                0.29    0.20     0.29     0.39
## AZD8055                  0.15                0.16    0.32     0.23     0.24
## Rapamycin                0.20                0.19    0.17     0.43     0.35
## MI-503                   0.05                0.11    0.17     0.12     0.36
## Imatinib                 0.14                0.35    0.17     0.20     0.31
## Sunitinib               -0.06                0.26    0.15     0.09     0.26
## Foretinib                0.16                0.18    0.17     0.23     0.26
## Tozasertib               0.21                0.19    0.18     0.25     0.36
## Ruxolitinib              0.27                0.19    0.23     0.32     0.41
## Tofacitinib              0.41                0.32    0.22     0.07     0.17
## PF-3758309               0.05                0.19    0.04     0.16     0.08
## OTX015                   0.06                0.15    0.07     0.30     0.06
## Volasertib               0.11                0.25    0.12     0.30     0.16
## Ganetespib               0.20                0.26    0.20     0.22     0.26
## Onalespib                0.19                0.29    0.18     0.18     0.27
## SCH772984                0.05                0.16    0.19     0.35     0.36
## Cobimetinib             -0.04                0.05    0.21     0.29     0.21
## Trametinib               0.04                0.14    0.24     0.33     0.31
## JNK-IN-8                 1.00                0.36    0.18     0.12     0.18
## Menin-MLL Inhibitor      0.36                1.00    0.10     0.35     0.20
## AZD6738                  0.18                0.10    1.00     0.21     0.19
## KU-55933                 0.12                0.35    0.21     1.00     0.44
## SGC 0946                 0.18                0.20    0.19     0.44     1.00
## 
## $corrPos
##                     xName                yName  x  y  corr
## 1              BMS-509744           BMS-509744  1 62  1.00
## 2              BMS-509744            Ceritinib  1 61  0.48
## 3              BMS-509744          Fludarabine  1 60  0.19
## 4              BMS-509744            Selinexor  1 59  0.22
## 5              BMS-509744            Nutlin-3a  1 58  0.38
## 6              BMS-509744           Venetoclax  1 57  0.16
## 7              BMS-509744           Cytarabine  1 56  0.17
## 8              BMS-509744               RO5963  1 55  0.44
## 9              BMS-509744            A-1210477  1 54  0.26
## 10             BMS-509744         Panobinostat  1 53  0.25
## 11             BMS-509744             A-674563  1 52  0.28
## 12             BMS-509744          Palbociclib  1 51  0.39
## 13             BMS-509744           Dabrafenib  1 50 -0.32
## 14             BMS-509744            ZM 336372  1 49  0.11
## 15             BMS-509744             EPZ-6438  1 48 -0.10
## 16             BMS-509744             ONO-4059  1 47  0.38
## 17             BMS-509744          Midostaurin  1 46  0.04
## 18             BMS-509744         Methotrexate  1 45 -0.07
## 19             BMS-509744            Motolimod  1 44 -0.04
## 20             BMS-509744             Olaparib  1 43  0.34
## 21             BMS-509744            Cisplatin  1 42  0.16
## 22             BMS-509744               BGJ398  1 41  0.18
## 23             BMS-509744              BML-277  1 40  0.13
## 24             BMS-509744                AMI-1  1 39  0.14
## 25             BMS-509744           Vismodegib  1 38 -0.04
## 26             BMS-509744           Selisistat  1 37  0.22
## 27             BMS-509744                TW-37  1 36  0.10
## 28             BMS-509744               D 4476  1 35  0.03
## 29             BMS-509744         Doxorubicine  1 34  0.11
## 30             BMS-509744            Dasatinib  1 33  0.15
## 31             BMS-509744            Duvelisib  1 32  0.40
## 32             BMS-509744           Idelalisib  1 31  0.39
## 33             BMS-509744            Ibrutinib  1 30  0.18
## 34             BMS-509744            PRT062607  1 29  0.28
## 35             BMS-509744             Afatinib  1 28  0.19
## 36             BMS-509744            SB 203580  1 27  0.10
## 37             BMS-509744 IRAK-1/4 Inhibitor I  1 26  0.20
## 38             BMS-509744          Quizartinib  1 25  0.21
## 39             BMS-509744              MK-2206  1 24  0.37
## 40             BMS-509744              AZD1208  1 23  0.39
## 41             BMS-509744              AZD8055  1 22  0.35
## 42             BMS-509744            Rapamycin  1 21  0.34
## 43             BMS-509744               MI-503  1 20  0.12
## 44             BMS-509744             Imatinib  1 19  0.30
## 45             BMS-509744            Sunitinib  1 18  0.30
## 46             BMS-509744            Foretinib  1 17  0.47
## 47             BMS-509744           Tozasertib  1 16  0.36
## 48             BMS-509744          Ruxolitinib  1 15  0.06
## 49             BMS-509744          Tofacitinib  1 14 -0.06
## 50             BMS-509744           PF-3758309  1 13 -0.10
## 51             BMS-509744               OTX015  1 12 -0.18
## 52             BMS-509744           Volasertib  1 11 -0.09
## 53             BMS-509744           Ganetespib  1 10  0.09
## 54             BMS-509744            Onalespib  1  9  0.18
## 55             BMS-509744            SCH772984  1  8  0.06
## 56             BMS-509744          Cobimetinib  1  7  0.02
## 57             BMS-509744           Trametinib  1  6  0.02
## 58             BMS-509744             JNK-IN-8  1  5  0.10
## 59             BMS-509744  Menin-MLL Inhibitor  1  4  0.05
## 60             BMS-509744              AZD6738  1  3  0.45
## 61             BMS-509744             KU-55933  1  2  0.30
## 62             BMS-509744             SGC 0946  1  1  0.26
## 63              Ceritinib            Ceritinib  2 61  1.00
## 64              Ceritinib          Fludarabine  2 60  0.14
## 65              Ceritinib            Selinexor  2 59  0.33
## 66              Ceritinib            Nutlin-3a  2 58  0.44
## 67              Ceritinib           Venetoclax  2 57  0.48
## 68              Ceritinib           Cytarabine  2 56  0.09
## 69              Ceritinib               RO5963  2 55  0.24
## 70              Ceritinib            A-1210477  2 54  0.30
## 71              Ceritinib         Panobinostat  2 53  0.27
## 72              Ceritinib             A-674563  2 52  0.34
## 73              Ceritinib          Palbociclib  2 51  0.31
## 74              Ceritinib           Dabrafenib  2 50 -0.31
## 75              Ceritinib            ZM 336372  2 49  0.09
## 76              Ceritinib             EPZ-6438  2 48 -0.10
## 77              Ceritinib             ONO-4059  2 47  0.07
## 78              Ceritinib          Midostaurin  2 46 -0.15
## 79              Ceritinib         Methotrexate  2 45 -0.16
## 80              Ceritinib            Motolimod  2 44 -0.27
## 81              Ceritinib             Olaparib  2 43  0.25
## 82              Ceritinib            Cisplatin  2 42  0.29
## 83              Ceritinib               BGJ398  2 41  0.10
## 84              Ceritinib              BML-277  2 40  0.28
## 85              Ceritinib                AMI-1  2 39  0.14
## 86              Ceritinib           Vismodegib  2 38  0.13
## 87              Ceritinib           Selisistat  2 37  0.04
## 88              Ceritinib                TW-37  2 36 -0.14
## 89              Ceritinib               D 4476  2 35 -0.15
## 90              Ceritinib         Doxorubicine  2 34 -0.10
## 91              Ceritinib            Dasatinib  2 33 -0.07
## 92              Ceritinib            Duvelisib  2 32  0.11
## 93              Ceritinib           Idelalisib  2 31  0.17
## 94              Ceritinib            Ibrutinib  2 30  0.17
## 95              Ceritinib            PRT062607  2 29  0.12
## 96              Ceritinib             Afatinib  2 28  0.41
## 97              Ceritinib            SB 203580  2 27  0.24
## 98              Ceritinib IRAK-1/4 Inhibitor I  2 26  0.25
## 99              Ceritinib          Quizartinib  2 25  0.23
## 100             Ceritinib              MK-2206  2 24  0.25
## 101             Ceritinib              AZD1208  2 23  0.44
## 102             Ceritinib              AZD8055  2 22  0.27
## 103             Ceritinib            Rapamycin  2 21 -0.01
## 104             Ceritinib               MI-503  2 20  0.20
## 105             Ceritinib             Imatinib  2 19  0.16
## 106             Ceritinib            Sunitinib  2 18  0.29
## 107             Ceritinib            Foretinib  2 17  0.19
## 108             Ceritinib           Tozasertib  2 16  0.20
## 109             Ceritinib          Ruxolitinib  2 15 -0.07
## 110             Ceritinib          Tofacitinib  2 14 -0.14
## 111             Ceritinib           PF-3758309  2 13 -0.05
## 112             Ceritinib               OTX015  2 12 -0.18
## 113             Ceritinib           Volasertib  2 11  0.00
## 114             Ceritinib           Ganetespib  2 10  0.12
## 115             Ceritinib            Onalespib  2  9  0.22
## 116             Ceritinib            SCH772984  2  8 -0.02
## 117             Ceritinib          Cobimetinib  2  7 -0.13
## 118             Ceritinib           Trametinib  2  6 -0.15
## 119             Ceritinib             JNK-IN-8  2  5 -0.05
## 120             Ceritinib  Menin-MLL Inhibitor  2  4  0.03
## 121             Ceritinib              AZD6738  2  3  0.17
## 122             Ceritinib             KU-55933  2  2  0.08
## 123             Ceritinib             SGC 0946  2  1  0.18
## 124           Fludarabine          Fludarabine  3 60  1.00
## 125           Fludarabine            Selinexor  3 59  0.59
## 126           Fludarabine            Nutlin-3a  3 58  0.62
## 127           Fludarabine           Venetoclax  3 57  0.60
## 128           Fludarabine           Cytarabine  3 56  0.43
## 129           Fludarabine               RO5963  3 55  0.51
## 130           Fludarabine            A-1210477  3 54  0.47
## 131           Fludarabine         Panobinostat  3 53  0.48
## 132           Fludarabine             A-674563  3 52  0.54
## 133           Fludarabine          Palbociclib  3 51  0.47
## 134           Fludarabine           Dabrafenib  3 50 -0.06
## 135           Fludarabine            ZM 336372  3 49 -0.04
## 136           Fludarabine             EPZ-6438  3 48  0.06
## 137           Fludarabine             ONO-4059  3 47  0.18
## 138           Fludarabine          Midostaurin  3 46  0.03
## 139           Fludarabine         Methotrexate  3 45 -0.36
## 140           Fludarabine            Motolimod  3 44 -0.34
## 141           Fludarabine             Olaparib  3 43  0.25
## 142           Fludarabine            Cisplatin  3 42  0.22
## 143           Fludarabine               BGJ398  3 41 -0.05
## 144           Fludarabine              BML-277  3 40  0.05
## 145           Fludarabine                AMI-1  3 39  0.04
## 146           Fludarabine           Vismodegib  3 38 -0.06
## 147           Fludarabine           Selisistat  3 37 -0.06
## 148           Fludarabine                TW-37  3 36 -0.10
## 149           Fludarabine               D 4476  3 35  0.02
## 150           Fludarabine         Doxorubicine  3 34  0.26
## 151           Fludarabine            Dasatinib  3 33 -0.10
## 152           Fludarabine            Duvelisib  3 32  0.18
## 153           Fludarabine           Idelalisib  3 31  0.30
## 154           Fludarabine            Ibrutinib  3 30  0.20
## 155           Fludarabine            PRT062607  3 29  0.01
## 156           Fludarabine             Afatinib  3 28  0.31
## 157           Fludarabine            SB 203580  3 27  0.36
## 158           Fludarabine IRAK-1/4 Inhibitor I  3 26  0.28
## 159           Fludarabine          Quizartinib  3 25  0.22
## 160           Fludarabine              MK-2206  3 24  0.02
## 161           Fludarabine              AZD1208  3 23  0.35
## 162           Fludarabine              AZD8055  3 22  0.24
## 163           Fludarabine            Rapamycin  3 21  0.32
## 164           Fludarabine               MI-503  3 20  0.16
## 165           Fludarabine             Imatinib  3 19  0.05
## 166           Fludarabine            Sunitinib  3 18  0.27
## 167           Fludarabine            Foretinib  3 17  0.27
## 168           Fludarabine           Tozasertib  3 16  0.04
## 169           Fludarabine          Ruxolitinib  3 15 -0.08
## 170           Fludarabine          Tofacitinib  3 14 -0.02
## 171           Fludarabine           PF-3758309  3 13  0.13
## 172           Fludarabine               OTX015  3 12  0.00
## 173           Fludarabine           Volasertib  3 11  0.05
## 174           Fludarabine           Ganetespib  3 10 -0.15
## 175           Fludarabine            Onalespib  3  9 -0.09
## 176           Fludarabine            SCH772984  3  8 -0.09
## 177           Fludarabine          Cobimetinib  3  7 -0.22
## 178           Fludarabine           Trametinib  3  6 -0.17
## 179           Fludarabine             JNK-IN-8  3  5  0.17
## 180           Fludarabine  Menin-MLL Inhibitor  3  4  0.14
## 181           Fludarabine              AZD6738  3  3  0.03
## 182           Fludarabine             KU-55933  3  2  0.07
## 183           Fludarabine             SGC 0946  3  1  0.24
## 184             Selinexor            Selinexor  4 59  1.00
## 185             Selinexor            Nutlin-3a  4 58  0.69
## 186             Selinexor           Venetoclax  4 57  0.64
## 187             Selinexor           Cytarabine  4 56  0.29
## 188             Selinexor               RO5963  4 55  0.46
## 189             Selinexor            A-1210477  4 54  0.43
## 190             Selinexor         Panobinostat  4 53  0.57
## 191             Selinexor             A-674563  4 52  0.56
## 192             Selinexor          Palbociclib  4 51  0.56
## 193             Selinexor           Dabrafenib  4 50 -0.32
## 194             Selinexor            ZM 336372  4 49 -0.08
## 195             Selinexor             EPZ-6438  4 48 -0.06
## 196             Selinexor             ONO-4059  4 47  0.01
## 197             Selinexor          Midostaurin  4 46 -0.12
## 198             Selinexor         Methotrexate  4 45 -0.30
## 199             Selinexor            Motolimod  4 44 -0.25
## 200             Selinexor             Olaparib  4 43  0.28
## 201             Selinexor            Cisplatin  4 42  0.24
## 202             Selinexor               BGJ398  4 41 -0.09
## 203             Selinexor              BML-277  4 40  0.05
## 204             Selinexor                AMI-1  4 39 -0.16
## 205             Selinexor           Vismodegib  4 38 -0.01
## 206             Selinexor           Selisistat  4 37 -0.01
## 207             Selinexor                TW-37  4 36 -0.03
## 208             Selinexor               D 4476  4 35 -0.10
## 209             Selinexor         Doxorubicine  4 34  0.31
## 210             Selinexor            Dasatinib  4 33 -0.07
## 211             Selinexor            Duvelisib  4 32  0.12
## 212             Selinexor           Idelalisib  4 31  0.28
## 213             Selinexor            Ibrutinib  4 30  0.10
## 214             Selinexor            PRT062607  4 29  0.03
## 215             Selinexor             Afatinib  4 28  0.43
## 216             Selinexor            SB 203580  4 27  0.36
## 217             Selinexor IRAK-1/4 Inhibitor I  4 26  0.27
## 218             Selinexor          Quizartinib  4 25  0.23
## 219             Selinexor              MK-2206  4 24  0.14
## 220             Selinexor              AZD1208  4 23  0.48
## 221             Selinexor              AZD8055  4 22  0.25
## 222             Selinexor            Rapamycin  4 21  0.23
## 223             Selinexor               MI-503  4 20  0.29
## 224             Selinexor             Imatinib  4 19  0.03
## 225             Selinexor            Sunitinib  4 18  0.29
## 226             Selinexor            Foretinib  4 17  0.27
## 227             Selinexor           Tozasertib  4 16  0.11
## 228             Selinexor          Ruxolitinib  4 15  0.11
## 229             Selinexor          Tofacitinib  4 14  0.00
## 230             Selinexor           PF-3758309  4 13  0.09
## 231             Selinexor               OTX015  4 12  0.05
## 232             Selinexor           Volasertib  4 11  0.14
## 233             Selinexor           Ganetespib  4 10 -0.06
## 234             Selinexor            Onalespib  4  9  0.00
## 235             Selinexor            SCH772984  4  8  0.05
## 236             Selinexor          Cobimetinib  4  7 -0.09
## 237             Selinexor           Trametinib  4  6 -0.08
## 238             Selinexor             JNK-IN-8  4  5  0.03
## 239             Selinexor  Menin-MLL Inhibitor  4  4  0.20
## 240             Selinexor              AZD6738  4  3  0.03
## 241             Selinexor             KU-55933  4  2  0.20
## 242             Selinexor             SGC 0946  4  1  0.26
## 243             Nutlin-3a            Nutlin-3a  5 58  1.00
## 244             Nutlin-3a           Venetoclax  5 57  0.79
## 245             Nutlin-3a           Cytarabine  5 56  0.35
## 246             Nutlin-3a               RO5963  5 55  0.57
## 247             Nutlin-3a            A-1210477  5 54  0.46
## 248             Nutlin-3a         Panobinostat  5 53  0.40
## 249             Nutlin-3a             A-674563  5 52  0.60
## 250             Nutlin-3a          Palbociclib  5 51  0.44
## 251             Nutlin-3a           Dabrafenib  5 50 -0.18
## 252             Nutlin-3a            ZM 336372  5 49  0.01
## 253             Nutlin-3a             EPZ-6438  5 48  0.06
## 254             Nutlin-3a             ONO-4059  5 47  0.27
## 255             Nutlin-3a          Midostaurin  5 46 -0.01
## 256             Nutlin-3a         Methotrexate  5 45 -0.30
## 257             Nutlin-3a            Motolimod  5 44 -0.44
## 258             Nutlin-3a             Olaparib  5 43  0.32
## 259             Nutlin-3a            Cisplatin  5 42  0.22
## 260             Nutlin-3a               BGJ398  5 41 -0.22
## 261             Nutlin-3a              BML-277  5 40  0.12
## 262             Nutlin-3a                AMI-1  5 39  0.02
## 263             Nutlin-3a           Vismodegib  5 38  0.07
## 264             Nutlin-3a           Selisistat  5 37  0.11
## 265             Nutlin-3a                TW-37  5 36 -0.06
## 266             Nutlin-3a               D 4476  5 35 -0.21
## 267             Nutlin-3a         Doxorubicine  5 34  0.11
## 268             Nutlin-3a            Dasatinib  5 33 -0.22
## 269             Nutlin-3a            Duvelisib  5 32 -0.05
## 270             Nutlin-3a           Idelalisib  5 31  0.21
## 271             Nutlin-3a            Ibrutinib  5 30  0.15
## 272             Nutlin-3a            PRT062607  5 29 -0.03
## 273             Nutlin-3a             Afatinib  5 28  0.41
## 274             Nutlin-3a            SB 203580  5 27  0.38
## 275             Nutlin-3a IRAK-1/4 Inhibitor I  5 26  0.34
## 276             Nutlin-3a          Quizartinib  5 25  0.33
## 277             Nutlin-3a              MK-2206  5 24  0.07
## 278             Nutlin-3a              AZD1208  5 23  0.35
## 279             Nutlin-3a              AZD8055  5 22  0.08
## 280             Nutlin-3a            Rapamycin  5 21  0.12
## 281             Nutlin-3a               MI-503  5 20  0.12
## 282             Nutlin-3a             Imatinib  5 19  0.03
## 283             Nutlin-3a            Sunitinib  5 18  0.21
## 284             Nutlin-3a            Foretinib  5 17  0.30
## 285             Nutlin-3a           Tozasertib  5 16  0.03
## 286             Nutlin-3a          Ruxolitinib  5 15 -0.17
## 287             Nutlin-3a          Tofacitinib  5 14 -0.17
## 288             Nutlin-3a           PF-3758309  5 13 -0.22
## 289             Nutlin-3a               OTX015  5 12 -0.32
## 290             Nutlin-3a           Volasertib  5 11 -0.14
## 291             Nutlin-3a           Ganetespib  5 10 -0.28
## 292             Nutlin-3a            Onalespib  5  9 -0.14
## 293             Nutlin-3a            SCH772984  5  8 -0.21
## 294             Nutlin-3a          Cobimetinib  5  7 -0.37
## 295             Nutlin-3a           Trametinib  5  6 -0.35
## 296             Nutlin-3a             JNK-IN-8  5  5  0.17
## 297             Nutlin-3a  Menin-MLL Inhibitor  5  4  0.18
## 298             Nutlin-3a              AZD6738  5  3  0.02
## 299             Nutlin-3a             KU-55933  5  2  0.10
## 300             Nutlin-3a             SGC 0946  5  1  0.23
## 301            Venetoclax           Venetoclax  6 57  1.00
## 302            Venetoclax           Cytarabine  6 56  0.14
## 303            Venetoclax               RO5963  6 55  0.41
## 304            Venetoclax            A-1210477  6 54  0.33
## 305            Venetoclax         Panobinostat  6 53  0.33
## 306            Venetoclax             A-674563  6 52  0.52
## 307            Venetoclax          Palbociclib  6 51  0.30
## 308            Venetoclax           Dabrafenib  6 50 -0.10
## 309            Venetoclax            ZM 336372  6 49  0.04
## 310            Venetoclax             EPZ-6438  6 48  0.02
## 311            Venetoclax             ONO-4059  6 47  0.12
## 312            Venetoclax          Midostaurin  6 46 -0.07
## 313            Venetoclax         Methotrexate  6 45 -0.45
## 314            Venetoclax            Motolimod  6 44 -0.52
## 315            Venetoclax             Olaparib  6 43  0.07
## 316            Venetoclax            Cisplatin  6 42  0.06
## 317            Venetoclax               BGJ398  6 41 -0.33
## 318            Venetoclax              BML-277  6 40  0.08
## 319            Venetoclax                AMI-1  6 39 -0.03
## 320            Venetoclax           Vismodegib  6 38 -0.11
## 321            Venetoclax           Selisistat  6 37 -0.14
## 322            Venetoclax                TW-37  6 36 -0.25
## 323            Venetoclax               D 4476  6 35 -0.28
## 324            Venetoclax         Doxorubicine  6 34  0.09
## 325            Venetoclax            Dasatinib  6 33 -0.36
## 326            Venetoclax            Duvelisib  6 32 -0.17
## 327            Venetoclax           Idelalisib  6 31  0.05
## 328            Venetoclax            Ibrutinib  6 30  0.06
## 329            Venetoclax            PRT062607  6 29 -0.11
## 330            Venetoclax             Afatinib  6 28  0.28
## 331            Venetoclax            SB 203580  6 27  0.41
## 332            Venetoclax IRAK-1/4 Inhibitor I  6 26  0.15
## 333            Venetoclax          Quizartinib  6 25  0.29
## 334            Venetoclax              MK-2206  6 24  0.01
## 335            Venetoclax              AZD1208  6 23  0.35
## 336            Venetoclax              AZD8055  6 22  0.00
## 337            Venetoclax            Rapamycin  6 21 -0.04
## 338            Venetoclax               MI-503  6 20  0.04
## 339            Venetoclax             Imatinib  6 19 -0.14
## 340            Venetoclax            Sunitinib  6 18  0.07
## 341            Venetoclax            Foretinib  6 17  0.02
## 342            Venetoclax           Tozasertib  6 16 -0.17
## 343            Venetoclax          Ruxolitinib  6 15 -0.21
## 344            Venetoclax          Tofacitinib  6 14 -0.20
## 345            Venetoclax           PF-3758309  6 13 -0.27
## 346            Venetoclax               OTX015  6 12 -0.34
## 347            Venetoclax           Volasertib  6 11 -0.18
## 348            Venetoclax           Ganetespib  6 10 -0.42
## 349            Venetoclax            Onalespib  6  9 -0.31
## 350            Venetoclax            SCH772984  6  8 -0.41
## 351            Venetoclax          Cobimetinib  6  7 -0.58
## 352            Venetoclax           Trametinib  6  6 -0.53
## 353            Venetoclax             JNK-IN-8  6  5  0.05
## 354            Venetoclax  Menin-MLL Inhibitor  6  4  0.09
## 355            Venetoclax              AZD6738  6  3 -0.06
## 356            Venetoclax             KU-55933  6  2  0.04
## 357            Venetoclax             SGC 0946  6  1  0.23
## 358            Cytarabine           Cytarabine  7 56  1.00
## 359            Cytarabine               RO5963  7 55  0.47
## 360            Cytarabine            A-1210477  7 54  0.31
## 361            Cytarabine         Panobinostat  7 53  0.40
## 362            Cytarabine             A-674563  7 52  0.31
## 363            Cytarabine          Palbociclib  7 51  0.32
## 364            Cytarabine           Dabrafenib  7 50 -0.19
## 365            Cytarabine            ZM 336372  7 49 -0.11
## 366            Cytarabine             EPZ-6438  7 48  0.17
## 367            Cytarabine             ONO-4059  7 47  0.19
## 368            Cytarabine          Midostaurin  7 46 -0.11
## 369            Cytarabine         Methotrexate  7 45 -0.12
## 370            Cytarabine            Motolimod  7 44 -0.18
## 371            Cytarabine             Olaparib  7 43  0.33
## 372            Cytarabine            Cisplatin  7 42  0.34
## 373            Cytarabine               BGJ398  7 41  0.32
## 374            Cytarabine              BML-277  7 40  0.07
## 375            Cytarabine                AMI-1  7 39 -0.03
## 376            Cytarabine           Vismodegib  7 38  0.01
## 377            Cytarabine           Selisistat  7 37  0.22
## 378            Cytarabine                TW-37  7 36  0.25
## 379            Cytarabine               D 4476  7 35  0.03
## 380            Cytarabine         Doxorubicine  7 34 -0.01
## 381            Cytarabine            Dasatinib  7 33  0.36
## 382            Cytarabine            Duvelisib  7 32  0.34
## 383            Cytarabine           Idelalisib  7 31  0.44
## 384            Cytarabine            Ibrutinib  7 30  0.41
## 385            Cytarabine            PRT062607  7 29  0.20
## 386            Cytarabine             Afatinib  7 28  0.44
## 387            Cytarabine            SB 203580  7 27  0.28
## 388            Cytarabine IRAK-1/4 Inhibitor I  7 26  0.45
## 389            Cytarabine          Quizartinib  7 25  0.07
## 390            Cytarabine              MK-2206  7 24  0.23
## 391            Cytarabine              AZD1208  7 23  0.37
## 392            Cytarabine              AZD8055  7 22  0.28
## 393            Cytarabine            Rapamycin  7 21  0.34
## 394            Cytarabine               MI-503  7 20  0.20
## 395            Cytarabine             Imatinib  7 19  0.31
## 396            Cytarabine            Sunitinib  7 18  0.45
## 397            Cytarabine            Foretinib  7 17  0.46
## 398            Cytarabine           Tozasertib  7 16  0.35
## 399            Cytarabine          Ruxolitinib  7 15  0.22
## 400            Cytarabine          Tofacitinib  7 14  0.17
## 401            Cytarabine           PF-3758309  7 13  0.24
## 402            Cytarabine               OTX015  7 12  0.09
## 403            Cytarabine           Volasertib  7 11  0.13
## 404            Cytarabine           Ganetespib  7 10  0.30
## 405            Cytarabine            Onalespib  7  9  0.29
## 406            Cytarabine            SCH772984  7  8  0.20
## 407            Cytarabine          Cobimetinib  7  7  0.15
## 408            Cytarabine           Trametinib  7  6  0.13
## 409            Cytarabine             JNK-IN-8  7  5  0.29
## 410            Cytarabine  Menin-MLL Inhibitor  7  4  0.24
## 411            Cytarabine              AZD6738  7  3  0.19
## 412            Cytarabine             KU-55933  7  2  0.08
## 413            Cytarabine             SGC 0946  7  1  0.23
## 414                RO5963               RO5963  8 55  1.00
## 415                RO5963            A-1210477  8 54  0.36
## 416                RO5963         Panobinostat  8 53  0.38
## 417                RO5963             A-674563  8 52  0.38
## 418                RO5963          Palbociclib  8 51  0.38
## 419                RO5963           Dabrafenib  8 50 -0.41
## 420                RO5963            ZM 336372  8 49  0.02
## 421                RO5963             EPZ-6438  8 48 -0.07
## 422                RO5963             ONO-4059  8 47  0.47
## 423                RO5963          Midostaurin  8 46 -0.17
## 424                RO5963         Methotrexate  8 45 -0.30
## 425                RO5963            Motolimod  8 44 -0.32
## 426                RO5963             Olaparib  8 43  0.26
## 427                RO5963            Cisplatin  8 42  0.17
## 428                RO5963               BGJ398  8 41  0.10
## 429                RO5963              BML-277  8 40  0.06
## 430                RO5963                AMI-1  8 39 -0.04
## 431                RO5963           Vismodegib  8 38 -0.06
## 432                RO5963           Selisistat  8 37  0.20
## 433                RO5963                TW-37  8 36  0.14
## 434                RO5963               D 4476  8 35  0.15
## 435                RO5963         Doxorubicine  8 34  0.32
## 436                RO5963            Dasatinib  8 33  0.12
## 437                RO5963            Duvelisib  8 32  0.40
## 438                RO5963           Idelalisib  8 31  0.62
## 439                RO5963            Ibrutinib  8 30  0.44
## 440                RO5963            PRT062607  8 29  0.23
## 441                RO5963             Afatinib  8 28  0.25
## 442                RO5963            SB 203580  8 27  0.46
## 443                RO5963 IRAK-1/4 Inhibitor I  8 26  0.33
## 444                RO5963          Quizartinib  8 25  0.22
## 445                RO5963              MK-2206  8 24  0.15
## 446                RO5963              AZD1208  8 23  0.38
## 447                RO5963              AZD8055  8 22  0.30
## 448                RO5963            Rapamycin  8 21  0.41
## 449                RO5963               MI-503  8 20  0.29
## 450                RO5963             Imatinib  8 19  0.15
## 451                RO5963            Sunitinib  8 18  0.35
## 452                RO5963            Foretinib  8 17  0.46
## 453                RO5963           Tozasertib  8 16  0.27
## 454                RO5963          Ruxolitinib  8 15  0.14
## 455                RO5963          Tofacitinib  8 14  0.05
## 456                RO5963           PF-3758309  8 13  0.05
## 457                RO5963               OTX015  8 12 -0.06
## 458                RO5963           Volasertib  8 11 -0.04
## 459                RO5963           Ganetespib  8 10  0.00
## 460                RO5963            Onalespib  8  9  0.08
## 461                RO5963            SCH772984  8  8  0.06
## 462                RO5963          Cobimetinib  8  7 -0.02
## 463                RO5963           Trametinib  8  6 -0.04
## 464                RO5963             JNK-IN-8  8  5  0.22
## 465                RO5963  Menin-MLL Inhibitor  8  4  0.05
## 466                RO5963              AZD6738  8  3  0.23
## 467                RO5963             KU-55933  8  2  0.15
## 468                RO5963             SGC 0946  8  1  0.09
## 469             A-1210477            A-1210477  9 54  1.00
## 470             A-1210477         Panobinostat  9 53  0.52
## 471             A-1210477             A-674563  9 52  0.54
## 472             A-1210477          Palbociclib  9 51  0.46
## 473             A-1210477           Dabrafenib  9 50 -0.11
## 474             A-1210477            ZM 336372  9 49 -0.14
## 475             A-1210477             EPZ-6438  9 48 -0.02
## 476             A-1210477             ONO-4059  9 47  0.30
## 477             A-1210477          Midostaurin  9 46 -0.14
## 478             A-1210477         Methotrexate  9 45  0.02
## 479             A-1210477            Motolimod  9 44 -0.28
## 480             A-1210477             Olaparib  9 43  0.26
## 481             A-1210477            Cisplatin  9 42  0.22
## 482             A-1210477               BGJ398  9 41  0.05
## 483             A-1210477              BML-277  9 40  0.08
## 484             A-1210477                AMI-1  9 39 -0.09
## 485             A-1210477           Vismodegib  9 38 -0.04
## 486             A-1210477           Selisistat  9 37  0.06
## 487             A-1210477                TW-37  9 36 -0.21
## 488             A-1210477               D 4476  9 35 -0.03
## 489             A-1210477         Doxorubicine  9 34  0.06
## 490             A-1210477            Dasatinib  9 33  0.07
## 491             A-1210477            Duvelisib  9 32  0.29
## 492             A-1210477           Idelalisib  9 31  0.41
## 493             A-1210477            Ibrutinib  9 30  0.37
## 494             A-1210477            PRT062607  9 29  0.21
## 495             A-1210477             Afatinib  9 28  0.43
## 496             A-1210477            SB 203580  9 27  0.36
## 497             A-1210477 IRAK-1/4 Inhibitor I  9 26  0.34
## 498             A-1210477          Quizartinib  9 25  0.17
## 499             A-1210477              MK-2206  9 24  0.11
## 500             A-1210477              AZD1208  9 23  0.34
## 501             A-1210477              AZD8055  9 22  0.35
## 502             A-1210477            Rapamycin  9 21  0.32
## 503             A-1210477               MI-503  9 20  0.27
## 504             A-1210477             Imatinib  9 19 -0.01
## 505             A-1210477            Sunitinib  9 18  0.24
## 506             A-1210477            Foretinib  9 17  0.25
## 507             A-1210477           Tozasertib  9 16  0.23
## 508             A-1210477          Ruxolitinib  9 15  0.17
## 509             A-1210477          Tofacitinib  9 14 -0.02
## 510             A-1210477           PF-3758309  9 13  0.27
## 511             A-1210477               OTX015  9 12  0.19
## 512             A-1210477           Volasertib  9 11  0.31
## 513             A-1210477           Ganetespib  9 10  0.19
## 514             A-1210477            Onalespib  9  9  0.23
## 515             A-1210477            SCH772984  9  8  0.25
## 516             A-1210477          Cobimetinib  9  7  0.17
## 517             A-1210477           Trametinib  9  6  0.16
## 518             A-1210477             JNK-IN-8  9  5  0.22
## 519             A-1210477  Menin-MLL Inhibitor  9  4  0.22
## 520             A-1210477              AZD6738  9  3  0.11
## 521             A-1210477             KU-55933  9  2  0.27
## 522             A-1210477             SGC 0946  9  1  0.41
## 523          Panobinostat         Panobinostat 10 53  1.00
## 524          Panobinostat             A-674563 10 52  0.58
## 525          Panobinostat          Palbociclib 10 51  0.57
## 526          Panobinostat           Dabrafenib 10 50 -0.10
## 527          Panobinostat            ZM 336372 10 49 -0.08
## 528          Panobinostat             EPZ-6438 10 48  0.07
## 529          Panobinostat             ONO-4059 10 47  0.06
## 530          Panobinostat          Midostaurin 10 46 -0.11
## 531          Panobinostat         Methotrexate 10 45  0.04
## 532          Panobinostat            Motolimod 10 44 -0.09
## 533          Panobinostat             Olaparib 10 43  0.38
## 534          Panobinostat            Cisplatin 10 42  0.18
## 535          Panobinostat               BGJ398 10 41  0.20
## 536          Panobinostat              BML-277 10 40  0.05
## 537          Panobinostat                AMI-1 10 39 -0.08
## 538          Panobinostat           Vismodegib 10 38  0.06
## 539          Panobinostat           Selisistat 10 37  0.00
## 540          Panobinostat                TW-37 10 36 -0.20
## 541          Panobinostat               D 4476 10 35 -0.07
## 542          Panobinostat         Doxorubicine 10 34  0.21
## 543          Panobinostat            Dasatinib 10 33  0.20
## 544          Panobinostat            Duvelisib 10 32  0.42
## 545          Panobinostat           Idelalisib 10 31  0.51
## 546          Panobinostat            Ibrutinib 10 30  0.23
## 547          Panobinostat            PRT062607 10 29  0.28
## 548          Panobinostat             Afatinib 10 28  0.40
## 549          Panobinostat            SB 203580 10 27  0.49
## 550          Panobinostat IRAK-1/4 Inhibitor I 10 26  0.41
## 551          Panobinostat          Quizartinib 10 25  0.25
## 552          Panobinostat              MK-2206 10 24  0.43
## 553          Panobinostat              AZD1208 10 23  0.60
## 554          Panobinostat              AZD8055 10 22  0.63
## 555          Panobinostat            Rapamycin 10 21  0.49
## 556          Panobinostat               MI-503 10 20  0.34
## 557          Panobinostat             Imatinib 10 19  0.19
## 558          Panobinostat            Sunitinib 10 18  0.35
## 559          Panobinostat            Foretinib 10 17  0.37
## 560          Panobinostat           Tozasertib 10 16  0.40
## 561          Panobinostat          Ruxolitinib 10 15  0.41
## 562          Panobinostat          Tofacitinib 10 14  0.31
## 563          Panobinostat           PF-3758309 10 13  0.42
## 564          Panobinostat               OTX015 10 12  0.35
## 565          Panobinostat           Volasertib 10 11  0.40
## 566          Panobinostat           Ganetespib 10 10  0.34
## 567          Panobinostat            Onalespib 10  9  0.37
## 568          Panobinostat            SCH772984 10  8  0.28
## 569          Panobinostat          Cobimetinib 10  7  0.19
## 570          Panobinostat           Trametinib 10  6  0.22
## 571          Panobinostat             JNK-IN-8 10  5  0.32
## 572          Panobinostat  Menin-MLL Inhibitor 10  4  0.34
## 573          Panobinostat              AZD6738 10  3  0.26
## 574          Panobinostat             KU-55933 10  2  0.38
## 575          Panobinostat             SGC 0946 10  1  0.33
## 576              A-674563             A-674563 11 52  1.00
## 577              A-674563          Palbociclib 11 51  0.71
## 578              A-674563           Dabrafenib 11 50 -0.13
## 579              A-674563            ZM 336372 11 49 -0.14
## 580              A-674563             EPZ-6438 11 48  0.00
## 581              A-674563             ONO-4059 11 47  0.28
## 582              A-674563          Midostaurin 11 46  0.20
## 583              A-674563         Methotrexate 11 45 -0.16
## 584              A-674563            Motolimod 11 44 -0.36
## 585              A-674563             Olaparib 11 43  0.21
## 586              A-674563            Cisplatin 11 42  0.09
## 587              A-674563               BGJ398 11 41 -0.04
## 588              A-674563              BML-277 11 40 -0.03
## 589              A-674563                AMI-1 11 39 -0.02
## 590              A-674563           Vismodegib 11 38  0.08
## 591              A-674563           Selisistat 11 37  0.01
## 592              A-674563                TW-37 11 36 -0.34
## 593              A-674563               D 4476 11 35 -0.18
## 594              A-674563         Doxorubicine 11 34  0.03
## 595              A-674563            Dasatinib 11 33  0.05
## 596              A-674563            Duvelisib 11 32  0.42
## 597              A-674563           Idelalisib 11 31  0.54
## 598              A-674563            Ibrutinib 11 30  0.47
## 599              A-674563            PRT062607 11 29  0.42
## 600              A-674563             Afatinib 11 28  0.53
## 601              A-674563            SB 203580 11 27  0.48
## 602              A-674563 IRAK-1/4 Inhibitor I 11 26  0.58
## 603              A-674563          Quizartinib 11 25  0.53
## 604              A-674563              MK-2206 11 24  0.29
## 605              A-674563              AZD1208 11 23  0.67
## 606              A-674563              AZD8055 11 22  0.48
## 607              A-674563            Rapamycin 11 21  0.44
## 608              A-674563               MI-503 11 20  0.38
## 609              A-674563             Imatinib 11 19  0.32
## 610              A-674563            Sunitinib 11 18  0.59
## 611              A-674563            Foretinib 11 17  0.47
## 612              A-674563           Tozasertib 11 16  0.41
## 613              A-674563          Ruxolitinib 11 15  0.27
## 614              A-674563          Tofacitinib 11 14  0.25
## 615              A-674563           PF-3758309 11 13  0.36
## 616              A-674563               OTX015 11 12  0.15
## 617              A-674563           Volasertib 11 11  0.30
## 618              A-674563           Ganetespib 11 10  0.24
## 619              A-674563            Onalespib 11  9  0.33
## 620              A-674563            SCH772984 11  8  0.22
## 621              A-674563          Cobimetinib 11  7  0.08
## 622              A-674563           Trametinib 11  6  0.14
## 623              A-674563             JNK-IN-8 11  5  0.20
## 624              A-674563  Menin-MLL Inhibitor 11  4  0.48
## 625              A-674563              AZD6738 11  3  0.17
## 626              A-674563             KU-55933 11  2  0.27
## 627              A-674563             SGC 0946 11  1  0.49
## 628           Palbociclib          Palbociclib 12 51  1.00
## 629           Palbociclib           Dabrafenib 12 50 -0.24
## 630           Palbociclib            ZM 336372 12 49 -0.07
## 631           Palbociclib             EPZ-6438 12 48 -0.11
## 632           Palbociclib             ONO-4059 12 47  0.32
## 633           Palbociclib          Midostaurin 12 46  0.12
## 634           Palbociclib         Methotrexate 12 45 -0.07
## 635           Palbociclib            Motolimod 12 44 -0.14
## 636           Palbociclib             Olaparib 12 43  0.39
## 637           Palbociclib            Cisplatin 12 42  0.26
## 638           Palbociclib               BGJ398 12 41  0.15
## 639           Palbociclib              BML-277 12 40  0.10
## 640           Palbociclib                AMI-1 12 39 -0.04
## 641           Palbociclib           Vismodegib 12 38  0.01
## 642           Palbociclib           Selisistat 12 37  0.16
## 643           Palbociclib                TW-37 12 36 -0.07
## 644           Palbociclib               D 4476 12 35  0.04
## 645           Palbociclib         Doxorubicine 12 34  0.11
## 646           Palbociclib            Dasatinib 12 33  0.20
## 647           Palbociclib            Duvelisib 12 32  0.53
## 648           Palbociclib           Idelalisib 12 31  0.58
## 649           Palbociclib            Ibrutinib 12 30  0.39
## 650           Palbociclib            PRT062607 12 29  0.47
## 651           Palbociclib             Afatinib 12 28  0.57
## 652           Palbociclib            SB 203580 12 27  0.31
## 653           Palbociclib IRAK-1/4 Inhibitor I 12 26  0.56
## 654           Palbociclib          Quizartinib 12 25  0.40
## 655           Palbociclib              MK-2206 12 24  0.44
## 656           Palbociclib              AZD1208 12 23  0.55
## 657           Palbociclib              AZD8055 12 22  0.56
## 658           Palbociclib            Rapamycin 12 21  0.57
## 659           Palbociclib               MI-503 12 20  0.51
## 660           Palbociclib             Imatinib 12 19  0.46
## 661           Palbociclib            Sunitinib 12 18  0.58
## 662           Palbociclib            Foretinib 12 17  0.62
## 663           Palbociclib           Tozasertib 12 16  0.57
## 664           Palbociclib          Ruxolitinib 12 15  0.28
## 665           Palbociclib          Tofacitinib 12 14  0.16
## 666           Palbociclib           PF-3758309 12 13  0.51
## 667           Palbociclib               OTX015 12 12  0.37
## 668           Palbociclib           Volasertib 12 11  0.47
## 669           Palbociclib           Ganetespib 12 10  0.47
## 670           Palbociclib            Onalespib 12  9  0.53
## 671           Palbociclib            SCH772984 12  8  0.35
## 672           Palbociclib          Cobimetinib 12  7  0.27
## 673           Palbociclib           Trametinib 12  6  0.30
## 674           Palbociclib             JNK-IN-8 12  5  0.11
## 675           Palbociclib  Menin-MLL Inhibitor 12  4  0.31
## 676           Palbociclib              AZD6738 12  3  0.17
## 677           Palbociclib             KU-55933 12  2  0.35
## 678           Palbociclib             SGC 0946 12  1  0.43
## 679            Dabrafenib           Dabrafenib 13 50  1.00
## 680            Dabrafenib            ZM 336372 13 49  0.30
## 681            Dabrafenib             EPZ-6438 13 48  0.14
## 682            Dabrafenib             ONO-4059 13 47 -0.04
## 683            Dabrafenib          Midostaurin 13 46  0.27
## 684            Dabrafenib         Methotrexate 13 45  0.13
## 685            Dabrafenib            Motolimod 13 44  0.18
## 686            Dabrafenib             Olaparib 13 43 -0.21
## 687            Dabrafenib            Cisplatin 13 42 -0.19
## 688            Dabrafenib               BGJ398 13 41 -0.11
## 689            Dabrafenib              BML-277 13 40  0.07
## 690            Dabrafenib                AMI-1 13 39  0.12
## 691            Dabrafenib           Vismodegib 13 38  0.09
## 692            Dabrafenib           Selisistat 13 37 -0.11
## 693            Dabrafenib                TW-37 13 36 -0.17
## 694            Dabrafenib               D 4476 13 35  0.24
## 695            Dabrafenib         Doxorubicine 13 34 -0.15
## 696            Dabrafenib            Dasatinib 13 33 -0.12
## 697            Dabrafenib            Duvelisib 13 32 -0.29
## 698            Dabrafenib           Idelalisib 13 31 -0.28
## 699            Dabrafenib            Ibrutinib 13 30 -0.25
## 700            Dabrafenib            PRT062607 13 29 -0.30
## 701            Dabrafenib             Afatinib 13 28 -0.18
## 702            Dabrafenib            SB 203580 13 27 -0.21
## 703            Dabrafenib IRAK-1/4 Inhibitor I 13 26 -0.32
## 704            Dabrafenib          Quizartinib 13 25 -0.03
## 705            Dabrafenib              MK-2206 13 24 -0.16
## 706            Dabrafenib              AZD1208 13 23 -0.27
## 707            Dabrafenib              AZD8055 13 22 -0.23
## 708            Dabrafenib            Rapamycin 13 21 -0.17
## 709            Dabrafenib               MI-503 13 20 -0.15
## 710            Dabrafenib             Imatinib 13 19 -0.24
## 711            Dabrafenib            Sunitinib 13 18 -0.28
## 712            Dabrafenib            Foretinib 13 17 -0.29
## 713            Dabrafenib           Tozasertib 13 16 -0.35
## 714            Dabrafenib          Ruxolitinib 13 15 -0.11
## 715            Dabrafenib          Tofacitinib 13 14  0.09
## 716            Dabrafenib           PF-3758309 13 13 -0.06
## 717            Dabrafenib               OTX015 13 12  0.15
## 718            Dabrafenib           Volasertib 13 11  0.11
## 719            Dabrafenib           Ganetespib 13 10 -0.24
## 720            Dabrafenib            Onalespib 13  9 -0.31
## 721            Dabrafenib            SCH772984 13  8 -0.28
## 722            Dabrafenib          Cobimetinib 13  7 -0.17
## 723            Dabrafenib           Trametinib 13  6 -0.12
## 724            Dabrafenib             JNK-IN-8 13  5  0.11
## 725            Dabrafenib  Menin-MLL Inhibitor 13  4 -0.08
## 726            Dabrafenib              AZD6738 13  3 -0.10
## 727            Dabrafenib             KU-55933 13  2 -0.13
## 728            Dabrafenib             SGC 0946 13  1 -0.18
## 729             ZM 336372            ZM 336372 14 49  1.00
## 730             ZM 336372             EPZ-6438 14 48 -0.01
## 731             ZM 336372             ONO-4059 14 47  0.14
## 732             ZM 336372          Midostaurin 14 46 -0.04
## 733             ZM 336372         Methotrexate 14 45 -0.15
## 734             ZM 336372            Motolimod 14 44  0.26
## 735             ZM 336372             Olaparib 14 43 -0.08
## 736             ZM 336372            Cisplatin 14 42  0.11
## 737             ZM 336372               BGJ398 14 41  0.04
## 738             ZM 336372              BML-277 14 40  0.16
## 739             ZM 336372                AMI-1 14 39  0.16
## 740             ZM 336372           Vismodegib 14 38  0.00
## 741             ZM 336372           Selisistat 14 37  0.23
## 742             ZM 336372                TW-37 14 36  0.15
## 743             ZM 336372               D 4476 14 35  0.18
## 744             ZM 336372         Doxorubicine 14 34  0.01
## 745             ZM 336372            Dasatinib 14 33 -0.12
## 746             ZM 336372            Duvelisib 14 32 -0.04
## 747             ZM 336372           Idelalisib 14 31 -0.08
## 748             ZM 336372            Ibrutinib 14 30 -0.24
## 749             ZM 336372            PRT062607 14 29 -0.24
## 750             ZM 336372             Afatinib 14 28 -0.19
## 751             ZM 336372            SB 203580 14 27 -0.18
## 752             ZM 336372 IRAK-1/4 Inhibitor I 14 26 -0.31
## 753             ZM 336372          Quizartinib 14 25  0.05
## 754             ZM 336372              MK-2206 14 24  0.02
## 755             ZM 336372              AZD1208 14 23 -0.07
## 756             ZM 336372              AZD8055 14 22 -0.05
## 757             ZM 336372            Rapamycin 14 21 -0.08
## 758             ZM 336372               MI-503 14 20  0.06
## 759             ZM 336372             Imatinib 14 19 -0.17
## 760             ZM 336372            Sunitinib 14 18 -0.14
## 761             ZM 336372            Foretinib 14 17 -0.16
## 762             ZM 336372           Tozasertib 14 16 -0.27
## 763             ZM 336372          Ruxolitinib 14 15 -0.19
## 764             ZM 336372          Tofacitinib 14 14  0.03
## 765             ZM 336372           PF-3758309 14 13 -0.22
## 766             ZM 336372               OTX015 14 12 -0.03
## 767             ZM 336372           Volasertib 14 11 -0.08
## 768             ZM 336372           Ganetespib 14 10 -0.16
## 769             ZM 336372            Onalespib 14  9 -0.14
## 770             ZM 336372            SCH772984 14  8 -0.25
## 771             ZM 336372          Cobimetinib 14  7 -0.11
## 772             ZM 336372           Trametinib 14  6 -0.09
## 773             ZM 336372             JNK-IN-8 14  5 -0.11
## 774             ZM 336372  Menin-MLL Inhibitor 14  4 -0.28
## 775             ZM 336372              AZD6738 14  3  0.11
## 776             ZM 336372             KU-55933 14  2 -0.22
## 777             ZM 336372             SGC 0946 14  1  0.01
## 778              EPZ-6438             EPZ-6438 15 48  1.00
## 779              EPZ-6438             ONO-4059 15 47  0.24
## 780              EPZ-6438          Midostaurin 15 46 -0.05
## 781              EPZ-6438         Methotrexate 15 45 -0.05
## 782              EPZ-6438            Motolimod 15 44 -0.08
## 783              EPZ-6438             Olaparib 15 43 -0.08
## 784              EPZ-6438            Cisplatin 15 42 -0.03
## 785              EPZ-6438               BGJ398 15 41  0.09
## 786              EPZ-6438              BML-277 15 40  0.20
## 787              EPZ-6438                AMI-1 15 39  0.14
## 788              EPZ-6438           Vismodegib 15 38  0.35
## 789              EPZ-6438           Selisistat 15 37  0.26
## 790              EPZ-6438                TW-37 15 36  0.18
## 791              EPZ-6438               D 4476 15 35 -0.06
## 792              EPZ-6438         Doxorubicine 15 34 -0.29
## 793              EPZ-6438            Dasatinib 15 33  0.03
## 794              EPZ-6438            Duvelisib 15 32 -0.09
## 795              EPZ-6438           Idelalisib 15 31  0.00
## 796              EPZ-6438            Ibrutinib 15 30  0.19
## 797              EPZ-6438            PRT062607 15 29  0.07
## 798              EPZ-6438             Afatinib 15 28 -0.06
## 799              EPZ-6438            SB 203580 15 27  0.10
## 800              EPZ-6438 IRAK-1/4 Inhibitor I 15 26  0.18
## 801              EPZ-6438          Quizartinib 15 25  0.02
## 802              EPZ-6438              MK-2206 15 24 -0.09
## 803              EPZ-6438              AZD1208 15 23  0.01
## 804              EPZ-6438              AZD8055 15 22 -0.04
## 805              EPZ-6438            Rapamycin 15 21 -0.02
## 806              EPZ-6438               MI-503 15 20 -0.14
## 807              EPZ-6438             Imatinib 15 19 -0.10
## 808              EPZ-6438            Sunitinib 15 18 -0.16
## 809              EPZ-6438            Foretinib 15 17 -0.13
## 810              EPZ-6438           Tozasertib 15 16 -0.03
## 811              EPZ-6438          Ruxolitinib 15 15  0.18
## 812              EPZ-6438          Tofacitinib 15 14  0.07
## 813              EPZ-6438           PF-3758309 15 13  0.01
## 814              EPZ-6438               OTX015 15 12 -0.04
## 815              EPZ-6438           Volasertib 15 11  0.00
## 816              EPZ-6438           Ganetespib 15 10  0.02
## 817              EPZ-6438            Onalespib 15  9  0.10
## 818              EPZ-6438            SCH772984 15  8 -0.05
## 819              EPZ-6438          Cobimetinib 15  7 -0.16
## 820              EPZ-6438           Trametinib 15  6 -0.08
## 821              EPZ-6438             JNK-IN-8 15  5  0.35
## 822              EPZ-6438  Menin-MLL Inhibitor 15  4 -0.01
## 823              EPZ-6438              AZD6738 15  3 -0.11
## 824              EPZ-6438             KU-55933 15  2 -0.18
## 825              EPZ-6438             SGC 0946 15  1  0.24
## 826              ONO-4059             ONO-4059 16 47  1.00
## 827              ONO-4059          Midostaurin 16 46  0.09
## 828              ONO-4059         Methotrexate 16 45 -0.16
## 829              ONO-4059            Motolimod 16 44 -0.19
## 830              ONO-4059             Olaparib 16 43 -0.03
## 831              ONO-4059            Cisplatin 16 42 -0.01
## 832              ONO-4059               BGJ398 16 41  0.01
## 833              ONO-4059              BML-277 16 40  0.08
## 834              ONO-4059                AMI-1 16 39 -0.09
## 835              ONO-4059           Vismodegib 16 38  0.02
## 836              ONO-4059           Selisistat 16 37  0.33
## 837              ONO-4059                TW-37 16 36  0.04
## 838              ONO-4059               D 4476 16 35  0.03
## 839              ONO-4059         Doxorubicine 16 34 -0.09
## 840              ONO-4059            Dasatinib 16 33  0.31
## 841              ONO-4059            Duvelisib 16 32  0.37
## 842              ONO-4059           Idelalisib 16 31  0.53
## 843              ONO-4059            Ibrutinib 16 30  0.60
## 844              ONO-4059            PRT062607 16 29  0.50
## 845              ONO-4059             Afatinib 16 28  0.17
## 846              ONO-4059            SB 203580 16 27  0.30
## 847              ONO-4059 IRAK-1/4 Inhibitor I 16 26  0.23
## 848              ONO-4059          Quizartinib 16 25  0.27
## 849              ONO-4059              MK-2206 16 24  0.09
## 850              ONO-4059              AZD1208 16 23  0.27
## 851              ONO-4059              AZD8055 16 22  0.18
## 852              ONO-4059            Rapamycin 16 21  0.44
## 853              ONO-4059               MI-503 16 20  0.20
## 854              ONO-4059             Imatinib 16 19  0.18
## 855              ONO-4059            Sunitinib 16 18  0.20
## 856              ONO-4059            Foretinib 16 17  0.45
## 857              ONO-4059           Tozasertib 16 16  0.32
## 858              ONO-4059          Ruxolitinib 16 15  0.22
## 859              ONO-4059          Tofacitinib 16 14 -0.02
## 860              ONO-4059           PF-3758309 16 13  0.08
## 861              ONO-4059               OTX015 16 12 -0.07
## 862              ONO-4059           Volasertib 16 11 -0.06
## 863              ONO-4059           Ganetespib 16 10  0.17
## 864              ONO-4059            Onalespib 16  9  0.25
## 865              ONO-4059            SCH772984 16  8  0.10
## 866              ONO-4059          Cobimetinib 16  7  0.06
## 867              ONO-4059           Trametinib 16  6  0.05
## 868              ONO-4059             JNK-IN-8 16  5  0.18
## 869              ONO-4059  Menin-MLL Inhibitor 16  4 -0.14
## 870              ONO-4059              AZD6738 16  3  0.02
## 871              ONO-4059             KU-55933 16  2  0.22
## 872              ONO-4059             SGC 0946 16  1  0.35
## 873           Midostaurin          Midostaurin 17 46  1.00
## 874           Midostaurin         Methotrexate 17 45  0.18
## 875           Midostaurin            Motolimod 17 44  0.15
## 876           Midostaurin             Olaparib 17 43  0.11
## 877           Midostaurin            Cisplatin 17 42 -0.02
## 878           Midostaurin               BGJ398 17 41 -0.05
## 879           Midostaurin              BML-277 17 40 -0.03
## 880           Midostaurin                AMI-1 17 39  0.20
## 881           Midostaurin           Vismodegib 17 38  0.21
## 882           Midostaurin           Selisistat 17 37  0.02
## 883           Midostaurin                TW-37 17 36  0.00
## 884           Midostaurin               D 4476 17 35 -0.02
## 885           Midostaurin         Doxorubicine 17 34 -0.15
## 886           Midostaurin            Dasatinib 17 33 -0.20
## 887           Midostaurin            Duvelisib 17 32 -0.14
## 888           Midostaurin           Idelalisib 17 31 -0.12
## 889           Midostaurin            Ibrutinib 17 30 -0.04
## 890           Midostaurin            PRT062607 17 29  0.03
## 891           Midostaurin             Afatinib 17 28 -0.01
## 892           Midostaurin            SB 203580 17 27 -0.21
## 893           Midostaurin IRAK-1/4 Inhibitor I 17 26  0.20
## 894           Midostaurin          Quizartinib 17 25  0.48
## 895           Midostaurin              MK-2206 17 24  0.13
## 896           Midostaurin              AZD1208 17 23 -0.04
## 897           Midostaurin              AZD8055 17 22 -0.02
## 898           Midostaurin            Rapamycin 17 21 -0.04
## 899           Midostaurin               MI-503 17 20  0.04
## 900           Midostaurin             Imatinib 17 19  0.18
## 901           Midostaurin            Sunitinib 17 18  0.27
## 902           Midostaurin            Foretinib 17 17  0.28
## 903           Midostaurin           Tozasertib 17 16  0.13
## 904           Midostaurin          Ruxolitinib 17 15 -0.07
## 905           Midostaurin          Tofacitinib 17 14  0.12
## 906           Midostaurin           PF-3758309 17 13 -0.03
## 907           Midostaurin               OTX015 17 12 -0.13
## 908           Midostaurin           Volasertib 17 11 -0.10
## 909           Midostaurin           Ganetespib 17 10  0.02
## 910           Midostaurin            Onalespib 17  9  0.01
## 911           Midostaurin            SCH772984 17  8 -0.13
## 912           Midostaurin          Cobimetinib 17  7 -0.14
## 913           Midostaurin           Trametinib 17  6 -0.13
## 914           Midostaurin             JNK-IN-8 17  5  0.10
## 915           Midostaurin  Menin-MLL Inhibitor 17  4  0.19
## 916           Midostaurin              AZD6738 17  3 -0.01
## 917           Midostaurin             KU-55933 17  2 -0.03
## 918           Midostaurin             SGC 0946 17  1 -0.05
## 919          Methotrexate         Methotrexate 18 45  1.00
## 920          Methotrexate            Motolimod 18 44  0.35
## 921          Methotrexate             Olaparib 18 43  0.13
## 922          Methotrexate            Cisplatin 18 42  0.10
## 923          Methotrexate               BGJ398 18 41  0.14
## 924          Methotrexate              BML-277 18 40 -0.04
## 925          Methotrexate                AMI-1 18 39  0.12
## 926          Methotrexate           Vismodegib 18 38  0.14
## 927          Methotrexate           Selisistat 18 37 -0.04
## 928          Methotrexate                TW-37 18 36 -0.01
## 929          Methotrexate               D 4476 18 35  0.03
## 930          Methotrexate         Doxorubicine 18 34 -0.23
## 931          Methotrexate            Dasatinib 18 33  0.15
## 932          Methotrexate            Duvelisib 18 32 -0.04
## 933          Methotrexate           Idelalisib 18 31 -0.10
## 934          Methotrexate            Ibrutinib 18 30 -0.12
## 935          Methotrexate            PRT062607 18 29  0.15
## 936          Methotrexate             Afatinib 18 28  0.07
## 937          Methotrexate            SB 203580 18 27 -0.16
## 938          Methotrexate IRAK-1/4 Inhibitor I 18 26  0.11
## 939          Methotrexate          Quizartinib 18 25 -0.11
## 940          Methotrexate              MK-2206 18 24 -0.02
## 941          Methotrexate              AZD1208 18 23 -0.24
## 942          Methotrexate              AZD8055 18 22 -0.07
## 943          Methotrexate            Rapamycin 18 21 -0.14
## 944          Methotrexate               MI-503 18 20  0.04
## 945          Methotrexate             Imatinib 18 19 -0.01
## 946          Methotrexate            Sunitinib 18 18 -0.06
## 947          Methotrexate            Foretinib 18 17 -0.07
## 948          Methotrexate           Tozasertib 18 16  0.11
## 949          Methotrexate          Ruxolitinib 18 15  0.19
## 950          Methotrexate          Tofacitinib 18 14  0.15
## 951          Methotrexate           PF-3758309 18 13  0.18
## 952          Methotrexate               OTX015 18 12  0.28
## 953          Methotrexate           Volasertib 18 11  0.26
## 954          Methotrexate           Ganetespib 18 10  0.37
## 955          Methotrexate            Onalespib 18  9  0.30
## 956          Methotrexate            SCH772984 18  8  0.35
## 957          Methotrexate          Cobimetinib 18  7  0.36
## 958          Methotrexate           Trametinib 18  6  0.35
## 959          Methotrexate             JNK-IN-8 18  5  0.06
## 960          Methotrexate  Menin-MLL Inhibitor 18  4  0.16
## 961          Methotrexate              AZD6738 18  3 -0.01
## 962          Methotrexate             KU-55933 18  2  0.17
## 963          Methotrexate             SGC 0946 18  1 -0.06
## 964             Motolimod            Motolimod 19 44  1.00
## 965             Motolimod             Olaparib 19 43  0.20
## 966             Motolimod            Cisplatin 19 42  0.12
## 967             Motolimod               BGJ398 19 41  0.24
## 968             Motolimod              BML-277 19 40  0.08
## 969             Motolimod                AMI-1 19 39  0.02
## 970             Motolimod           Vismodegib 19 38  0.04
## 971             Motolimod           Selisistat 19 37  0.14
## 972             Motolimod                TW-37 19 36  0.11
## 973             Motolimod               D 4476 19 35  0.28
## 974             Motolimod         Doxorubicine 19 34  0.22
## 975             Motolimod            Dasatinib 19 33  0.06
## 976             Motolimod            Duvelisib 19 32  0.07
## 977             Motolimod           Idelalisib 19 31 -0.11
## 978             Motolimod            Ibrutinib 19 30 -0.30
## 979             Motolimod            PRT062607 19 29 -0.18
## 980             Motolimod             Afatinib 19 28 -0.18
## 981             Motolimod            SB 203580 19 27 -0.36
## 982             Motolimod IRAK-1/4 Inhibitor I 19 26 -0.20
## 983             Motolimod          Quizartinib 19 25 -0.19
## 984             Motolimod              MK-2206 19 24  0.14
## 985             Motolimod              AZD1208 19 23 -0.27
## 986             Motolimod              AZD8055 19 22  0.06
## 987             Motolimod            Rapamycin 19 21 -0.03
## 988             Motolimod               MI-503 19 20 -0.06
## 989             Motolimod             Imatinib 19 19  0.01
## 990             Motolimod            Sunitinib 19 18 -0.18
## 991             Motolimod            Foretinib 19 17 -0.11
## 992             Motolimod           Tozasertib 19 16 -0.02
## 993             Motolimod          Ruxolitinib 19 15  0.00
## 994             Motolimod          Tofacitinib 19 14  0.09
## 995             Motolimod           PF-3758309 19 13  0.08
## 996             Motolimod               OTX015 19 12  0.32
## 997             Motolimod           Volasertib 19 11  0.18
## 998             Motolimod           Ganetespib 19 10  0.22
## 999             Motolimod            Onalespib 19  9  0.17
## 1000            Motolimod            SCH772984 19  8  0.17
## 1001            Motolimod          Cobimetinib 19  7  0.34
## 1002            Motolimod           Trametinib 19  6  0.31
## 1003            Motolimod             JNK-IN-8 19  5  0.00
## 1004            Motolimod  Menin-MLL Inhibitor 19  4  0.09
## 1005            Motolimod              AZD6738 19  3  0.03
## 1006            Motolimod             KU-55933 19  2  0.11
## 1007            Motolimod             SGC 0946 19  1 -0.25
## 1008             Olaparib             Olaparib 20 43  1.00
## 1009             Olaparib            Cisplatin 20 42  0.40
## 1010             Olaparib               BGJ398 20 41  0.40
## 1011             Olaparib              BML-277 20 40  0.28
## 1012             Olaparib                AMI-1 20 39  0.25
## 1013             Olaparib           Vismodegib 20 38  0.16
## 1014             Olaparib           Selisistat 20 37  0.35
## 1015             Olaparib                TW-37 20 36  0.28
## 1016             Olaparib               D 4476 20 35  0.12
## 1017             Olaparib         Doxorubicine 20 34  0.00
## 1018             Olaparib            Dasatinib 20 33  0.02
## 1019             Olaparib            Duvelisib 20 32  0.13
## 1020             Olaparib           Idelalisib 20 31  0.09
## 1021             Olaparib            Ibrutinib 20 30 -0.04
## 1022             Olaparib            PRT062607 20 29 -0.09
## 1023             Olaparib             Afatinib 20 28  0.32
## 1024             Olaparib            SB 203580 20 27 -0.07
## 1025             Olaparib IRAK-1/4 Inhibitor I 20 26  0.32
## 1026             Olaparib          Quizartinib 20 25  0.00
## 1027             Olaparib              MK-2206 20 24  0.40
## 1028             Olaparib              AZD1208 20 23  0.13
## 1029             Olaparib              AZD8055 20 22  0.34
## 1030             Olaparib            Rapamycin 20 21  0.17
## 1031             Olaparib               MI-503 20 20  0.20
## 1032             Olaparib             Imatinib 20 19  0.30
## 1033             Olaparib            Sunitinib 20 18  0.23
## 1034             Olaparib            Foretinib 20 17  0.38
## 1035             Olaparib           Tozasertib 20 16  0.37
## 1036             Olaparib          Ruxolitinib 20 15  0.07
## 1037             Olaparib          Tofacitinib 20 14  0.04
## 1038             Olaparib           PF-3758309 20 13  0.04
## 1039             Olaparib               OTX015 20 12  0.12
## 1040             Olaparib           Volasertib 20 11  0.19
## 1041             Olaparib           Ganetespib 20 10  0.34
## 1042             Olaparib            Onalespib 20  9  0.33
## 1043             Olaparib            SCH772984 20  8  0.19
## 1044             Olaparib          Cobimetinib 20  7  0.22
## 1045             Olaparib           Trametinib 20  6  0.18
## 1046             Olaparib             JNK-IN-8 20  5  0.28
## 1047             Olaparib  Menin-MLL Inhibitor 20  4  0.20
## 1048             Olaparib              AZD6738 20  3  0.25
## 1049             Olaparib             KU-55933 20  2  0.13
## 1050             Olaparib             SGC 0946 20  1  0.00
## 1051            Cisplatin            Cisplatin 21 42  1.00
## 1052            Cisplatin               BGJ398 21 41  0.46
## 1053            Cisplatin              BML-277 21 40  0.41
## 1054            Cisplatin                AMI-1 21 39  0.30
## 1055            Cisplatin           Vismodegib 21 38  0.31
## 1056            Cisplatin           Selisistat 21 37  0.34
## 1057            Cisplatin                TW-37 21 36  0.31
## 1058            Cisplatin               D 4476 21 35  0.23
## 1059            Cisplatin         Doxorubicine 21 34  0.19
## 1060            Cisplatin            Dasatinib 21 33  0.10
## 1061            Cisplatin            Duvelisib 21 32  0.11
## 1062            Cisplatin           Idelalisib 21 31  0.23
## 1063            Cisplatin            Ibrutinib 21 30  0.12
## 1064            Cisplatin            PRT062607 21 29  0.01
## 1065            Cisplatin             Afatinib 21 28  0.30
## 1066            Cisplatin            SB 203580 21 27  0.08
## 1067            Cisplatin IRAK-1/4 Inhibitor I 21 26  0.42
## 1068            Cisplatin          Quizartinib 21 25 -0.02
## 1069            Cisplatin              MK-2206 21 24  0.01
## 1070            Cisplatin              AZD1208 21 23  0.03
## 1071            Cisplatin              AZD8055 21 22 -0.01
## 1072            Cisplatin            Rapamycin 21 21 -0.06
## 1073            Cisplatin               MI-503 21 20  0.35
## 1074            Cisplatin             Imatinib 21 19  0.21
## 1075            Cisplatin            Sunitinib 21 18  0.29
## 1076            Cisplatin            Foretinib 21 17  0.27
## 1077            Cisplatin           Tozasertib 21 16  0.19
## 1078            Cisplatin          Ruxolitinib 21 15  0.16
## 1079            Cisplatin          Tofacitinib 21 14  0.03
## 1080            Cisplatin           PF-3758309 21 13  0.00
## 1081            Cisplatin               OTX015 21 12  0.08
## 1082            Cisplatin           Volasertib 21 11  0.15
## 1083            Cisplatin           Ganetespib 21 10  0.18
## 1084            Cisplatin            Onalespib 21  9  0.16
## 1085            Cisplatin            SCH772984 21  8  0.36
## 1086            Cisplatin          Cobimetinib 21  7  0.19
## 1087            Cisplatin           Trametinib 21  6  0.21
## 1088            Cisplatin             JNK-IN-8 21  5 -0.03
## 1089            Cisplatin  Menin-MLL Inhibitor 21  4  0.13
## 1090            Cisplatin              AZD6738 21  3  0.16
## 1091            Cisplatin             KU-55933 21  2  0.15
## 1092            Cisplatin             SGC 0946 21  1  0.25
## 1093               BGJ398               BGJ398 22 41  1.00
## 1094               BGJ398              BML-277 22 40  0.50
## 1095               BGJ398                AMI-1 22 39  0.13
## 1096               BGJ398           Vismodegib 22 38  0.14
## 1097               BGJ398           Selisistat 22 37  0.34
## 1098               BGJ398                TW-37 22 36  0.30
## 1099               BGJ398               D 4476 22 35  0.26
## 1100               BGJ398         Doxorubicine 22 34 -0.05
## 1101               BGJ398            Dasatinib 22 33  0.39
## 1102               BGJ398            Duvelisib 22 32  0.36
## 1103               BGJ398           Idelalisib 22 31  0.25
## 1104               BGJ398            Ibrutinib 22 30  0.13
## 1105               BGJ398            PRT062607 22 29  0.21
## 1106               BGJ398             Afatinib 22 28  0.19
## 1107               BGJ398            SB 203580 22 27  0.06
## 1108               BGJ398 IRAK-1/4 Inhibitor I 22 26  0.33
## 1109               BGJ398          Quizartinib 22 25  0.01
## 1110               BGJ398              MK-2206 22 24  0.31
## 1111               BGJ398              AZD1208 22 23  0.18
## 1112               BGJ398              AZD8055 22 22  0.30
## 1113               BGJ398            Rapamycin 22 21  0.21
## 1114               BGJ398               MI-503 22 20  0.35
## 1115               BGJ398             Imatinib 22 19  0.38
## 1116               BGJ398            Sunitinib 22 18  0.37
## 1117               BGJ398            Foretinib 22 17  0.31
## 1118               BGJ398           Tozasertib 22 16  0.43
## 1119               BGJ398          Ruxolitinib 22 15  0.45
## 1120               BGJ398          Tofacitinib 22 14  0.17
## 1121               BGJ398           PF-3758309 22 13  0.39
## 1122               BGJ398               OTX015 22 12  0.39
## 1123               BGJ398           Volasertib 22 11  0.42
## 1124               BGJ398           Ganetespib 22 10  0.48
## 1125               BGJ398            Onalespib 22  9  0.42
## 1126               BGJ398            SCH772984 22  8  0.46
## 1127               BGJ398          Cobimetinib 22  7  0.47
## 1128               BGJ398           Trametinib 22  6  0.43
## 1129               BGJ398             JNK-IN-8 22  5  0.04
## 1130               BGJ398  Menin-MLL Inhibitor 22  4  0.00
## 1131               BGJ398              AZD6738 22  3  0.28
## 1132               BGJ398             KU-55933 22  2  0.03
## 1133               BGJ398             SGC 0946 22  1  0.02
## 1134              BML-277              BML-277 23 40  1.00
## 1135              BML-277                AMI-1 23 39  0.38
## 1136              BML-277           Vismodegib 23 38  0.31
## 1137              BML-277           Selisistat 23 37  0.34
## 1138              BML-277                TW-37 23 36  0.17
## 1139              BML-277               D 4476 23 35  0.18
## 1140              BML-277         Doxorubicine 23 34  0.05
## 1141              BML-277            Dasatinib 23 33 -0.01
## 1142              BML-277            Duvelisib 23 32 -0.08
## 1143              BML-277           Idelalisib 23 31 -0.09
## 1144              BML-277            Ibrutinib 23 30 -0.06
## 1145              BML-277            PRT062607 23 29 -0.13
## 1146              BML-277             Afatinib 23 28  0.14
## 1147              BML-277            SB 203580 23 27  0.04
## 1148              BML-277 IRAK-1/4 Inhibitor I 23 26  0.08
## 1149              BML-277          Quizartinib 23 25  0.01
## 1150              BML-277              MK-2206 23 24 -0.02
## 1151              BML-277              AZD1208 23 23 -0.07
## 1152              BML-277              AZD8055 23 22 -0.03
## 1153              BML-277            Rapamycin 23 21 -0.14
## 1154              BML-277               MI-503 23 20  0.15
## 1155              BML-277             Imatinib 23 19  0.10
## 1156              BML-277            Sunitinib 23 18  0.04
## 1157              BML-277            Foretinib 23 17 -0.01
## 1158              BML-277           Tozasertib 23 16  0.05
## 1159              BML-277          Ruxolitinib 23 15  0.14
## 1160              BML-277          Tofacitinib 23 14 -0.03
## 1161              BML-277           PF-3758309 23 13  0.01
## 1162              BML-277               OTX015 23 12  0.09
## 1163              BML-277           Volasertib 23 11  0.22
## 1164              BML-277           Ganetespib 23 10  0.08
## 1165              BML-277            Onalespib 23  9  0.10
## 1166              BML-277            SCH772984 23  8  0.09
## 1167              BML-277          Cobimetinib 23  7  0.07
## 1168              BML-277           Trametinib 23  6  0.04
## 1169              BML-277             JNK-IN-8 23  5  0.09
## 1170              BML-277  Menin-MLL Inhibitor 23  4 -0.13
## 1171              BML-277              AZD6738 23  3  0.02
## 1172              BML-277             KU-55933 23  2 -0.14
## 1173              BML-277             SGC 0946 23  1 -0.01
## 1174                AMI-1                AMI-1 24 39  1.00
## 1175                AMI-1           Vismodegib 24 38  0.57
## 1176                AMI-1           Selisistat 24 37  0.24
## 1177                AMI-1                TW-37 24 36  0.33
## 1178                AMI-1               D 4476 24 35  0.31
## 1179                AMI-1         Doxorubicine 24 34 -0.08
## 1180                AMI-1            Dasatinib 24 33 -0.11
## 1181                AMI-1            Duvelisib 24 32 -0.23
## 1182                AMI-1           Idelalisib 24 31 -0.19
## 1183                AMI-1            Ibrutinib 24 30 -0.09
## 1184                AMI-1            PRT062607 24 29 -0.19
## 1185                AMI-1             Afatinib 24 28 -0.01
## 1186                AMI-1            SB 203580 24 27 -0.20
## 1187                AMI-1 IRAK-1/4 Inhibitor I 24 26 -0.02
## 1188                AMI-1          Quizartinib 24 25 -0.12
## 1189                AMI-1              MK-2206 24 24 -0.28
## 1190                AMI-1              AZD1208 24 23 -0.22
## 1191                AMI-1              AZD8055 24 22 -0.22
## 1192                AMI-1            Rapamycin 24 21 -0.35
## 1193                AMI-1               MI-503 24 20  0.07
## 1194                AMI-1             Imatinib 24 19  0.04
## 1195                AMI-1            Sunitinib 24 18  0.01
## 1196                AMI-1            Foretinib 24 17 -0.10
## 1197                AMI-1           Tozasertib 24 16  0.03
## 1198                AMI-1          Ruxolitinib 24 15  0.02
## 1199                AMI-1          Tofacitinib 24 14  0.22
## 1200                AMI-1           PF-3758309 24 13 -0.14
## 1201                AMI-1               OTX015 24 12 -0.08
## 1202                AMI-1           Volasertib 24 11  0.07
## 1203                AMI-1           Ganetespib 24 10 -0.06
## 1204                AMI-1            Onalespib 24  9 -0.08
## 1205                AMI-1            SCH772984 24  8 -0.07
## 1206                AMI-1          Cobimetinib 24  7 -0.08
## 1207                AMI-1           Trametinib 24  6 -0.04
## 1208                AMI-1             JNK-IN-8 24  5  0.09
## 1209                AMI-1  Menin-MLL Inhibitor 24  4  0.00
## 1210                AMI-1              AZD6738 24  3  0.17
## 1211                AMI-1             KU-55933 24  2 -0.25
## 1212                AMI-1             SGC 0946 24  1 -0.05
## 1213           Vismodegib           Vismodegib 25 38  1.00
## 1214           Vismodegib           Selisistat 25 37  0.39
## 1215           Vismodegib                TW-37 25 36  0.26
## 1216           Vismodegib               D 4476 25 35  0.19
## 1217           Vismodegib         Doxorubicine 25 34 -0.03
## 1218           Vismodegib            Dasatinib 25 33  0.05
## 1219           Vismodegib            Duvelisib 25 32 -0.18
## 1220           Vismodegib           Idelalisib 25 31  0.00
## 1221           Vismodegib            Ibrutinib 25 30  0.12
## 1222           Vismodegib            PRT062607 25 29  0.03
## 1223           Vismodegib             Afatinib 25 28  0.10
## 1224           Vismodegib            SB 203580 25 27  0.05
## 1225           Vismodegib IRAK-1/4 Inhibitor I 25 26  0.20
## 1226           Vismodegib          Quizartinib 25 25 -0.05
## 1227           Vismodegib              MK-2206 25 24 -0.20
## 1228           Vismodegib              AZD1208 25 23 -0.07
## 1229           Vismodegib              AZD8055 25 22 -0.17
## 1230           Vismodegib            Rapamycin 25 21 -0.22
## 1231           Vismodegib               MI-503 25 20  0.02
## 1232           Vismodegib             Imatinib 25 19  0.03
## 1233           Vismodegib            Sunitinib 25 18  0.02
## 1234           Vismodegib            Foretinib 25 17 -0.04
## 1235           Vismodegib           Tozasertib 25 16  0.09
## 1236           Vismodegib          Ruxolitinib 25 15  0.25
## 1237           Vismodegib          Tofacitinib 25 14  0.34
## 1238           Vismodegib           PF-3758309 25 13  0.03
## 1239           Vismodegib               OTX015 25 12  0.01
## 1240           Vismodegib           Volasertib 25 11  0.09
## 1241           Vismodegib           Ganetespib 25 10  0.14
## 1242           Vismodegib            Onalespib 25  9  0.16
## 1243           Vismodegib            SCH772984 25  8  0.10
## 1244           Vismodegib          Cobimetinib 25  7  0.00
## 1245           Vismodegib           Trametinib 25  6  0.02
## 1246           Vismodegib             JNK-IN-8 25  5  0.17
## 1247           Vismodegib  Menin-MLL Inhibitor 25  4  0.15
## 1248           Vismodegib              AZD6738 25  3  0.09
## 1249           Vismodegib             KU-55933 25  2 -0.10
## 1250           Vismodegib             SGC 0946 25  1 -0.05
## 1251           Selisistat           Selisistat 26 37  1.00
## 1252           Selisistat                TW-37 26 36  0.48
## 1253           Selisistat               D 4476 26 35  0.19
## 1254           Selisistat         Doxorubicine 26 34  0.04
## 1255           Selisistat            Dasatinib 26 33  0.08
## 1256           Selisistat            Duvelisib 26 32  0.11
## 1257           Selisistat           Idelalisib 26 31  0.21
## 1258           Selisistat            Ibrutinib 26 30  0.05
## 1259           Selisistat            PRT062607 26 29  0.03
## 1260           Selisistat             Afatinib 26 28  0.03
## 1261           Selisistat            SB 203580 26 27 -0.11
## 1262           Selisistat IRAK-1/4 Inhibitor I 26 26  0.21
## 1263           Selisistat          Quizartinib 26 25 -0.03
## 1264           Selisistat              MK-2206 26 24  0.28
## 1265           Selisistat              AZD1208 26 23  0.01
## 1266           Selisistat              AZD8055 26 22  0.18
## 1267           Selisistat            Rapamycin 26 21  0.19
## 1268           Selisistat               MI-503 26 20  0.21
## 1269           Selisistat             Imatinib 26 19  0.25
## 1270           Selisistat            Sunitinib 26 18  0.11
## 1271           Selisistat            Foretinib 26 17  0.26
## 1272           Selisistat           Tozasertib 26 16  0.19
## 1273           Selisistat          Ruxolitinib 26 15  0.15
## 1274           Selisistat          Tofacitinib 26 14  0.01
## 1275           Selisistat           PF-3758309 26 13 -0.02
## 1276           Selisistat               OTX015 26 12  0.03
## 1277           Selisistat           Volasertib 26 11  0.07
## 1278           Selisistat           Ganetespib 26 10  0.20
## 1279           Selisistat            Onalespib 26  9  0.24
## 1280           Selisistat            SCH772984 26  8  0.18
## 1281           Selisistat          Cobimetinib 26  7  0.20
## 1282           Selisistat           Trametinib 26  6  0.22
## 1283           Selisistat             JNK-IN-8 26  5  0.09
## 1284           Selisistat  Menin-MLL Inhibitor 26  4 -0.01
## 1285           Selisistat              AZD6738 26  3  0.26
## 1286           Selisistat             KU-55933 26  2 -0.05
## 1287           Selisistat             SGC 0946 26  1  0.12
## 1288                TW-37                TW-37 27 36  1.00
## 1289                TW-37               D 4476 27 35  0.32
## 1290                TW-37         Doxorubicine 27 34  0.02
## 1291                TW-37            Dasatinib 27 33  0.11
## 1292                TW-37            Duvelisib 27 32 -0.07
## 1293                TW-37           Idelalisib 27 31 -0.03
## 1294                TW-37            Ibrutinib 27 30 -0.19
## 1295                TW-37            PRT062607 27 29 -0.15
## 1296                TW-37             Afatinib 27 28  0.02
## 1297                TW-37            SB 203580 27 27 -0.29
## 1298                TW-37 IRAK-1/4 Inhibitor I 27 26 -0.03
## 1299                TW-37          Quizartinib 27 25 -0.37
## 1300                TW-37              MK-2206 27 24 -0.01
## 1301                TW-37              AZD1208 27 23 -0.32
## 1302                TW-37              AZD8055 27 22 -0.14
## 1303                TW-37            Rapamycin 27 21 -0.09
## 1304                TW-37               MI-503 27 20  0.02
## 1305                TW-37             Imatinib 27 19  0.05
## 1306                TW-37            Sunitinib 27 18 -0.05
## 1307                TW-37            Foretinib 27 17  0.10
## 1308                TW-37           Tozasertib 27 16  0.04
## 1309                TW-37          Ruxolitinib 27 15  0.09
## 1310                TW-37          Tofacitinib 27 14  0.10
## 1311                TW-37           PF-3758309 27 13 -0.24
## 1312                TW-37               OTX015 27 12 -0.06
## 1313                TW-37           Volasertib 27 11 -0.11
## 1314                TW-37           Ganetespib 27 10 -0.02
## 1315                TW-37            Onalespib 27  9 -0.06
## 1316                TW-37            SCH772984 27  8  0.06
## 1317                TW-37          Cobimetinib 27  7  0.09
## 1318                TW-37           Trametinib 27  6  0.09
## 1319                TW-37             JNK-IN-8 27  5  0.01
## 1320                TW-37  Menin-MLL Inhibitor 27  4 -0.29
## 1321                TW-37              AZD6738 27  3  0.19
## 1322                TW-37             KU-55933 27  2 -0.11
## 1323                TW-37             SGC 0946 27  1  0.05
## 1324               D 4476               D 4476 28 35  1.00
## 1325               D 4476         Doxorubicine 28 34  0.30
## 1326               D 4476            Dasatinib 28 33  0.18
## 1327               D 4476            Duvelisib 28 32  0.07
## 1328               D 4476           Idelalisib 28 31  0.16
## 1329               D 4476            Ibrutinib 28 30  0.06
## 1330               D 4476            PRT062607 28 29 -0.12
## 1331               D 4476             Afatinib 28 28 -0.01
## 1332               D 4476            SB 203580 28 27 -0.15
## 1333               D 4476 IRAK-1/4 Inhibitor I 28 26 -0.12
## 1334               D 4476          Quizartinib 28 25 -0.23
## 1335               D 4476              MK-2206 28 24 -0.12
## 1336               D 4476              AZD1208 28 23 -0.20
## 1337               D 4476              AZD8055 28 22 -0.09
## 1338               D 4476            Rapamycin 28 21  0.05
## 1339               D 4476               MI-503 28 20  0.20
## 1340               D 4476             Imatinib 28 19  0.13
## 1341               D 4476            Sunitinib 28 18 -0.06
## 1342               D 4476            Foretinib 28 17  0.02
## 1343               D 4476           Tozasertib 28 16  0.03
## 1344               D 4476          Ruxolitinib 28 15  0.11
## 1345               D 4476          Tofacitinib 28 14  0.19
## 1346               D 4476           PF-3758309 28 13  0.04
## 1347               D 4476               OTX015 28 12  0.31
## 1348               D 4476           Volasertib 28 11  0.25
## 1349               D 4476           Ganetespib 28 10  0.05
## 1350               D 4476            Onalespib 28  9  0.00
## 1351               D 4476            SCH772984 28  8  0.07
## 1352               D 4476          Cobimetinib 28  7  0.18
## 1353               D 4476           Trametinib 28  6  0.18
## 1354               D 4476             JNK-IN-8 28  5  0.29
## 1355               D 4476  Menin-MLL Inhibitor 28  4  0.05
## 1356               D 4476              AZD6738 28  3  0.19
## 1357               D 4476             KU-55933 28  2  0.09
## 1358               D 4476             SGC 0946 28  1 -0.07
## 1359         Doxorubicine         Doxorubicine 29 34  1.00
## 1360         Doxorubicine            Dasatinib 29 33 -0.09
## 1361         Doxorubicine            Duvelisib 29 32  0.16
## 1362         Doxorubicine           Idelalisib 29 31  0.24
## 1363         Doxorubicine            Ibrutinib 29 30 -0.14
## 1364         Doxorubicine            PRT062607 29 29 -0.15
## 1365         Doxorubicine             Afatinib 29 28 -0.17
## 1366         Doxorubicine            SB 203580 29 27  0.09
## 1367         Doxorubicine IRAK-1/4 Inhibitor I 29 26 -0.15
## 1368         Doxorubicine          Quizartinib 29 25 -0.15
## 1369         Doxorubicine              MK-2206 29 24  0.06
## 1370         Doxorubicine              AZD1208 29 23  0.04
## 1371         Doxorubicine              AZD8055 29 22  0.14
## 1372         Doxorubicine            Rapamycin 29 21  0.20
## 1373         Doxorubicine               MI-503 29 20  0.00
## 1374         Doxorubicine             Imatinib 29 19 -0.04
## 1375         Doxorubicine            Sunitinib 29 18 -0.01
## 1376         Doxorubicine            Foretinib 29 17 -0.01
## 1377         Doxorubicine           Tozasertib 29 16 -0.14
## 1378         Doxorubicine          Ruxolitinib 29 15 -0.11
## 1379         Doxorubicine          Tofacitinib 29 14 -0.15
## 1380         Doxorubicine           PF-3758309 29 13  0.01
## 1381         Doxorubicine               OTX015 29 12  0.20
## 1382         Doxorubicine           Volasertib 29 11  0.08
## 1383         Doxorubicine           Ganetespib 29 10 -0.26
## 1384         Doxorubicine            Onalespib 29  9 -0.20
## 1385         Doxorubicine            SCH772984 29  8 -0.01
## 1386         Doxorubicine          Cobimetinib 29  7  0.04
## 1387         Doxorubicine           Trametinib 29  6  0.00
## 1388         Doxorubicine             JNK-IN-8 29  5 -0.20
## 1389         Doxorubicine  Menin-MLL Inhibitor 29  4  0.13
## 1390         Doxorubicine              AZD6738 29  3  0.03
## 1391         Doxorubicine             KU-55933 29  2  0.35
## 1392         Doxorubicine             SGC 0946 29  1 -0.08
## 1393            Dasatinib            Dasatinib 30 33  1.00
## 1394            Dasatinib            Duvelisib 30 32  0.55
## 1395            Dasatinib           Idelalisib 30 31  0.50
## 1396            Dasatinib            Ibrutinib 30 30  0.59
## 1397            Dasatinib            PRT062607 30 29  0.66
## 1398            Dasatinib             Afatinib 30 28  0.35
## 1399            Dasatinib            SB 203580 30 27  0.34
## 1400            Dasatinib IRAK-1/4 Inhibitor I 30 26  0.25
## 1401            Dasatinib          Quizartinib 30 25  0.01
## 1402            Dasatinib              MK-2206 30 24  0.10
## 1403            Dasatinib              AZD1208 30 23  0.34
## 1404            Dasatinib              AZD8055 30 22  0.26
## 1405            Dasatinib            Rapamycin 30 21  0.41
## 1406            Dasatinib               MI-503 30 20  0.27
## 1407            Dasatinib             Imatinib 30 19  0.52
## 1408            Dasatinib            Sunitinib 30 18  0.40
## 1409            Dasatinib            Foretinib 30 17  0.44
## 1410            Dasatinib           Tozasertib 30 16  0.56
## 1411            Dasatinib          Ruxolitinib 30 15  0.58
## 1412            Dasatinib          Tofacitinib 30 14  0.43
## 1413            Dasatinib           PF-3758309 30 13  0.45
## 1414            Dasatinib               OTX015 30 12  0.25
## 1415            Dasatinib           Volasertib 30 11  0.20
## 1416            Dasatinib           Ganetespib 30 10  0.57
## 1417            Dasatinib            Onalespib 30  9  0.54
## 1418            Dasatinib            SCH772984 30  8  0.52
## 1419            Dasatinib          Cobimetinib 30  7  0.52
## 1420            Dasatinib           Trametinib 30  6  0.48
## 1421            Dasatinib             JNK-IN-8 30  5  0.12
## 1422            Dasatinib  Menin-MLL Inhibitor 30  4  0.05
## 1423            Dasatinib              AZD6738 30  3  0.09
## 1424            Dasatinib             KU-55933 30  2  0.14
## 1425            Dasatinib             SGC 0946 30  1  0.20
## 1426            Duvelisib            Duvelisib 31 32  1.00
## 1427            Duvelisib           Idelalisib 31 31  0.83
## 1428            Duvelisib            Ibrutinib 31 30  0.60
## 1429            Duvelisib            PRT062607 31 29  0.67
## 1430            Duvelisib             Afatinib 31 28  0.33
## 1431            Duvelisib            SB 203580 31 27  0.34
## 1432            Duvelisib IRAK-1/4 Inhibitor I 31 26  0.44
## 1433            Duvelisib          Quizartinib 31 25  0.27
## 1434            Duvelisib              MK-2206 31 24  0.51
## 1435            Duvelisib              AZD1208 31 23  0.58
## 1436            Duvelisib              AZD8055 31 22  0.74
## 1437            Duvelisib            Rapamycin 31 21  0.79
## 1438            Duvelisib               MI-503 31 20  0.43
## 1439            Duvelisib             Imatinib 31 19  0.47
## 1440            Duvelisib            Sunitinib 31 18  0.60
## 1441            Duvelisib            Foretinib 31 17  0.63
## 1442            Duvelisib           Tozasertib 31 16  0.69
## 1443            Duvelisib          Ruxolitinib 31 15  0.47
## 1444            Duvelisib          Tofacitinib 31 14  0.31
## 1445            Duvelisib           PF-3758309 31 13  0.65
## 1446            Duvelisib               OTX015 31 12  0.43
## 1447            Duvelisib           Volasertib 31 11  0.37
## 1448            Duvelisib           Ganetespib 31 10  0.62
## 1449            Duvelisib            Onalespib 31  9  0.63
## 1450            Duvelisib            SCH772984 31  8  0.58
## 1451            Duvelisib          Cobimetinib 31  7  0.60
## 1452            Duvelisib           Trametinib 31  6  0.60
## 1453            Duvelisib             JNK-IN-8 31  5  0.09
## 1454            Duvelisib  Menin-MLL Inhibitor 31  4  0.12
## 1455            Duvelisib              AZD6738 31  3  0.31
## 1456            Duvelisib             KU-55933 31  2  0.35
## 1457            Duvelisib             SGC 0946 31  1  0.34
## 1458           Idelalisib           Idelalisib 32 31  1.00
## 1459           Idelalisib            Ibrutinib 32 30  0.73
## 1460           Idelalisib            PRT062607 32 29  0.66
## 1461           Idelalisib             Afatinib 32 28  0.38
## 1462           Idelalisib            SB 203580 32 27  0.55
## 1463           Idelalisib IRAK-1/4 Inhibitor I 32 26  0.56
## 1464           Idelalisib          Quizartinib 32 25  0.31
## 1465           Idelalisib              MK-2206 32 24  0.35
## 1466           Idelalisib              AZD1208 32 23  0.60
## 1467           Idelalisib              AZD8055 32 22  0.60
## 1468           Idelalisib            Rapamycin 32 21  0.70
## 1469           Idelalisib               MI-503 32 20  0.49
## 1470           Idelalisib             Imatinib 32 19  0.42
## 1471           Idelalisib            Sunitinib 32 18  0.56
## 1472           Idelalisib            Foretinib 32 17  0.62
## 1473           Idelalisib           Tozasertib 32 16  0.60
## 1474           Idelalisib          Ruxolitinib 32 15  0.52
## 1475           Idelalisib          Tofacitinib 32 14  0.31
## 1476           Idelalisib           PF-3758309 32 13  0.48
## 1477           Idelalisib               OTX015 32 12  0.27
## 1478           Idelalisib           Volasertib 32 11  0.25
## 1479           Idelalisib           Ganetespib 32 10  0.47
## 1480           Idelalisib            Onalespib 32  9  0.53
## 1481           Idelalisib            SCH772984 32  8  0.50
## 1482           Idelalisib          Cobimetinib 32  7  0.40
## 1483           Idelalisib           Trametinib 32  6  0.42
## 1484           Idelalisib             JNK-IN-8 32  5  0.15
## 1485           Idelalisib  Menin-MLL Inhibitor 32  4  0.25
## 1486           Idelalisib              AZD6738 32  3  0.29
## 1487           Idelalisib             KU-55933 32  2  0.40
## 1488           Idelalisib             SGC 0946 32  1  0.43
## 1489            Ibrutinib            Ibrutinib 33 30  1.00
## 1490            Ibrutinib            PRT062607 33 29  0.75
## 1491            Ibrutinib             Afatinib 33 28  0.44
## 1492            Ibrutinib            SB 203580 33 27  0.57
## 1493            Ibrutinib IRAK-1/4 Inhibitor I 33 26  0.58
## 1494            Ibrutinib          Quizartinib 33 25  0.33
## 1495            Ibrutinib              MK-2206 33 24  0.04
## 1496            Ibrutinib              AZD1208 33 23  0.54
## 1497            Ibrutinib              AZD8055 33 22  0.30
## 1498            Ibrutinib            Rapamycin 33 21  0.46
## 1499            Ibrutinib               MI-503 33 20  0.34
## 1500            Ibrutinib             Imatinib 33 19  0.39
## 1501            Ibrutinib            Sunitinib 33 18  0.52
## 1502            Ibrutinib            Foretinib 33 17  0.50
## 1503            Ibrutinib           Tozasertib 33 16  0.57
## 1504            Ibrutinib          Ruxolitinib 33 15  0.49
## 1505            Ibrutinib          Tofacitinib 33 14  0.32
## 1506            Ibrutinib           PF-3758309 33 13  0.46
## 1507            Ibrutinib               OTX015 33 12  0.11
## 1508            Ibrutinib           Volasertib 33 11  0.15
## 1509            Ibrutinib           Ganetespib 33 10  0.49
## 1510            Ibrutinib            Onalespib 33  9  0.54
## 1511            Ibrutinib            SCH772984 33  8  0.42
## 1512            Ibrutinib          Cobimetinib 33  7  0.29
## 1513            Ibrutinib           Trametinib 33  6  0.27
## 1514            Ibrutinib             JNK-IN-8 33  5  0.28
## 1515            Ibrutinib  Menin-MLL Inhibitor 33  4  0.24
## 1516            Ibrutinib              AZD6738 33  3  0.04
## 1517            Ibrutinib             KU-55933 33  2  0.17
## 1518            Ibrutinib             SGC 0946 33  1  0.37
## 1519            PRT062607            PRT062607 34 29  1.00
## 1520            PRT062607             Afatinib 34 28  0.46
## 1521            PRT062607            SB 203580 34 27  0.53
## 1522            PRT062607 IRAK-1/4 Inhibitor I 34 26  0.53
## 1523            PRT062607          Quizartinib 34 25  0.33
## 1524            PRT062607              MK-2206 34 24  0.26
## 1525            PRT062607              AZD1208 34 23  0.55
## 1526            PRT062607              AZD8055 34 22  0.39
## 1527            PRT062607            Rapamycin 34 21  0.53
## 1528            PRT062607               MI-503 34 20  0.39
## 1529            PRT062607             Imatinib 34 19  0.42
## 1530            PRT062607            Sunitinib 34 18  0.58
## 1531            PRT062607            Foretinib 34 17  0.57
## 1532            PRT062607           Tozasertib 34 16  0.70
## 1533            PRT062607          Ruxolitinib 34 15  0.60
## 1534            PRT062607          Tofacitinib 34 14  0.34
## 1535            PRT062607           PF-3758309 34 13  0.57
## 1536            PRT062607               OTX015 34 12  0.23
## 1537            PRT062607           Volasertib 34 11  0.21
## 1538            PRT062607           Ganetespib 34 10  0.60
## 1539            PRT062607            Onalespib 34  9  0.64
## 1540            PRT062607            SCH772984 34  8  0.57
## 1541            PRT062607          Cobimetinib 34  7  0.45
## 1542            PRT062607           Trametinib 34  6  0.44
## 1543            PRT062607             JNK-IN-8 34  5  0.02
## 1544            PRT062607  Menin-MLL Inhibitor 34  4  0.12
## 1545            PRT062607              AZD6738 34  3  0.07
## 1546            PRT062607             KU-55933 34  2  0.31
## 1547            PRT062607             SGC 0946 34  1  0.43
## 1548             Afatinib             Afatinib 35 28  1.00
## 1549             Afatinib            SB 203580 35 27  0.45
## 1550             Afatinib IRAK-1/4 Inhibitor I 35 26  0.46
## 1551             Afatinib          Quizartinib 35 25  0.18
## 1552             Afatinib              MK-2206 35 24  0.14
## 1553             Afatinib              AZD1208 35 23  0.44
## 1554             Afatinib              AZD8055 35 22  0.22
## 1555             Afatinib            Rapamycin 35 21  0.22
## 1556             Afatinib               MI-503 35 20  0.37
## 1557             Afatinib             Imatinib 35 19  0.25
## 1558             Afatinib            Sunitinib 35 18  0.50
## 1559             Afatinib            Foretinib 35 17  0.49
## 1560             Afatinib           Tozasertib 35 16  0.43
## 1561             Afatinib          Ruxolitinib 35 15  0.33
## 1562             Afatinib          Tofacitinib 35 14  0.30
## 1563             Afatinib           PF-3758309 35 13  0.37
## 1564             Afatinib               OTX015 35 12  0.16
## 1565             Afatinib           Volasertib 35 11  0.26
## 1566             Afatinib           Ganetespib 35 10  0.42
## 1567             Afatinib            Onalespib 35  9  0.43
## 1568             Afatinib            SCH772984 35  8  0.30
## 1569             Afatinib          Cobimetinib 35  7  0.19
## 1570             Afatinib           Trametinib 35  6  0.19
## 1571             Afatinib             JNK-IN-8 35  5  0.16
## 1572             Afatinib  Menin-MLL Inhibitor 35  4  0.23
## 1573             Afatinib              AZD6738 35  3  0.02
## 1574             Afatinib             KU-55933 35  2  0.19
## 1575             Afatinib             SGC 0946 35  1  0.26
## 1576            SB 203580            SB 203580 36 27  1.00
## 1577            SB 203580 IRAK-1/4 Inhibitor I 36 26  0.40
## 1578            SB 203580          Quizartinib 36 25  0.32
## 1579            SB 203580              MK-2206 36 24  0.06
## 1580            SB 203580              AZD1208 36 23  0.57
## 1581            SB 203580              AZD8055 36 22  0.27
## 1582            SB 203580            Rapamycin 36 21  0.38
## 1583            SB 203580               MI-503 36 20  0.15
## 1584            SB 203580             Imatinib 36 19  0.09
## 1585            SB 203580            Sunitinib 36 18  0.36
## 1586            SB 203580            Foretinib 36 17  0.32
## 1587            SB 203580           Tozasertib 36 16  0.30
## 1588            SB 203580          Ruxolitinib 36 15  0.38
## 1589            SB 203580          Tofacitinib 36 14  0.24
## 1590            SB 203580           PF-3758309 36 13  0.31
## 1591            SB 203580               OTX015 36 12  0.02
## 1592            SB 203580           Volasertib 36 11  0.07
## 1593            SB 203580           Ganetespib 36 10  0.16
## 1594            SB 203580            Onalespib 36  9  0.24
## 1595            SB 203580            SCH772984 36  8  0.17
## 1596            SB 203580          Cobimetinib 36  7 -0.02
## 1597            SB 203580           Trametinib 36  6 -0.03
## 1598            SB 203580             JNK-IN-8 36  5  0.10
## 1599            SB 203580  Menin-MLL Inhibitor 36  4  0.21
## 1600            SB 203580              AZD6738 36  3 -0.10
## 1601            SB 203580             KU-55933 36  2  0.19
## 1602            SB 203580             SGC 0946 36  1  0.24
## 1603 IRAK-1/4 Inhibitor I IRAK-1/4 Inhibitor I 37 26  1.00
## 1604 IRAK-1/4 Inhibitor I          Quizartinib 37 25  0.54
## 1605 IRAK-1/4 Inhibitor I              MK-2206 37 24  0.30
## 1606 IRAK-1/4 Inhibitor I              AZD1208 37 23  0.41
## 1607 IRAK-1/4 Inhibitor I              AZD8055 37 22  0.36
## 1608 IRAK-1/4 Inhibitor I            Rapamycin 37 21  0.30
## 1609 IRAK-1/4 Inhibitor I               MI-503 37 20  0.34
## 1610 IRAK-1/4 Inhibitor I             Imatinib 37 19  0.46
## 1611 IRAK-1/4 Inhibitor I            Sunitinib 37 18  0.61
## 1612 IRAK-1/4 Inhibitor I            Foretinib 37 17  0.59
## 1613 IRAK-1/4 Inhibitor I           Tozasertib 37 16  0.58
## 1614 IRAK-1/4 Inhibitor I          Ruxolitinib 37 15  0.42
## 1615 IRAK-1/4 Inhibitor I          Tofacitinib 37 14  0.26
## 1616 IRAK-1/4 Inhibitor I           PF-3758309 37 13  0.36
## 1617 IRAK-1/4 Inhibitor I               OTX015 37 12  0.04
## 1618 IRAK-1/4 Inhibitor I           Volasertib 37 11  0.19
## 1619 IRAK-1/4 Inhibitor I           Ganetespib 37 10  0.47
## 1620 IRAK-1/4 Inhibitor I            Onalespib 37  9  0.55
## 1621 IRAK-1/4 Inhibitor I            SCH772984 37  8  0.45
## 1622 IRAK-1/4 Inhibitor I          Cobimetinib 37  7  0.23
## 1623 IRAK-1/4 Inhibitor I           Trametinib 37  6  0.25
## 1624 IRAK-1/4 Inhibitor I             JNK-IN-8 37  5  0.22
## 1625 IRAK-1/4 Inhibitor I  Menin-MLL Inhibitor 37  4  0.42
## 1626 IRAK-1/4 Inhibitor I              AZD6738 37  3  0.17
## 1627 IRAK-1/4 Inhibitor I             KU-55933 37  2  0.16
## 1628 IRAK-1/4 Inhibitor I             SGC 0946 37  1  0.40
## 1629          Quizartinib          Quizartinib 38 25  1.00
## 1630          Quizartinib              MK-2206 38 24  0.34
## 1631          Quizartinib              AZD1208 38 23  0.46
## 1632          Quizartinib              AZD8055 38 22  0.32
## 1633          Quizartinib            Rapamycin 38 21  0.30
## 1634          Quizartinib               MI-503 38 20  0.24
## 1635          Quizartinib             Imatinib 38 19  0.31
## 1636          Quizartinib            Sunitinib 38 18  0.56
## 1637          Quizartinib            Foretinib 38 17  0.56
## 1638          Quizartinib           Tozasertib 38 16  0.38
## 1639          Quizartinib          Ruxolitinib 38 15  0.01
## 1640          Quizartinib          Tofacitinib 38 14  0.06
## 1641          Quizartinib           PF-3758309 38 13  0.17
## 1642          Quizartinib               OTX015 38 12 -0.20
## 1643          Quizartinib           Volasertib 38 11 -0.08
## 1644          Quizartinib           Ganetespib 38 10  0.14
## 1645          Quizartinib            Onalespib 38  9  0.25
## 1646          Quizartinib            SCH772984 38  8 -0.05
## 1647          Quizartinib          Cobimetinib 38  7 -0.16
## 1648          Quizartinib           Trametinib 38  6 -0.14
## 1649          Quizartinib             JNK-IN-8 38  5  0.08
## 1650          Quizartinib  Menin-MLL Inhibitor 38  4  0.25
## 1651          Quizartinib              AZD6738 38  3 -0.08
## 1652          Quizartinib             KU-55933 38  2 -0.08
## 1653          Quizartinib             SGC 0946 38  1  0.16
## 1654              MK-2206              MK-2206 39 24  1.00
## 1655              MK-2206              AZD1208 39 23  0.51
## 1656              MK-2206              AZD8055 39 22  0.71
## 1657              MK-2206            Rapamycin 39 21  0.65
## 1658              MK-2206               MI-503 39 20  0.30
## 1659              MK-2206             Imatinib 39 19  0.47
## 1660              MK-2206            Sunitinib 39 18  0.46
## 1661              MK-2206            Foretinib 39 17  0.54
## 1662              MK-2206           Tozasertib 39 16  0.49
## 1663              MK-2206          Ruxolitinib 39 15  0.15
## 1664              MK-2206          Tofacitinib 39 14 -0.02
## 1665              MK-2206           PF-3758309 39 13  0.27
## 1666              MK-2206               OTX015 39 12  0.20
## 1667              MK-2206           Volasertib 39 11  0.18
## 1668              MK-2206           Ganetespib 39 10  0.44
## 1669              MK-2206            Onalespib 39  9  0.46
## 1670              MK-2206            SCH772984 39  8  0.16
## 1671              MK-2206          Cobimetinib 39  7  0.24
## 1672              MK-2206           Trametinib 39  6  0.24
## 1673              MK-2206             JNK-IN-8 39  5  0.12
## 1674              MK-2206  Menin-MLL Inhibitor 39  4  0.25
## 1675              MK-2206              AZD6738 39  3  0.31
## 1676              MK-2206             KU-55933 39  2  0.35
## 1677              MK-2206             SGC 0946 39  1  0.25
## 1678              AZD1208              AZD1208 40 23  1.00
## 1679              AZD1208              AZD8055 40 22  0.66
## 1680              AZD1208            Rapamycin 40 21  0.66
## 1681              AZD1208               MI-503 40 20  0.35
## 1682              AZD1208             Imatinib 40 19  0.40
## 1683              AZD1208            Sunitinib 40 18  0.66
## 1684              AZD1208            Foretinib 40 17  0.56
## 1685              AZD1208           Tozasertib 40 16  0.54
## 1686              AZD1208          Ruxolitinib 40 15  0.33
## 1687              AZD1208          Tofacitinib 40 14  0.12
## 1688              AZD1208           PF-3758309 40 13  0.49
## 1689              AZD1208               OTX015 40 12  0.19
## 1690              AZD1208           Volasertib 40 11  0.26
## 1691              AZD1208           Ganetespib 40 10  0.39
## 1692              AZD1208            Onalespib 40  9  0.45
## 1693              AZD1208            SCH772984 40  8  0.22
## 1694              AZD1208          Cobimetinib 40  7  0.17
## 1695              AZD1208           Trametinib 40  6  0.16
## 1696              AZD1208             JNK-IN-8 40  5  0.06
## 1697              AZD1208  Menin-MLL Inhibitor 40  4  0.29
## 1698              AZD1208              AZD6738 40  3  0.20
## 1699              AZD1208             KU-55933 40  2  0.29
## 1700              AZD1208             SGC 0946 40  1  0.39
## 1701              AZD8055              AZD8055 41 22  1.00
## 1702              AZD8055            Rapamycin 41 21  0.79
## 1703              AZD8055               MI-503 41 20  0.35
## 1704              AZD8055             Imatinib 41 19  0.42
## 1705              AZD8055            Sunitinib 41 18  0.52
## 1706              AZD8055            Foretinib 41 17  0.54
## 1707              AZD8055           Tozasertib 41 16  0.59
## 1708              AZD8055          Ruxolitinib 41 15  0.30
## 1709              AZD8055          Tofacitinib 41 14  0.16
## 1710              AZD8055           PF-3758309 41 13  0.62
## 1711              AZD8055               OTX015 41 12  0.43
## 1712              AZD8055           Volasertib 41 11  0.39
## 1713              AZD8055           Ganetespib 41 10  0.57
## 1714              AZD8055            Onalespib 41  9  0.62
## 1715              AZD8055            SCH772984 41  8  0.39
## 1716              AZD8055          Cobimetinib 41  7  0.46
## 1717              AZD8055           Trametinib 41  6  0.44
## 1718              AZD8055             JNK-IN-8 41  5  0.15
## 1719              AZD8055  Menin-MLL Inhibitor 41  4  0.16
## 1720              AZD8055              AZD6738 41  3  0.32
## 1721              AZD8055             KU-55933 41  2  0.23
## 1722              AZD8055             SGC 0946 41  1  0.24
## 1723            Rapamycin            Rapamycin 42 21  1.00
## 1724            Rapamycin               MI-503 42 20  0.37
## 1725            Rapamycin             Imatinib 42 19  0.47
## 1726            Rapamycin            Sunitinib 42 18  0.52
## 1727            Rapamycin            Foretinib 42 17  0.66
## 1728            Rapamycin           Tozasertib 42 16  0.60
## 1729            Rapamycin          Ruxolitinib 42 15  0.37
## 1730            Rapamycin          Tofacitinib 42 14  0.16
## 1731            Rapamycin           PF-3758309 42 13  0.59
## 1732            Rapamycin               OTX015 42 12  0.41
## 1733            Rapamycin           Volasertib 42 11  0.34
## 1734            Rapamycin           Ganetespib 42 10  0.48
## 1735            Rapamycin            Onalespib 42  9  0.50
## 1736            Rapamycin            SCH772984 42  8  0.37
## 1737            Rapamycin          Cobimetinib 42  7  0.43
## 1738            Rapamycin           Trametinib 42  6  0.43
## 1739            Rapamycin             JNK-IN-8 42  5  0.20
## 1740            Rapamycin  Menin-MLL Inhibitor 42  4  0.19
## 1741            Rapamycin              AZD6738 42  3  0.17
## 1742            Rapamycin             KU-55933 42  2  0.43
## 1743            Rapamycin             SGC 0946 42  1  0.35
## 1744               MI-503               MI-503 43 20  1.00
## 1745               MI-503             Imatinib 43 19  0.44
## 1746               MI-503            Sunitinib 43 18  0.52
## 1747               MI-503            Foretinib 43 17  0.45
## 1748               MI-503           Tozasertib 43 16  0.48
## 1749               MI-503          Ruxolitinib 43 15  0.44
## 1750               MI-503          Tofacitinib 43 14  0.21
## 1751               MI-503           PF-3758309 43 13  0.39
## 1752               MI-503               OTX015 43 12  0.35
## 1753               MI-503           Volasertib 43 11  0.40
## 1754               MI-503           Ganetespib 43 10  0.40
## 1755               MI-503            Onalespib 43  9  0.35
## 1756               MI-503            SCH772984 43  8  0.44
## 1757               MI-503          Cobimetinib 43  7  0.38
## 1758               MI-503           Trametinib 43  6  0.38
## 1759               MI-503             JNK-IN-8 43  5  0.05
## 1760               MI-503  Menin-MLL Inhibitor 43  4  0.11
## 1761               MI-503              AZD6738 43  3  0.17
## 1762               MI-503             KU-55933 43  2  0.12
## 1763               MI-503             SGC 0946 43  1  0.36
## 1764             Imatinib             Imatinib 44 19  1.00
## 1765             Imatinib            Sunitinib 44 18  0.59
## 1766             Imatinib            Foretinib 44 17  0.62
## 1767             Imatinib           Tozasertib 44 16  0.65
## 1768             Imatinib          Ruxolitinib 44 15  0.32
## 1769             Imatinib          Tofacitinib 44 14  0.25
## 1770             Imatinib           PF-3758309 44 13  0.33
## 1771             Imatinib               OTX015 44 12  0.18
## 1772             Imatinib           Volasertib 44 11  0.25
## 1773             Imatinib           Ganetespib 44 10  0.54
## 1774             Imatinib            Onalespib 44  9  0.53
## 1775             Imatinib            SCH772984 44  8  0.41
## 1776             Imatinib          Cobimetinib 44  7  0.40
## 1777             Imatinib           Trametinib 44  6  0.41
## 1778             Imatinib             JNK-IN-8 44  5  0.14
## 1779             Imatinib  Menin-MLL Inhibitor 44  4  0.35
## 1780             Imatinib              AZD6738 44  3  0.17
## 1781             Imatinib             KU-55933 44  2  0.20
## 1782             Imatinib             SGC 0946 44  1  0.31
## 1783            Sunitinib            Sunitinib 45 18  1.00
## 1784            Sunitinib            Foretinib 45 17  0.76
## 1785            Sunitinib           Tozasertib 45 16  0.69
## 1786            Sunitinib          Ruxolitinib 45 15  0.34
## 1787            Sunitinib          Tofacitinib 45 14  0.20
## 1788            Sunitinib           PF-3758309 45 13  0.54
## 1789            Sunitinib               OTX015 45 12  0.18
## 1790            Sunitinib           Volasertib 45 11  0.27
## 1791            Sunitinib           Ganetespib 45 10  0.49
## 1792            Sunitinib            Onalespib 45  9  0.53
## 1793            Sunitinib            SCH772984 45  8  0.35
## 1794            Sunitinib          Cobimetinib 45  7  0.32
## 1795            Sunitinib           Trametinib 45  6  0.28
## 1796            Sunitinib             JNK-IN-8 45  5 -0.06
## 1797            Sunitinib  Menin-MLL Inhibitor 45  4  0.26
## 1798            Sunitinib              AZD6738 45  3  0.15
## 1799            Sunitinib             KU-55933 45  2  0.09
## 1800            Sunitinib             SGC 0946 45  1  0.26
## 1801            Foretinib            Foretinib 46 17  1.00
## 1802            Foretinib           Tozasertib 46 16  0.79
## 1803            Foretinib          Ruxolitinib 46 15  0.27
## 1804            Foretinib          Tofacitinib 46 14  0.14
## 1805            Foretinib           PF-3758309 46 13  0.36
## 1806            Foretinib               OTX015 46 12  0.04
## 1807            Foretinib           Volasertib 46 11  0.07
## 1808            Foretinib           Ganetespib 46 10  0.47
## 1809            Foretinib            Onalespib 46  9  0.50
## 1810            Foretinib            SCH772984 46  8  0.34
## 1811            Foretinib          Cobimetinib 46  7  0.27
## 1812            Foretinib           Trametinib 46  6  0.25
## 1813            Foretinib             JNK-IN-8 46  5  0.16
## 1814            Foretinib  Menin-MLL Inhibitor 46  4  0.18
## 1815            Foretinib              AZD6738 46  3  0.17
## 1816            Foretinib             KU-55933 46  2  0.23
## 1817            Foretinib             SGC 0946 46  1  0.26
## 1818           Tozasertib           Tozasertib 47 16  1.00
## 1819           Tozasertib          Ruxolitinib 47 15  0.52
## 1820           Tozasertib          Tofacitinib 47 14  0.34
## 1821           Tozasertib           PF-3758309 47 13  0.55
## 1822           Tozasertib               OTX015 47 12  0.25
## 1823           Tozasertib           Volasertib 47 11  0.30
## 1824           Tozasertib           Ganetespib 47 10  0.72
## 1825           Tozasertib            Onalespib 47  9  0.71
## 1826           Tozasertib            SCH772984 47  8  0.59
## 1827           Tozasertib          Cobimetinib 47  7  0.54
## 1828           Tozasertib           Trametinib 47  6  0.52
## 1829           Tozasertib             JNK-IN-8 47  5  0.21
## 1830           Tozasertib  Menin-MLL Inhibitor 47  4  0.19
## 1831           Tozasertib              AZD6738 47  3  0.18
## 1832           Tozasertib             KU-55933 47  2  0.25
## 1833           Tozasertib             SGC 0946 47  1  0.36
## 1834          Ruxolitinib          Ruxolitinib 48 15  1.00
## 1835          Ruxolitinib          Tofacitinib 48 14  0.69
## 1836          Ruxolitinib           PF-3758309 48 13  0.52
## 1837          Ruxolitinib               OTX015 48 12  0.43
## 1838          Ruxolitinib           Volasertib 48 11  0.44
## 1839          Ruxolitinib           Ganetespib 48 10  0.60
## 1840          Ruxolitinib            Onalespib 48  9  0.50
## 1841          Ruxolitinib            SCH772984 48  8  0.73
## 1842          Ruxolitinib          Cobimetinib 48  7  0.61
## 1843          Ruxolitinib           Trametinib 48  6  0.65
## 1844          Ruxolitinib             JNK-IN-8 48  5  0.27
## 1845          Ruxolitinib  Menin-MLL Inhibitor 48  4  0.19
## 1846          Ruxolitinib              AZD6738 48  3  0.23
## 1847          Ruxolitinib             KU-55933 48  2  0.32
## 1848          Ruxolitinib             SGC 0946 48  1  0.41
## 1849          Tofacitinib          Tofacitinib 49 14  1.00
## 1850          Tofacitinib           PF-3758309 49 13  0.36
## 1851          Tofacitinib               OTX015 49 12  0.30
## 1852          Tofacitinib           Volasertib 49 11  0.28
## 1853          Tofacitinib           Ganetespib 49 10  0.44
## 1854          Tofacitinib            Onalespib 49  9  0.33
## 1855          Tofacitinib            SCH772984 49  8  0.41
## 1856          Tofacitinib          Cobimetinib 49  7  0.36
## 1857          Tofacitinib           Trametinib 49  6  0.44
## 1858          Tofacitinib             JNK-IN-8 49  5  0.41
## 1859          Tofacitinib  Menin-MLL Inhibitor 49  4  0.32
## 1860          Tofacitinib              AZD6738 49  3  0.22
## 1861          Tofacitinib             KU-55933 49  2  0.07
## 1862          Tofacitinib             SGC 0946 49  1  0.17
## 1863           PF-3758309           PF-3758309 50 13  1.00
## 1864           PF-3758309               OTX015 50 12  0.78
## 1865           PF-3758309           Volasertib 50 11  0.74
## 1866           PF-3758309           Ganetespib 50 10  0.71
## 1867           PF-3758309            Onalespib 50  9  0.68
## 1868           PF-3758309            SCH772984 50  8  0.60
## 1869           PF-3758309          Cobimetinib 50  7  0.65
## 1870           PF-3758309           Trametinib 50  6  0.62
## 1871           PF-3758309             JNK-IN-8 50  5  0.05
## 1872           PF-3758309  Menin-MLL Inhibitor 50  4  0.19
## 1873           PF-3758309              AZD6738 50  3  0.04
## 1874           PF-3758309             KU-55933 50  2  0.16
## 1875           PF-3758309             SGC 0946 50  1  0.08
## 1876               OTX015               OTX015 51 12  1.00
## 1877               OTX015           Volasertib 51 11  0.91
## 1878               OTX015           Ganetespib 51 10  0.54
## 1879               OTX015            Onalespib 51  9  0.46
## 1880               OTX015            SCH772984 51  8  0.55
## 1881               OTX015          Cobimetinib 51  7  0.68
## 1882               OTX015           Trametinib 51  6  0.68
## 1883               OTX015             JNK-IN-8 51  5  0.06
## 1884               OTX015  Menin-MLL Inhibitor 51  4  0.15
## 1885               OTX015              AZD6738 51  3  0.07
## 1886               OTX015             KU-55933 51  2  0.30
## 1887               OTX015             SGC 0946 51  1  0.06
## 1888           Volasertib           Volasertib 52 11  1.00
## 1889           Volasertib           Ganetespib 52 10  0.53
## 1890           Volasertib            Onalespib 52  9  0.47
## 1891           Volasertib            SCH772984 52  8  0.52
## 1892           Volasertib          Cobimetinib 52  7  0.59
## 1893           Volasertib           Trametinib 52  6  0.61
## 1894           Volasertib             JNK-IN-8 52  5  0.11
## 1895           Volasertib  Menin-MLL Inhibitor 52  4  0.25
## 1896           Volasertib              AZD6738 52  3  0.12
## 1897           Volasertib             KU-55933 52  2  0.30
## 1898           Volasertib             SGC 0946 52  1  0.16
## 1899           Ganetespib           Ganetespib 53 10  1.00
## 1900           Ganetespib            Onalespib 53  9  0.95
## 1901           Ganetespib            SCH772984 53  8  0.73
## 1902           Ganetespib          Cobimetinib 53  7  0.76
## 1903           Ganetespib           Trametinib 53  6  0.75
## 1904           Ganetespib             JNK-IN-8 53  5  0.20
## 1905           Ganetespib  Menin-MLL Inhibitor 53  4  0.26
## 1906           Ganetespib              AZD6738 53  3  0.20
## 1907           Ganetespib             KU-55933 53  2  0.22
## 1908           Ganetespib             SGC 0946 53  1  0.26
## 1909            Onalespib            Onalespib 54  9  1.00
## 1910            Onalespib            SCH772984 54  8  0.65
## 1911            Onalespib          Cobimetinib 54  7  0.66
## 1912            Onalespib           Trametinib 54  6  0.65
## 1913            Onalespib             JNK-IN-8 54  5  0.19
## 1914            Onalespib  Menin-MLL Inhibitor 54  4  0.29
## 1915            Onalespib              AZD6738 54  3  0.18
## 1916            Onalespib             KU-55933 54  2  0.18
## 1917            Onalespib             SGC 0946 54  1  0.27
## 1918            SCH772984            SCH772984 55  8  1.00
## 1919            SCH772984          Cobimetinib 55  7  0.88
## 1920            SCH772984           Trametinib 55  6  0.91
## 1921            SCH772984             JNK-IN-8 55  5  0.05
## 1922            SCH772984  Menin-MLL Inhibitor 55  4  0.16
## 1923            SCH772984              AZD6738 55  3  0.19
## 1924            SCH772984             KU-55933 55  2  0.35
## 1925            SCH772984             SGC 0946 55  1  0.36
## 1926          Cobimetinib          Cobimetinib 56  7  1.00
## 1927          Cobimetinib           Trametinib 56  6  0.96
## 1928          Cobimetinib             JNK-IN-8 56  5 -0.04
## 1929          Cobimetinib  Menin-MLL Inhibitor 56  4  0.05
## 1930          Cobimetinib              AZD6738 56  3  0.21
## 1931          Cobimetinib             KU-55933 56  2  0.29
## 1932          Cobimetinib             SGC 0946 56  1  0.21
## 1933           Trametinib           Trametinib 57  6  1.00
## 1934           Trametinib             JNK-IN-8 57  5  0.04
## 1935           Trametinib  Menin-MLL Inhibitor 57  4  0.14
## 1936           Trametinib              AZD6738 57  3  0.24
## 1937           Trametinib             KU-55933 57  2  0.33
## 1938           Trametinib             SGC 0946 57  1  0.31
## 1939             JNK-IN-8             JNK-IN-8 58  5  1.00
## 1940             JNK-IN-8  Menin-MLL Inhibitor 58  4  0.36
## 1941             JNK-IN-8              AZD6738 58  3  0.18
## 1942             JNK-IN-8             KU-55933 58  2  0.12
## 1943             JNK-IN-8             SGC 0946 58  1  0.18
## 1944  Menin-MLL Inhibitor  Menin-MLL Inhibitor 59  4  1.00
## 1945  Menin-MLL Inhibitor              AZD6738 59  3  0.10
## 1946  Menin-MLL Inhibitor             KU-55933 59  2  0.35
## 1947  Menin-MLL Inhibitor             SGC 0946 59  1  0.20
## 1948              AZD6738              AZD6738 60  3  1.00
## 1949              AZD6738             KU-55933 60  2  0.21
## 1950              AZD6738             SGC 0946 60  1  0.19
## 1951             KU-55933             KU-55933 61  2  1.00
## 1952             KU-55933             SGC 0946 61  1  0.44
## 1953             SGC 0946             SGC 0946 62  1  1.00
## 
## $arg
## $arg$type
## [1] "lower"
grid.echo()

P2 <- grid.grab()
grid.draw(P2)

#Plot2
# save correlation matrix colors to a vector, then make coloured matrix grob transparent
matrix.colors2 <- getGrob(P2, gPath("square"), grep = TRUE)[["gp"]][["fill"]]
P2 <- editGrob(P2,
               gPath("square"), grep = TRUE,
               gp = gpar(col = NA,
                         fill = NA))

# apply the saved colours to the underlying matrix grob
P2 <- editGrob(P2,
               gPath("symbols-rect-1"), grep = TRUE,
               gp = gpar(fill = matrix.colors2))

# convert the background fill from white to transparent, while we are at it
P2 <- editGrob(P2,
               gPath("background"), grep = TRUE,
               gp = gpar(fill = NA))


#create a separate legend for pathways
colors_cor_heatmap <- df_pathway |> 
  filter(Pathway_mod %in% c("AKT/mTOR", "MAPK" , "B-cell receptor", "PI3K", "Stress pathway"))

colors_cor_heatmap$Pathway_mod[colors_cor_heatmap$Pathway_mod=="MAPK"] <- "MEK/ERK"
colors_cor_heatmap$random_value <- seq(1,nrow(colors_cor_heatmap),1)

legend_plot <- ggplot(colors_cor_heatmap, aes(x = Drug, y = random_value, fill = Pathway_mod)) +
  geom_tile() +
  scale_fill_manual(values = colors_cor_heatmap) +
  labs(fill = "Pathway") +
  theme_minimal() +
  theme(
  legend.title = element_text(size=8, face="bold"), 
  legend.text=element_text(size=8), legend.key.size = unit(0.3, 'cm'),
  legend.direction="vertical")+
  guides(fill = guide_legend(
    title.position="top", 
    title.hjust = 0,
    override.aes = list(shape = 1)))
  
legend <- get_legend(legend_plot)  
## Warning: No shared levels found between `names(values)` of the manual scale and the
## data's fill values.
## Warning: No shared levels found between `names(values)` of the manual scale and the
## data's fill values.
#put all plots together
fig_corrplot <- grid.arrange(P1, P2, ncol = 2)

Fig4a <- plot_grid(P1, P2, ncol = 2, nrow = 1, align = "h", scale=1, rel_heights = c(1, 1), rel_widths = c(1, 1), greedy = TRUE)+
          draw_plot(legend, x=0.82, y=0.4, height=0.25, width=0.25)+
          theme(plot.margin = margin(t=1, unit = "cm"))
## Warning in as_grob.default(plot): Cannot convert object of class NULL into a
## grob.
Fig4a

ggsave(path=(paste0(filepath,"figures")), filename = "Fig4a_correlation_heatmap.svg", width=42, height=30, units = "cm")

6.2 Scatter plots for drug-drug correlations (Fig. 4B)

#select drugs
drugs_show_corr <- c("SCH772984", "Cobimetinib", "Ibrutinib", "Idelalisib", "Cobimetinib", "Rapamycin")

#helper function for CLL
corr_drugs_cll <- screen_means |> 
  filter(diagnosis == c("CLL"), drug %in% drugs_show_corr) |> 
  pivot_wider(names_from = drug, values_from = mean_viab)

corr_drugs_aml <- screen_means |> 
  filter(diagnosis == c("AML"), drug %in% drugs_show_corr) |> 
  pivot_wider(names_from = drug, values_from = mean_viab)

corr_drugs <- rbind(corr_drugs_cll, corr_drugs_aml)

plot_corr <- function(data, x, y, xlab, ylab) {
  
  corr_labels <- data |> 
    group_by(diagnosis) |> 
    summarize(corr=cor(.data[[x]], .data[[y]], use = "complete.obs"),
              .groups = "drop")
  
  ggplot(data, aes_string(x = x, y = y)) +
    geom_point(aes(color = diagnosis), alpha = 0.5) +
    geom_smooth(method = "lm", se = TRUE,
                color = "black", fill = "lightgrey") + 
    labs(x = xlab, y = ylab, color="Diagnosis")+
    facet_wrap(~diagnosis)+
    theme_figures + 
    theme(strip.background = element_blank(),
          strip.text.x = element_blank())+
    geom_text(data = corr_labels, aes(x = 0.8, y = 1.1, 
                                      label = paste0("italic(R) == ", round(corr, 2))), size=3, parse = TRUE) +
    xlim(0.4,1.2) + ylim(0.4,1.2) +
    scale_color_manual(values = colors_diag)
}

#plot
p1 <- plot_corr(corr_drugs, "SCH772984", "Cobimetinib", xlab="SCH772984 (ERK)", ylab= "Cobimetinib (MEK)")
## Warning: `aes_string()` was deprecated in ggplot2 3.0.0.
## ℹ Please use tidy evaluation idioms with `aes()`.
## ℹ See also `vignette("ggplot2-in-packages")` for more information.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
p2 <- plot_corr(corr_drugs, "Ibrutinib", "Idelalisib", xlab="Ibrutinib (BTK)", ylab= "Idelalisib (PI3K)")
p3 <- plot_corr(corr_drugs, "Ibrutinib", "Cobimetinib", xlab="Ibrutinib (BTK)", ylab= "Cobimetinib (MEK)")
p4 <- plot_corr(corr_drugs, "Rapamycin", "Idelalisib", xlab="Rapamycin (mTOR)", ylab= "Idelalisib (PI3K)")

Fig4b <- p1+plot_spacer()+p2+plot_spacer()+p3+plot_spacer()+p4+plot_layout(ncol=7, widths = c(4, 0.5, 4, 0.5, 4, 0.5, 4), guides = 'collect') & theme(legend.position='right', plot.margin = margin(t=1, l=0.5, unit = "cm"))
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'
## `geom_smooth()` using formula = 'y ~ x'

7 Genotype-phenotype associations in CLL

7.1 P value scatterplot

#prepare data
#pTab <- ... (adapt from Junyans script)

pTab <- read.csv(paste0(filepath,"data/pTable_drug_VS_gene.csv"), sep=";") |> 
  mutate(across(c(p, p.adj, diff), ~as.numeric(gsub(",", ".", as.character(.)))))

#number of significant associations per gene (10% FDR)
plotTab1 <- filter(pTab, p.adj <= 0.1) %>% group_by(gene) %>%
  summarise(number = length(drug)) %>%
  arrange(desc(number)) %>% mutate(gene = factor(gene, levels = gene))

#p value scatter plot (IGHV not shown)
top_genes <- as.vector(unlist(plotTab1[2:8,"gene"]))
showGenes <- sort(top_genes)
append(showGenes, "other")
## [1] "DDX3X"     "del11q"    "del13q"    "del17p"    "gain19p"   "TP53"     
## [7] "trisomy12" "other"
#define colors for each gene
library(RColorBrewer)
colorList <- c(colorRampPalette(brewer.pal(7, 'Set2'))(7), 
               "grey80", "grey90")
  
names(colorList) = c(showGenes, "other", "Below 10% FDR")

colorList["del17p"] <- "#FC8D62" 
colorList["del11q"] <- "#E5C494"
colorList["trisomy12"] <- "#FFD92F"
colorList["DDX3X"] <- "#E78AC3"
colorList["TP53"] <- "#66C2A5"

#define shapes for viability
shapeList <- ifelse(names(colorList) %in% showGenes, 19,1)
names(shapeList) <- names(colorList)
shapeList["other"] <- 19

shapeList <- c(1, 25, 24)
names(shapeList) = c("Below 10% FDR", "Down", "Up")

#order drugs by their association similarity
pMat <- dplyr::select(pTab, drug, gene, p) %>% 
  filter(gene!="IGHV.status") %>%
  spread(key = gene, value = p) %>%
  column_to_rownames("drug") %>% 
  as.matrix()

hc <- hclust(dist(pMat), method = "ward.D2")
drugOrder <- rownames(pMat)[hc$order]

#order drugs by p value
pval_list <- pTab |> 
  filter(gene != "IGHV.status") |> 
  group_by(drug) |> 
  summarize(pval = min(p)) |> 
  arrange(pval, descending = FALSE)

drugOrder2 <- pval_list$drug

#prepare plot table
plotTab <- pTab %>% filter(gene != "IGHV.status") %>%
  mutate(gene = ifelse(gene %in% showGenes, gene, "other")) %>%
  mutate(gene_FDR = ifelse(p.adj < 0.1, gene, "Below 10% FDR"),
         drug = factor(drug, levels = drugOrder2),
         gene = factor(gene, levels = names(colorList)),
         direction = ifelse(gene_FDR == "Below 10% FDR", "Below 10% FDR", ifelse(sign(diff)>0, "Down", "Up"))) 

#plot
Fig5a <- ggplot(plotTab, aes(x=drug, y = -log10(p), color = gene, shape = direction)) +
  geom_point(size =2, alpha = 0.8, stroke = 1) + scale_color_manual(values = colorList) +
  scale_shape_manual(values = shapeList, name = "Viability effect") + theme_bw() +
  labs(x="", y = expression(-log[10]*italic(P)), color = "Genetic aberration")+
  theme(axis.text.x = element_text(angle = 45, hjust =1, vjust=1, 
                                   color="black", size=8), 
        axis.text.y = element_text(color="black", size=8), 
        axis.title.y = element_text(size=8), 
        legend.title = element_text(size=8, face="bold"), 
        legend.text=element_text(size=8),
        panel.grid.major.x = element_line(size=.1, color="grey50", 
                                          linetype = "dotted"),
        panel.grid.major.y = element_blank(),
        panel.grid.minor.y = element_blank(),
        panel.border = element_rect(color = 'black', 
                                    fill = NA, 
                                    size = 1),
        plot.margin = margin(t=1, l=1, unit = "cm"),
        legend.position = c(.95, .95),
        legend.justification = c("right", "top"),
        legend.box.just = "right",
        legend.box = "horizontal", 
        legend.margin = margin(6, 6, 6, 6))+
  geom_hline(yintercept=-log10(0.004706046), linetype = "dashed", linewidth=0.3, color="black")+
  annotate("text", label="FDR 10%", size=3, x=60, y=3)+
  guides(shape = guide_legend(order = 1),
         color = guide_legend(order = 2))
## Warning: The `size` argument of `element_rect()` is deprecated as of ggplot2 3.4.0.
## ℹ Please use the `linewidth` argument instead.
## This warning is displayed once every 8 hours.
## Call `lifecycle::last_lifecycle_warnings()` to see where this warning was
## generated.
Fig5a

ggsave(path=(paste0(filepath,"figures")), filename = "Fig5a_pvalue_scatterplot.svg")
## Saving 8 x 5 in image

7.2 Volcano plots (for IGHV, trisomy12 and TP53)

7.3 Dose-response relationship in DDX3X-mutated U-CLL

7.3.1 BTK vs PI3K

7.4 Lasso model

7.5 del11q

7.6 trisomy(12) in M-CLL and U-CLL

7.7 Fludarabine and nutlin-3a in TP53-mutated CLL

8 DDX3X

8.1 Overview of mutations

8.1.1 Table

8.1.2 Lollipop plot

8.1.3 RNA-seq gene set signature

8.1.4 RNA seq volcano plot for single genes

8.1.5 Heatmaps

8.1.6 Genes of interest: NLRP3 and DDX3Y

9 Longitudinal analysis

9.1 Distribution

9.2 Treatment contexts

9.3 Longitudinal changes in drug response

9.3.1 P value heatmap

9.3.2 Drugs of interest

9.3.3 Absolute differences in mean viability

#Clinical correlation…

```